CN100343257C - 治疗固有活性脱髓鞘炎性病症的ccr1拮抗剂 - Google Patents
治疗固有活性脱髓鞘炎性病症的ccr1拮抗剂 Download PDFInfo
- Publication number
- CN100343257C CN100343257C CNB2003801086866A CN200380108686A CN100343257C CN 100343257 C CN100343257 C CN 100343257C CN B2003801086866 A CNB2003801086866 A CN B2003801086866A CN 200380108686 A CN200380108686 A CN 200380108686A CN 100343257 C CN100343257 C CN 100343257C
- Authority
- CN
- China
- Prior art keywords
- compound
- application
- disease
- medicine
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42594702P | 2002-11-13 | 2002-11-13 | |
US60/425,947 | 2002-11-13 | ||
PCT/US2003/035817 WO2004043965A1 (en) | 2002-11-13 | 2003-11-12 | Ccr1 antagonists for the treatment of i.a. demyelinating inflammatory disease |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1738824A CN1738824A (zh) | 2006-02-22 |
CN100343257C true CN100343257C (zh) | 2007-10-17 |
Family
ID=32313083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2003801086866A Expired - Fee Related CN100343257C (zh) | 2002-11-13 | 2003-11-12 | 治疗固有活性脱髓鞘炎性病症的ccr1拮抗剂 |
Country Status (25)
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7271176B2 (en) * | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
TWI291467B (en) * | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
US7838522B2 (en) | 2004-11-17 | 2010-11-23 | Ares Trading S.A. | Benzothiazole formulations and use thereof |
EP1841429B1 (en) * | 2004-12-17 | 2012-04-18 | Millennium Pharmaceuticals, Inc. | Solid forms of a chemokine receptor antagonist and methods of use thereof |
JP5021488B2 (ja) | 2004-12-21 | 2012-09-05 | メルク セローノ ソシエテ アノニム | スルホニルアミノ環式誘導体及びその使用 |
DK1844032T3 (da) | 2005-01-31 | 2011-10-24 | Merck Serono Sa | N-hydroxyamid-derivater og deres anvendelse |
BRPI0613042A2 (pt) | 2005-07-15 | 2010-12-14 | Serono Lab | inibidores de jnk para o tratamento de endometriose |
KR20080044836A (ko) | 2005-07-15 | 2008-05-21 | 라보라뚜와르 세로노 에스. 에이. | 자궁내막증 치료용 jnk 억제제 |
CA2616479A1 (en) | 2005-09-01 | 2007-03-08 | Ares Trading S.A. | Treatment of optic neuritis |
US7601844B2 (en) | 2006-01-27 | 2009-10-13 | Bristol-Myers Squibb Company | Piperidinyl derivatives as modulators of chemokine receptor activity |
EA014695B1 (ru) * | 2006-07-14 | 2010-12-30 | Эли Лилли Энд Компани | Модулятор рецепторов глюкокортикостероидов и его применение |
CN101808991A (zh) * | 2007-07-24 | 2010-08-18 | 百时美施贵宝公司 | 作为趋化因子受体活性调节剂的哌啶基衍生物 |
WO2009082526A2 (en) * | 2007-10-05 | 2009-07-02 | Pharmacopeia, Inc. | Ortho pyrrolidine, benzyl-substituted heterocycle ccr1 antagonists for autoimmune diseases & inflammation |
EP2231675A1 (en) * | 2007-11-30 | 2010-09-29 | Millennium Pharmaceuticals, Inc. | Process for the preparation of 5-cyclopropyl-5, 11-dihydro (1) benzoxepino (3, 4-b) -pyridin-5-ol using tmeda |
US20090286823A1 (en) * | 2007-12-17 | 2009-11-19 | Millennium Pharmaceuticals Inc. | CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders |
EA017288B1 (ru) | 2008-01-11 | 2012-11-30 | Эли Лилли Энд Компани | (E)-N-{3-[1-(8-ФТОР-11Н-10-ОКСА-1-АЗАДИБЕНЗО[a,d]ЦИКЛОГЕПТЕН-5-ИЛИДЕН)ПРОПИЛ]ФЕНИЛ}МЕТАНСУЛЬФОНАМИД В КАЧЕСТВЕ МОДУЛЯТОРА РЕЦЕПТОРОВ ГЛЮКОКОРТИКОИДОВ ДЛЯ ЛЕЧЕНИЯ РЕВМАТИЗМА |
TWI433838B (zh) | 2008-06-25 | 2014-04-11 | 必治妥美雅史谷比公司 | 作為趨化因子受體活性調節劑之六氫吡啶衍生物 |
EP2771484A1 (en) | 2011-10-28 | 2014-09-03 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001009138A2 (en) * | 1999-07-28 | 2001-02-08 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
CN1289336A (zh) * | 1998-01-21 | 2001-03-28 | 千禧药品公司 | 趋化因子受体拮抗剂和其使用方法 |
Family Cites Families (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE80449C (US07732459-20100608-C00008.png) | ||||
DD80449A (US07732459-20100608-C00008.png) | ||||
US377729A (en) * | 1888-02-07 | Half to phillips | ||
GB1003292A (en) | 1960-12-08 | 1965-09-02 | Sandoz Ag | Improvements in or relating to 4-azathiaxanthene derivatives |
FR1332145A (US07732459-20100608-C00008.png) | 1961-06-08 | 1963-12-16 | ||
CH416624A (de) | 1962-10-23 | 1966-07-15 | Sandoz Ag | Verfahren zur Herstellung von neuen heterocyclischen Verbindungen |
NL132137C (US07732459-20100608-C00008.png) | 1963-04-24 | |||
FR88751E (US07732459-20100608-C00008.png) | 1963-07-09 | 1967-06-07 | ||
GB1085406A (en) | 1963-10-14 | 1967-10-04 | Pfizer & Co C | Aminoalkylphosphorus compounds, preparation thereof and reaction products with ketones |
FR145F (US07732459-20100608-C00008.png) | 1964-06-01 | |||
CH421138A (de) | 1965-11-04 | 1966-09-30 | Wander Ag Dr A | Verfahren zur Herstellung von Thioxanthenderivaten |
US3409621A (en) * | 1966-04-01 | 1968-11-05 | Schering Corp | Piperazino-aza-dibenzo-[a, d]-cycloheptenes |
US3625974A (en) | 1967-04-28 | 1971-12-07 | Fujisawa Pharmaceutical Co | Dibenzothiazepine derivatives |
GB1206216A (en) | 1967-07-18 | 1970-09-23 | Pfizer & Co C | Aminopropylidene dibenzoxepine tranquilizers |
NL6905642A (US07732459-20100608-C00008.png) | 1968-04-12 | 1969-10-14 | ||
JPS4830064B1 (US07732459-20100608-C00008.png) | 1968-12-23 | 1973-09-17 | ||
JPS4840356Y1 (US07732459-20100608-C00008.png) | 1969-12-22 | 1973-11-27 | ||
GB1330966A (en) | 1970-12-22 | 1973-09-19 | Yoshitomi Pharmaceutical | N-substituted piperidine compounds methods for their production and pharmaceutical compositions containing them |
DE2163657A1 (de) * | 1970-12-22 | 1972-07-13 | Yoshitomi Pharmaceutical Industries Ltd., Osaka (Japan) | N-substituierte Piperidinverbindungen |
JPS5146625Y2 (US07732459-20100608-C00008.png) | 1971-03-24 | 1976-11-10 | ||
GB1347935A (en) | 1971-04-10 | 1974-02-27 | Yoshitomi Pharmaceutical | Piperazine derivatives methods for their production and phar maceutical compositions containing them |
CA1010870A (en) * | 1972-12-08 | 1977-05-24 | Niels Lassen | Thiaxanthene derivative and method |
US4250176A (en) * | 1976-12-21 | 1981-02-10 | Janssen Pharmaceutica N.V. | Piperazine derivatives |
US4335122A (en) * | 1981-03-18 | 1982-06-15 | Hoechst-Roussel Pharmaceuticals Inc. | Dihydro-dibenzoxepines-thiepines and -morphanthridones, compositions and use |
DE3326641A1 (de) | 1982-07-27 | 1984-02-02 | Basf Ag, 6700 Ludwigshafen | 5,6-dihydro-11-h-morphantridin-6-one, ihre herstellung und diese enthaltende arzneimittel |
CA1237428A (en) * | 1983-06-24 | 1988-05-31 | Hiroshi Tanaka | ¬1| benzepino¬3,4-b|pyridine derivative |
ES8502099A1 (es) | 1983-08-02 | 1984-12-16 | Espanola Farma Therapeut | Procedimiento de obtencion de nuevos compuestos derivados de la difenil-metilen-etilamina. |
DE3402060A1 (de) * | 1984-01-21 | 1985-08-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | Substituierte 5,11-dihydro-6h-dibenz(b,e)azepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
CS236549B1 (cs) | 1984-02-02 | 1985-05-15 | Miroslav Protiva | Piperazinoalkanoly dibenzo(b,e)thiepinové řady a jejich soli s kyselinou maleinovou |
CS236550B1 (cs) | 1984-02-02 | 1985-05-15 | Miroslav Protiva | Způsob přípravy esterů piperazinoalkanolů dibenzo(b,e)thiepinové řady a jejich solí s kyselinou maleinovou |
CS240698B1 (cs) | 1984-10-12 | 1986-02-13 | Miroslav Protiva | Substituované ll-(piperidinoalkyl)-6,ll-dihydrodibenzo (b,e)thiepin-ll-karbonitrily |
JPH0665664B2 (ja) | 1985-01-18 | 1994-08-24 | 大塚製薬株式会社 | モルフアントリジン誘導体 |
SE8500273D0 (sv) * | 1985-01-22 | 1985-01-22 | Leo Ab | Nya tricykliska foreningar, kompositioner innehallande sadana foreningar, framstellningsforfaranden och behandlingsmetoder |
JPS6310784A (ja) | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
EP0270692A4 (en) | 1986-06-26 | 1990-12-12 | Kyowa Hakko Kogyo Co., Ltd. | Antiarrhythmic agent |
US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
IT8721978A0 (it) | 1987-09-21 | 1987-09-21 | Angeli Inst Spa | Nuovi derivati ammidinici triciclici. |
US4882351A (en) * | 1987-10-14 | 1989-11-21 | Roussel Uclaf | Tricyclic compounds |
AU612437B2 (en) | 1987-12-14 | 1991-07-11 | Kyowa Hakko Kogyo Co. Ltd. | Tricyclic compounds |
EP0411048A1 (en) | 1988-04-28 | 1991-02-06 | Schering Corporation | Novel benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use |
US5242931A (en) * | 1988-06-09 | 1993-09-07 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds as TXA2 antagonists |
US4999363A (en) * | 1988-06-09 | 1991-03-12 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds |
DE3827093A1 (de) | 1988-08-10 | 1990-02-15 | Nattermann A & Cie | Verfahren zur herstellung von hochreinem ebselen |
DE3838912A1 (de) * | 1988-11-17 | 1990-05-23 | Thomae Gmbh Dr K | Mittel zur behandlung von akuten und chronischen obstruktiven atemwegserkrankungen |
JPH0694464B2 (ja) * | 1991-01-23 | 1994-11-24 | 協和醗酵工業株式会社 | 三環式化合物およびその中間体 |
EP0511477B1 (en) * | 1991-03-11 | 1996-07-10 | Kyowa Hakko Kogyo Co., Ltd. | Indole derivatives |
WO1992016226A1 (en) | 1991-03-19 | 1992-10-01 | Smithkline Beecham Corporation | Il-1 inhibitors |
AU2028892A (en) | 1991-05-23 | 1992-12-30 | Schering Corporation | Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use |
EP0524784A1 (en) | 1991-07-23 | 1993-01-27 | Schering Corporation | Benzopyrido piperidylidene compounds as PAF antagonists |
US5378701A (en) * | 1991-12-27 | 1995-01-03 | Kyowa Hakko Kogyo | Tricyclic compounds |
US5679703A (en) * | 1992-09-16 | 1997-10-21 | Kyowa Hakko Kogyo, Co., Ltd. | Tricyclic compounds having ACAT inhibiting activity |
JP3664176B2 (ja) | 1992-11-10 | 2005-06-22 | ジェネンテック・インコーポレーテッド | C−c ckr−1,c−cケモカインレセプター |
US5538986A (en) * | 1993-12-06 | 1996-07-23 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
MY113463A (en) * | 1994-01-04 | 2002-03-30 | Novo Nordisk As | Novel heterocyclic compounds |
WO1996031470A1 (en) | 1995-04-07 | 1996-10-10 | Novo Nordisk A/S | Novel heterocyclic compounds |
US5801175A (en) * | 1995-04-07 | 1998-09-01 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
UA54385C2 (uk) * | 1995-04-07 | 2003-03-17 | Ново Нордіск А/С | N-заміщені азагетероциклічні карбонові кислоти та їх ефіри, спосіб їх одержання, фармацевтична композиція та спосіб лікування |
US5712280A (en) * | 1995-04-07 | 1998-01-27 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
AU5270796A (en) | 1995-04-07 | 1996-10-23 | Novo Nordisk A/S | N-substituted azaheterocyclic carboxylic acids and esters th ereof |
JPH0940662A (ja) | 1995-05-24 | 1997-02-10 | Kyowa Hakko Kogyo Co Ltd | 三環式化合物 |
ATE218126T1 (de) * | 1995-09-13 | 2002-06-15 | Kyowa Hakko Kogyo Kk | Phenylpiperidin-derivate |
AU1208397A (en) | 1995-12-28 | 1997-07-28 | Takeda Chemical Industries Ltd. | Diphenylmethane derivatives as mip-1alpha/rantes receptor antagonists |
DE29602088U1 (de) | 1996-02-07 | 1996-04-04 | Buemach Engineering Internatio | Verschraubbarer druckmittelbetätigter Arbeitszylinder mit Verschlußteilen zur Kopplung des Zylinderrohres |
EP0914319B1 (en) | 1996-05-20 | 2001-11-21 | Teijin Limited | Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists |
AU729415B2 (en) | 1996-07-12 | 2001-02-01 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US6323206B1 (en) | 1996-07-12 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
AU3633997A (en) | 1996-07-29 | 1998-02-20 | Banyu Pharmaceutical Co., Ltd. | Chemokine receptor antagonists |
EP0929544B1 (en) | 1996-09-13 | 2004-11-10 | Schering Corporation | Tricyclic antitumor compounds being farnesyl protein transferase inhibitors |
DE69733142T2 (de) | 1996-09-13 | 2006-03-16 | Schering Corp. | Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren |
EP0927181A1 (en) | 1996-09-13 | 1999-07-07 | Schering Corporation | Tricyclic compounds useful as fpt inhibitors |
PL332253A1 (en) | 1996-09-13 | 1999-08-30 | Schering Corp | Derivatives of subtituted benzocycloheptapyridine useful in inhibiting proteinous farnesil transferase |
WO1998011093A1 (en) | 1996-09-13 | 1998-03-19 | Schering Corporation | Tricyclic inhibitors of farnesyl protein transferase |
CN1237170A (zh) | 1996-09-13 | 1999-12-01 | 先灵公司 | 用作法呢基蛋白转移酶抑制剂的新的三环哌啶基化合物 |
ID22045A (id) | 1996-09-13 | 1999-08-26 | Schering Corp | Senyawa-senyawa trisiklik yang berguna untuk penghambatan fungsi protein-g dan untuk pengobatan penyakit-penyakit proliferatif |
ZA978792B (en) | 1996-10-04 | 1998-04-06 | Novo Nordisk As | N-substituted azaheterocyclic compounds. |
DK0934312T3 (da) | 1996-10-04 | 2003-07-21 | Novo Nordisk As | 1,4-disubstituerede piperaziner |
JP2001501629A (ja) | 1996-10-04 | 2001-02-06 | ノボ ノルディスク アクティーゼルスカブ | N―置換アザ複素環式化合物 |
WO1998025604A1 (en) | 1996-12-13 | 1998-06-18 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
AU5803398A (en) | 1996-12-13 | 1998-07-03 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
AU5522498A (en) | 1996-12-13 | 1998-07-03 | Merck & Co., Inc. | Substituted aryl piperazines as modulators of chemokine receptor activity |
AU5812498A (en) | 1996-12-20 | 1998-07-17 | Merck & Co., Inc. | Substituted aminoquinolines as modulators of chemokine receptor activity |
US5919776A (en) * | 1996-12-20 | 1999-07-06 | Merck & Co., Inc. | Substituted aminoquinolines as modulators of chemokine receptor activity |
AU6517398A (en) | 1997-03-27 | 1998-10-22 | Kyowa Hakko Kogyo Co. Ltd. | Therapeutic agent for autoimmune diseases |
US5877177A (en) * | 1997-06-17 | 1999-03-02 | Schering Corporation | Carboxy piperidylacetamide tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US6040318A (en) | 1997-06-25 | 2000-03-21 | Novo Nordisk A/S | Tricycle substituted with azaheterocyclic carboxylic acids |
JP2002515914A (ja) | 1997-06-25 | 2002-05-28 | ノボ ノルディスク アクティーゼルスカブ | 新規へテロ環式化合物 |
US6048856A (en) * | 1997-12-17 | 2000-04-11 | Novo Nordisk A/S | Heterocyclic compounds |
US6613905B1 (en) * | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
CA2318088A1 (en) * | 1998-01-21 | 1999-07-29 | Yoshisuke Nakasato | Chemokine receptor antagonists and methods of use therefor |
US7271176B2 (en) * | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
US6503926B2 (en) | 1998-09-04 | 2003-01-07 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
EP1109815A1 (en) | 1998-09-04 | 2001-06-27 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
EA008060B1 (ru) | 1998-09-04 | 2007-02-27 | Милленниум Фармасьютикалз, Инк. | Антагонисты хемокинного рецептора и способы их применения |
US20020169155A1 (en) * | 1998-09-04 | 2002-11-14 | Millennium Pharmaceuticals, Inc. | Chemokine receptor anagonists and methods of use therefor |
AU1549500A (en) | 1998-12-02 | 2000-06-19 | Novo Nordisk A/S | Use of n-substituted azaheterocyclic compounds for the manufacture of a pharmaceutical composition for the treatment of indications related to angiogenesis |
AU6499100A (en) | 1999-07-28 | 2001-02-19 | Kyowa Hakko Kogyo Co. Ltd. | Chemokine receptor antagonists and methods of use therefor |
EP1204664A1 (en) * | 1999-07-28 | 2002-05-15 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
EP1448566B3 (en) * | 2001-11-21 | 2009-04-08 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
TWI291467B (en) * | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
CN100524575C (zh) | 2005-04-20 | 2009-08-05 | 三菱电机株式会社 | 过电流继电器 |
JP4715952B2 (ja) | 2009-02-18 | 2011-07-06 | 村田機械株式会社 | フロッグレッグ型移載装置 |
-
2003
- 2003-11-11 TW TW92131488A patent/TWI291467B/zh not_active IP Right Cessation
- 2003-11-12 US US10/706,835 patent/US20040106639A1/en not_active Abandoned
- 2003-11-12 AT AT03768852T patent/ATE325124T1/de active
- 2003-11-12 SI SI200330325T patent/SI1562954T1/sl unknown
- 2003-11-12 CN CNB2003801086866A patent/CN100343257C/zh not_active Expired - Fee Related
- 2003-11-12 KR KR1020057008518A patent/KR101109348B1/ko not_active IP Right Cessation
- 2003-11-12 MX MXPA05005105A patent/MXPA05005105A/es active IP Right Grant
- 2003-11-12 AU AU2003291452A patent/AU2003291452A1/en not_active Abandoned
- 2003-11-12 PL PL377715A patent/PL211022B1/pl unknown
- 2003-11-12 DE DE60332663T patent/DE60332663D1/de not_active Expired - Lifetime
- 2003-11-12 WO PCT/US2003/035817 patent/WO2004043965A1/en active Application Filing
- 2003-11-12 PT PT03768852T patent/PT1562954E/pt unknown
- 2003-11-12 AT AT06004508T patent/ATE468340T1/de not_active IP Right Cessation
- 2003-11-12 EP EP20030768852 patent/EP1562954B1/en not_active Expired - Lifetime
- 2003-11-12 ES ES03768852T patent/ES2261979T3/es not_active Expired - Lifetime
- 2003-11-12 EA EA200500803A patent/EA007748B1/ru not_active IP Right Cessation
- 2003-11-12 ES ES06004508T patent/ES2346337T3/es not_active Expired - Lifetime
- 2003-11-12 EP EP20060004508 patent/EP1669356B1/en not_active Expired - Lifetime
- 2003-11-12 DK DK03768852T patent/DK1562954T3/da active
- 2003-11-12 BR BR0316261A patent/BR0316261A/pt not_active Application Discontinuation
- 2003-11-12 CA CA 2505874 patent/CA2505874C/en not_active Expired - Fee Related
- 2003-11-12 JP JP2004552003A patent/JP4644491B2/ja not_active Expired - Fee Related
- 2003-11-12 AR ARP030104145 patent/AR041942A1/es active IP Right Grant
- 2003-11-12 DE DE2003605063 patent/DE60305063T2/de not_active Expired - Lifetime
-
2005
- 2005-05-04 IL IL168384A patent/IL168384A/en not_active IP Right Cessation
- 2005-05-10 NO NO20052272A patent/NO331855B1/no not_active IP Right Cessation
- 2005-05-23 ZA ZA200504144A patent/ZA200504144B/en unknown
- 2005-08-16 US US11/204,930 patent/US20050288319A1/en not_active Abandoned
- 2005-08-23 HK HK05107405A patent/HK1074046A1/xx not_active IP Right Cessation
- 2005-08-23 HK HK06108230A patent/HK1086011A1/xx not_active IP Right Cessation
-
2006
- 2006-07-21 CY CY061101015T patent/CY1107985T1/el unknown
- 2006-09-20 ZA ZA2006/07868A patent/ZA200607868B/en unknown
-
2007
- 2007-09-13 US US11/900,744 patent/US7732459B2/en not_active Expired - Fee Related
-
2008
- 2008-07-03 AU AU2008202965A patent/AU2008202965B2/en not_active Ceased
-
2010
- 2010-04-22 US US12/765,070 patent/US7977350B2/en not_active Expired - Fee Related
- 2010-12-16 IL IL210046A patent/IL210046A/en active IP Right Grant
-
2011
- 2011-06-02 US US13/151,701 patent/US8394817B2/en not_active Expired - Fee Related
-
2013
- 2013-01-22 US US13/746,688 patent/US20130289063A1/en not_active Abandoned
-
2014
- 2014-02-04 US US14/172,398 patent/US9334283B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1289336A (zh) * | 1998-01-21 | 2001-03-28 | 千禧药品公司 | 趋化因子受体拮抗剂和其使用方法 |
WO2001009138A2 (en) * | 1999-07-28 | 2001-02-08 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100343257C (zh) | 治疗固有活性脱髓鞘炎性病症的ccr1拮抗剂 | |
CN1048492C (zh) | 奎宁环衍生物的制备方法 | |
CN1104430C (zh) | 抑制血管生成的哒嗪胺 | |
CN1052005C (zh) | 咪唑并吡啶、其制法和药用 | |
CN1071168A (zh) | 稠合的三环含氮杂环化合物 | |
CN1200114A (zh) | 作为gnrh拮抗剂的喹啉衍生物 | |
CN1074764C (zh) | 苯并噁嗪酮多巴胺d4受体拮抗剂 | |
CN1007352B (zh) | 新的4h-1-苯并吡喃-4-酮的生产方法 | |
CN1055929A (zh) | 新的2,9-二取代-4H一吡啶并[1,2-a]嘧啶-4-酮 | |
CN1032754C (zh) | 免疫刺激性6-芳基-5,6-二氢咪唑并[2,1-b]噻唑衍生物的制备方法 | |
CN1009826B (zh) | 制备喹啉基化合物的方法 | |
CN1061043C (zh) | 苯并异噻唑基取代的氨甲基苯并二氢吡喃 | |
CN1122666C (zh) | 新的2,3-二氢化茚醇化合物,其制备方法和包含它们的药物组合物 | |
CN1131868C (zh) | 作为药物的三环△3-哌啶 | |
CN1067391C (zh) | 哌啶基甲基噁唑烷酮 | |
EP2286811B1 (en) | Chemokine receptor antagonists and methods of use thereof | |
CN1014992B (zh) | 喹唑啉二酮和吡啶并嘧啶二酮的制备方法 | |
CN1303085C (zh) | C6-和c9-取代的异噁唑啉衍生物和它们作为抗抑郁药的用途 | |
CN1642553A (zh) | N -{ [ ( 2 s ) - 4 - ( 3 , 4-二氟苄基 )吗啉 - 2 -基}甲基} - 2 -{ 3 - [ (甲基磺酰基 )氨基 ]苯基}乙酰胺作为ccr3拮抗剂用于治疗炎症 | |
CN1154646C (zh) | 作为α2-拮抗剂的苯并异噁唑和苯基酮 | |
CN1158287C (zh) | 作为α2拮抗剂的苯并噻吩并[3,2-c]吡啶 | |
CN1649875A (zh) | 作为肿瘤坏死因子产生抑制剂的2-硫杂-二苯并薁及用于其制备的中间体 | |
CN1665821A (zh) | 作为肿瘤坏死因子产生的抑制剂的1-氧杂-二苯并薁类和制备该类化合物的中间体 | |
CN1950378A (zh) | 作为ikk抑制剂的噻吩并哒嗪类化合物 | |
CN1040589A (zh) | 抗高血压药3-哌啶基吲唑衍生物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20071017 Termination date: 20191112 |