CO2019001385A2 - Compuestos y métodos para la reducción de la expresión de tau - Google Patents

Compuestos y métodos para la reducción de la expresión de tau

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Publication number
CO2019001385A2
CO2019001385A2 CONC2019/0001385A CO2019001385A CO2019001385A2 CO 2019001385 A2 CO2019001385 A2 CO 2019001385A2 CO 2019001385 A CO2019001385 A CO 2019001385A CO 2019001385 A2 CO2019001385 A2 CO 2019001385A2
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methods
compounds
amount
animal
cell
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CONC2019/0001385A
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English (en)
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Holly Kordasiewicz
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Ionis Pharmaceuticals Inc
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Publication of CO2019001385A2 publication Critical patent/CO2019001385A2/es

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Abstract

RESUMEN Se proporcionan compuestos, métodos y composiciones farmacéuticas para reducir la cantidad o la actividad del ARNm de Tau en una célula o animal, y en determinados casos para reducir la cantidad de proteína Tau en una célula o animal. Tales compuestos, métodos y composiciones farmacéuticas son útiles para mejorar al menos un síntoma de una enfermedad neurodegenerativa. Dichos síntomas incluyen pérdida de memoria, pérdida de la función motora y aumento en la cantidad y/o el volumen de las inclusiones neurofibrilares. Dichas enfermedades neurodegenerativos incluyen taupatías, enfermedad de Alzheimer, demencia frontotemporal (FTD), FTDP-17, parálisis supranuclear progresiva (PSP), encefalopatía traumática crónica (CTE), degeneración gangliónica corticobasal (CBD), epilepsia y síndrome de Dravet.
CONC2019/0001385A 2016-09-29 2019-02-15 Compuestos y métodos para la reducción de la expresión de tau CO2019001385A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662401723P 2016-09-29 2016-09-29
US201762450469P 2017-01-25 2017-01-25
PCT/US2017/054540 WO2018064593A1 (en) 2016-09-29 2017-09-29 Compounds and methods for reducing tau expression

Publications (1)

Publication Number Publication Date
CO2019001385A2 true CO2019001385A2 (es) 2019-02-19

Family

ID=61760152

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Application Number Title Priority Date Filing Date
CONC2019/0001385A CO2019001385A2 (es) 2016-09-29 2019-02-15 Compuestos y métodos para la reducción de la expresión de tau

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Country Link
US (2) US10407680B2 (es)
EP (2) EP3519572B1 (es)
JP (3) JP6738004B2 (es)
KR (2) KR102286223B1 (es)
CN (2) CN109790543B (es)
AU (3) AU2017336093B2 (es)
BR (2) BR112019003162B1 (es)
CA (1) CA3038891A1 (es)
CL (2) CL2019000703A1 (es)
CO (1) CO2019001385A2 (es)
CR (2) CR20210028A (es)
DK (1) DK3519572T3 (es)
ES (1) ES2963428T3 (es)
FI (1) FI3519572T3 (es)
HR (1) HRP20231606T1 (es)
HU (1) HUE065170T2 (es)
IL (3) IL299615A (es)
JO (1) JOP20190065A1 (es)
LT (1) LT3519572T (es)
MD (1) MD3519572T2 (es)
MX (2) MX2019003633A (es)
NZ (1) NZ750642A (es)
PE (1) PE20190655A1 (es)
PL (1) PL3519572T3 (es)
PT (1) PT3519572T (es)
RS (1) RS64941B1 (es)
SG (1) SG11201901140QA (es)
SI (1) SI3519572T1 (es)
WO (1) WO2018064593A1 (es)
ZA (2) ZA201900920B (es)

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TWI657819B (zh) 2013-07-19 2019-05-01 美商Ionis製藥公司 用於調節τ蛋白表現之組合物
JOP20190065A1 (ar) 2016-09-29 2019-03-28 Ionis Pharmaceuticals Inc مركبات وطرق لتقليل التعبير عن tau
CA3088112A1 (en) 2018-01-12 2019-07-18 Bristol-Myers Squibb Company Antisense oligonucleotides targeting alpha-synuclein and uses thereof
CR20210179A (es) * 2018-07-03 2022-05-23 Hoffmann La Roche OLIGONUCLEÓTIDOS PARA MODULAR LA EXPRESIÓN DE TAU (Divisional 2021-0058)
US20220195437A1 (en) * 2020-12-11 2022-06-23 Eisai R&D Management Co., Ltd. Tau-targeting oligonucleotide gapmers
TW202304473A (zh) 2021-04-01 2023-02-01 美商百健Ｍａ公司 向中樞神經系統之核酸遞送
CN117500815A (zh) 2021-06-18 2024-02-02 Ionis制药公司 用于降低ifnar1表达的化合物和方法
TW202310854A (zh) * 2021-07-23 2023-03-16 美商百健Ｍａ公司 用於減少ｔａｕ表現之方法
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