CH679207A5 - - Google Patents

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Publication number
CH679207A5
CH679207A5 CH2829/89A CH282989A CH679207A5 CH 679207 A5 CH679207 A5 CH 679207A5 CH 2829/89 A CH2829/89 A CH 2829/89A CH 282989 A CH282989 A CH 282989A CH 679207 A5 CH679207 A5 CH 679207A5
Authority
CH
Switzerland
Prior art keywords
trp
microparticles
tyr
copolymer
leu
Prior art date
Application number
CH2829/89A
Other languages
English (en)
French (fr)
Inventor
Piero Orsolini
Original Assignee
Debiopharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm Sa filed Critical Debiopharm Sa
Priority to CH2829/89A priority Critical patent/CH679207A5/fr
Priority to IE259290A priority patent/IE65397B1/en
Priority to GB9015722A priority patent/GB2234169B/en
Priority to IL9512090A priority patent/IL95120A/en
Priority to ZA905654A priority patent/ZA905654B/xx
Priority to BE9000729A priority patent/BE1003093A3/fr
Priority to AU59103/90A priority patent/AU619996B2/en
Priority to NL9001646A priority patent/NL194858C/nl
Priority to FI903643A priority patent/FI97688C/fi
Priority to FR909009333A priority patent/FR2650182B1/fr
Priority to DE4023134A priority patent/DE4023134C2/de
Priority to US07/555,973 priority patent/US5134122A/en
Priority to CA002021767A priority patent/CA2021767C/en
Priority to AT0154590A priority patent/AT397197B/de
Priority to NO903264A priority patent/NO300304B1/no
Priority to IT02101990A priority patent/IT1243357B/it
Priority to ES9001976A priority patent/ES2020890A6/es
Priority to LU87772A priority patent/LU87772A1/fr
Priority to GR900100568A priority patent/GR1001215B/el
Priority to DK199001807A priority patent/DK175495B1/da
Priority to PT94842A priority patent/PT94842B/pt
Priority to SE9002522A priority patent/SE504279C2/sv
Priority to JP2201063A priority patent/JPH0662427B2/ja
Priority to US07/790,033 priority patent/US5439688A/en
Publication of CH679207A5 publication Critical patent/CH679207A5/fr
Priority to US07/836,478 priority patent/US5225205A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
CH2829/89A 1989-07-28 1989-07-28 CH679207A5 (forum.php)

Priority Applications (25)

Application Number Priority Date Filing Date Title
CH2829/89A CH679207A5 (forum.php) 1989-07-28 1989-07-28
IE259290A IE65397B1 (en) 1989-07-28 1990-07-16 A method for preparing a sustained-release pharmaceutical peptide composition
GB9015722A GB2234169B (en) 1989-07-28 1990-07-17 A method for preparing a sustained-release pharmaceutical peptide composition
IL9512090A IL95120A (en) 1989-07-28 1990-07-18 Preparation of sustained release pharmaceutical compositions comprising peptide salts, in the form of microparticles
ZA905654A ZA905654B (en) 1989-07-28 1990-07-18 A method for preparing a pharmaceutical composition in the form of microparticles
BE9000729A BE1003093A3 (fr) 1989-07-28 1990-07-18 Procede de preparation d'une composition pharmaceutique sous forme de microparticules.
AU59103/90A AU619996B2 (en) 1989-07-28 1990-07-18 A method for preparing a pharmaceutical composition in the form of microparticles
NL9001646A NL194858C (nl) 1989-07-28 1990-07-19 Werkwijze voor de bereiding van een farmaceutisch preparaat in de vorm van microdeeltjes, en een werkwijze voor de bereiding van farmaceutisch preparaat in de vorm van een injecteerbare suspentie van microdeeltjes.
FI903643A FI97688C (fi) 1989-07-28 1990-07-19 Menetelmä mikrohiukkasten muodossa olevan farmaseuttisen koostumuksen valmistamiseksi
US07/555,973 US5134122A (en) 1989-07-28 1990-07-20 Method for preparing a pharmaceutical composition in the form of microparticles
DE4023134A DE4023134C2 (de) 1989-07-28 1990-07-20 Verfahren zur Herstellung einer pharmazeutischen Zubereitung in Form von Mikropartikeln
FR909009333A FR2650182B1 (fr) 1989-07-28 1990-07-20 Procede de preparation d'une composition pharmaceutique sous forme de microparticules
CA002021767A CA2021767C (en) 1989-07-28 1990-07-23 Method for preparing a pharmaceutical composition in the form of microparticles
AT0154590A AT397197B (de) 1989-07-28 1990-07-23 Verfahren zur herstellung einer pharmazeutischen zubereitung in form von mikropartikeln zur herstellung von injizierbaren suspensionen zur verzögerten und kontrollierten abgabe eines peptids
NO903264A NO300304B1 (no) 1989-07-28 1990-07-23 Fremgangsmåte for fremstilling av et farmasöytisk preparat i form av mikropartikler
IT02101990A IT1243357B (it) 1989-07-28 1990-07-23 Metodo per preparare una composizione farmaceutica in forma di microparticelle
ES9001976A ES2020890A6 (es) 1989-07-28 1990-07-23 Procedimiento de preparacion de una composicion farmaceutica en forma de microparticulas.
GR900100568A GR1001215B (el) 1989-07-28 1990-07-25 Μεθοδος για την παρασκευη μιας συνθεσης με την μορφη μικροσωματιδιων.
LU87772A LU87772A1 (fr) 1989-07-28 1990-07-25 Procede de preparation d'une composition pharmaceutique sous forme de microparticules
DK199001807A DK175495B1 (da) 1989-07-28 1990-07-27 Fremstilling af farmaceutisk præparat
PT94842A PT94842B (pt) 1989-07-28 1990-07-27 Processo para a preparacao de uma composicao farmaceutica sob a forma de microparticulas de um copolimero de acido lactico e glicolico e incorporando como substancia activa um pamoato, tanato, estearato ou palmitato de um peptido natural ou sintetico
SE9002522A SE504279C2 (sv) 1989-07-28 1990-07-27 Metod för framställning av en farmaceutisk komposition i form av mikropartiklar innehållande peptider
JP2201063A JPH0662427B2 (ja) 1989-07-28 1990-07-27 微粒子状の薬剤組成物、その調製方法およびこの薬剤組成物より調製した懸濁剤
US07/790,033 US5439688A (en) 1989-07-28 1991-11-12 Process for preparing a pharmaceutical composition
US07/836,478 US5225205A (en) 1989-07-28 1992-02-18 Pharmaceutical composition in the form of microparticles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH2829/89A CH679207A5 (forum.php) 1989-07-28 1989-07-28

Publications (1)

Publication Number Publication Date
CH679207A5 true CH679207A5 (forum.php) 1992-01-15

Family

ID=4242536

Family Applications (1)

Application Number Title Priority Date Filing Date
CH2829/89A CH679207A5 (forum.php) 1989-07-28 1989-07-28

Country Status (23)

Country Link
US (1) US5134122A (forum.php)
JP (1) JPH0662427B2 (forum.php)
AT (1) AT397197B (forum.php)
AU (1) AU619996B2 (forum.php)
BE (1) BE1003093A3 (forum.php)
CA (1) CA2021767C (forum.php)
CH (1) CH679207A5 (forum.php)
DE (1) DE4023134C2 (forum.php)
DK (1) DK175495B1 (forum.php)
ES (1) ES2020890A6 (forum.php)
FI (1) FI97688C (forum.php)
FR (1) FR2650182B1 (forum.php)
GB (1) GB2234169B (forum.php)
GR (1) GR1001215B (forum.php)
IE (1) IE65397B1 (forum.php)
IL (1) IL95120A (forum.php)
IT (1) IT1243357B (forum.php)
LU (1) LU87772A1 (forum.php)
NL (1) NL194858C (forum.php)
NO (1) NO300304B1 (forum.php)
PT (1) PT94842B (forum.php)
SE (1) SE504279C2 (forum.php)
ZA (1) ZA905654B (forum.php)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245346B1 (en) 1996-05-06 2001-06-12 Debio Recherche Pharmaceutique S.A. Pharmaceutical compositions for the sustained release of insoluble active principles
EP2630964A1 (en) 2012-02-22 2013-08-28 Immundiagnostik AG Method and medicament for treating patients in risk of prediabetes and type-2 diabetes
EP3431077A1 (en) 2007-06-06 2019-01-23 Debiopharm Research & Manufacturing SA Slow release pharmaceutical composition made of microparticles

Families Citing this family (77)

* Cited by examiner, † Cited by third party
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US5538739A (en) * 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
PH30995A (en) * 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
CH681425A5 (forum.php) * 1990-11-14 1993-03-31 Debio Rech Pharma Sa
DK0528978T3 (da) * 1990-05-16 2003-02-17 Southern Res Inst Mikrokapsler til reguleret afgivelse og deres anvendelse i stimulering af nervefibervækst
US6517859B1 (en) 1990-05-16 2003-02-11 Southern Research Institute Microcapsules for administration of neuroactive agents
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US5470582A (en) * 1992-02-07 1995-11-28 Syntex (U.S.A.) Inc. Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
US5456917A (en) * 1993-04-12 1995-10-10 Cambridge Scientific, Inc. Method for making a bioerodible material for the sustained release of a medicament and the material made from the method
CA2178592C (en) * 1993-12-09 2009-07-28 Jurgen Engel Long-acting injection suspensions and a process for their preparation
DE4342092B4 (de) * 1993-12-09 2007-01-11 Zentaris Gmbh Langwirkende Injektionssuspension und Verfahren zur Herstellung
US5417982A (en) * 1994-02-17 1995-05-23 Modi; Pankaj Controlled release of drugs or hormones in biodegradable polymer microspheres
US5569468A (en) * 1994-02-17 1996-10-29 Modi; Pankaj Vaccine delivery system for immunization, using biodegradable polymer microspheres
US5430021A (en) * 1994-03-18 1995-07-04 Pharmavene, Inc. Hydrophobic drug delivery systems
US5595760A (en) * 1994-09-02 1997-01-21 Delab Sustained release of peptides from pharmaceutical compositions
US5945128A (en) * 1996-09-04 1999-08-31 Romano Deghenghi Process to manufacture implants containing bioactive peptides
AU4571097A (en) * 1996-10-09 1998-05-05 Takeda Chemical Industries Ltd. A method for producing a microparticle
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US6071982A (en) * 1997-04-18 2000-06-06 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245346B1 (en) 1996-05-06 2001-06-12 Debio Recherche Pharmaceutique S.A. Pharmaceutical compositions for the sustained release of insoluble active principles
EP3431077A1 (en) 2007-06-06 2019-01-23 Debiopharm Research & Manufacturing SA Slow release pharmaceutical composition made of microparticles
EP2630964A1 (en) 2012-02-22 2013-08-28 Immundiagnostik AG Method and medicament for treating patients in risk of prediabetes and type-2 diabetes

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GB9015722D0 (en) 1990-09-05
CA2021767C (en) 1996-10-22
DE4023134A1 (de) 1991-01-31
IE65397B1 (en) 1995-10-18
JPH0662427B2 (ja) 1994-08-17
IT9021019A0 (it) 1990-07-23
DE4023134C2 (de) 1997-04-17
FI97688B (fi) 1996-10-31
JPH0366625A (ja) 1991-03-22
IL95120A (en) 1994-10-07
NL9001646A (nl) 1991-02-18
GB2234169B (en) 1993-02-10
AT397197B (de) 1994-02-25
IL95120A0 (en) 1991-06-10
FR2650182A1 (fr) 1991-02-01
BE1003093A3 (fr) 1991-11-19
GB2234169A (en) 1991-01-30
DK180790D0 (da) 1990-07-27
FR2650182B1 (fr) 1992-05-15
FI97688C (fi) 1997-02-10
DK180790A (da) 1991-01-29
GR1001215B (el) 1993-06-21
AU5910390A (en) 1991-01-31
IT1243357B (it) 1994-06-10
CA2021767A1 (en) 1991-01-29
DK175495B1 (da) 2004-11-08
PT94842A (pt) 1991-03-20
SE9002522L (sv) 1991-01-29
IT9021019A1 (it) 1992-01-23
PT94842B (pt) 1997-04-30
NO903264L (no) 1991-01-29
SE9002522D0 (sv) 1990-07-27
LU87772A1 (fr) 1990-12-11
US5134122A (en) 1992-07-28
FI903643A0 (fi) 1990-07-19
SE504279C2 (sv) 1996-12-23
NO903264D0 (no) 1990-07-23
NL194858B (nl) 2003-01-06
ES2020890A6 (es) 1991-10-01
ATA154590A (de) 1993-07-15
AU619996B2 (en) 1992-02-06
NL194858C (nl) 2003-05-06
IE902592A1 (en) 1991-02-27
NO300304B1 (no) 1997-05-12
ZA905654B (en) 1991-05-29
GR900100568A (en) 1991-12-10

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