CH625245A5 - - Google Patents

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Publication number
CH625245A5
CH625245A5 CH218276A CH218276A CH625245A5 CH 625245 A5 CH625245 A5 CH 625245A5 CH 218276 A CH218276 A CH 218276A CH 218276 A CH218276 A CH 218276A CH 625245 A5 CH625245 A5 CH 625245A5
Authority
CH
Switzerland
Prior art keywords
cephem
methyl
carboxylic acid
mixture
abq
Prior art date
Application number
CH218276A
Other languages
German (de)
English (en)
Inventor
Susumu Tsushima
Michiyuki Sendai
Mitsuru Shiraishi
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2315875A external-priority patent/JPS5837316B2/ja
Priority claimed from JP3375975A external-priority patent/JPS5951553B2/ja
Priority claimed from JP3471475A external-priority patent/JPS5951554B2/ja
Priority claimed from JP127476A external-priority patent/JPS5283869A/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to CH242978A priority Critical patent/CH636358A5/de
Priority to CH310180A priority patent/CH629210A5/de
Publication of CH625245A5 publication Critical patent/CH625245A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
CH218276A 1975-02-24 1976-02-23 CH625245A5 (da)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CH242978A CH636358A5 (en) 1975-02-24 1978-03-06 Process for preparing 7-aminoceph-3-em-4-carboxylic acid derivatives
CH310180A CH629210A5 (en) 1975-02-24 1980-04-22 Process for the preparation of cephem compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2315875A JPS5837316B2 (ja) 1975-02-24 1975-02-24 セフアロスポリンカゴウブツノ セイゾウホウ
JP3375975A JPS5951553B2 (ja) 1975-03-20 1975-03-20 セフアロスポリン化合物の製造法
JP3471475A JPS5951554B2 (ja) 1975-03-21 1975-03-21 セフアロスポリン化合物の製造法
JP127476A JPS5283869A (en) 1976-01-01 1976-01-01 Cephalosporin compounds

Publications (1)

Publication Number Publication Date
CH625245A5 true CH625245A5 (da) 1981-09-15

Family

ID=27453366

Family Applications (1)

Application Number Title Priority Date Filing Date
CH218276A CH625245A5 (da) 1975-02-24 1976-02-23

Country Status (18)

Country Link
US (1) US4245088A (da)
AT (1) AT346486B (da)
AU (1) AU496914B2 (da)
BE (1) BE838833A (da)
CA (1) CA1092095A (da)
CH (1) CH625245A5 (da)
DE (1) DE2607064C2 (da)
DK (3) DK159154C (da)
ES (2) ES445348A1 (da)
FR (1) FR2301528A1 (da)
GB (1) GB1544103A (da)
HK (1) HK2482A (da)
HU (2) HU179598B (da)
MX (1) MX3635E (da)
NL (1) NL187166C (da)
NO (1) NO760590L (da)
PH (1) PH16245A (da)
SE (2) SE435182B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4323676A (en) * 1975-02-24 1982-04-06 Takeda Chemical Industries, Ltd. Process for preparing cephalosporins
BE878433A (fr) * 1978-08-31 1980-02-25 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
GR70261B (da) * 1977-12-12 1982-09-02 Takeda Chemical Industries Ltd
ATE31535T1 (de) * 1981-07-17 1988-01-15 Glaxo Group Ltd Cephalosporinverbindungen.
US4584371A (en) * 1984-03-01 1986-04-22 The Upjohn Company Catalytic process for preparing 3-ester-methyl cephalosporins from desacetyl-7-aminocephalosporanic acid
JP2867438B2 (ja) * 1988-08-10 1999-03-08 武田薬品工業株式会社 セファロスポリン化合物の製造法
US5552542A (en) * 1995-05-10 1996-09-03 Bristol-Myers Squibb Company Preparation and use of 7-[(2-carboalkoxy-1-methylethenyl)amino]-3-hydroxymethyl-3-cephem-4-carboxylic acids
US8198434B2 (en) * 2008-05-07 2012-06-12 Idexx Laboratories, Inc. Process for preparing cefsulodin sodium
CN103601737B (zh) * 2013-12-04 2016-02-03 哈药集团制药总厂 一种盐酸头孢替安的制备方法
EP3426663B1 (en) * 2016-03-07 2020-01-29 Dhanuka Laboratories Ltd. A process for alkylating the hydroxymethyl group at position -3 of cephalosporins
NL2022854B1 (en) * 2019-04-03 2020-10-08 Univ Leiden Prodrug inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1241657A (en) * 1967-08-21 1971-08-04 Glaxo Lab Ltd Improvements in or relating to cephalosporin compounds
US4007178A (en) * 1972-04-10 1977-02-08 Smithkline Corporation O-acyl-7-acylaminocephalosporadesic acids

Also Published As

Publication number Publication date
FR2301528A1 (fr) 1976-09-17
SE435182B (sv) 1984-09-10
ATA126476A (de) 1978-03-15
NL187166C (nl) 1991-06-17
PH16245A (en) 1983-08-16
US4245088A (en) 1981-01-13
ES459261A1 (es) 1978-03-16
ES445348A1 (es) 1977-10-16
CA1092095A (en) 1980-12-23
DK160313B (da) 1991-02-25
HU179070B (en) 1982-08-28
SE7907455L (sv) 1979-09-07
HU179598B (en) 1982-11-29
DK44076A (da) 1976-08-25
DE2607064A1 (de) 1976-09-02
DK161201B (da) 1991-06-10
DE2607064C2 (de) 1984-12-13
AU1134976A (en) 1977-09-01
AU496914B2 (en) 1978-11-09
DK159154C (da) 1991-02-11
BE838833A (fr) 1976-08-23
DK63990A (da) 1990-03-12
DK63990D0 (da) 1990-03-12
AT346486B (de) 1978-11-10
NL7601902A (nl) 1976-08-26
SE7907454L (sv) 1979-09-07
DK159154B (da) 1990-09-10
DK76190D0 (da) 1990-03-23
HK2482A (en) 1982-02-14
DK76190A (da) 1990-03-23
NO760590L (da) 1976-08-25
SE435183B (sv) 1984-09-10
DK160313C (da) 1991-07-29
MX3635E (es) 1981-04-13
DK161201C (da) 1991-11-25
GB1544103A (en) 1979-04-11
FR2301528B1 (da) 1979-04-20

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Legal Events

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PL Patent ceased