CL2022000763A1 - Derivados de 2-isoindol-1,3,4-oxadiazol útiles como inhibidores de la histona desacetilasa 6 (hdac6) - Google Patents
Derivados de 2-isoindol-1,3,4-oxadiazol útiles como inhibidores de la histona desacetilasa 6 (hdac6)Info
- Publication number
- CL2022000763A1 CL2022000763A1 CL2022000763A CL2022000763A CL2022000763A1 CL 2022000763 A1 CL2022000763 A1 CL 2022000763A1 CL 2022000763 A CL2022000763 A CL 2022000763A CL 2022000763 A CL2022000763 A CL 2022000763A CL 2022000763 A1 CL2022000763 A1 CL 2022000763A1
- Authority
- CL
- Chile
- Prior art keywords
- hdac6
- isoindole
- inhibitors
- histone deacetylase
- oxadiazole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019177815 | 2019-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2022000763A1 true CL2022000763A1 (es) | 2023-01-20 |
Family
ID=73040188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2022000763A CL2022000763A1 (es) | 2019-09-27 | 2022-03-25 | Derivados de 2-isoindol-1,3,4-oxadiazol útiles como inhibidores de la histona desacetilasa 6 (hdac6) |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US11453661B2 (enExample) |
| EP (1) | EP4034536A1 (enExample) |
| JP (1) | JP7602546B2 (enExample) |
| KR (1) | KR20220070465A (enExample) |
| CN (1) | CN114846012B (enExample) |
| AR (1) | AR120040A1 (enExample) |
| AU (1) | AU2020353984B2 (enExample) |
| BR (1) | BR112022005595A2 (enExample) |
| CA (1) | CA3156060A1 (enExample) |
| CL (1) | CL2022000763A1 (enExample) |
| CO (1) | CO2022005059A2 (enExample) |
| EC (1) | ECSP22026524A (enExample) |
| IL (1) | IL291413B2 (enExample) |
| MX (1) | MX2022003490A (enExample) |
| PE (1) | PE20220711A1 (enExample) |
| PH (1) | PH12022550748A1 (enExample) |
| TW (1) | TWI882012B (enExample) |
| WO (1) | WO2021060567A1 (enExample) |
| ZA (1) | ZA202204666B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| WO2021021979A2 (en) | 2019-07-30 | 2021-02-04 | Eikonizo Therapapeutics, Inc. | Hdac6 inhibitors and uses thereof |
| AU2020353984B2 (en) * | 2019-09-27 | 2025-09-25 | Takeda Pharmaceutical Company Limited | 2-isoindol-1,3,4-oxadiazole derivatives useful as HDAC6 inhibitors |
| CN114980887A (zh) | 2019-12-20 | 2022-08-30 | 特纳亚治疗股份有限公司 | 氟代烷基-噁二唑及其用途 |
| IL307883A (en) | 2021-04-23 | 2023-12-01 | Tenaya Therapeutics Inc | HDAC6 inhibitors for use in the treatment of dilated myocardial disease |
| WO2022235842A1 (en) | 2021-05-04 | 2022-11-10 | Tenaya Therapeutics, Inc. | 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef |
| CN114166824B (zh) * | 2021-12-08 | 2024-01-23 | 桂林医学院 | 一种辅剂示踪分析保健品中药物含量的方法 |
| EP4504190A4 (en) | 2022-04-08 | 2026-03-25 | Eikonizo Therapeutics Inc | OXADIAZOLE HDAC6 INHIBITORS AND THEIR USES |
| TW202400147A (zh) * | 2022-04-15 | 2024-01-01 | 大陸商勤浩醫藥(蘇州)有限公司 | 噁二唑化合物、包含其的藥物組合物及其用途 |
| AU2024240637A1 (en) * | 2023-03-21 | 2025-09-18 | Vivozon,Inc. | Double regulator for mglur5 and hdac6 and use thereof |
| WO2025067416A1 (zh) * | 2023-09-28 | 2025-04-03 | 勤浩医药（苏州）有限公司 | 一种hdac6抑制剂的结晶形式及其制备方法 |
| WO2025215092A1 (en) | 2024-04-10 | 2025-10-16 | Institut National de la Santé et de la Recherche Médicale | Selective hdac6 inhibitors for use in the treatment of myotonic dystrophy type 1 |
| CN119823019A (zh) * | 2025-01-06 | 2025-04-15 | 沈阳药科大学 | 一种具有治疗特发性肺纤维化作用的吲哚类化合物及其制备方法和应用 |
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| ES2310213T3 (es) | 2001-05-02 | 2009-01-01 | The Regents Of The University Of California | Procedimiento para tratar trastornos neurodegenerativos, psiquiatricos y otros trastornos con inhibidores de desacetilasa. |
| US20040142859A1 (en) | 2002-05-02 | 2004-07-22 | Steffan Joan S. | Method for treating neurodegenerative, psychiatric, and other disorders with deacetylase inhibitors |
| WO2003032921A2 (en) | 2001-10-16 | 2003-04-24 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases and cancer of the brain |
| NZ550185A (en) | 2002-03-04 | 2008-10-31 | Merck Hdac Res Llc | Methods of inducing terminal differentiation Methods of inducing terminal differentiation |
| WO2003080864A1 (fr) | 2002-03-26 | 2003-10-02 | Exhonit Therapeutics Sa | Histone deacetylase: nouvelle cible moleculaire de la neurotoxicite |
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| ITMI20040876A1 (it) | 2004-04-30 | 2004-07-30 | Univ Degli Studi Milano | Inibitori delle istone deacetilasi-hdac-quali agenti ipolipidemizzati per la terapia e la prevenzione dell'arteriosclerosi e malattie cardiovascolari |
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| JP6910984B2 (ja) | 2018-03-30 | 2021-07-28 | 株式会社ホンダアクセス | 脱出ハンマー収容具 |
| KR102316234B1 (ko) * | 2018-07-26 | 2021-10-22 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| HRP20250048T1 (hr) | 2018-10-22 | 2025-03-28 | Alumis Inc. | Inhibitori tyk2 i njihova uporaba |
| JP7470058B2 (ja) | 2019-01-30 | 2024-04-17 | 武田薬品工業株式会社 | 複素環化合物 |
| AU2020353984B2 (en) * | 2019-09-27 | 2025-09-25 | Takeda Pharmaceutical Company Limited | 2-isoindol-1,3,4-oxadiazole derivatives useful as HDAC6 inhibitors |
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2020
- 2020-09-24 AU AU2020353984A patent/AU2020353984B2/en active Active
- 2020-09-24 PE PE2022000460A patent/PE20220711A1/es unknown
- 2020-09-24 MX MX2022003490A patent/MX2022003490A/es unknown
- 2020-09-24 AR ARP200102652A patent/AR120040A1/es unknown
- 2020-09-24 EP EP20800345.9A patent/EP4034536A1/en active Pending
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| TW202126643A (zh) | 2021-07-16 |
| US12384770B2 (en) | 2025-08-12 |
| AU2020353984A1 (en) | 2022-04-21 |
| CO2022005059A2 (es) | 2022-07-08 |
| EP4034536A1 (en) | 2022-08-03 |
| AU2020353984A2 (en) | 2022-08-04 |
| WO2021060567A1 (en) | 2021-04-01 |
| CN114846012A (zh) | 2022-08-02 |
| JP7602546B2 (ja) | 2024-12-18 |
| AU2020353984B2 (en) | 2025-09-25 |
| TWI882012B (zh) | 2025-05-01 |
| US20230183227A1 (en) | 2023-06-15 |
| JP2022552444A (ja) | 2022-12-15 |
| MX2022003490A (es) | 2022-04-25 |
| IL291413B1 (en) | 2024-11-01 |
| KR20220070465A (ko) | 2022-05-31 |
| PE20220711A1 (es) | 2022-05-04 |
| US20210094944A1 (en) | 2021-04-01 |
| CA3156060A1 (en) | 2021-04-01 |
| US20240343721A1 (en) | 2024-10-17 |
| US11958845B2 (en) | 2024-04-16 |
| ZA202204666B (en) | 2023-11-29 |
| PH12022550748A1 (en) | 2023-11-20 |
| CN114846012B (zh) | 2024-01-26 |
| IL291413A (en) | 2022-05-01 |
| AR120040A1 (es) | 2022-01-26 |
| BR112022005595A2 (pt) | 2022-07-19 |
| ECSP22026524A (es) | 2022-05-31 |
| US11453661B2 (en) | 2022-09-27 |
| IL291413B2 (en) | 2025-03-01 |
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