CH670644A5 - - Google Patents

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Publication number
CH670644A5
CH670644A5 CH5051/86A CH505186A CH670644A5 CH 670644 A5 CH670644 A5 CH 670644A5 CH 5051/86 A CH5051/86 A CH 5051/86A CH 505186 A CH505186 A CH 505186A CH 670644 A5 CH670644 A5 CH 670644A5
Authority
CH
Switzerland
Prior art keywords
group
formula
alkali metal
unsubstituted
compound
Prior art date
Application number
CH5051/86A
Other languages
German (de)
English (en)
Inventor
John Dr Mcgarrity
Leander Dr Tenud
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Priority to CH5051/86A priority Critical patent/CH670644A5/de
Priority to DK638287A priority patent/DK638287A/da
Priority to IE330787A priority patent/IE60518B1/en
Priority to FI875371A priority patent/FI90423C/fi
Priority to IL84770A priority patent/IL84770A/xx
Priority to DE8787118342T priority patent/DE3778135D1/de
Priority to AT87118342T priority patent/ATE74606T1/de
Priority to ES198787118342T priority patent/ES2032428T3/es
Priority to EP87118342A priority patent/EP0273270B1/de
Priority to SU874203838A priority patent/SU1600631A3/ru
Priority to JP62317297A priority patent/JP2560360B2/ja
Priority to US07/134,210 priority patent/US4876350A/en
Priority to YU229487A priority patent/YU46432B/sh
Priority to PT86401A priority patent/PT86401B/pt
Priority to CA000554630A priority patent/CA1322757C/en
Priority to NO875279A priority patent/NO166941C/no
Priority to HU875756A priority patent/HU199475B/hu
Priority to DD87310744A priority patent/DD264920A5/de
Priority to US07/271,180 priority patent/US5117003A/en
Publication of CH670644A5 publication Critical patent/CH670644A5/de
Priority to US07/777,914 priority patent/US5162540A/en
Priority to CA000616416A priority patent/CA1329936C/en
Priority to LV930120A priority patent/LV5265A3/xx
Priority to LTRP360A priority patent/LT2103B/xx
Priority to GEAP1993998A priority patent/GEP19960473B/en
Priority to JP8105162A priority patent/JPH08319290A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CH5051/86A 1986-10-18 1986-12-18 CH670644A5 (US20030204162A1-20031030-M00001.png)

Priority Applications (25)

Application Number Priority Date Filing Date Title
CH5051/86A CH670644A5 (US20030204162A1-20031030-M00001.png) 1986-12-18 1986-12-18
DK638287A DK638287A (da) 1986-12-18 1987-12-04 Fremgangsmaade til fremstilling af (+)-biotin
IE330787A IE60518B1 (en) 1986-12-18 1987-12-04 Process for the preparation of (+)-biotin
FI875371A FI90423C (fi) 1986-12-18 1987-12-07 Menetelmä (+)-biotiinin valmistamiseksi
IL84770A IL84770A (en) 1986-12-18 1987-12-09 Process for the preparation of (+)-biotin from 1-(1-phenylalkyl)-1h-furo- (3,4-d)-imidazole-2,4 (3h, 6h)-dione derivatives and the new intermediate (3as, 6ar)-3a, 6a-dihydro-1- (1-phenylalkyl)-1h-furo (3,4-d)-imidazole 2,4 (3h, 6h)-dione
DE8787118342T DE3778135D1 (de) 1986-12-18 1987-12-10 Verfahren zur herstellung von (+)-biotin.
AT87118342T ATE74606T1 (de) 1986-12-18 1987-12-10 Verfahren zur herstellung von (+)-biotin.
ES198787118342T ES2032428T3 (es) 1986-12-18 1987-12-10 Procedimiento para preparar (+)-biotina.
EP87118342A EP0273270B1 (de) 1986-12-18 1987-12-10 Verfahren zur Herstellung von (+)-Biotin
SU874203838A SU1600631A3 (ru) 1986-12-18 1987-12-15 Способ получени (3 @ S,6 @ R)-1-(1-фенилэтил)-дигидро-1Н-фуро-(3,4- @ )-имидазол-2,4(3Н,3 @ Н)-дионов
JP62317297A JP2560360B2 (ja) 1986-12-18 1987-12-15 （＋）−ビオチンの製造方法
US07/134,210 US4876350A (en) 1986-10-18 1987-12-16 Process for the production of (+) biotin
YU229487A YU46432B (sh) 1986-12-18 1987-12-16 NOVI (3aS, 6aR)-1-(1-FENILETIL)-DIHIDRO-1H-FURO (3,4-d)-IMIDAZOL-2-4-(3H,3aH)-DIONI IN POSTOPEK ZA NJIHOVO PRIPRANO
PT86401A PT86401B (pt) 1986-12-18 1987-12-17 Processo de preparacao de (+)-biotina
CA000554630A CA1322757C (en) 1986-12-18 1987-12-17 Process for the production of (+) biotin
NO875279A NO166941C (no) 1986-12-18 1987-12-17 Fremgangsmaate for fremstilling av (+)-biotin.
HU875756A HU199475B (en) 1986-12-18 1987-12-17 Process for producing 1-(1-phenylethyl)-dihydro-1h-furo/3,4-d/imidazole-2,4(3h,3ah)-dione derivatives
DD87310744A DD264920A5 (de) 1986-12-18 1987-12-18 Verfahren zur herstellung von (+)-biotin
US07/271,180 US5117003A (en) 1986-12-18 1989-01-10 Process for the production of (+) biotin
US07/777,914 US5162540A (en) 1986-12-18 1991-10-17 Process for the production of (+) biotin
CA000616416A CA1329936C (en) 1986-12-18 1992-06-23 Intermediates for the production of (+) biotin
LV930120A LV5265A3 (lv) 1986-12-18 1993-02-16 Panemiens (3as,6ar)-1-(1-feniletil)-dihidro-1h-furo-(3,4-d)-imidazol-2,4(3h,3ah)-dionu iegusanai
LTRP360A LT2103B (lt) 1986-12-18 1993-02-26 (3as,6ar)-1-(1-feniletil)-dihidro-ih-furo-(3,4d)-imidazol-2,4 (3h,3ah)-dionu gavimo budas
GEAP1993998A GEP19960473B (en) 1986-12-18 1993-07-12 Method of producing (3as, 6ar)-1-(phenylethyl)-dihydro-1n-(3,4-d)-imidazol-2,4(3n, 3an)-dions
JP8105162A JPH08319290A (ja) 1986-12-18 1996-04-25 イミダゾール誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH5051/86A CH670644A5 (US20030204162A1-20031030-M00001.png) 1986-12-18 1986-12-18

Publications (1)

Publication Number Publication Date
CH670644A5 true CH670644A5 (US20030204162A1-20031030-M00001.png) 1989-06-30

Family

ID=4287129

Family Applications (1)

Application Number Title Priority Date Filing Date
CH5051/86A CH670644A5 (US20030204162A1-20031030-M00001.png) 1986-10-18 1986-12-18

Country Status (19)

Country Link
US (2) US4876350A (US20030204162A1-20031030-M00001.png)
EP (1) EP0273270B1 (US20030204162A1-20031030-M00001.png)
JP (2) JP2560360B2 (US20030204162A1-20031030-M00001.png)
AT (1) ATE74606T1 (US20030204162A1-20031030-M00001.png)
CA (1) CA1322757C (US20030204162A1-20031030-M00001.png)
CH (1) CH670644A5 (US20030204162A1-20031030-M00001.png)
DD (1) DD264920A5 (US20030204162A1-20031030-M00001.png)
DE (1) DE3778135D1 (US20030204162A1-20031030-M00001.png)
DK (1) DK638287A (US20030204162A1-20031030-M00001.png)
ES (1) ES2032428T3 (US20030204162A1-20031030-M00001.png)
FI (1) FI90423C (US20030204162A1-20031030-M00001.png)
GE (1) GEP19960473B (US20030204162A1-20031030-M00001.png)
HU (1) HU199475B (US20030204162A1-20031030-M00001.png)
IE (1) IE60518B1 (US20030204162A1-20031030-M00001.png)
IL (1) IL84770A (US20030204162A1-20031030-M00001.png)
NO (1) NO166941C (US20030204162A1-20031030-M00001.png)
PT (1) PT86401B (US20030204162A1-20031030-M00001.png)
SU (1) SU1600631A3 (US20030204162A1-20031030-M00001.png)
YU (1) YU46432B (US20030204162A1-20031030-M00001.png)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8720394D0 (en) * 1987-08-28 1987-10-07 Ici Plc Nucleotide probes
FI95034C (fi) * 1989-03-15 1995-12-11 Lonza Ag Menetelmä 1,3-substituoidun tetrahydro-1H-tieno/3,4-d/-imidatsol-2(3H)-on-4-ylideenipentaanihappoesterin valmistamiseksi
DE4107121C1 (US20030204162A1-20031030-M00001.png) * 1991-03-06 1992-06-11 Merck Patent Gmbh, 6100 Darmstadt, De
FI935609A (fi) * 1992-12-18 1994-06-19 Lonza Ag Dihydrofuroimidatsolijohdannaisten asymmetrinen hydraus
AU6679494A (en) * 1993-04-20 1994-11-08 Lonza Ltd. Asymmetric hydrogenation of furoimidazole derivatives
CA2122511A1 (en) * 1993-05-14 1994-11-15 John Mcgarrity Asymmetric hydrogenation of furoimidazole derivatives
DE4411101C2 (de) * 1994-03-30 1996-02-01 Merck Patent Gmbh Verfahren zur Herstellung eines D-(+)-Biotin-Zwischenproduktes
WO1998015557A1 (de) * 1996-10-09 1998-04-16 Lonza Ag Verfahren zur herstellung von (+)-biotin
PL210697B1 (pl) * 2001-10-19 2012-02-29 Isotechnika Inc Kompozycja zawierająca mieszaninę izomerów analogu cyklosporyny i zastosowanie tej mieszaniny
PT1436321E (pt) * 2001-10-19 2006-10-31 Isotechnika Inc Sintese de analogos de ciclosporina
CN103936759B (zh) * 2014-03-11 2016-01-13 新发药业有限公司 （3aS,6aR）-1,3-二苄基-四氢-4H-噻吩并[3,4-d]咪唑-2,4-（1H）-二酮的简便制备方法
CN104530076B (zh) * 2014-12-17 2016-08-17 新发药业有限公司 （3aS,6aR）-1,3-二苄基四氢-4H-噻吩并[3,4-d]咪唑-2,4-（1H）-二酮的合成方法
CN107686488B (zh) * 2016-08-05 2020-04-28 浙江医药股份有限公司新昌制药厂 一种生物素中间体的合成方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE154225C (US20030204162A1-20031030-M00001.png) *
US2784191A (en) * 1957-03-05 Process for the production of lactams
US2489235A (en) * 1947-07-24 1949-11-22 Hoffmann La Roche Synthesis of biotin
US2535010A (en) * 1948-10-02 1950-12-19 Rohm & Haas Transetherification of beta-ethersubstituted esters
DE850007C (de) * 1950-12-22 1952-09-22 Basf Ag Verfahren zur Herstellung von N-Aryl-ª‡-pyrrolidonen
JPS463580Y1 (US20030204162A1-20031030-M00001.png) * 1967-06-13 1971-02-06
BE759512A (fr) * 1969-11-29 1971-05-27 Hoffmann La Roche Lactone
DD111577A5 (US20030204162A1-20031030-M00001.png) * 1972-06-22 1975-02-20
JPS5315074B2 (US20030204162A1-20031030-M00001.png) * 1973-06-14 1978-05-22
JPS5067627A (US20030204162A1-20031030-M00001.png) * 1973-10-17 1975-06-06
IT1045043B (it) * 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
IT1075280B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
IT1075564B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
JPS603387B2 (ja) * 1980-07-10 1985-01-28 住友化学工業株式会社 新規光学活性イミダゾリジン−２−オン誘導体およびその製法
DD154225A1 (de) * 1980-11-10 1982-03-03 Horst Seiferth Verfahren zur herstellung beschichteter textiler flaechengebilde
JPS5812272B2 (ja) * 1981-04-28 1983-03-07 電気化学工業株式会社 ４−ヒドロキシ−２−ピロリドンの製造法
DE3268046D1 (en) * 1981-12-07 1986-01-30 Hoffmann La Roche Process for the preparation of an optically active lactone, and starting products for the process
JPS58124791A (ja) * 1982-01-19 1983-07-25 Sumitomo Chem Co Ltd ビオチンの製造法
DK43985A (da) * 1984-03-09 1985-09-10 Hoffmann La Roche Fremgangsmaade til fremstilling af heterocycliske forbindelser
DE3580390D1 (de) * 1984-05-18 1990-12-13 Hoffmann La Roche Verfahren zur herstellung eines lactons.
DE3575717D1 (de) * 1984-08-25 1990-03-08 Merck Patent Gmbh Verfahren zur herstellung von (3a5,6ar)-und/oder(3ar,6a5)-1,3-dibenzyl-hexahydro-1h-furo(3,4-d)imidazol-2,4-dion.
FI83510C (fi) * 1985-02-22 1991-07-25 Ciba Geigy Ag Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara bi-2h- pyrroli(di)ndioner.
CH671227A5 (US20030204162A1-20031030-M00001.png) * 1986-12-02 1989-08-15 Lonza Ag

Also Published As

Publication number Publication date
IE60518B1 (en) 1994-07-27
PT86401B (pt) 1990-11-20
SU1600631A3 (ru) 1990-10-15
JPH08319290A (ja) 1996-12-03
HUT47290A (en) 1989-02-28
NO875279L (no) 1988-06-20
YU229487A (en) 1988-10-31
JPS63165387A (ja) 1988-07-08
DK638287D0 (da) 1987-12-04
IL84770A0 (en) 1988-05-31
NO875279D0 (no) 1987-12-17
ATE74606T1 (de) 1992-04-15
US5117003A (en) 1992-05-26
NO166941B (no) 1991-06-10
DK638287A (da) 1988-06-19
EP0273270A1 (de) 1988-07-06
CA1322757C (en) 1993-10-05
EP0273270B1 (de) 1992-04-08
GEP19960473B (en) 1996-06-26
FI875371A0 (fi) 1987-12-07
JP2560360B2 (ja) 1996-12-04
YU46432B (sh) 1993-10-20
DD264920A5 (de) 1989-02-15
ES2032428T3 (es) 1993-02-16
DE3778135D1 (de) 1992-05-14
HU199475B (en) 1990-02-28
NO166941C (no) 1991-09-18
PT86401A (de) 1988-01-01
US4876350A (en) 1989-10-24
FI90423B (fi) 1993-10-29
FI90423C (fi) 1994-02-10
IL84770A (en) 1993-05-13
IE873307L (en) 1988-06-18
FI875371A (fi) 1988-06-19

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