WO2008156142A1 - 新規なマロン酸スルホンアミド誘導体およびその医薬用途 - Google Patents

新規なマロン酸スルホンアミド誘導体およびその医薬用途 Download PDF

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Publication number
WO2008156142A1
WO2008156142A1 PCT/JP2008/061248 JP2008061248W WO2008156142A1 WO 2008156142 A1 WO2008156142 A1 WO 2008156142A1 JP 2008061248 W JP2008061248 W JP 2008061248W WO 2008156142 A1 WO2008156142 A1 WO 2008156142A1
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WIPO (PCT)
Prior art keywords
malonic acid
sulfonamide derivative
pharmaceutical use
acid sulfonamide
novel
Prior art date
Application number
PCT/JP2008/061248
Other languages
English (en)
French (fr)
Inventor
Tomohiro Yoshida
Hiroshi Sakashita
Atsushi Numata
Saori Tahara
Hisashi Kawasumi
Original Assignee
Mitsubishi Tanabe Pharma Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corporation filed Critical Mitsubishi Tanabe Pharma Corporation
Priority to US12/665,537 priority Critical patent/US8461209B2/en
Priority to BRPI0813105-8A priority patent/BRPI0813105A2/pt
Priority to DK08777408.9T priority patent/DK2172450T3/da
Priority to CA2690226A priority patent/CA2690226C/en
Priority to PL08777408T priority patent/PL2172450T3/pl
Priority to AU2008264458A priority patent/AU2008264458B2/en
Priority to ES08777408.9T priority patent/ES2442003T3/es
Priority to MX2009013971A priority patent/MX2009013971A/es
Priority to KR1020107001363A priority patent/KR101251933B1/ko
Priority to KR1020127031104A priority patent/KR20130008625A/ko
Priority to CN200880103671.3A priority patent/CN101784520B/zh
Priority to EP08777408.9A priority patent/EP2172450B9/en
Priority to JP2009520534A priority patent/JP5498786B2/ja
Publication of WO2008156142A1 publication Critical patent/WO2008156142A1/ja

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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

　AT2受容体アゴニスト作用を有し、医薬品として期待することの出来る新規化合物を提供し、各種疾患に対する治療又は予防方法を提供すること。 　本発明の新規なマロン酸スルホンアミド誘導体、またはその薬理学的に許容される塩及びそれらの溶媒和物は、AT2受容体アゴニスト作用により各種疾患に対する治療及び／又は予防効果を有し、レニン－アンジオテンシン－アルドステロン（RAAS）系が関与する疾患の治療及び／又は予防のための医薬として有用である。
PCT/JP2008/061248 2007-06-20 2008-06-19 新規なマロン酸スルホンアミド誘導体およびその医薬用途 WO2008156142A1 (ja)

Priority Applications (13)

Application Number Priority Date Filing Date Title
US12/665,537 US8461209B2 (en) 2007-06-20 2008-06-19 Malonic acid sulfonamide derivative and pharmaceutical use thereof
BRPI0813105-8A BRPI0813105A2 (pt) 2007-06-20 2008-06-19 Derivado de sulfonamida de ácido malônico e uso faramacêutico do mesmo
DK08777408.9T DK2172450T3 (da) 2007-06-20 2008-06-19 Nye malonsyre- og sulfonamidderivater og farmaceutisk brug deraf.
CA2690226A CA2690226C (en) 2007-06-20 2008-06-19 Novel malonic acid sulfonamide derivative and pharmaceutical use thereof
PL08777408T PL2172450T3 (pl) 2007-06-20 2008-06-19 Nowe pochodne sulfonamidowe kwasu malonowego i ich zastosowanie farmaceutyczne
AU2008264458A AU2008264458B2 (en) 2007-06-20 2008-06-19 Novel malonic acid sulfonamide derivative and pharmaceutical use thereof
ES08777408.9T ES2442003T3 (es) 2007-06-20 2008-06-19 Nuevo derivado de sulfonamida de ácido malónico y uso farmacéutico del mismo
MX2009013971A MX2009013971A (es) 2007-06-20 2008-06-19 Derivado de sulfonamida de acido malonico novedoso y su uso farmaceutico.
KR1020107001363A KR101251933B1 (ko) 2007-06-20 2008-06-19 신규한 말론산술폰아미드 유도체 및 그 의약 용도
KR1020127031104A KR20130008625A (ko) 2007-06-20 2008-06-19 신규한 말론산술폰아미드 유도체 및 그 의약 용도
CN200880103671.3A CN101784520B (zh) 2007-06-20 2008-06-19 磺酰基丙二酰胺衍生物和其药物用途
EP08777408.9A EP2172450B9 (en) 2007-06-20 2008-06-19 Novel malonic acid sulfonamide derivative and pharmaceutical use thereof
JP2009520534A JP5498786B2 (ja) 2007-06-20 2008-06-19 新規なマロン酸スルホンアミド誘導体およびその医薬用途

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JP2007163099 2007-06-20
JP2007-163099 2007-06-20

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EP (1) EP2172450B9 (ja)
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CN (1) CN101784520B (ja)
AR (1) AR070502A1 (ja)
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WO2015152393A1 (ja) * 2014-04-03 2015-10-08 国立研究開発法人国立循環器病研究センター 悪性腫瘍転移抑制用医薬
JPWO2015152393A1 (ja) * 2014-04-03 2017-04-13 国立研究開発法人国立循環器病研究センター 悪性腫瘍転移抑制用医薬
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JP2019510810A (ja) * 2016-02-09 2019-04-18 インベンティスバイオ インコーポレイテッド インドールアミン−２，３−ジオキシゲナーゼ（ｉｄｏ）阻害剤
WO2017204163A1 (ja) * 2016-05-23 2017-11-30 国立研究開発法人国立循環器病研究センター 肺障害の予防または抑制用医薬
US11833156B2 (en) 2017-09-22 2023-12-05 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
US11426412B2 (en) 2017-10-18 2022-08-30 Jubilant Epipad LLC Imidazo-pyridine compounds as PAD inhibitors
US11629135B2 (en) 2017-11-06 2023-04-18 Jubilant Prodell Llc Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
US11459338B2 (en) 2017-11-24 2022-10-04 Jubilant Episcribe Llc Heterocyclic compounds as PRMT5 inhibitors
US11529341B2 (en) 2018-03-13 2022-12-20 Jubilant Prodel LLC Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation

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