CN100357279C - 缬沙坦的制备方法 - Google Patents

缬沙坦的制备方法 Download PDF

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Publication number
CN100357279C
CN100357279C CNB038245140A CN03824514A CN100357279C CN 100357279 C CN100357279 C CN 100357279C CN B038245140 A CNB038245140 A CN B038245140A CN 03824514 A CN03824514 A CN 03824514A CN 100357279 C CN100357279 C CN 100357279C
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CN
China
Prior art keywords
formula
compound
alkyl
methyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB038245140A
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English (en)
Chinese (zh)
Other versions
CN1688556A (zh
Inventor
D·登尼-迪斯舍尔
H·希尔特
D·内维尔
G·塞德尔迈耶
A·施奈德尔
N·德里安
D·考夫曼
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Novartis AG
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Novartis AG
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9944606&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN100357279(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1688556A publication Critical patent/CN1688556A/zh
Application granted granted Critical
Publication of CN100357279C publication Critical patent/CN100357279C/zh
Anticipated expiration legal-status Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CNB038245140A 2002-09-23 2003-09-22 缬沙坦的制备方法 Expired - Fee Related CN100357279C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0222056.4A GB0222056D0 (en) 2002-09-23 2002-09-23 Process for the manufacture of organic compounds
GB0222056.4 2002-09-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2007101692527A Division CN101153027B (zh) 2002-09-23 2003-09-22 缬沙坦的制备方法

Publications (2)

Publication Number Publication Date
CN1688556A CN1688556A (zh) 2005-10-26
CN100357279C true CN100357279C (zh) 2007-12-26

Family

ID=9944606

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB038245140A Expired - Fee Related CN100357279C (zh) 2002-09-23 2003-09-22 缬沙坦的制备方法
CN2007101692527A Expired - Fee Related CN101153027B (zh) 2002-09-23 2003-09-22 缬沙坦的制备方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2007101692527A Expired - Fee Related CN101153027B (zh) 2002-09-23 2003-09-22 缬沙坦的制备方法

Country Status (29)

Country Link
US (3) US20060069268A1 (cg-RX-API-DMAC10.html)
EP (2) EP1546122B8 (cg-RX-API-DMAC10.html)
JP (2) JP4787498B2 (cg-RX-API-DMAC10.html)
KR (2) KR20050057529A (cg-RX-API-DMAC10.html)
CN (2) CN100357279C (cg-RX-API-DMAC10.html)
AR (1) AR041360A1 (cg-RX-API-DMAC10.html)
AU (1) AU2003270241B2 (cg-RX-API-DMAC10.html)
BR (1) BR0314132A (cg-RX-API-DMAC10.html)
CA (1) CA2502629A1 (cg-RX-API-DMAC10.html)
CY (1) CY1107878T1 (cg-RX-API-DMAC10.html)
DE (1) DE60317690T2 (cg-RX-API-DMAC10.html)
DK (1) DK1546122T3 (cg-RX-API-DMAC10.html)
EC (2) ECSP055695A (cg-RX-API-DMAC10.html)
ES (1) ES2295623T3 (cg-RX-API-DMAC10.html)
GB (1) GB0222056D0 (cg-RX-API-DMAC10.html)
IL (1) IL167426A (cg-RX-API-DMAC10.html)
MX (1) MXPA05003140A (cg-RX-API-DMAC10.html)
MY (1) MY138618A (cg-RX-API-DMAC10.html)
NO (2) NO20051970L (cg-RX-API-DMAC10.html)
NZ (2) NZ566863A (cg-RX-API-DMAC10.html)
PE (2) PE20050088A1 (cg-RX-API-DMAC10.html)
PL (1) PL374862A1 (cg-RX-API-DMAC10.html)
PT (1) PT1546122E (cg-RX-API-DMAC10.html)
RU (2) RU2348619C2 (cg-RX-API-DMAC10.html)
SG (1) SG155049A1 (cg-RX-API-DMAC10.html)
SI (1) SI1546122T1 (cg-RX-API-DMAC10.html)
TW (2) TWI329106B (cg-RX-API-DMAC10.html)
WO (1) WO2004026847A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200502159B (cg-RX-API-DMAC10.html)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7199144B2 (en) 2003-04-21 2007-04-03 Teva Pharmaceuticals Industries, Ltd. Process for the preparation of valsartan and intermediates thereof
DE602004013405T2 (de) 2003-03-17 2009-05-07 Teva Pharmaceutical Industries Ltd. Polymorphe formen von valsartan
WO2004094391A2 (en) * 2003-04-21 2004-11-04 Teva Pharmaceutical Industries Ltd. Process for the preparation of valsartan and intermediates thereof
EP1618097A1 (en) 2003-04-21 2006-01-25 Teva Pharmaceutical Industries Ltd Process for the preparation of valsartan
GB0316546D0 (en) 2003-07-15 2003-08-20 Novartis Ag Process for the manufacture of organic compounds
GB0402262D0 (en) * 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds
EP1661891A1 (en) * 2004-11-30 2006-05-31 KRKA, D.D., Novo Mesto A process for the synthesis of valsartan
GB0514206D0 (en) * 2005-07-11 2005-08-17 Novartis Ag Organic compounds
ES2288376B1 (es) * 2005-10-20 2008-11-01 Inke, S.A. Procedimiento para la obtencion de intermedios utiles en la obtencion de un compuesto farmaceuticamente activo.
WO2007057919A2 (en) * 2005-10-25 2007-05-24 Alembic Limited An improved process for preparation of (s)-n-(1-carboxy-2-methyl-prop-1-yl)-n-pentanoyl-n-[2'-(1h-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine
US7880015B2 (en) * 2006-07-03 2011-02-01 Aurobindo Pharma Ltd. Process for the preparation of angiotensin II antagonist
ES2315141B1 (es) * 2006-11-23 2009-12-22 Quimica Sintetica, S.A Procedimiento para la preparacion de cardesartan cilexetilo en forma cristalina.
CN101200455B (zh) * 2007-09-29 2010-08-18 泰兴市江神化工有限公司 沙坦类治疗高血压药物主环5-(4'-甲酰基联苯-2-基)-1h-四氮唑的制备方法
EP2090567A3 (en) 2008-02-13 2011-06-01 Ranbaxy Laboratories Limited Processes for the preparation of intermediates of valsartan
KR101012135B1 (ko) * 2008-12-18 2011-02-07 주식회사 대희화학 발사르탄 메틸 에스테르의 제조방법
EP2316821A1 (en) 2009-10-27 2011-05-04 Novartis AG Process for the manufacture of organic compounds
WO2012016969A1 (en) * 2010-08-03 2012-02-09 Novartis Ag Highly crystalline valsartan
CN102351804B (zh) * 2011-09-30 2013-07-31 浙江新赛科药业有限公司 一种缬沙坦消旋体的回收方法
CN103554047A (zh) * 2013-10-11 2014-02-05 镇江市高等专科学校 制备缬沙坦的方法
CN103923028B (zh) * 2014-05-04 2017-05-24 青岛雪洁助剂有限公司 一种缬沙坦甲酯的制备方法
CN104072433A (zh) * 2014-07-16 2014-10-01 南京正大天晴制药有限公司 一种缬沙坦的水解杂质化合物及其制备方法、检测方法和用途
CN104151199A (zh) * 2014-08-13 2014-11-19 苏州卫生职业技术学院 一种缬沙坦的合成方法
CN104844476B (zh) * 2015-04-03 2016-08-24 李凌 一种医药中间体联苯类化合物的合成方法
CN112014479A (zh) * 2019-05-28 2020-12-01 珠海润都制药股份有限公司 一种缬沙坦中正戊酰氯的检测方法
CN116655498B (zh) * 2023-05-24 2025-01-28 江苏阿尔法集团福瑞药业(宿迁)有限公司 一种沙库巴曲中间体的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1149294A (zh) * 1994-05-27 1997-05-07 森德克斯(美国)股份有限公司 1-丁基-2-[2-(2h-四唑-5-基)-联苯-4-基甲基)-1h-吲哚-3-羧酸的制备方法
US5965592A (en) * 1990-02-19 1999-10-12 Novartis Corporation Acyl compounds
CN1317485A (zh) * 2000-04-07 2001-10-17 常州四药制药有限公司 一种合成缬沙坦的改进方法
WO2002006253A1 (en) * 2000-07-19 2002-01-24 Novartis Ag Valsartan salts

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US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US5260325A (en) * 1991-08-19 1993-11-09 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking tertiary amides
FR2688503B1 (fr) * 1992-03-16 1994-05-06 Synthelabo Procede de preparation de derives de 2-(tetrazol-5-yl)-[1,1'-biphenyle].
EP0550313A1 (fr) * 1991-12-30 1993-07-07 Synthelabo Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists
JPH08165292A (ja) * 1993-10-07 1996-06-25 Techno Res Kk アデニン誘導体、その製造法及び用途
US5412102A (en) * 1994-05-27 1995-05-02 Syntex (U.S.A.) Inc. Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) biphenyl-4-ylmethyl]-1H-indole-3-carboxylic acid
ATE176784T1 (de) * 1994-09-20 1999-03-15 Wakunaga Seiyaku Kk Verfahren zur herstellung von n- biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen
EP0846117B1 (en) * 1995-06-07 2003-05-14 Wyeth Process for preparation of biphenyl derivatives
JPH11513395A (ja) * 1995-10-06 1999-11-16 ノバルティス・アクチエンゲゼルシャフト 虚血後腎不全の予防および処置並びに虚血腎臓の保護のためのａｔ１−レセプターアンタゴニスト
JP4537678B2 (ja) * 2003-09-04 2010-09-01 住友化学株式会社 ２’−（１ｈ−テトラゾール−５−イル）ビフェニル−４−カルボアルデヒド結晶およびその製造方法
GB0402262D0 (en) * 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965592A (en) * 1990-02-19 1999-10-12 Novartis Corporation Acyl compounds
CN1149294A (zh) * 1994-05-27 1997-05-07 森德克斯(美国)股份有限公司 1-丁基-2-[2-(2h-四唑-5-基)-联苯-4-基甲基)-1h-吲哚-3-羧酸的制备方法
CN1317485A (zh) * 2000-04-07 2001-10-17 常州四药制药有限公司 一种合成缬沙坦的改进方法
WO2002006253A1 (en) * 2000-07-19 2002-01-24 Novartis Ag Valsartan salts

Also Published As

Publication number Publication date
AU2003270241A1 (en) 2004-04-08
ECSP055695A (es) 2005-05-30
PE20050088A1 (es) 2005-02-21
CY1107878T1 (el) 2013-06-19
RU2348619C2 (ru) 2009-03-10
NO20110856L (no) 2005-06-16
NZ566863A (en) 2009-08-28
SI1546122T1 (sl) 2008-04-30
JP2006502178A (ja) 2006-01-19
US20100249429A1 (en) 2010-09-30
MY138618A (en) 2009-07-31
US20060069268A1 (en) 2006-03-30
WO2004026847A1 (en) 2004-04-01
TW200413337A (en) 2004-08-01
BR0314132A (pt) 2005-06-28
TWI338003B (en) 2011-03-01
PE20091387A1 (es) 2009-10-13
JP2010254709A (ja) 2010-11-11
PT1546122E (pt) 2008-02-14
TWI329106B (en) 2010-08-21
IL167426A (en) 2010-11-30
EP1878729A1 (en) 2008-01-16
KR20110015703A (ko) 2011-02-16
DK1546122T3 (da) 2008-03-03
PL374862A1 (en) 2005-11-14
RU2005112444A (ru) 2006-01-20
EP1546122B1 (en) 2007-11-21
AU2003270241B2 (en) 2007-08-23
DE60317690T2 (de) 2008-10-30
EP1546122A1 (en) 2005-06-29
EP1546122B8 (en) 2008-05-28
KR20050057529A (ko) 2005-06-16
CA2502629A1 (en) 2004-04-01
CN1688556A (zh) 2005-10-26
GB0222056D0 (en) 2002-10-30
ECSP105695A (es) 2010-03-31
TW201016673A (en) 2010-05-01
SG155049A1 (en) 2009-09-30
DE60317690D1 (de) 2008-01-03
NO20051970L (no) 2005-06-16
US20090111995A1 (en) 2009-04-30
NZ538927A (en) 2008-05-30
CN101153027B (zh) 2010-08-18
ES2295623T3 (es) 2008-04-16
MXPA05003140A (es) 2005-06-22
JP4787498B2 (ja) 2011-10-05
RU2412173C2 (ru) 2011-02-20
RU2008133680A (ru) 2010-02-27
CN101153027A (zh) 2008-04-02
AR041360A1 (es) 2005-05-11
ZA200502159B (en) 2005-09-21
HK1079771A1 (en) 2006-04-13

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Granted publication date: 20071226

Termination date: 20120922