DD133943A5 - PROCESS FOR PREPARING OPTICALLY ACTIVE AZABICYCLOALKANES - Google Patents

PROCESS FOR PREPARING OPTICALLY ACTIVE AZABICYCLOALKANES

Info

Publication number
DD133943A5
DD133943A5 DD77201039A DD20103977A DD133943A5 DD 133943 A5 DD133943 A5 DD 133943A5 DD 77201039 A DD77201039 A DD 77201039A DD 20103977 A DD20103977 A DD 20103977A DD 133943 A5 DD133943 A5 DD 133943A5
Authority
DD
German Democratic Republic
Prior art keywords
azabicycloalkanes
optically active
preparing optically
preparing
active
Prior art date
Application number
DD77201039A
Other languages
German (de)
Inventor
William J Fanshawe
Joseph W Epstein
Lantz S Crawley
Corris M Hofmann
Sidney R Safir
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/809,341 external-priority patent/US4118393A/en
Priority claimed from US05/809,340 external-priority patent/US4118417A/en
Priority claimed from US05/809,339 external-priority patent/US4131611A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DD133943A5 publication Critical patent/DD133943A5/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
DD77201039A 1976-09-15 1977-09-15 PROCESS FOR PREPARING OPTICALLY ACTIVE AZABICYCLOALKANES DD133943A5 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72340276A 1976-09-15 1976-09-15
US05/809,341 US4118393A (en) 1977-06-23 1977-06-23 Phenyl azabicyclohexanones
US05/809,340 US4118417A (en) 1977-06-23 1977-06-23 Process for resolving cis-1-substituted phenyl-1,2-cyclopropanedicarboxylic acids
US05/809,339 US4131611A (en) 1975-07-31 1977-06-23 Azabicyclohexanes

Publications (1)

Publication Number Publication Date
DD133943A5 true DD133943A5 (en) 1979-01-31

Family

ID=27505564

Family Applications (1)

Application Number Title Priority Date Filing Date
DD77201039A DD133943A5 (en) 1976-09-15 1977-09-15 PROCESS FOR PREPARING OPTICALLY ACTIVE AZABICYCLOALKANES

Country Status (16)

Country Link
JP (1) JPS5337656A (en)
AR (2) AR220684A1 (en)
AT (2) AT367036B (en)
AU (1) AU519620B2 (en)
BE (1) BE858683A (en)
CH (2) CH637929A5 (en)
DD (1) DD133943A5 (en)
DE (1) DE2740562A1 (en)
DK (3) DK146245C (en)
FR (1) FR2375212A1 (en)
GR (1) GR72713B (en)
HU (1) HU177531B (en)
NL (1) NL189041C (en)
PL (1) PL115869B1 (en)
SE (2) SE435384B (en)
YU (2) YU39499B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007128A1 (en) * 1978-07-06 1980-01-23 Shell Internationale Researchmaatschappij B.V. Derivatives of 3-azabicyclo(3.1.0)hexane and processes for their preparation
EP0007652A1 (en) * 1978-06-27 1980-02-06 Shell Internationale Researchmaatschappij B.V. Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
EP0008813A1 (en) * 1978-07-06 1980-03-19 Shell Internationale Researchmaatschappij B.V. Processes for the preparation of 3-azabicyclo(3.1.0)hexane derivatives

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65843A (en) * 1977-08-11 1986-12-31 American Cyanamid Co Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type
JPS6332100A (en) * 1986-07-25 1988-02-10 東京電力株式会社 Shield excavator
JPH0658037B2 (en) * 1989-09-01 1994-08-03 日本鋼管株式会社 Shield excavator
US6372919B1 (en) 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en) 2001-08-24 2003-05-27 Dov Pharmaceuticals Inc. (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US20080081834A1 (en) 2002-07-31 2008-04-03 Lippa Arnold S Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
EP1773320A1 (en) * 2004-07-22 2007-04-18 Wyeth Method for treating nervous system disorders and conditions
AU2005266997A1 (en) * 2004-07-22 2006-02-02 Wyeth Method for treating nervous system disorders and conditions
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
RU2008107336A (en) 2005-07-27 2009-09-10 Дов Фармасьютикал, Инк. (Us) NEW 1-Aryl-3-Azabicyclo {3.1.0.} HEXANES: OBTAINING AND APPLICATION FOR TREATMENT OF PSYCHONEUROLOGICAL DISORDERS
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1351754A (en) * 1970-07-02 1974-05-01 Allen & Hanburys Ltd Indenopyrrole derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007652A1 (en) * 1978-06-27 1980-02-06 Shell Internationale Researchmaatschappij B.V. Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
EP0007128A1 (en) * 1978-07-06 1980-01-23 Shell Internationale Researchmaatschappij B.V. Derivatives of 3-azabicyclo(3.1.0)hexane and processes for their preparation
EP0008813A1 (en) * 1978-07-06 1980-03-19 Shell Internationale Researchmaatschappij B.V. Processes for the preparation of 3-azabicyclo(3.1.0)hexane derivatives

Also Published As

Publication number Publication date
JPS6129341B2 (en) 1986-07-05
DK407577A (en) 1978-03-16
YU217477A (en) 1983-01-21
AR227507A1 (en) 1982-11-15
AT367036B (en) 1982-05-25
DE2740562C2 (en) 1989-05-03
JPS5337656A (en) 1978-04-06
ATA288280A (en) 1981-10-15
SE7710367L (en) 1978-03-16
SE8203437L (en) 1982-06-03
PL200831A1 (en) 1980-02-11
AU2844177A (en) 1979-03-08
SE452610B (en) 1987-12-07
SE435384B (en) 1984-09-24
ATA661577A (en) 1981-10-15
PL115869B1 (en) 1981-05-30
AU519620B2 (en) 1981-12-17
FR2375212A1 (en) 1978-07-21
DK438480A (en) 1980-10-16
NL189041C (en) 1992-12-16
YU43523B (en) 1989-08-31
FR2375212B1 (en) 1981-07-31
CH637931A5 (en) 1983-08-31
DE2740562A1 (en) 1978-03-23
HU177531B (en) 1981-11-28
YU39499B (en) 1984-12-31
AT367037B (en) 1982-05-25
YU188582A (en) 1985-03-20
CH637929A5 (en) 1983-08-31
BE858683A (en) 1978-03-14
DK146245C (en) 1984-01-16
AR220684A1 (en) 1980-11-28
NL189041B (en) 1992-07-16
NL7709691A (en) 1978-03-17
DK438580A (en) 1980-10-16
DK146245B (en) 1983-08-08
GR72713B (en) 1983-12-01

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