CN1003712B - ６－（１－酰基１－羟甲基或乙酰氧甲基）青霉烷酸衍生物的制备方法 - Google Patents

６－（１－酰基１－羟甲基或乙酰氧甲基）青霉烷酸衍生物的制备方法 Download PDF

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Publication number
CN1003712B
CN1003712B CN86102736.1A CN86102736A CN1003712B CN 1003712 B CN1003712 B CN 1003712B CN 86102736 A CN86102736 A CN 86102736A CN 1003712 B CN1003712 B CN 1003712B
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CN
China
Prior art keywords
product
named
ethyl acetate
nmr
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CN86102736.1A
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English (en)
Chinese (zh)
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CN86102736A (zh
Inventor
劳伦斯·安德鲁·里德三世
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
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Pfizer Corp SRL
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Filing date
Publication date
Application filed by Pfizer Corp SRL filed Critical Pfizer Corp SRL
Publication of CN86102736A publication Critical patent/CN86102736A/zh
Publication of CN1003712B publication Critical patent/CN1003712B/zh
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN86102736.1A 1985-04-18 1986-04-17 ６－（１－酰基１－羟甲基或乙酰氧甲基）青霉烷酸衍生物的制备方法 Expired CN1003712B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72485785A 1985-04-18 1985-04-18
US724,857 1985-04-18

Publications (2)

Publication Number Publication Date
CN86102736A CN86102736A (zh) 1986-10-15
CN1003712B true CN1003712B (zh) 1989-03-29

Family

ID=24912209

Family Applications (1)

Application Number Title Priority Date Filing Date
CN86102736.1A Expired CN1003712B (zh) 1985-04-18 1986-04-17 ６－（１－酰基１－羟甲基或乙酰氧甲基）青霉烷酸衍生物的制备方法

Country Status (27)

Country Link
US (1) US4675186A (enExample)
EP (1) EP0201221B1 (enExample)
JP (1) JPS61243089A (enExample)
KR (1) KR880000974B1 (enExample)
CN (1) CN1003712B (enExample)
AT (1) ATE55133T1 (enExample)
AU (1) AU565926B2 (enExample)
CA (1) CA1270814A (enExample)
CS (1) CS255871B2 (enExample)
DD (1) DD258020A5 (enExample)
DE (1) DE3673057D1 (enExample)
DK (1) DK175186A (enExample)
EG (1) EG18288A (enExample)
ES (1) ES8800233A1 (enExample)
FI (1) FI85272C (enExample)
GR (1) GR860997B (enExample)
HU (1) HU196807B (enExample)
IE (1) IE58666B1 (enExample)
IL (1) IL78509A (enExample)
NO (2) NO861508L (enExample)
NZ (1) NZ215863A (enExample)
PH (2) PH22795A (enExample)
PL (1) PL147619B1 (enExample)
PT (1) PT82401B (enExample)
SU (1) SU1468425A3 (enExample)
YU (1) YU45013B (enExample)
ZA (1) ZA862876B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19540361A1 (de) 1995-10-30 1997-05-07 Basf Ag Phenylessigsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung zur Bekämpfung von Schadpilzen und tierischen Schädlingen
FR2956400A1 (fr) * 2010-02-15 2011-08-19 Finorga Procede de preparation de composes adamantyles
CN109422765B (zh) * 2017-09-05 2020-08-28 香港理工大学深圳研究院 C类β-内酰胺酶抑制剂及其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1377661A (en) 1971-06-05 1974-12-18 Yamanouchi Pharma Co Ltd Oxofuryl ester derivatives of penicillin and cephalosporin
US4207323A (en) * 1975-11-21 1980-06-10 Merck & Co., Inc. 6-Substituted methyl penicillins, derivatives and analogues thereof
US4282149A (en) * 1977-03-21 1981-08-04 Massachusetts Institute Of Technology Carbon and oxygen analogs of penicillin
US4234579A (en) 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
US4272439A (en) * 1978-06-02 1981-06-09 Schering Corporation 6-(Substituted-hydroxymethylene penams)
DE2927004A1 (de) * 1979-07-04 1981-05-27 Bayer Ag, 5090 Leverkusen Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel
US4342768A (en) * 1979-10-22 1982-08-03 Pfizer Inc. Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics
US4287181A (en) * 1979-10-22 1981-09-01 Pfizer Inc. Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors
JPS6019908B2 (ja) 1980-04-30 1985-05-18 カネボウ株式会社 １，３−ジオキソレン−２−オン誘導体
US4348264A (en) 1980-05-14 1982-09-07 Pfizer Inc. Photocatalyzed process for producing carbapenams and carbapen-2-ems
JPS5832882A (ja) 1981-07-18 1983-02-25 Kanebo Ltd ６−〔（ヘキサヒドロ−１ｈ−アゼピン−１−イル）メチレンアミノ〕ペニシラン酸の新規エステルおよびその製造法
US4457924A (en) 1981-12-22 1984-07-03 Pfizer, Inc. 1,1-Alkanediol dicarboxylate linked antibacterial agents
US4452796A (en) 1982-06-14 1984-06-05 Pfizer Inc. 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
EP0083977A1 (en) 1982-01-11 1983-07-20 Pfizer Inc. 6-Alpha-hydroxymethylpenicillanic acid sulfone as a beta-lactamase inhibitor
US4503040A (en) 1984-02-27 1985-03-05 Pfizer Inc. 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lactamase inhibitors
US4590073A (en) * 1984-10-22 1986-05-20 Pfizer Inc. 6-substituted penicillanic acid 1,1-dioxide compounds

Also Published As

Publication number Publication date
HUT40669A (en) 1987-01-28
ATE55133T1 (de) 1990-08-15
ES8800233A1 (es) 1987-10-16
IL78509A0 (en) 1986-08-31
PL147619B1 (en) 1989-07-31
DK175186A (da) 1986-10-19
FI85272B (fi) 1991-12-13
FI85272C (fi) 1992-03-25
KR880000974B1 (ko) 1988-06-07
DE3673057D1 (de) 1990-09-06
EG18288A (en) 1992-10-30
YU45013B (en) 1991-06-30
AU565926B2 (en) 1987-10-01
SU1468425A3 (ru) 1989-03-23
NO873599L (no) 1986-10-20
NZ215863A (en) 1988-07-28
NO861508L (no) 1986-10-20
CS275986A2 (en) 1987-07-16
CN86102736A (zh) 1986-10-15
JPS61243089A (ja) 1986-10-29
IL78509A (en) 1991-03-10
DK175186D0 (da) 1986-04-17
CA1270814A (en) 1990-06-26
HU196807B (en) 1989-01-30
YU62286A (en) 1988-02-29
US4675186A (en) 1987-06-23
NO873599D0 (no) 1987-08-26
KR860008187A (ko) 1986-11-12
PT82401A (en) 1986-05-01
ZA862876B (en) 1987-11-25
IE861014L (en) 1986-10-18
PH23560A (en) 1989-08-25
ES554118A0 (es) 1987-10-16
CS255871B2 (en) 1988-03-15
IE58666B1 (en) 1993-11-03
DD258020A5 (de) 1988-07-06
PH22795A (en) 1988-12-12
JPH0534358B2 (enExample) 1993-05-21
PT82401B (pt) 1988-08-17
FI861630A0 (fi) 1986-04-17
EP0201221B1 (en) 1990-08-01
GR860997B (en) 1986-08-12
AU5631886A (en) 1986-10-23
EP0201221A1 (en) 1986-11-12
FI861630L (fi) 1986-10-19

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