AT367036B - METHOD FOR PRODUCING NEW, OPTICALLY ACTIVE 3-AZABICYCLO (3.1.0) HEXAN DERIVATIVES AND THEIR NON-TOXIC, PHARMACEUTICALLY COMPATIBLE SALTS - Google Patents

METHOD FOR PRODUCING NEW, OPTICALLY ACTIVE 3-AZABICYCLO (3.1.0) HEXAN DERIVATIVES AND THEIR NON-TOXIC, PHARMACEUTICALLY COMPATIBLE SALTS

Info

Publication number
AT367036B
AT367036B AT0661577A AT661577A AT367036B AT 367036 B AT367036 B AT 367036B AT 0661577 A AT0661577 A AT 0661577A AT 661577 A AT661577 A AT 661577A AT 367036 B AT367036 B AT 367036B
Authority
AT
Austria
Prior art keywords
hexan
azabicyclo
toxic
derivatives
optically active
Prior art date
Application number
AT0661577A
Other languages
German (de)
Other versions
ATA661577A (en
Inventor
William Joseph Fanshawe
Joseph William Epstein
Lantz Stephen Crawley
Corris Mabelle Hofmann
Sidney Robert Safir
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/809,341 external-priority patent/US4118393A/en
Priority claimed from US05/809,339 external-priority patent/US4131611A/en
Priority claimed from US05/809,340 external-priority patent/US4118417A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ATA661577A publication Critical patent/ATA661577A/en
Application granted granted Critical
Publication of AT367036B publication Critical patent/AT367036B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT0661577A 1976-09-15 1977-09-14 METHOD FOR PRODUCING NEW, OPTICALLY ACTIVE 3-AZABICYCLO (3.1.0) HEXAN DERIVATIVES AND THEIR NON-TOXIC, PHARMACEUTICALLY COMPATIBLE SALTS AT367036B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72340276A 1976-09-15 1976-09-15
US05/809,341 US4118393A (en) 1977-06-23 1977-06-23 Phenyl azabicyclohexanones
US05/809,339 US4131611A (en) 1975-07-31 1977-06-23 Azabicyclohexanes
US05/809,340 US4118417A (en) 1977-06-23 1977-06-23 Process for resolving cis-1-substituted phenyl-1,2-cyclopropanedicarboxylic acids

Publications (2)

Publication Number Publication Date
ATA661577A ATA661577A (en) 1981-10-15
AT367036B true AT367036B (en) 1982-05-25

Family

ID=27505564

Family Applications (2)

Application Number Title Priority Date Filing Date
AT0661577A AT367036B (en) 1976-09-15 1977-09-14 METHOD FOR PRODUCING NEW, OPTICALLY ACTIVE 3-AZABICYCLO (3.1.0) HEXAN DERIVATIVES AND THEIR NON-TOXIC, PHARMACEUTICALLY COMPATIBLE SALTS
AT0288280A AT367037B (en) 1976-09-15 1980-05-30 METHOD FOR THE PRODUCTION OF NEW, OPTICALLY ACTIVE 3-AZABICYCLO- (3.1.0) HEXANE DERIVATIVES, RAZEMIC MIXTURES OF THESE COMPOUNDS, THEIR MIRROR ISOMERS AND NON-TOXIC, PHARMACEUTICALLY COMPATIBLE SALTS OF THESE COMPOUNDS

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT0288280A AT367037B (en) 1976-09-15 1980-05-30 METHOD FOR THE PRODUCTION OF NEW, OPTICALLY ACTIVE 3-AZABICYCLO- (3.1.0) HEXANE DERIVATIVES, RAZEMIC MIXTURES OF THESE COMPOUNDS, THEIR MIRROR ISOMERS AND NON-TOXIC, PHARMACEUTICALLY COMPATIBLE SALTS OF THESE COMPOUNDS

Country Status (16)

Country Link
JP (1) JPS5337656A (en)
AR (2) AR220684A1 (en)
AT (2) AT367036B (en)
AU (1) AU519620B2 (en)
BE (1) BE858683A (en)
CH (2) CH637929A5 (en)
DD (1) DD133943A5 (en)
DE (1) DE2740562A1 (en)
DK (3) DK146245C (en)
FR (1) FR2375212A1 (en)
GR (1) GR72713B (en)
HU (1) HU177531B (en)
NL (1) NL189041C (en)
PL (1) PL115869B1 (en)
SE (2) SE435384B (en)
YU (2) YU39499B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183857A (en) * 1978-07-06 1980-01-15 Shell Oil Company 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione
IL65843A (en) * 1977-08-11 1986-12-31 American Cyanamid Co Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type
CA1117127A (en) * 1978-06-27 1982-01-26 Janet A. Day Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
US4225499A (en) * 1978-07-06 1980-09-30 Shell Oil Company Process for preparing 3-azabicyclo(3.1.0)hexane-2-carbonitrile
JPS6332100A (en) * 1986-07-25 1988-02-10 東京電力株式会社 Shield excavator
JPH0658037B2 (en) * 1989-09-01 1994-08-03 日本鋼管株式会社 Shield excavator
US6372919B1 (en) 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en) 2001-08-24 2003-05-27 Dov Pharmaceuticals Inc. (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US20080081834A1 (en) 2002-07-31 2008-04-03 Lippa Arnold S Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
BRPI0512182A (en) * 2004-07-22 2008-02-19 Wyeth Corp Method for treating nervous system conditions and disorders
KR20070034126A (en) * 2004-07-22 2007-03-27 와이어쓰 Methods of treatment of diseases and disorders of the nervous system
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
KR101733180B1 (en) * 2005-07-27 2017-05-08 뉴로반스, 인크. Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1351754A (en) * 1970-07-02 1974-05-01 Allen & Hanburys Ltd Indenopyrrole derivatives

Also Published As

Publication number Publication date
NL189041B (en) 1992-07-16
DK407577A (en) 1978-03-16
ATA288280A (en) 1981-10-15
NL189041C (en) 1992-12-16
YU217477A (en) 1983-01-21
DE2740562C2 (en) 1989-05-03
AR220684A1 (en) 1980-11-28
PL200831A1 (en) 1980-02-11
SE8203437L (en) 1982-06-03
DK146245B (en) 1983-08-08
AT367037B (en) 1982-05-25
AR227507A1 (en) 1982-11-15
JPS6129341B2 (en) 1986-07-05
FR2375212A1 (en) 1978-07-21
YU43523B (en) 1989-08-31
HU177531B (en) 1981-11-28
DE2740562A1 (en) 1978-03-23
AU2844177A (en) 1979-03-08
CH637929A5 (en) 1983-08-31
AU519620B2 (en) 1981-12-17
DK438480A (en) 1980-10-16
NL7709691A (en) 1978-03-17
SE435384B (en) 1984-09-24
YU39499B (en) 1984-12-31
DD133943A5 (en) 1979-01-31
SE7710367L (en) 1978-03-16
JPS5337656A (en) 1978-04-06
CH637931A5 (en) 1983-08-31
DK146245C (en) 1984-01-16
YU188582A (en) 1985-03-20
SE452610B (en) 1987-12-07
ATA661577A (en) 1981-10-15
DK438580A (en) 1980-10-16
FR2375212B1 (en) 1981-07-31
PL115869B1 (en) 1981-05-30
BE858683A (en) 1978-03-14
GR72713B (en) 1983-12-01

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Legal Events

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ELJ Ceased due to non-payment of the annual fee