KR101174112B1 - 종양 억제 활성을 갖는 캄토테신의 7-이미노 유도체 - Google Patents

종양 억제 활성을 갖는 캄토테신의 7-이미노 유도체 Download PDF

Info

Publication number
KR101174112B1
KR101174112B1 KR1020057015243A KR20057015243A KR101174112B1 KR 101174112 B1 KR101174112 B1 KR 101174112B1 KR 1020057015243 A KR1020057015243 A KR 1020057015243A KR 20057015243 A KR20057015243 A KR 20057015243A KR 101174112 B1 KR101174112 B1 KR 101174112B1
Authority
KR
South Korea
Prior art keywords
compound
formula
group
tumor
camptothecin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020057015243A
Other languages
English (en)
Korean (ko)
Other versions
KR20050107756A (ko
Inventor
사브리나 달라발레
세르지오 펜코
클라우디오 피사노
프란코 주니노
Original Assignee
이스티튜토나치오날레페르로스튜디오에라쿠라데이투모리
시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이스티튜토나치오날레페르로스튜디오에라쿠라데이투모리, 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. filed Critical 이스티튜토나치오날레페르로스튜디오에라쿠라데이투모리
Publication of KR20050107756A publication Critical patent/KR20050107756A/ko
Application granted granted Critical
Publication of KR101174112B1 publication Critical patent/KR101174112B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020057015243A 2003-03-17 2004-03-10 종양 억제 활성을 갖는 캄토테신의 7-이미노 유도체 Expired - Fee Related KR101174112B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/388,587 US7105492B2 (en) 1999-03-09 2003-03-17 Camptothecin derivatives having antitumor activity
US10/388,587 2003-03-17

Publications (2)

Publication Number Publication Date
KR20050107756A KR20050107756A (ko) 2005-11-15
KR101174112B1 true KR101174112B1 (ko) 2012-08-16

Family

ID=33029646

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057015243A Expired - Fee Related KR101174112B1 (ko) 2003-03-17 2004-03-10 종양 억제 활성을 갖는 캄토테신의 7-이미노 유도체

Country Status (19)

Country Link
US (2) US7105492B2 (https=)
EP (1) EP1603919B1 (https=)
JP (1) JP4791355B2 (https=)
KR (1) KR101174112B1 (https=)
CN (1) CN100372855C (https=)
AR (1) AR043620A1 (https=)
AT (1) ATE417851T1 (https=)
AU (1) AU2004222044B2 (https=)
BR (1) BRPI0408380A (https=)
CA (1) CA2517450C (https=)
CY (1) CY1108890T1 (https=)
DE (1) DE602004018468D1 (https=)
DK (1) DK1603919T3 (https=)
ES (1) ES2319293T3 (https=)
PL (1) PL1603919T3 (https=)
PT (1) PT1603919E (https=)
SI (1) SI1603919T1 (https=)
TW (1) TWI341840B (https=)
WO (1) WO2004083214A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
US8975248B2 (en) * 2004-12-15 2015-03-10 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Combinations of therapeutic agents for treating cancer
US7291936B1 (en) * 2006-05-03 2007-11-06 Robson John H Submersible electrical power generating plant
CN102731516B (zh) * 2011-04-07 2014-07-02 宁波天衡药业股份有限公司 一类具有抗肿瘤活性的喜树碱衍生物
WO2022140504A1 (en) * 2020-12-23 2022-06-30 Shanghai Ruotuo Biosciences Co., Ltd. Antibody-drug conjugates, pharmaceutical compositions, and therapeutic applications

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
JPS58154582A (ja) * 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
DK0612248T3 (da) * 1991-11-15 2003-12-08 Smithkline Beecham Corp Præparat, der indeholder cisplatin og topotecan som antitumormiddel
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
US5972955A (en) * 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
IT1282673B1 (it) 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
IL127800A (en) 1996-08-19 2005-11-20 Bionumerik Pharmaceuticals Inc Highly lipophilic 7-substituted camptothecin derivatives and pharmaceutical compositions containing them
ATE216998T1 (de) 1999-03-09 2002-05-15 Sigma Tau Ind Farmaceuti Camptothecin-derivate mit antitumor-wirkung
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity

Also Published As

Publication number Publication date
DE602004018468D1 (de) 2009-01-29
ES2319293T3 (es) 2009-05-06
HK1089160A1 (zh) 2006-11-24
PL1603919T3 (pl) 2009-06-30
AR043620A1 (es) 2005-08-03
EP1603919B1 (en) 2008-12-17
DK1603919T3 (da) 2009-03-09
WO2004083214A1 (en) 2004-09-30
US20040018988A1 (en) 2004-01-29
US7105492B2 (en) 2006-09-12
US7351714B2 (en) 2008-04-01
JP2006520807A (ja) 2006-09-14
CA2517450C (en) 2011-06-14
TW200504076A (en) 2005-02-01
CA2517450A1 (en) 2004-09-30
CN100372855C (zh) 2008-03-05
CY1108890T1 (el) 2014-07-02
EP1603919A1 (en) 2005-12-14
US20060167033A1 (en) 2006-07-27
SI1603919T1 (sl) 2009-04-30
PT1603919E (pt) 2009-02-16
JP4791355B2 (ja) 2011-10-12
CN1761668A (zh) 2006-04-19
AU2004222044A1 (en) 2004-09-30
TWI341840B (en) 2011-05-11
KR20050107756A (ko) 2005-11-15
ATE417851T1 (de) 2009-01-15
AU2004222044B2 (en) 2010-02-25
BRPI0408380A (pt) 2006-03-21

Similar Documents

Publication Publication Date Title
JP4610743B2 (ja) 抗腫瘍活性を有するカンプトテシン誘導体
KR101174112B1 (ko) 종양 억제 활성을 갖는 캄토테신의 7-이미노 유도체
CN102731519B (zh) 用于抗肿瘤药物的对硝基芳甲氧基喜树碱缺氧激活前药
RU2561118C2 (ru) Производные камптотецина, обладающие противоопухолевой активностью
CN100484940C (zh) 一类水溶性喜树碱衍生物及其制备方法和应用
HK1089160B (en) 7-imino derivatives of camptothecin having antitumor activity
KR101398591B1 (ko) 제암성 활성을 갖는 캠토테신 유도체
HK1031222B (en) Camptothecin derivatives having antitumor activity

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20150724

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

R17-X000 Change to representative recorded

St.27 status event code: A-5-5-R10-R17-oth-X000

FPAY Annual fee payment

Payment date: 20160726

Year of fee payment: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20170809

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20170809