CL2020000183A1 - Compuestos y métodos para la reducción de la expresión de tau. (divisional solicitud 201900703) - Google Patents

Compuestos y métodos para la reducción de la expresión de tau. (divisional solicitud 201900703)

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Publication number
CL2020000183A1
CL2020000183A1 CL2020000183A CL2020000183A CL2020000183A1 CL 2020000183 A1 CL2020000183 A1 CL 2020000183A1 CL 2020000183 A CL2020000183 A CL 2020000183A CL 2020000183 A CL2020000183 A CL 2020000183A CL 2020000183 A1 CL2020000183 A1 CL 2020000183A1
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CL
Chile
Prior art keywords
compounds
methods
cbd
chronic
animal
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CL2020000183A
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English (en)
Inventor
Holly Kordasiewicz
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Ionis Pharmaceuticals Inc
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Publication of CL2020000183A1 publication Critical patent/CL2020000183A1/es

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    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy

Abstract

SE PROPORCIONAN COMPUESTOS, MÉTODOS Y COMPOSICIONES FARMACÉUTICAS PARA REDUCIR LA CANTIDAD O LA ACTIVIDAD DEL ARNM DE TAU EN UNA CÉLULA O ANIMAL, Y EN DETERMINADOS CASOS PARA REDUCIR LA CANTIDAD DE PROTEÍNA TAU EN UNA CÉLULA O ANIMAL. TALES COMPUESTOS, MÉTODOS Y COMPOSICIONES FARMACÉUTICAS SON ÚTILES PARA MEJORAR AL MENOS UN SÍNTOMA DE UNA ENFERMEDAD NEURODEGENERATIVA. DICHOS SÍNTOMAS INCLUYEN PÉRDIDA DE MEMORIA, PÉRDIDA DE LA FUNCIÓN MOTORA Y AUMENTO EN LA CANTIDAD Y/O EL VOLUMEN DE LAS INCLUSIONES NEUROFIBRILARES. DICHAS ENFERMEDADES NEURODEGENERATIVOS INCLUYEN TAUPATÍAS, ENFERMEDAD DE ALZHEIMER, DEMENCIA FRONTOTEMPORAL (FTD), FTDP-17, PARÁLISIS SUPRANUCLEAR PROGRESIVA (PSP), ENCEFALOPATÍA TRAUMÁTICA CRÓNICA (CTE), DEGENERACIÓN GANGLIÓNICA CORTICOBASAL (CBD), EPILEPSIA Y SÍNDROME DE DRAVET.
CL2020000183A 2016-09-29 2020-01-21 Compuestos y métodos para la reducción de la expresión de tau. (divisional solicitud 201900703) CL2020000183A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662401723P 2016-09-29 2016-09-29
US201762450469P 2017-01-25 2017-01-25

Publications (1)

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CL2020000183A1 true CL2020000183A1 (es) 2020-07-24

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CL2019000703A CL2019000703A1 (es) 2016-09-29 2019-03-18 Compuestos y métodos para la reducción de la expresión de tau.
CL2020000183A CL2020000183A1 (es) 2016-09-29 2020-01-21 Compuestos y métodos para la reducción de la expresión de tau. (divisional solicitud 201900703)

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US (2) US10407680B2 (es)
EP (2) EP3519572B1 (es)
JP (2) JP6738004B2 (es)
KR (2) KR20210097228A (es)
CN (2) CN113481201A (es)
AU (3) AU2017336093B2 (es)
BR (2) BR112019003162B1 (es)
CA (1) CA3038891A1 (es)
CL (2) CL2019000703A1 (es)
CO (1) CO2019001385A2 (es)
CR (2) CR20190214A (es)
DK (1) DK3519572T3 (es)
ES (1) ES2963428T3 (es)
FI (1) FI3519572T3 (es)
HR (1) HRP20231606T1 (es)
IL (3) IL299615A (es)
JO (1) JOP20190065A1 (es)
LT (1) LT3519572T (es)
MD (1) MD3519572T2 (es)
MX (1) MX2019003633A (es)
NZ (1) NZ750642A (es)
PE (1) PE20190655A1 (es)
PL (1) PL3519572T3 (es)
PT (1) PT3519572T (es)
RS (1) RS64941B1 (es)
SG (1) SG11201901140QA (es)
SI (1) SI3519572T1 (es)
WO (1) WO2018064593A1 (es)
ZA (2) ZA201900920B (es)

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US11447775B2 (en) 2018-01-12 2022-09-20 Bristol-Myers Squibb Company Antisense oligonucleotides targeting alpha-synuclein and uses thereof
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JP2024513403A (ja) 2021-04-01 2024-03-25 バイオジェン・エムエイ・インコーポレイテッド 中枢神経系への核酸送達
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