AU2004222044B2 - 7-imino derivatives of camptothecin having antitumor activity - Google Patents

7-imino derivatives of camptothecin having antitumor activity Download PDF

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Publication number
AU2004222044B2
AU2004222044B2 AU2004222044A AU2004222044A AU2004222044B2 AU 2004222044 B2 AU2004222044 B2 AU 2004222044B2 AU 2004222044 A AU2004222044 A AU 2004222044A AU 2004222044 A AU2004222044 A AU 2004222044A AU 2004222044 B2 AU2004222044 B2 AU 2004222044B2
Authority
AU
Australia
Prior art keywords
formula
group
compounds
compound
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004222044A
Other languages
English (en)
Other versions
AU2004222044A1 (en
Inventor
Sabrina Dallavalle
Sergio Penco
Claudio Pisano
Franco Zunino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Nazionale per lo Studio e la Cura die Tumori, Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Istituto Nazionale per lo Studio e la Cura die Tumori
Publication of AU2004222044A1 publication Critical patent/AU2004222044A1/en
Application granted granted Critical
Publication of AU2004222044B2 publication Critical patent/AU2004222044B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2004222044A 2003-03-17 2004-03-10 7-imino derivatives of camptothecin having antitumor activity Ceased AU2004222044B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/388,587 US7105492B2 (en) 1999-03-09 2003-03-17 Camptothecin derivatives having antitumor activity
US10/388,587 2003-03-17
PCT/IT2004/000118 WO2004083214A1 (en) 2003-03-17 2004-03-10 7-imino derivatives of camptothecin having antitumor activity

Publications (2)

Publication Number Publication Date
AU2004222044A1 AU2004222044A1 (en) 2004-09-30
AU2004222044B2 true AU2004222044B2 (en) 2010-02-25

Family

ID=33029646

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004222044A Ceased AU2004222044B2 (en) 2003-03-17 2004-03-10 7-imino derivatives of camptothecin having antitumor activity

Country Status (19)

Country Link
US (2) US7105492B2 (https=)
EP (1) EP1603919B1 (https=)
JP (1) JP4791355B2 (https=)
KR (1) KR101174112B1 (https=)
CN (1) CN100372855C (https=)
AR (1) AR043620A1 (https=)
AT (1) ATE417851T1 (https=)
AU (1) AU2004222044B2 (https=)
BR (1) BRPI0408380A (https=)
CA (1) CA2517450C (https=)
CY (1) CY1108890T1 (https=)
DE (1) DE602004018468D1 (https=)
DK (1) DK1603919T3 (https=)
ES (1) ES2319293T3 (https=)
PL (1) PL1603919T3 (https=)
PT (1) PT1603919E (https=)
SI (1) SI1603919T1 (https=)
TW (1) TWI341840B (https=)
WO (1) WO2004083214A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
CN101080227B (zh) * 2004-12-15 2011-08-31 诺瓦提斯公司 用于治疗癌症的治疗剂的组合
US7291936B1 (en) * 2006-05-03 2007-11-06 Robson John H Submersible electrical power generating plant
CN102731516B (zh) * 2011-04-07 2014-07-02 宁波天衡药业股份有限公司 一类具有抗肿瘤活性的喜树碱衍生物
WO2022140504A1 (en) * 2020-12-23 2022-06-30 Shanghai Ruotuo Biosciences Co., Ltd. Antibody-drug conjugates, pharmaceutical compositions, and therapeutic applications

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1044977A1 (en) * 1999-03-09 2000-10-18 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Camptothecin derivatives having antitumor activity

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
JPS58154582A (ja) 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
ATE247471T1 (de) 1991-11-15 2003-09-15 Smithkline Beecham Corp Cisplatin und topotecan enthaltende zusammensetzung als antitumor.
US5614529A (en) 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
US5972955A (en) 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
IT1282673B1 (it) 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
KR100516593B1 (ko) 1996-08-19 2005-09-22 바이오누머릭 파마슈티칼스, 인코포레이티드 고 친유성 캠프토테신 유도체
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1044977A1 (en) * 1999-03-09 2000-10-18 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Camptothecin derivatives having antitumor activity
US6242457B1 (en) * 1999-03-09 2001-06-05 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Dallavale et al, "Novel Cytotoxic 7-Iminomethyl and 7-Aminomethyl Derivatives of Camptothecin", (2001), Bioorganic & Medicinal Chemistry Letters, 11, 291-294 *

Also Published As

Publication number Publication date
AR043620A1 (es) 2005-08-03
KR101174112B1 (ko) 2012-08-16
AU2004222044A1 (en) 2004-09-30
WO2004083214A1 (en) 2004-09-30
HK1089160A1 (zh) 2006-11-24
CN100372855C (zh) 2008-03-05
JP4791355B2 (ja) 2011-10-12
DK1603919T3 (da) 2009-03-09
US7105492B2 (en) 2006-09-12
US7351714B2 (en) 2008-04-01
US20060167033A1 (en) 2006-07-27
EP1603919A1 (en) 2005-12-14
PT1603919E (pt) 2009-02-16
CY1108890T1 (el) 2014-07-02
CA2517450C (en) 2011-06-14
DE602004018468D1 (de) 2009-01-29
CA2517450A1 (en) 2004-09-30
TW200504076A (en) 2005-02-01
US20040018988A1 (en) 2004-01-29
TWI341840B (en) 2011-05-11
JP2006520807A (ja) 2006-09-14
PL1603919T3 (pl) 2009-06-30
CN1761668A (zh) 2006-04-19
SI1603919T1 (sl) 2009-04-30
ATE417851T1 (de) 2009-01-15
BRPI0408380A (pt) 2006-03-21
KR20050107756A (ko) 2005-11-15
ES2319293T3 (es) 2009-05-06
EP1603919B1 (en) 2008-12-17

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KR101398591B1 (ko) 제암성 활성을 갖는 캠토테신 유도체
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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired