CN100341867C - 多酚的合成方法 - Google Patents

多酚的合成方法 Download PDF

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Publication number
CN100341867C
CN100341867C CNB988119412A CN98811941A CN100341867C CN 100341867 C CN100341867 C CN 100341867C CN B988119412 A CNB988119412 A CN B988119412A CN 98811941 A CN98811941 A CN 98811941A CN 100341867 C CN100341867 C CN 100341867C
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CN
China
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substituted
protected
group
polyphenol
proanthocyanidin
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Expired - Fee Related
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CNB988119412A
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English (en)
Chinese (zh)
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CN1302295A (zh
Inventor
小L·J·罗曼赛克
A·P·科兹科夫斯基
W·特克曼特尔
M·E·利普曼
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Mars Inc
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Mars Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
CNB988119412A 1997-10-09 1998-10-09 多酚的合成方法 Expired - Fee Related CN100341867C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/948,226 US6207842B1 (en) 1997-10-09 1997-10-09 Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
US08/948,226 1997-10-09

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2007100018908A Division CN101066962A (zh) 1997-10-09 1998-10-09 多酚的合成方法

Publications (2)

Publication Number Publication Date
CN1302295A CN1302295A (zh) 2001-07-04
CN100341867C true CN100341867C (zh) 2007-10-10

Family

ID=25487506

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB988119412A Expired - Fee Related CN100341867C (zh) 1997-10-09 1998-10-09 多酚的合成方法
CNA2007100018908A Pending CN101066962A (zh) 1997-10-09 1998-10-09 多酚的合成方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2007100018908A Pending CN101066962A (zh) 1997-10-09 1998-10-09 多酚的合成方法

Country Status (13)

Country Link
US (6) US6207842B1 (https=)
EP (1) EP1027345B1 (https=)
JP (1) JP2001519426A (https=)
KR (1) KR100560463B1 (https=)
CN (2) CN100341867C (https=)
AT (1) ATE232857T1 (https=)
AU (1) AU760031B2 (https=)
CA (1) CA2306851A1 (https=)
DE (1) DE69811526T2 (https=)
DK (1) DK1027345T3 (https=)
ES (1) ES2189260T3 (https=)
IL (1) IL135344A (https=)
WO (1) WO1999019319A1 (https=)

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US7514107B2 (en) 2002-03-21 2009-04-07 Mars, Incorporated Treatment of diseases involving defective gap junctional communication
US7595074B2 (en) * 2002-04-05 2009-09-29 University Of Massachusetts Lowell Polymeric antioxidants
EP1492856A4 (en) * 2002-04-05 2010-11-10 Univ Massachusetts Lowell POLYMER ANTIOXIDANTS
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EP1524270B1 (en) * 2003-05-26 2009-08-26 Amino Up Chemical Co. Ltd. Sulfur-containing proanthocyanidin oligomer composition and process for producing the same
JP2007508316A (ja) * 2003-10-10 2007-04-05 マーズ　インコーポレイテッド ＥｒｂＢ２キナーゼ過剰発現に関連する病気の治療
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JP2008507613A (ja) * 2004-07-23 2008-03-13 ポルノクス コーポレーション 抗酸化マクロモノマーおよび抗酸化ポリマー、ならびにその作製方法および使用方法
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CN117658967A (zh) * 2023-10-09 2024-03-08 朗华生物科学(深圳)有限公司 一种黄烷-3,4-二醇类衍生物的制备方法
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Publication number Publication date
US6528664B2 (en) 2003-03-04
AU760031B2 (en) 2003-05-08
AU1076699A (en) 1999-05-03
WO1999019319A1 (en) 1999-04-22
US20040236123A1 (en) 2004-11-25
US6849746B2 (en) 2005-02-01
US20030176620A1 (en) 2003-09-18
US20020128493A1 (en) 2002-09-12
ATE232857T1 (de) 2003-03-15
DE69811526T2 (de) 2003-11-06
DK1027345T3 (da) 2003-06-10
CN101066962A (zh) 2007-11-07
KR20010030986A (ko) 2001-04-16
EP1027345A1 (en) 2000-08-16
EP1027345B1 (en) 2003-02-19
CN1302295A (zh) 2001-07-04
CA2306851A1 (en) 1999-04-22
IL135344A (en) 2005-11-20
JP2001519426A (ja) 2001-10-23
KR100560463B1 (ko) 2006-03-13
US20040235941A1 (en) 2004-11-25
ES2189260T3 (es) 2003-07-01
US7268240B2 (en) 2007-09-11
IL135344A0 (en) 2001-05-20
US6420572B1 (en) 2002-07-16
US6207842B1 (en) 2001-03-27
DE69811526D1 (en) 2003-03-27

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