MX2022003490A - Derivados de 2-isoindol-1,3,4-oxadiazol utiles como inhibidores de la histona desacetilasa 6 (hdac6). - Google Patents

Derivados de 2-isoindol-1,3,4-oxadiazol utiles como inhibidores de la histona desacetilasa 6 (hdac6).

Info

Publication number
MX2022003490A
MX2022003490A MX2022003490A MX2022003490A MX2022003490A MX 2022003490 A MX2022003490 A MX 2022003490A MX 2022003490 A MX2022003490 A MX 2022003490A MX 2022003490 A MX2022003490 A MX 2022003490A MX 2022003490 A MX2022003490 A MX 2022003490A
Authority
MX
Mexico
Prior art keywords
isoindol
oxadiazole derivatives
derivatives useful
hdac6 inhibitors
compound
Prior art date
Application number
MX2022003490A
Other languages
English (en)
Inventor
Takeshi Yamamoto
Masato Yoshikawa
Keiko Kakegawa
Hideyuki Sugiyama
Masahiro Ito
Jinxing Li
Junsi Wang
Takahito Kasahara
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of MX2022003490A publication Critical patent/MX2022003490A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

La presente proporciona un compuesto heterocíclico que tiene una acción inhibitoria de HDAC6, el cual es útil para el tratamiento de enfermedades del sistema nervioso central, que incluyen enfermedades neurodegenerativas y similares, y un medicamento que comprende el compuesto. La presente invención se refiere a un compuesto representado por la fórmula (I): (ver Fórmula) en la que cada símbolo está de acuerdo con lo definido en la descripción, o una sal del mismo.
MX2022003490A 2019-09-27 2020-09-24 Derivados de 2-isoindol-1,3,4-oxadiazol utiles como inhibidores de la histona desacetilasa 6 (hdac6). MX2022003490A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019177815 2019-09-27
PCT/JP2020/037386 WO2021060567A1 (en) 2019-09-27 2020-09-24 2-isoindol-1,3,4-oxadiazole derivatives useful as hdac6 inhibitors

Publications (1)

Publication Number Publication Date
MX2022003490A true MX2022003490A (es) 2022-04-25

Family

ID=73040188

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022003490A MX2022003490A (es) 2019-09-27 2020-09-24 Derivados de 2-isoindol-1,3,4-oxadiazol utiles como inhibidores de la histona desacetilasa 6 (hdac6).

Country Status (18)

Country Link
US (2) US11453661B2 (es)
EP (1) EP4034536A1 (es)
JP (1) JP2022552444A (es)
KR (1) KR20220070465A (es)
CN (1) CN114846012B (es)
AR (1) AR120040A1 (es)
AU (1) AU2020353984A1 (es)
BR (1) BR112022005595A2 (es)
CA (1) CA3156060A1 (es)
CL (1) CL2022000763A1 (es)
CO (1) CO2022005059A2 (es)
EC (1) ECSP22026524A (es)
IL (1) IL291413A (es)
MX (1) MX2022003490A (es)
PE (1) PE20220711A1 (es)
TW (1) TW202126643A (es)
WO (1) WO2021060567A1 (es)
ZA (1) ZA202204666B (es)

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CN114166824B (zh) * 2021-12-08 2024-01-23 桂林医学院 一种辅剂示踪分析保健品中药物含量的方法
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CO2022005059A2 (es) 2022-07-08
TW202126643A (zh) 2021-07-16
CL2022000763A1 (es) 2023-01-20
PE20220711A1 (es) 2022-05-04
EP4034536A1 (en) 2022-08-03
CN114846012B (zh) 2024-01-26
US11453661B2 (en) 2022-09-27
CN114846012A (zh) 2022-08-02
US11958845B2 (en) 2024-04-16
IL291413A (en) 2022-05-01
ECSP22026524A (es) 2022-05-31
AU2020353984A2 (en) 2022-08-04
US20230183227A1 (en) 2023-06-15
AR120040A1 (es) 2022-01-26
BR112022005595A2 (pt) 2022-07-19
JP2022552444A (ja) 2022-12-15
WO2021060567A1 (en) 2021-04-01
ZA202204666B (en) 2023-11-29
KR20220070465A (ko) 2022-05-31
CA3156060A1 (en) 2021-04-01
AU2020353984A1 (en) 2022-04-21
US20210094944A1 (en) 2021-04-01

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