CL2022000763A1 - Derivados de 2-isoindol-1,3,4-oxadiazol útiles como inhibidores de la histona desacetilasa 6 (hdac6) - Google Patents
Derivados de 2-isoindol-1,3,4-oxadiazol útiles como inhibidores de la histona desacetilasa 6 (hdac6)Info
- Publication number
- CL2022000763A1 CL2022000763A1 CL2022000763A CL2022000763A CL2022000763A1 CL 2022000763 A1 CL2022000763 A1 CL 2022000763A1 CL 2022000763 A CL2022000763 A CL 2022000763A CL 2022000763 A CL2022000763 A CL 2022000763A CL 2022000763 A1 CL2022000763 A1 CL 2022000763A1
- Authority
- CL
- Chile
- Prior art keywords
- hdac6
- isoindole
- inhibitors
- histone deacetylase
- oxadiazole derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente proporciona un compuesto heterocíclico que tiene una acción inhibitoria de HDAC6, el cual es útil para el tratamiento de enfermedades del sistema nervioso central, que incluyen enfermedades neurodegenerativas y similares, y un medicamento que comprende el compuesto. La presente invención se refiere a un compuesto representado por la fórmula (I): en la que cada símbolo está de acuerdo con lo definido en las reivindicaciones, o una sal del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2019177815 | 2019-09-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2022000763A1 true CL2022000763A1 (es) | 2023-01-20 |
Family
ID=73040188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2022000763A CL2022000763A1 (es) | 2019-09-27 | 2022-03-25 | Derivados de 2-isoindol-1,3,4-oxadiazol útiles como inhibidores de la histona desacetilasa 6 (hdac6) |
Country Status (18)
Country | Link |
---|---|
US (2) | US11453661B2 (es) |
EP (1) | EP4034536A1 (es) |
JP (1) | JP2022552444A (es) |
KR (1) | KR20220070465A (es) |
CN (1) | CN114846012B (es) |
AR (1) | AR120040A1 (es) |
AU (1) | AU2020353984A1 (es) |
BR (1) | BR112022005595A2 (es) |
CA (1) | CA3156060A1 (es) |
CL (1) | CL2022000763A1 (es) |
CO (1) | CO2022005059A2 (es) |
EC (1) | ECSP22026524A (es) |
IL (1) | IL291413A (es) |
MX (1) | MX2022003490A (es) |
PE (1) | PE20220711A1 (es) |
TW (1) | TW202126643A (es) |
WO (1) | WO2021060567A1 (es) |
ZA (1) | ZA202204666B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10357493B2 (en) | 2017-03-10 | 2019-07-23 | Selenity Therapeutics (Bermuda), Ltd. | Metalloenzyme inhibitor compounds |
CN117561059A (zh) | 2021-04-23 | 2024-02-13 | 特纳亚治疗股份有限公司 | 用于治疗扩张型心肌病的hdac6抑制剂 |
CA3216768A1 (en) | 2021-05-04 | 2022-11-10 | Jin Yang | 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef |
CN114166824B (zh) * | 2021-12-08 | 2024-01-23 | 桂林医学院 | 一种辅剂示踪分析保健品中药物含量的方法 |
TW202400147A (zh) * | 2022-04-15 | 2024-01-01 | 大陸商勤浩醫藥(蘇州)有限公司 | 噁二唑化合物、包含其的藥物組合物及其用途 |
Family Cites Families (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
US20040142859A1 (en) | 2002-05-02 | 2004-07-22 | Steffan Joan S. | Method for treating neurodegenerative, psychiatric, and other disorders with deacetylase inhibitors |
US20050227915A1 (en) | 2001-05-02 | 2005-10-13 | Steffan Joan S | Methods and reagents for treating neurodegenerative diseases and motor deficit disorders |
DE60227658D1 (de) | 2001-05-02 | 2008-08-28 | Univ California | Verfahren zur behandlung neurodegenerativer, psychiatrischer und anderer störungen mit deacetylaseinhibitoren |
WO2003032921A2 (en) | 2001-10-16 | 2003-04-24 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases and cancer of the brain |
RU2320331C2 (ru) | 2002-03-04 | 2008-03-27 | МЕРК ЭйчДиЭйСи Рисерч, ЛЛС. | Способ индукции конечной дифференцировки |
EP1488005A1 (fr) | 2002-03-26 | 2004-12-22 | Exhonit Therapeutics SA | Histone deacetylase : nouvelle cible moleculaire de la neurotoxicite |
US20040077591A1 (en) | 2002-03-28 | 2004-04-22 | The Brigham And Women's Hospital, Inc. | Histone deacetylase inhibitors for the treatment of multiple sclerosis, amyotrophic lateral sclerosis and Alzheimer's Disease |
ITMI20040876A1 (it) | 2004-04-30 | 2004-07-30 | Univ Degli Studi Milano | Inibitori delle istone deacetilasi-hdac-quali agenti ipolipidemizzati per la terapia e la prevenzione dell'arteriosclerosi e malattie cardiovascolari |
US20060018921A1 (en) | 2004-07-16 | 2006-01-26 | Baylor College Of Medicine | Histone deacetylase inhibitors and cognitive applications |
GT200500321A (es) | 2004-11-09 | 2006-09-04 | Compuestos y composiciones como inhibidores de proteina kinase. | |
CN101056632B (zh) * | 2004-11-09 | 2011-12-07 | Irm责任有限公司 | 用作蛋白激酶抑制剂的化合物和组合物 |
US20060135612A1 (en) | 2004-12-17 | 2006-06-22 | U.S. Department Of Veterans Affairs | Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as amyotrophic lateral sclerosis (ALS), by using a HDAC inhibiting agent |
CA2937005A1 (en) | 2005-03-22 | 2006-09-28 | President And Fellows Of Harvard College | Treatment of protein degradation disorders |
NZ565953A (en) | 2005-07-27 | 2012-01-12 | Univ Florida | Small compounds that correct protein misfolding and uses thereof |
US20070078083A1 (en) | 2005-09-07 | 2007-04-05 | Braincells, Inc. | MODULATION OF NEUORGENESIS BY HDac INHIBITION |
WO2007049262A1 (en) | 2005-10-27 | 2007-05-03 | Berand Limited | Methods and compositions for the promotion of neuronal growth and the treatment of asociality and affective disorders |
US8026260B2 (en) | 2005-11-03 | 2011-09-27 | Merck Sharp & Dohme Corp. | Histone deacetylase inhibitors with aryl-pyrazolyl-motifs |
US20070207950A1 (en) | 2005-12-21 | 2007-09-06 | Duke University | Methods and compositions for regulating HDAC6 activity |
GB0612273D0 (en) | 2006-06-21 | 2006-08-02 | Friedrich Miescher Inst For Bi | Prevention of muscle atrophy |
US8088951B2 (en) | 2006-11-30 | 2012-01-03 | Massachusetts Institute Of Technology | Epigenetic mechanisms re-establish access to long-term memory after neuronal loss |
WO2008073733A1 (en) | 2006-12-08 | 2008-06-19 | Kalypsys, Inc. | Salts of inhibitors of histone deacetylase for the treatment of disease |
US20100022514A1 (en) | 2006-12-15 | 2010-01-28 | Norvartis Ag | Heterocycle Compounds and Methods of Use Thereof |
WO2008126932A2 (en) | 2007-04-09 | 2008-10-23 | Riken | Epigenetical regulation of brain plasticity |
US8389553B2 (en) | 2007-06-27 | 2013-03-05 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
WO2009027349A2 (en) | 2007-08-24 | 2009-03-05 | Oryzon Genomics Sa | Treatment and prevention of neurodegenerative diseases |
US20090136461A1 (en) | 2007-11-28 | 2009-05-28 | Moon Suk Kim | Neuronal differentiation method of adult stem cells using small molecules |
AU2013203735A1 (en) * | 2007-12-04 | 2013-05-02 | F. Hoffmann-La Roche Ag | Isoxazolo-pyridine derivatives |
EP2516395A1 (en) * | 2009-12-22 | 2012-10-31 | Celgene Corporation | (methylsulfonyl) ethyl benzene isoindoline derivatives and their therapeutical uses |
AU2011205283B2 (en) | 2010-01-13 | 2014-07-10 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
US8981084B2 (en) | 2010-01-13 | 2015-03-17 | Tempero Pharmaceuticals, Inc. | Oxadiazole HDAC inhibitors |
WO2012018499A2 (en) | 2010-08-05 | 2012-02-09 | Acetylon Pharmaceuticals | Specific regulation of cytokine levels by hdac6 inhibitors |
CA2812855C (en) | 2010-10-08 | 2017-12-19 | Vib Vzw | Hdac inhibitors to treat charcot-marie-tooth disease |
EP2632900A2 (en) | 2010-10-28 | 2013-09-04 | Merck Sharp & Dohme Corp. | Caprolactam mglur5 receptor modulators |
AU2012223509B2 (en) | 2011-02-28 | 2016-11-10 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
EP2712655B1 (en) | 2011-04-28 | 2019-12-18 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
WO2012162535A1 (en) | 2011-05-24 | 2012-11-29 | Lixte Biotechnology, Inc. | Use of phosphatase inhibitors or histone deacetylase inhibitors to treat diseases characterized by loss of protein function |
WO2013006408A1 (en) | 2011-07-01 | 2013-01-10 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
EP2729454B1 (en) | 2011-07-08 | 2015-09-16 | Novartis AG | Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease |
WO2013009827A1 (en) | 2011-07-13 | 2013-01-17 | Tempero Pharmaceuticals, Inc. | Methods of treatment |
WO2013009830A1 (en) | 2011-07-13 | 2013-01-17 | Tempero Pharmaceuticals, Inc. | Methods of treatment |
WO2013009810A1 (en) * | 2011-07-13 | 2013-01-17 | Tempero Pharmaceuticals, Inc. | Methods of treatment |
US9512083B2 (en) | 2011-07-20 | 2016-12-06 | The General Hospital Corporation | Histone deacetylase 6 selective inhibitors for the treatment of bone disease |
WO2013066833A1 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods to inhibit histone deacetylase (hdac) enzymes |
WO2013066835A2 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
WO2013066831A1 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
WO2013066838A1 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
WO2013066839A2 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
JP5966014B2 (ja) | 2011-11-28 | 2016-08-10 | ノバルティス アーゲー | 新規トリフルオロメチル−オキサジアゾール誘導体および疾患の処置におけるその使用 |
US9480673B2 (en) | 2012-03-29 | 2016-11-01 | The Regents Of The University Of Colorado, A Body Corporate | Composition and method for treating neurodegenerative disease |
WO2013163455A2 (en) | 2012-04-25 | 2013-10-31 | The Regents Of The University Of California | A drug screening platform for rett syndrome |
US20150184154A1 (en) | 2012-07-05 | 2015-07-02 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Resear | New treatment for neurodegenerative diseases |
CN104894060B (zh) | 2014-03-03 | 2018-11-06 | 中国科学院上海生命科学研究院 | 诱导体细胞转分化为神经干细胞的方法及其应用 |
JP6392888B2 (ja) * | 2014-03-12 | 2018-09-19 | チョン クン ダン ファーマシューティカル コーポレーション | ヒストン脱アセチル化酵素6阻害剤としての新規化合物およびこれを含む薬剤学的組成物 |
JP6556146B2 (ja) | 2014-08-26 | 2019-08-07 | 武田薬品工業株式会社 | 複素環化合物 |
JPWO2016039398A1 (ja) | 2014-09-09 | 2017-06-15 | 国立大学法人大阪大学 | 含窒素複素環誘導体、神経保護剤及び癌治療用医薬組成物 |
CA2975605C (en) | 2015-02-02 | 2023-12-12 | Forma Therapeutics, Inc. | 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors |
US10357484B2 (en) | 2015-07-17 | 2019-07-23 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
US10308643B2 (en) | 2015-07-17 | 2019-06-04 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
JP6560436B2 (ja) | 2015-07-27 | 2019-08-14 | チョン クン ダン ファーマシューティカル コーポレーション | ヒストン脱アセチル化酵素6阻害剤としての1,3,4−オキサジアゾールスルホンアミド誘導体化合物及びこれを含有する薬剤学的組成物 |
AU2016299485B2 (en) | 2015-07-27 | 2019-02-07 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same |
BR112017027798B1 (pt) | 2015-07-27 | 2023-12-19 | Chong Kun Dang Pharmaceutical Corp | Compostos de derivado de 1,3,4-oxadiazol sulfamida como inibidor de histona desacetilase 6 e a composição farmacêutica que compreende os mesmos |
ES2903214T3 (es) | 2015-08-04 | 2022-03-31 | Chong Kun Dang Pharmaceutical Corp | Compuestos derivados de 1,3,4-oxadiazol como inhibidores de la histona desacetilasa 6 y la composición farmacéutica que comprende los mismos |
EP3342772A4 (en) | 2015-08-25 | 2019-03-27 | Takeda Pharmaceutical Company Limited | HETEROCYCLIC COMPOUND |
PL3362445T3 (pl) * | 2015-10-12 | 2023-08-07 | Chong Kun Dang Pharmaceutical Corp. | Związki będące pochodnymi oksadiazoloamin jako inhibitor deacetylazy histonowej 6 oraz kompozycja farmaceutyczna obejmujące takie związki |
WO2017222952A1 (en) * | 2016-06-23 | 2017-12-28 | Merck Sharp & Dohme Corp. | 3- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors |
US20180016314A1 (en) | 2016-07-12 | 2018-01-18 | Children's Hospital Medical Center | Treatment of disease via transcription factor modulation |
US10357493B2 (en) * | 2017-03-10 | 2019-07-23 | Selenity Therapeutics (Bermuda), Ltd. | Metalloenzyme inhibitor compounds |
US20200085812A1 (en) | 2017-05-24 | 2020-03-19 | Orphazyme A/S | Heat shock protein inducers and frontotemporal disorders |
WO2019027054A1 (en) * | 2017-07-31 | 2019-02-07 | Takeda Pharmaceutical Company Limited | HETEROCYCLIC COMPOUND |
EP3664789B1 (en) | 2017-08-09 | 2023-11-22 | Children's Hospital Medical Center | Methods for treating diseases and nerve injury |
EP3664828A1 (en) | 2017-08-10 | 2020-06-17 | Friedrich Miescher Institute for Biomedical Research | Hdac6 and protein aggregation |
JP6910984B2 (ja) | 2018-03-30 | 2021-07-28 | 株式会社ホンダアクセス | 脱出ハンマー収容具 |
KR102316234B1 (ko) | 2018-07-26 | 2021-10-22 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
EP3870579A4 (en) | 2018-10-22 | 2022-10-19 | Alumis Inc. | TYK2 INHIBITORS AND THEIR USES |
JP7470058B2 (ja) | 2019-01-30 | 2024-04-17 | 武田薬品工業株式会社 | 複素環化合物 |
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2020
- 2020-09-24 CA CA3156060A patent/CA3156060A1/en active Pending
- 2020-09-24 US US17/030,504 patent/US11453661B2/en active Active
- 2020-09-24 BR BR112022005595A patent/BR112022005595A2/pt unknown
- 2020-09-24 EP EP20800345.9A patent/EP4034536A1/en active Pending
- 2020-09-24 PE PE2022000460A patent/PE20220711A1/es unknown
- 2020-09-24 AR ARP200102652A patent/AR120040A1/es unknown
- 2020-09-24 CN CN202080068097.3A patent/CN114846012B/zh active Active
- 2020-09-24 AU AU2020353984A patent/AU2020353984A1/en active Pending
- 2020-09-24 KR KR1020227012924A patent/KR20220070465A/ko unknown
- 2020-09-24 WO PCT/JP2020/037386 patent/WO2021060567A1/en active Application Filing
- 2020-09-24 JP JP2022545275A patent/JP2022552444A/ja active Pending
- 2020-09-24 MX MX2022003490A patent/MX2022003490A/es unknown
- 2020-09-24 TW TW109133124A patent/TW202126643A/zh unknown
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2022
- 2022-03-16 IL IL291413A patent/IL291413A/en unknown
- 2022-03-25 CL CL2022000763A patent/CL2022000763A1/es unknown
- 2022-04-04 EC ECSENADI202226524A patent/ECSP22026524A/es unknown
- 2022-04-22 CO CONC2022/0005059A patent/CO2022005059A2/es unknown
- 2022-04-26 ZA ZA2022/04666A patent/ZA202204666B/en unknown
- 2022-09-26 US US17/952,546 patent/US11958845B2/en active Active
Also Published As
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IL291413A (en) | 2022-05-01 |
US20230183227A1 (en) | 2023-06-15 |
US20210094944A1 (en) | 2021-04-01 |
JP2022552444A (ja) | 2022-12-15 |
CO2022005059A2 (es) | 2022-07-08 |
WO2021060567A1 (en) | 2021-04-01 |
AU2020353984A2 (en) | 2022-08-04 |
ECSP22026524A (es) | 2022-05-31 |
MX2022003490A (es) | 2022-04-25 |
PE20220711A1 (es) | 2022-05-04 |
US11958845B2 (en) | 2024-04-16 |
AR120040A1 (es) | 2022-01-26 |
ZA202204666B (en) | 2023-11-29 |
TW202126643A (zh) | 2021-07-16 |
AU2020353984A1 (en) | 2022-04-21 |
EP4034536A1 (en) | 2022-08-03 |
BR112022005595A2 (pt) | 2022-07-19 |
CN114846012A (zh) | 2022-08-02 |
CA3156060A1 (en) | 2021-04-01 |
US11453661B2 (en) | 2022-09-27 |
KR20220070465A (ko) | 2022-05-31 |
CN114846012B (zh) | 2024-01-26 |
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