AU519620B2 - Azabicyclohexanes, methods of use and preparation - Google Patents

Azabicyclohexanes, methods of use and preparation

Info

Publication number
AU519620B2
AU519620B2 AU28441/77A AU2844177A AU519620B2 AU 519620 B2 AU519620 B2 AU 519620B2 AU 28441/77 A AU28441/77 A AU 28441/77A AU 2844177 A AU2844177 A AU 2844177A AU 519620 B2 AU519620 B2 AU 519620B2
Authority
AU
Australia
Prior art keywords
azabicyclohexanes
preparation
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU28441/77A
Other versions
AU2844177A (en
Inventor
Joseph William Epstein
William Joseph Fanshawe
Corris Mabelle Hofmann
Sidney Robert Safir
stephen crawley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/809,340 external-priority patent/US4118417A/en
Priority claimed from US05/809,341 external-priority patent/US4118393A/en
Priority claimed from US05/809,339 external-priority patent/US4131611A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of AU2844177A publication Critical patent/AU2844177A/en
Application granted granted Critical
Publication of AU519620B2 publication Critical patent/AU519620B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU28441/77A 1976-09-15 1977-09-01 Azabicyclohexanes, methods of use and preparation Ceased AU519620B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72340276A 1976-09-15 1976-09-15
US05/809,340 US4118417A (en) 1977-06-23 1977-06-23 Process for resolving cis-1-substituted phenyl-1,2-cyclopropanedicarboxylic acids
US05/809,341 US4118393A (en) 1977-06-23 1977-06-23 Phenyl azabicyclohexanones
US05/809,339 US4131611A (en) 1975-07-31 1977-06-23 Azabicyclohexanes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU74835/81A Division AU534404B2 (en) 1981-09-01 1981-09-01 Cyclopropane derivatives

Publications (2)

Publication Number Publication Date
AU2844177A AU2844177A (en) 1979-03-08
AU519620B2 true AU519620B2 (en) 1981-12-17

Family

ID=27505564

Family Applications (1)

Application Number Title Priority Date Filing Date
AU28441/77A Ceased AU519620B2 (en) 1976-09-15 1977-09-01 Azabicyclohexanes, methods of use and preparation

Country Status (16)

Country Link
JP (1) JPS5337656A (en)
AR (2) AR220684A1 (en)
AT (2) AT367036B (en)
AU (1) AU519620B2 (en)
BE (1) BE858683A (en)
CH (2) CH637929A5 (en)
DD (1) DD133943A5 (en)
DE (1) DE2740562A1 (en)
DK (3) DK146245C (en)
FR (1) FR2375212A1 (en)
GR (1) GR72713B (en)
HU (1) HU177531B (en)
NL (1) NL189041C (en)
PL (1) PL115869B1 (en)
SE (2) SE435384B (en)
YU (2) YU39499B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8765801B2 (en) 2004-08-18 2014-07-01 Euthymics Bioscience, Inc. Polymorphs of azabicyclohexane
US8877798B2 (en) 2005-07-27 2014-11-04 Neurovance, Inc. 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US9393204B2 (en) 2002-07-31 2016-07-19 Ebi Life Sciences, Inc. Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
US12042481B2 (en) 2011-07-30 2024-07-23 Otsuka America Pharmaceutical, Inc. Use of (1R,5S)-(+)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane in the treatment of conditions affected by monoamine neurotransmitters

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183857A (en) * 1978-07-06 1980-01-15 Shell Oil Company 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione
IL65843A (en) * 1977-08-11 1986-12-31 American Cyanamid Co Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type
CA1117127A (en) * 1978-06-27 1982-01-26 Janet A. Day Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
US4225499A (en) * 1978-07-06 1980-09-30 Shell Oil Company Process for preparing 3-azabicyclo(3.1.0)hexane-2-carbonitrile
JPS6332100A (en) * 1986-07-25 1988-02-10 東京電力株式会社 Shield excavator
JPH0658037B2 (en) * 1989-09-01 1994-08-03 日本鋼管株式会社 Shield excavator
US6372919B1 (en) 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en) 2001-08-24 2003-05-27 Dov Pharmaceuticals Inc. (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
CN101014337A (en) * 2004-07-22 2007-08-08 惠氏公司 Method for treating nervous system disorders and conditions
CA2574310A1 (en) * 2004-07-22 2006-02-02 Wyeth Method for treating nervous system disorders and conditions
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1351754A (en) * 1970-07-02 1974-05-01 Allen & Hanburys Ltd Indenopyrrole derivatives

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9393204B2 (en) 2002-07-31 2016-07-19 Ebi Life Sciences, Inc. Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
US8765801B2 (en) 2004-08-18 2014-07-01 Euthymics Bioscience, Inc. Polymorphs of azabicyclohexane
US9139521B2 (en) 2004-08-18 2015-09-22 Euthymics Bioscience, Inc. Polymorphs of azabicyclohexane
US9770436B2 (en) 2004-08-18 2017-09-26 Euthymics Bioscience, Inc. Polymorphs of azabicyclohexane
US8877798B2 (en) 2005-07-27 2014-11-04 Neurovance, Inc. 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US9205074B2 (en) 2005-07-27 2015-12-08 Neurovance, Inc. 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US9737506B2 (en) 2005-07-27 2017-08-22 Neurovance, Inc. 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US10039746B2 (en) 2005-07-27 2018-08-07 Otsuka America Pharmaceutical, Inc. 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US9597315B2 (en) 2007-06-06 2017-03-21 Euthymics Bioscience, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US12042481B2 (en) 2011-07-30 2024-07-23 Otsuka America Pharmaceutical, Inc. Use of (1R,5S)-(+)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane in the treatment of conditions affected by monoamine neurotransmitters

Also Published As

Publication number Publication date
CH637929A5 (en) 1983-08-31
DK146245B (en) 1983-08-08
NL189041B (en) 1992-07-16
FR2375212B1 (en) 1981-07-31
DK438480A (en) 1980-10-16
CH637931A5 (en) 1983-08-31
YU43523B (en) 1989-08-31
AR227507A1 (en) 1982-11-15
DD133943A5 (en) 1979-01-31
DK438580A (en) 1980-10-16
YU39499B (en) 1984-12-31
SE8203437L (en) 1982-06-03
NL7709691A (en) 1978-03-17
SE7710367L (en) 1978-03-16
DE2740562A1 (en) 1978-03-23
FR2375212A1 (en) 1978-07-21
BE858683A (en) 1978-03-14
ATA288280A (en) 1981-10-15
DE2740562C2 (en) 1989-05-03
AT367037B (en) 1982-05-25
GR72713B (en) 1983-12-01
DK146245C (en) 1984-01-16
SE435384B (en) 1984-09-24
YU188582A (en) 1985-03-20
AR220684A1 (en) 1980-11-28
NL189041C (en) 1992-12-16
PL200831A1 (en) 1980-02-11
AU2844177A (en) 1979-03-08
SE452610B (en) 1987-12-07
ATA661577A (en) 1981-10-15
PL115869B1 (en) 1981-05-30
DK407577A (en) 1978-03-16
HU177531B (en) 1981-11-28
JPS6129341B2 (en) 1986-07-05
JPS5337656A (en) 1978-04-06
AT367036B (en) 1982-05-25
YU217477A (en) 1983-01-21

Similar Documents

Publication Publication Date Title
NZ184527A (en) Preparation of 6a,10a-transhexahydro-dibenzo-(b,d)pyran-9-ones
AU507697B2 (en) Noble-metal-containing catalyst, its preparation and use
AU519620B2 (en) Azabicyclohexanes, methods of use and preparation
AU512626B2 (en) 4-Hydroxyphenylalkanolamine derivatives and preparation thereof
AU512709B2 (en) Preparation of phenoxybenzaldehyde
AU528732B2 (en) Preparation of 4-hydroxy-5-alkyl and 2, 5-dialkyl-3-oxo-2h-furans
AU508349B2 (en) Novel g-acetamidophenol derivatives, their preparation and their use as therapeutic agents
AU510607B2 (en) Preparation of sulphates
AU518375B2 (en) Ester of mm4550, mm13902 and mm17880
AU509040B2 (en) Dehydrooligopeptides and their medical use
AU511838B2 (en) Disinfectant preparation and its use
NZ184530A (en) Preparation of 6a, 10a-cis-hexahydrodil-benzopyranones
AU505101B2 (en) Preparation of 7-alkoxy-3-chloromethylcephems
AU514888B2 (en) Mono-insulin and method for preparation thereof
AU510764B2 (en) Preparation of 2, 3-Dichloroanisole
NZ184528A (en) Preparation of 6a,10a-cis-hexahydro-di-benzo-pyranones
AU510536B2 (en) Aqueous Pronidazole solution and preparation thereof
AU507347B2 (en) Preparation of 2, 4, 5, 6 tetraaminopyrimidine
NZ184754A (en) Preparation of isoindole derivatives, and intermediates
AU504351B2 (en) Preparation of hexachlorocyclobutene
IL53636A0 (en) Novel 7-halo-3,20-dioxo-1,4-pregnadienes and -4-pregnenes and their preparation
AU495937B2 (en) Preparation of gamma-pyrones
ZA774821B (en) Azabicyclohexanes,methods of use and preparation
PT66306A (en) New isobutyramides and preparation thereof
IE44762L (en) Preparation of trifluoromethylthioacetic acid and alkyl¹esters.