CH637929A5 - Process for the preparation of optically active azabicycloalkanes - Google Patents

Process for the preparation of optically active azabicycloalkanes Download PDF

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Publication number
CH637929A5
CH637929A5 CH1118977A CH1118977A CH637929A5 CH 637929 A5 CH637929 A5 CH 637929A5 CH 1118977 A CH1118977 A CH 1118977A CH 1118977 A CH1118977 A CH 1118977A CH 637929 A5 CH637929 A5 CH 637929A5
Authority
CH
Switzerland
Prior art keywords
solution
mixture
benzene
azabicyclo
acid
Prior art date
Application number
CH1118977A
Other languages
German (de)
English (en)
Inventor
William Joseph Fanshawe
Joseph William Epstein
Lantz Stephen Crawley
Corris Mabelle Hofmann
Sidney Robert Safir
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/809,340 external-priority patent/US4118417A/en
Priority claimed from US05/809,339 external-priority patent/US4131611A/en
Priority claimed from US05/809,341 external-priority patent/US4118393A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Priority to CH209382A priority Critical patent/CH637931A5/de
Publication of CH637929A5 publication Critical patent/CH637929A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CH1118977A 1976-09-15 1977-09-13 Process for the preparation of optically active azabicycloalkanes CH637929A5 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CH209382A CH637931A5 (en) 1976-09-15 1982-04-05 Process for the preparation of optically active azabicycloalkanes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72340276A 1976-09-15 1976-09-15
US05/809,340 US4118417A (en) 1977-06-23 1977-06-23 Process for resolving cis-1-substituted phenyl-1,2-cyclopropanedicarboxylic acids
US05/809,339 US4131611A (en) 1975-07-31 1977-06-23 Azabicyclohexanes
US05/809,341 US4118393A (en) 1977-06-23 1977-06-23 Phenyl azabicyclohexanones

Publications (1)

Publication Number Publication Date
CH637929A5 true CH637929A5 (en) 1983-08-31

Family

ID=27505564

Family Applications (2)

Application Number Title Priority Date Filing Date
CH1118977A CH637929A5 (en) 1976-09-15 1977-09-13 Process for the preparation of optically active azabicycloalkanes
CH209382A CH637931A5 (en) 1976-09-15 1982-04-05 Process for the preparation of optically active azabicycloalkanes

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH209382A CH637931A5 (en) 1976-09-15 1982-04-05 Process for the preparation of optically active azabicycloalkanes

Country Status (16)

Country Link
JP (1) JPS5337656A (ko)
AR (2) AR220684A1 (ko)
AT (2) AT367036B (ko)
AU (1) AU519620B2 (ko)
BE (1) BE858683A (ko)
CH (2) CH637929A5 (ko)
DD (1) DD133943A5 (ko)
DE (1) DE2740562A1 (ko)
DK (3) DK146245C (ko)
FR (1) FR2375212A1 (ko)
GR (1) GR72713B (ko)
HU (1) HU177531B (ko)
NL (1) NL189041C (ko)
PL (1) PL115869B1 (ko)
SE (2) SE435384B (ko)
YU (2) YU39499B (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183857A (en) * 1978-07-06 1980-01-15 Shell Oil Company 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione
IL65843A (en) * 1977-08-11 1986-12-31 American Cyanamid Co Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type
CA1117127A (en) * 1978-06-27 1982-01-26 Janet A. Day Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
US4225499A (en) * 1978-07-06 1980-09-30 Shell Oil Company Process for preparing 3-azabicyclo(3.1.0)hexane-2-carbonitrile
JPS6332100A (ja) * 1986-07-25 1988-02-10 東京電力株式会社 シ−ルド掘進機
JPH0658037B2 (ja) * 1989-09-01 1994-08-03 日本鋼管株式会社 シールド掘進装置
US6372919B1 (en) 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en) 2001-08-24 2003-05-27 Dov Pharmaceuticals Inc. (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US20080081834A1 (en) 2002-07-31 2008-04-03 Lippa Arnold S Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
WO2006012477A1 (en) * 2004-07-22 2006-02-02 Wyeth Method for treating nervous system disorders and conditions
EP1773320A1 (en) * 2004-07-22 2007-04-18 Wyeth Method for treating nervous system disorders and conditions
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
BRPI0613943B1 (pt) 2005-07-27 2021-06-22 Otsuka America Pharmaceutical, Inc Composto, composição farmacêutica o compreendendo, usos de um composto e de uma composição farmacêutica, bem como composição neurobiologicamente ativa
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1351754A (en) * 1970-07-02 1974-05-01 Allen & Hanburys Ltd Indenopyrrole derivatives

Also Published As

Publication number Publication date
AR227507A1 (es) 1982-11-15
DK407577A (da) 1978-03-16
AU519620B2 (en) 1981-12-17
JPS6129341B2 (ko) 1986-07-05
ATA661577A (de) 1981-10-15
FR2375212B1 (ko) 1981-07-31
YU188582A (en) 1985-03-20
AT367037B (de) 1982-05-25
DE2740562A1 (de) 1978-03-23
NL7709691A (nl) 1978-03-17
BE858683A (fr) 1978-03-14
SE435384B (sv) 1984-09-24
NL189041C (nl) 1992-12-16
DK146245C (da) 1984-01-16
YU217477A (en) 1983-01-21
DK146245B (da) 1983-08-08
GR72713B (ko) 1983-12-01
AU2844177A (en) 1979-03-08
JPS5337656A (en) 1978-04-06
FR2375212A1 (fr) 1978-07-21
ATA288280A (de) 1981-10-15
DK438480A (da) 1980-10-16
DK438580A (da) 1980-10-16
PL200831A1 (ko) 1980-02-11
PL115869B1 (en) 1981-05-30
DD133943A5 (de) 1979-01-31
DE2740562C2 (ko) 1989-05-03
YU39499B (en) 1984-12-31
HU177531B (en) 1981-11-28
SE452610B (sv) 1987-12-07
AT367036B (de) 1982-05-25
CH637931A5 (en) 1983-08-31
SE7710367L (sv) 1978-03-16
YU43523B (en) 1989-08-31
AR220684A1 (es) 1980-11-28
SE8203437L (sv) 1982-06-03
NL189041B (nl) 1992-07-16

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