CL2016002382A1 - Derivados de quinoxalina útiles como moduladores de fgfr quinasa - Google Patents

Derivados de quinoxalina útiles como moduladores de fgfr quinasa

Info

Publication number
CL2016002382A1
CL2016002382A1 CL2016002382A CL2016002382A CL2016002382A1 CL 2016002382 A1 CL2016002382 A1 CL 2016002382A1 CL 2016002382 A CL2016002382 A CL 2016002382A CL 2016002382 A CL2016002382 A CL 2016002382A CL 2016002382 A1 CL2016002382 A1 CL 2016002382A1
Authority
CL
Chile
Prior art keywords
modulators
derivatives useful
quinoxaline derivatives
fgfr kinase
fgfr
Prior art date
Application number
CL2016002382A
Other languages
English (en)
Spanish (es)
Inventor
Wim Vermeulen
Steven Anna Hostyn
Filip Albert Celine Cuyckens
Russell Mark Jones
Diego Fernando Domenico Broggini
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50389854&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2016002382(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of CL2016002382A1 publication Critical patent/CL2016002382A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CL2016002382A 2014-03-26 2016-09-22 Derivados de quinoxalina útiles como moduladores de fgfr quinasa CL2016002382A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14161820 2014-03-26

Publications (1)

Publication Number Publication Date
CL2016002382A1 true CL2016002382A1 (es) 2017-01-20

Family

ID=50389854

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016002382A CL2016002382A1 (es) 2014-03-26 2016-09-22 Derivados de quinoxalina útiles como moduladores de fgfr quinasa

Country Status (38)

Country Link
US (2) US9902714B2 (OSRAM)
EP (1) EP3122742B1 (OSRAM)
JP (1) JP6625551B2 (OSRAM)
KR (1) KR102469506B1 (OSRAM)
CN (1) CN106459010B (OSRAM)
AP (1) AP2016009536A0 (OSRAM)
AR (1) AR099854A1 (OSRAM)
AU (1) AU2015238300C1 (OSRAM)
BR (1) BR112016022060B1 (OSRAM)
CA (1) CA2943683A1 (OSRAM)
CL (1) CL2016002382A1 (OSRAM)
CR (1) CR20160501A (OSRAM)
CY (1) CY1120969T1 (OSRAM)
DK (1) DK3122742T3 (OSRAM)
EA (1) EA032145B1 (OSRAM)
ES (1) ES2702450T3 (OSRAM)
HR (1) HRP20182073T1 (OSRAM)
HU (1) HUE041738T2 (OSRAM)
IL (1) IL247658B (OSRAM)
JO (1) JO3512B1 (OSRAM)
LT (1) LT3122742T (OSRAM)
MA (1) MA39783B1 (OSRAM)
MX (1) MX380829B (OSRAM)
MY (1) MY194074A (OSRAM)
NI (1) NI201600144A (OSRAM)
NZ (1) NZ724907A (OSRAM)
PH (1) PH12016501898B1 (OSRAM)
PL (1) PL3122742T3 (OSRAM)
PT (1) PT3122742T (OSRAM)
RS (1) RS58088B1 (OSRAM)
SG (1) SG11201607961QA (OSRAM)
SI (1) SI3122742T1 (OSRAM)
SM (1) SMT201800670T1 (OSRAM)
TR (1) TR201819138T4 (OSRAM)
TW (1) TWI686391B (OSRAM)
UA (1) UA117958C2 (OSRAM)
WO (1) WO2015144803A1 (OSRAM)
ZA (1) ZA201606942B (OSRAM)

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PE20180451A1 (es) 2015-09-24 2018-03-05 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores de atx
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CN113474337A (zh) * 2018-12-19 2021-10-01 奥瑞生物药品公司 作为fgfr抑制剂用于治疗癌症的7-((3，5-二甲氧基苯基)氨基)喹喔啉衍生物
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WO2020208592A1 (en) * 2019-04-12 2020-10-15 Dr. Reddy’S Laboratories Limited Process for preparation of erdafitinib, its purification and amorphous solid dispersion
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