CL2012000980A1 - Inmunoglobulina de dominio variable dual que comprende una cadena de polipeptidos con dos dominios variables que se unen a cd3 y a cd19 y; conjugado con la proteina de union; celula huesped, vector y acido nucleico, metodo de produccion, composicion, metodo in vitro que utiliza la proteina y usos para preparar un medicamento. - Google Patents
Inmunoglobulina de dominio variable dual que comprende una cadena de polipeptidos con dos dominios variables que se unen a cd3 y a cd19 y; conjugado con la proteina de union; celula huesped, vector y acido nucleico, metodo de produccion, composicion, metodo in vitro que utiliza la proteina y usos para preparar un medicamento.Info
- Publication number
- CL2012000980A1 CL2012000980A1 CL2012000980A CL2012000980A CL2012000980A1 CL 2012000980 A1 CL2012000980 A1 CL 2012000980A1 CL 2012000980 A CL2012000980 A CL 2012000980A CL 2012000980 A CL2012000980 A CL 2012000980A CL 2012000980 A1 CL2012000980 A1 CL 2012000980A1
- Authority
- CL
- Chile
- Prior art keywords
- protein
- vector
- nucleic acid
- polypeptide chain
- host cell
- Prior art date
Links
- 102000014914 Carrier Proteins Human genes 0.000 title abstract 3
- 108091008324 binding proteins Proteins 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 230000009977 dual effect Effects 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
- 238000000338 in vitro Methods 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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Applications Claiming Priority (1)
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| US12/605,094 US20100260668A1 (en) | 2008-04-29 | 2009-10-23 | Dual Variable Domain Immunoglobulins and Uses Thereof |
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| CL2012000980A CL2012000980A1 (es) | 2009-10-23 | 2012-04-18 | Inmunoglobulina de dominio variable dual que comprende una cadena de polipeptidos con dos dominios variables que se unen a cd3 y a cd19 y; conjugado con la proteina de union; celula huesped, vector y acido nucleico, metodo de produccion, composicion, metodo in vitro que utiliza la proteina y usos para preparar un medicamento. |
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-
2009
- 2009-10-23 US US12/605,094 patent/US20100260668A1/en not_active Abandoned
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2010
- 2010-10-22 WO PCT/US2010/053730 patent/WO2011050262A2/en not_active Ceased
- 2010-10-22 PH PH1/2012/500774A patent/PH12012500774A1/en unknown
- 2010-10-22 KR KR1020127013242A patent/KR20130004563A/ko not_active Withdrawn
- 2010-10-22 PE PE2012000522A patent/PE20121249A1/es not_active Application Discontinuation
- 2010-10-22 RU RU2012121189/10A patent/RU2012121189A/ru not_active Application Discontinuation
- 2010-10-22 JP JP2012535410A patent/JP2013507969A/ja not_active Withdrawn
- 2010-10-22 AR ARP100103871A patent/AR078728A1/es unknown
- 2010-10-22 CA CA2778176A patent/CA2778176A1/en not_active Abandoned
- 2010-10-22 BR BR112012009043A patent/BR112012009043A2/pt not_active IP Right Cessation
- 2010-10-22 AU AU2010310565A patent/AU2010310565B2/en not_active Ceased
- 2010-10-22 CN CN2010800577517A patent/CN102741423A/zh active Pending
- 2010-10-22 UY UY0001032965A patent/UY32965A/es not_active Application Discontinuation
- 2010-10-22 TW TW099136250A patent/TW201127956A/zh unknown
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- 2010-10-22 EP EP10825739.5A patent/EP2491129A4/en not_active Withdrawn
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| CA2778176A1 (en) | 2011-04-28 |
| PE20121249A1 (es) | 2012-10-06 |
| DOP2012000117A (es) | 2012-07-31 |
| DOP2012000122A (es) | 2013-09-15 |
| AR078728A1 (es) | 2011-11-30 |
| EP2491129A4 (en) | 2013-05-29 |
| WO2011050262A3 (en) | 2011-06-30 |
| TW201127956A (en) | 2011-08-16 |
| IL219205A0 (en) | 2012-06-28 |
| MX2012004775A (es) | 2012-06-01 |
| ECSP12011911A (es) | 2012-07-31 |
| AU2010310565A1 (en) | 2012-05-31 |
| EP2491129A2 (en) | 2012-08-29 |
| CR20120267A (es) | 2012-08-14 |
| US20100260668A1 (en) | 2010-10-14 |
| KR20130004563A (ko) | 2013-01-11 |
| RU2012121189A (ru) | 2013-11-27 |
| JP2013507969A (ja) | 2013-03-07 |
| AU2010310565B2 (en) | 2013-05-23 |
| CN102741423A (zh) | 2012-10-17 |
| WO2011050262A2 (en) | 2011-04-28 |
| UY32965A (es) | 2011-02-28 |
| BR112012009043A2 (pt) | 2015-09-08 |
| ZA201203688B (en) | 2014-12-23 |
| PH12012500774A1 (en) | 2012-11-26 |
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