ES8800233A1 - Un procedimiento para la preparacion de derivados de acido-6-(1-acil-1-hidroximetil)penicilanico. - Google Patents

Un procedimiento para la preparacion de derivados de acido-6-(1-acil-1-hidroximetil)penicilanico.

Info

Publication number
ES8800233A1
ES8800233A1 ES554118A ES554118A ES8800233A1 ES 8800233 A1 ES8800233 A1 ES 8800233A1 ES 554118 A ES554118 A ES 554118A ES 554118 A ES554118 A ES 554118A ES 8800233 A1 ES8800233 A1 ES 8800233A1
Authority
ES
Spain
Prior art keywords
acyl
acid derivatives
hydroxy methyl
penicillanic acid
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554118A
Other languages
English (en)
Other versions
ES554118A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES554118A0 publication Critical patent/ES554118A0/es
Publication of ES8800233A1 publication Critical patent/ES8800233A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ACIDO 6-(1-ACIL-1-HIDROXIMETIL)PENICILANICO. COMPRENDE: A) HIDROLIZAR UN C.D.F. (II) POR ACCION DE UN EQUIVALENTE MOLAR DE ETILHEXANOATO DE NA O K, EN PRESENCIA DE CANTIDADES CATALITICAS DE (C6H5)3 P Y PD [(C6H5)3P] Y EN UN DISOLVENTE INERTE, PARA OBTENER UN C.D.F. (I); B) HIDROGENAR CUALQUIER GRUPO PROTECTOR BENCILOXICARBONILO CON H2 EN PRESENCIA DE UN METAL NOBLE Y DE UN DISOLVENTE INERTE; C) TRANSFORMAR EN UNA SAL CATIONICA FARMACEUTICAMENTE ACEPTABLE. SIENDO: R, H, UN RADICAL QUE FORMA UN ESTER HIDROLIZABLE EN CONDICIONES FISIOLOGICAS; R ELEVADO A 1, ALQUILO DE C 1 A 7, CICLOALQUILO DE C 5 A 7 Y OTROS; X, HIDROXI U OCOR ELEVADO A 2; R ELEVADO A 2, H O ALQUILO DE C 1 A 4; N, 0, 1 O 2; Y C.D.F., COMPUESTO DE FORMULA. SE UTILIZAN COMO ANTIBACTERIANOS E INHIBIDORES DE BETA-LACTAMASA. *FORMULA* E
ES554118A 1985-04-18 1986-04-17 Un procedimiento para la preparacion de derivados de acido-6-(1-acil-1-hidroximetil)penicilanico. Expired ES8800233A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72485785A 1985-04-18 1985-04-18

Publications (2)

Publication Number Publication Date
ES554118A0 ES554118A0 (es) 1987-10-16
ES8800233A1 true ES8800233A1 (es) 1987-10-16

Family

ID=24912209

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554118A Expired ES8800233A1 (es) 1985-04-18 1986-04-17 Un procedimiento para la preparacion de derivados de acido-6-(1-acil-1-hidroximetil)penicilanico.

Country Status (27)

Country Link
US (1) US4675186A (es)
EP (1) EP0201221B1 (es)
JP (1) JPS61243089A (es)
KR (1) KR880000974B1 (es)
CN (1) CN1003712B (es)
AT (1) ATE55133T1 (es)
AU (1) AU565926B2 (es)
CA (1) CA1270814A (es)
CS (1) CS255871B2 (es)
DD (1) DD258020A5 (es)
DE (1) DE3673057D1 (es)
DK (1) DK175186A (es)
EG (1) EG18288A (es)
ES (1) ES8800233A1 (es)
FI (1) FI85272C (es)
GR (1) GR860997B (es)
HU (1) HU196807B (es)
IE (1) IE58666B1 (es)
IL (1) IL78509A (es)
NO (2) NO861508L (es)
NZ (1) NZ215863A (es)
PH (2) PH22795A (es)
PL (1) PL147619B1 (es)
PT (1) PT82401B (es)
SU (1) SU1468425A3 (es)
YU (1) YU45013B (es)
ZA (1) ZA862876B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19540361A1 (de) * 1995-10-30 1997-05-07 Basf Ag Phenylessigsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung zur Bekämpfung von Schadpilzen und tierischen Schädlingen
FR2956400A1 (fr) * 2010-02-15 2011-08-19 Finorga Procede de preparation de composes adamantyles
CN109422765B (zh) * 2017-09-05 2020-08-28 香港理工大学深圳研究院 C类β-内酰胺酶抑制剂及其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1377661A (en) 1971-06-05 1974-12-18 Yamanouchi Pharma Co Ltd Oxofuryl ester derivatives of penicillin and cephalosporin
US4207323A (en) * 1975-11-21 1980-06-10 Merck & Co., Inc. 6-Substituted methyl penicillins, derivatives and analogues thereof
US4282149A (en) * 1977-03-21 1981-08-04 Massachusetts Institute Of Technology Carbon and oxygen analogs of penicillin
US4234579A (en) 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
US4272439A (en) * 1978-06-02 1981-06-09 Schering Corporation 6-(Substituted-hydroxymethylene penams)
DE2927004A1 (de) * 1979-07-04 1981-05-27 Bayer Ag, 5090 Leverkusen Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel
US4287181A (en) * 1979-10-22 1981-09-01 Pfizer Inc. Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors
US4342768A (en) * 1979-10-22 1982-08-03 Pfizer Inc. Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics
JPS6019908B2 (ja) 1980-04-30 1985-05-18 カネボウ株式会社 １，３−ジオキソレン−２−オン誘導体
US4348264A (en) 1980-05-14 1982-09-07 Pfizer Inc. Photocatalyzed process for producing carbapenams and carbapen-2-ems
JPS5832882A (ja) 1981-07-18 1983-02-25 Kanebo Ltd ６−〔（ヘキサヒドロ−１ｈ−アゼピン−１−イル）メチレンアミノ〕ペニシラン酸の新規エステルおよびその製造法
US4457924A (en) 1981-12-22 1984-07-03 Pfizer, Inc. 1,1-Alkanediol dicarboxylate linked antibacterial agents
EP0083977A1 (en) 1982-01-11 1983-07-20 Pfizer Inc. 6-Alpha-hydroxymethylpenicillanic acid sulfone as a beta-lactamase inhibitor
US4452796A (en) 1982-06-14 1984-06-05 Pfizer Inc. 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
US4503040A (en) 1984-02-27 1985-03-05 Pfizer Inc. 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lactamase inhibitors
US4590073A (en) * 1984-10-22 1986-05-20 Pfizer Inc. 6-substituted penicillanic acid 1,1-dioxide compounds

Also Published As

Publication number Publication date
KR880000974B1 (ko) 1988-06-07
IE861014L (en) 1986-10-18
CA1270814A (en) 1990-06-26
YU45013B (en) 1991-06-30
DD258020A5 (de) 1988-07-06
PH23560A (en) 1989-08-25
ZA862876B (en) 1987-11-25
CN86102736A (zh) 1986-10-15
HU196807B (en) 1989-01-30
FI85272B (fi) 1991-12-13
CS275986A2 (en) 1987-07-16
PT82401A (en) 1986-05-01
CS255871B2 (en) 1988-03-15
PL147619B1 (en) 1989-07-31
NO861508L (no) 1986-10-20
IL78509A (en) 1991-03-10
JPS61243089A (ja) 1986-10-29
IL78509A0 (en) 1986-08-31
ES554118A0 (es) 1987-10-16
AU5631886A (en) 1986-10-23
SU1468425A3 (ru) 1989-03-23
US4675186A (en) 1987-06-23
FI85272C (fi) 1992-03-25
DK175186D0 (da) 1986-04-17
AU565926B2 (en) 1987-10-01
IE58666B1 (en) 1993-11-03
EP0201221A1 (en) 1986-11-12
EP0201221B1 (en) 1990-08-01
CN1003712B (zh) 1989-03-29
PH22795A (en) 1988-12-12
NO873599D0 (no) 1987-08-26
FI861630A0 (fi) 1986-04-17
NZ215863A (en) 1988-07-28
JPH0534358B2 (es) 1993-05-21
GR860997B (en) 1986-08-12
EG18288A (en) 1992-10-30
DE3673057D1 (de) 1990-09-06
YU62286A (en) 1988-02-29
PT82401B (pt) 1988-08-17
NO873599L (no) 1986-10-20
KR860008187A (ko) 1986-11-12
HUT40669A (en) 1987-01-28
FI861630A (fi) 1986-10-19
DK175186A (da) 1986-10-19
ATE55133T1 (de) 1990-08-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040625