ES2189260T3 - Metodos sinteticos para polifenoles. - Google Patents

Metodos sinteticos para polifenoles.

Info

Publication number
ES2189260T3
ES2189260T3 ES98953371T ES98953371T ES2189260T3 ES 2189260 T3 ES2189260 T3 ES 2189260T3 ES 98953371 T ES98953371 T ES 98953371T ES 98953371 T ES98953371 T ES 98953371T ES 2189260 T3 ES2189260 T3 ES 2189260T3
Authority
ES
Spain
Prior art keywords
polyphenol
protected
monomeric units
polyphenols
synthetic methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98953371T
Other languages
English (en)
Spanish (es)
Inventor
Leo J Romanczyk Jr
Alan P Kozikowski
Werner Tueckmantel
Marc E Lippman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mars Inc
Original Assignee
Mars Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mars Inc filed Critical Mars Inc
Application granted granted Critical
Publication of ES2189260T3 publication Critical patent/ES2189260T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
ES98953371T 1997-10-09 1998-10-09 Metodos sinteticos para polifenoles. Expired - Lifetime ES2189260T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/948,226 US6207842B1 (en) 1997-10-09 1997-10-09 Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives

Publications (1)

Publication Number Publication Date
ES2189260T3 true ES2189260T3 (es) 2003-07-01

Family

ID=25487506

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98953371T Expired - Lifetime ES2189260T3 (es) 1997-10-09 1998-10-09 Metodos sinteticos para polifenoles.

Country Status (13)

Country Link
US (6) US6207842B1 (https=)
EP (1) EP1027345B1 (https=)
JP (1) JP2001519426A (https=)
KR (1) KR100560463B1 (https=)
CN (2) CN100341867C (https=)
AT (1) ATE232857T1 (https=)
AU (1) AU760031B2 (https=)
CA (1) CA2306851A1 (https=)
DE (1) DE69811526T2 (https=)
DK (1) DK1027345T3 (https=)
ES (1) ES2189260T3 (https=)
IL (1) IL135344A (https=)
WO (1) WO1999019319A1 (https=)

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US20030017998A1 (en) * 1997-05-16 2003-01-23 Snow Alan D. Proanthocyanidins for the treatment of amyloid and alpha-synuclein diseases
US6207842B1 (en) * 1997-10-09 2001-03-27 Mars Incorporated Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
US7015338B1 (en) * 1999-04-15 2006-03-21 Mars Incorporated Synthetic methods for preparing procyanidin oligomers
US6562864B1 (en) * 1999-09-02 2003-05-13 Drake Larson Catechin multimers as therapeutic drug delivery agents
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US7514107B2 (en) 2002-03-21 2009-04-07 Mars, Incorporated Treatment of diseases involving defective gap junctional communication
US7595074B2 (en) * 2002-04-05 2009-09-29 University Of Massachusetts Lowell Polymeric antioxidants
EP1492856A4 (en) * 2002-04-05 2010-11-10 Univ Massachusetts Lowell POLYMER ANTIOXIDANTS
US7067679B2 (en) * 2002-10-02 2006-06-27 Mars, Inc. Synthesis of dimeric, trimeric, tetrameric pentameric, and higher oligomeric epicatechin-derived procyanidins having 4,8-interflavan linkages and their use to inhibit cancer cell growth through cell cycle arrest
AU2002348822A1 (en) * 2002-12-17 2004-07-09 Council Of Scientific And Industrial Research A new antioxidant from natural source
EP1524270B1 (en) * 2003-05-26 2009-08-26 Amino Up Chemical Co. Ltd. Sulfur-containing proanthocyanidin oligomer composition and process for producing the same
JP2007508316A (ja) * 2003-10-10 2007-04-05 マーズ　インコーポレイテッド ＥｒｂＢ２キナーゼ過剰発現に関連する病気の治療
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Also Published As

Publication number Publication date
US6528664B2 (en) 2003-03-04
AU760031B2 (en) 2003-05-08
AU1076699A (en) 1999-05-03
WO1999019319A1 (en) 1999-04-22
US20040236123A1 (en) 2004-11-25
US6849746B2 (en) 2005-02-01
US20030176620A1 (en) 2003-09-18
US20020128493A1 (en) 2002-09-12
ATE232857T1 (de) 2003-03-15
CN100341867C (zh) 2007-10-10
DE69811526T2 (de) 2003-11-06
DK1027345T3 (da) 2003-06-10
CN101066962A (zh) 2007-11-07
KR20010030986A (ko) 2001-04-16
EP1027345A1 (en) 2000-08-16
EP1027345B1 (en) 2003-02-19
CN1302295A (zh) 2001-07-04
CA2306851A1 (en) 1999-04-22
IL135344A (en) 2005-11-20
JP2001519426A (ja) 2001-10-23
KR100560463B1 (ko) 2006-03-13
US20040235941A1 (en) 2004-11-25
US7268240B2 (en) 2007-09-11
IL135344A0 (en) 2001-05-20
US6420572B1 (en) 2002-07-16
US6207842B1 (en) 2001-03-27
DE69811526D1 (en) 2003-03-27

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