MX2016013908A - Novedoso compuesto de 1,2,4-triazina disustituida. - Google Patents

Novedoso compuesto de 1,2,4-triazina disustituida.

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Publication number
MX2016013908A
MX2016013908A MX2016013908A MX2016013908A MX2016013908A MX 2016013908 A MX2016013908 A MX 2016013908A MX 2016013908 A MX2016013908 A MX 2016013908A MX 2016013908 A MX2016013908 A MX 2016013908A MX 2016013908 A MX2016013908 A MX 2016013908A
Authority
MX
Mexico
Prior art keywords
compound
formula
pharmaceutically acceptable
acceptable salt
triazine compound
Prior art date
Application number
MX2016013908A
Other languages
English (en)
Inventor
Fumihiko Akahoshi
Hideki Ushirogochi
Sasaki Wataru
Onda Yuichi
Sakakibara Ryo
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Publication of MX2016013908A publication Critical patent/MX2016013908A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

Esta invención proporciona un compuesto de 1,2,4-triazina disustituida novedoso o una sal farmacéuticamente aceptable del mismo, el cual tiene una actividad inhibidora de la aldosterona sintetasa y es útil para la prevención y/o tratamiento de varias enfermedades o condiciones de enfermedad asociadas a la aldosterona; un método para prepararlo; uso del mismo; así como una composición farmacéutica que lo comprende como un ingrediente activo; un compuesto de la fórmula general [I]: (ver Fórmula) en donde RA es, por ejemplo, un grupo de la siguiente fórmula (A-1): (ver Fórmula) en donde el anillo A1 es, por ejemplo, un grupo cicloalquilo que puede estar sustituido, y RB es, por ejemplo, un grupo cicloalquilo monocíclíco, o una sal farmacéuticamente aceptable del mismo.
MX2016013908A 2014-04-24 2015-04-23 Novedoso compuesto de 1,2,4-triazina disustituida. MX2016013908A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014090754 2014-04-24
PCT/JP2015/062440 WO2015163427A1 (ja) 2014-04-24 2015-04-23 新規二置換１，２，４－トリアジン化合物

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MX2016013908A true MX2016013908A (es) 2017-05-23

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MX2016013908A MX2016013908A (es) 2014-04-24 2015-04-23 Novedoso compuesto de 1,2,4-triazina disustituida.

Country Status (20)

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US (2) US10029993B2 (es)
EP (1) EP3135668B1 (es)
JP (1) JP6148402B2 (es)
KR (1) KR101921404B1 (es)
CN (1) CN106232587B (es)
AU (1) AU2015251030B2 (es)
BR (1) BR112016024571B1 (es)
CA (1) CA2946269C (es)
DK (1) DK3135668T3 (es)
ES (1) ES2774430T3 (es)
HU (1) HUE048341T2 (es)
MX (1) MX2016013908A (es)
MY (1) MY176401A (es)
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PL (1) PL3135668T3 (es)
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