CA3156060A1 - 2-ISOINDOL-1,3,4-OXADIAZOLE DERIVATIVES USEFUL AS HDAC6 INHIBITORS - Google Patents

2-ISOINDOL-1,3,4-OXADIAZOLE DERIVATIVES USEFUL AS HDAC6 INHIBITORS

Info

Publication number
CA3156060A1
CA3156060A1 CA3156060A CA3156060A CA3156060A1 CA 3156060 A1 CA3156060 A1 CA 3156060A1 CA 3156060 A CA3156060 A CA 3156060A CA 3156060 A CA3156060 A CA 3156060A CA 3156060 A1 CA3156060 A1 CA 3156060A1
Authority
CA
Canada
Prior art keywords
compound
optionally substituted
oxadiazol
dihydro
difluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3156060A
Other languages
English (en)
French (fr)
Inventor
Masahiro Ito
Hideyuki Sugiyama
Takeshi Yamamoto
Keiko KAKEGAWA
Jinxing LI
Junsi WANG
Takahito KASAHARA
Masato Yoshikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Publication of CA3156060A1 publication Critical patent/CA3156060A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3156060A 2019-09-27 2020-09-24 2-ISOINDOL-1,3,4-OXADIAZOLE DERIVATIVES USEFUL AS HDAC6 INHIBITORS Pending CA3156060A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019-177815 2019-09-27
JP2019177815 2019-09-27
PCT/JP2020/037386 WO2021060567A1 (en) 2019-09-27 2020-09-24 2-isoindol-1,3,4-oxadiazole derivatives useful as hdac6 inhibitors

Publications (1)

Publication Number Publication Date
CA3156060A1 true CA3156060A1 (en) 2021-04-01

Family

ID=73040188

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3156060A Pending CA3156060A1 (en) 2019-09-27 2020-09-24 2-ISOINDOL-1,3,4-OXADIAZOLE DERIVATIVES USEFUL AS HDAC6 INHIBITORS

Country Status (19)

Country Link
US (3) US11453661B2 (enExample)
EP (1) EP4034536A1 (enExample)
JP (1) JP7602546B2 (enExample)
KR (1) KR20220070465A (enExample)
CN (1) CN114846012B (enExample)
AR (1) AR120040A1 (enExample)
AU (1) AU2020353984B2 (enExample)
BR (1) BR112022005595A2 (enExample)
CA (1) CA3156060A1 (enExample)
CL (1) CL2022000763A1 (enExample)
CO (1) CO2022005059A2 (enExample)
EC (1) ECSP22026524A (enExample)
IL (1) IL291413B2 (enExample)
MX (1) MX2022003490A (enExample)
PE (1) PE20220711A1 (enExample)
PH (1) PH12022550748A1 (enExample)
TW (1) TWI882012B (enExample)
WO (1) WO2021060567A1 (enExample)
ZA (1) ZA202204666B (enExample)

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TW202400147A (zh) * 2022-04-15 2024-01-01 大陸商勤浩醫藥(蘇州)有限公司 噁二唑化合物、包含其的藥物組合物及其用途
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WO2025067416A1 (zh) * 2023-09-28 2025-04-03 勤浩医药（苏州）有限公司 一种hdac6抑制剂的结晶形式及其制备方法
WO2025215092A1 (en) 2024-04-10 2025-10-16 Institut National de la Santé et de la Recherche Médicale Selective hdac6 inhibitors for use in the treatment of myotonic dystrophy type 1
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TW202126643A (zh) 2021-07-16
US12384770B2 (en) 2025-08-12
AU2020353984A1 (en) 2022-04-21
CO2022005059A2 (es) 2022-07-08
EP4034536A1 (en) 2022-08-03
AU2020353984A2 (en) 2022-08-04
WO2021060567A1 (en) 2021-04-01
CN114846012A (zh) 2022-08-02
JP7602546B2 (ja) 2024-12-18
AU2020353984B2 (en) 2025-09-25
TWI882012B (zh) 2025-05-01
US20230183227A1 (en) 2023-06-15
JP2022552444A (ja) 2022-12-15
MX2022003490A (es) 2022-04-25
IL291413B1 (en) 2024-11-01
KR20220070465A (ko) 2022-05-31
PE20220711A1 (es) 2022-05-04
US20210094944A1 (en) 2021-04-01
US20240343721A1 (en) 2024-10-17
CL2022000763A1 (es) 2023-01-20
US11958845B2 (en) 2024-04-16
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PH12022550748A1 (en) 2023-11-20
CN114846012B (zh) 2024-01-26
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BR112022005595A2 (pt) 2022-07-19
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