CH624105A5 - Process for the preparation of novel azatetracyclic compounds - Google Patents

Process for the preparation of novel azatetracyclic compounds Download PDF

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Publication number
CH624105A5
CH624105A5 CH665076A CH665076A CH624105A5 CH 624105 A5 CH624105 A5 CH 624105A5 CH 665076 A CH665076 A CH 665076A CH 665076 A CH665076 A CH 665076A CH 624105 A5 CH624105 A5 CH 624105A5
Authority
CH
Switzerland
Prior art keywords
lower alkyl
mol
formula
dibenzo
azepine
Prior art date
Application number
CH665076A
Other languages
German (de)
English (en)
Inventor
Hans Blattner
Angelo Dr Storni
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority to CH665076A priority Critical patent/CH624105A5/de
Priority to CY1211A priority patent/CY1211A/xx
Priority to GB21304/77A priority patent/GB1578266A/en
Priority to DE19772723105 priority patent/DE2723105A1/de
Priority to FR7715703A priority patent/FR2352816A1/fr
Priority to PT66588A priority patent/PT66588B/pt
Priority to NL7705707A priority patent/NL7705707A/xx
Priority to CA278,990A priority patent/CA1104566A/en
Priority to GR53547A priority patent/GR72092B/el
Priority to FI771651A priority patent/FI64582C/fi
Priority to DD7700199101A priority patent/DD131169A5/xx
Priority to NZ184191A priority patent/NZ184191A/xx
Priority to ES459070A priority patent/ES459070A1/es
Priority to IE1074/77A priority patent/IE45204B1/en
Priority to ZA00773161A priority patent/ZA773161B/xx
Priority to BE177877A priority patent/BE855009A/xx
Priority to IL52168A priority patent/IL52168A/xx
Priority to NO771830A priority patent/NO148489C/no
Priority to AU25473/77A priority patent/AU510471B2/en
Priority to AT372577A priority patent/AT356114B/de
Priority to HU77CI1744A priority patent/HU177417B/hu
Priority to DK229977A priority patent/DK150301C/da
Priority to SE7706120A priority patent/SE427354B/sv
Priority to CS782988A priority patent/CS225106B2/cs
Priority to AR267787A priority patent/AR227608A1/es
Priority to JP6057877A priority patent/JPS52144687A/ja
Priority to CS773475A priority patent/CS225103B2/cs
Priority to AR272606A priority patent/AR228124A1/es
Priority to AT204379A priority patent/AT356119B/de
Priority to CH83380A priority patent/CH624106A5/de
Publication of CH624105A5 publication Critical patent/CH624105A5/de
Priority to SG63683A priority patent/SG63683G/en
Priority to KE3339A priority patent/KE3339A/xx
Priority to HK87/84A priority patent/HK8784A/xx
Priority to MY99/85A priority patent/MY8500099A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/14—[b,f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/74—Naphthothiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/14—[b,f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CH665076A 1976-05-21 1976-05-26 Process for the preparation of novel azatetracyclic compounds CH624105A5 (en)

Priority Applications (34)

Application Number Priority Date Filing Date Title
CH665076A CH624105A5 (en) 1976-05-26 1976-05-26 Process for the preparation of novel azatetracyclic compounds
CY1211A CY1211A (en) 1976-05-26 1977-05-20 Azatetracyclic compounds
GB21304/77A GB1578266A (en) 1976-05-26 1977-05-20 Azatetracyclic compounds
DE19772723105 DE2723105A1 (de) 1976-05-26 1977-05-21 Neue azatetracyclen
FR7715703A FR2352816A1 (fr) 1976-05-26 1977-05-23 Nouveaux composes azatetracycliques utiles comme medicaments
PT66588A PT66588B (en) 1976-05-26 1977-05-24 Process for the manufacture of azatetracyclic compounds
NL7705707A NL7705707A (nl) 1976-05-26 1977-05-24 Nieuwe azatetracyclenen.
CA278,990A CA1104566A (en) 1976-05-21 1977-05-24 Process for the manufacture of azatetracyclic compounds
GR53547A GR72092B (sv) 1976-05-26 1977-05-24
FI771651A FI64582C (fi) 1976-05-26 1977-05-24 Foerfarande foer framstaellning av foer behandling av agitationstillstaond laempliga 1,2,3,4,5,10-hexahydro-dibenso-(3,4:6,7)cyklohepta(1,2-d)azepiner och analoger med -o- -s- eller -nr3- i 10-staellningen
DD7700199101A DD131169A5 (de) 1976-05-26 1977-05-24 Verfahren zur herstellung neuer azatetracyclen
NZ184191A NZ184191A (en) 1976-05-26 1977-05-24 Azatetracyclic compounds and pharmaceutical compositions
ES459070A ES459070A1 (es) 1976-05-26 1977-05-24 Procedimiento para la obtencion de azatetraciclos.
NO771830A NO148489C (no) 1976-05-26 1977-05-25 Analogifremgangsmaate til fremstilling av terapeutiske aktive nye azatetracykler
ZA00773161A ZA773161B (en) 1976-05-26 1977-05-25 Novel azatetracyclic compounds
BE177877A BE855009A (fr) 1976-05-26 1977-05-25 Nouveaux composes azatetracycliques
IL52168A IL52168A (en) 1976-05-26 1977-05-25 Condensed 2,3,6,7-tetrahydro-1h-azepine compounds,their manufacture and pharmaceutical compositions containing them
IE1074/77A IE45204B1 (en) 1976-05-26 1977-05-25 Novel azatetracyclic compounds
AU25473/77A AU510471B2 (en) 1976-05-26 1977-05-25 Azatetracyclic compounds
AT372577A AT356114B (de) 1976-05-26 1977-05-25 Verfahren zur herstellung von neuen azepin- derivaten und deren saeureadditionssalzen und isomeren
HU77CI1744A HU177417B (en) 1976-05-26 1977-05-25 Process for preparing new azatetracyclic compounds
DK229977A DK150301C (da) 1976-05-26 1977-05-25 Analogifremgangsmaade til fremstilling af azatetracycliske forbindelser eller syreadditionssalte deraf
SE7706120A SE427354B (sv) 1976-05-26 1977-05-25 Sett att framstella azatetracykliska foreningar med verkan pa det centrala nervsystemet
AR267787A AR227608A1 (es) 1976-05-26 1977-05-26 Procedimiento para obtener nuevos compuestos de 1,2,3,4,5,10-hexahidrodibenzo(3,4:6,7)ciclohepta(1,2-d)azepinas,tioanalogos y aquellos con o,metileno,nh o n-alquilo(c1-c4)en lugar de s
CS782988A CS225106B2 (en) 1976-05-26 1977-05-26 The production of new tetrahyro-and hexahydro-aza-tetra cyclic compounds
JP6057877A JPS52144687A (en) 1976-05-26 1977-05-26 Production of novel azatetracycline and preparation thereof
CS773475A CS225103B2 (en) 1976-05-26 1977-05-26 The production of new tetrahydro-and hexahydro-aza-tetracyclic compounds
AR272606A AR228124A1 (es) 1976-05-26 1978-06-18 Procedimiento para obtener nuevos compuestos de 1,2,3,4,5,10-hexahidro-dibenzo(3,4:6,7)ciclohepta(1,2-d)azepinas,tioanalogos y aquellos con-o-,metileno o=n-r en lugar de-s-
AT204379A AT356119B (de) 1976-05-26 1979-03-19 Verfahren zur herstellung von neuen azepin- derivaten und deren saeureadditionssalzen und isomeren
CH83380A CH624106A5 (en) 1976-05-26 1980-02-01 Process for the preparation of novel azatetracyclic compounds
SG63683A SG63683G (en) 1976-05-26 1983-10-19 Novel azatetracyclic compounds
KE3339A KE3339A (en) 1976-05-26 1983-10-24 Novel azatetracyclic compounds
HK87/84A HK8784A (en) 1976-05-26 1984-02-01 Novel azatetracyclic compounds
MY99/85A MY8500099A (en) 1976-05-26 1985-12-30 Novel azatetracyclic compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH665076A CH624105A5 (en) 1976-05-26 1976-05-26 Process for the preparation of novel azatetracyclic compounds

Publications (1)

Publication Number Publication Date
CH624105A5 true CH624105A5 (en) 1981-07-15

Family

ID=4312888

Family Applications (2)

Application Number Title Priority Date Filing Date
CH665076A CH624105A5 (en) 1976-05-21 1976-05-26 Process for the preparation of novel azatetracyclic compounds
CH83380A CH624106A5 (en) 1976-05-26 1980-02-01 Process for the preparation of novel azatetracyclic compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH83380A CH624106A5 (en) 1976-05-26 1980-02-01 Process for the preparation of novel azatetracyclic compounds

Country Status (30)

Country Link
JP (1) JPS52144687A (sv)
AR (2) AR227608A1 (sv)
AT (1) AT356114B (sv)
AU (1) AU510471B2 (sv)
BE (1) BE855009A (sv)
CA (1) CA1104566A (sv)
CH (2) CH624105A5 (sv)
CS (2) CS225103B2 (sv)
CY (1) CY1211A (sv)
DD (1) DD131169A5 (sv)
DE (1) DE2723105A1 (sv)
DK (1) DK150301C (sv)
ES (1) ES459070A1 (sv)
FI (1) FI64582C (sv)
FR (1) FR2352816A1 (sv)
GB (1) GB1578266A (sv)
GR (1) GR72092B (sv)
HK (1) HK8784A (sv)
HU (1) HU177417B (sv)
IE (1) IE45204B1 (sv)
IL (1) IL52168A (sv)
KE (1) KE3339A (sv)
MY (1) MY8500099A (sv)
NL (1) NL7705707A (sv)
NO (1) NO148489C (sv)
NZ (1) NZ184191A (sv)
PT (1) PT66588B (sv)
SE (1) SE427354B (sv)
SG (1) SG63683G (sv)
ZA (1) ZA773161B (sv)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE9159T1 (de) * 1979-12-10 1984-09-15 Ciba-Geigy Ag Azatetracyclische carbonitrile.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL178593C (nl) * 1974-01-31 1986-04-16 Akzo Nv Werkwijze ter bereiding van een farmaceutisch preparaat op basis van een tetracyclische verbinding en werkwijze voor de bereiding van de daarbij te gebruiken tetracyclische verbindingen.
CH592095A5 (sv) * 1974-02-22 1977-10-14 Ciba Geigy Ag

Also Published As

Publication number Publication date
KE3339A (en) 1983-11-25
IE45204L (en) 1977-11-26
CS225103B2 (en) 1984-02-13
IE45204B1 (en) 1982-07-14
AR228124A1 (es) 1983-01-31
NZ184191A (en) 1979-12-11
IL52168A (en) 1981-07-31
ATA372577A (de) 1979-09-15
NO148489B (no) 1983-07-11
HU177417B (en) 1981-10-28
CA1104566A (en) 1981-07-07
AR227608A1 (es) 1982-11-30
DE2723105A1 (de) 1977-12-15
FI771651A (sv) 1977-11-27
GB1578266A (en) 1980-11-05
AU2547377A (en) 1978-11-30
GR72092B (sv) 1983-09-13
ES459070A1 (es) 1978-04-16
CH624106A5 (en) 1981-07-15
JPS52144687A (en) 1977-12-02
CS225106B2 (en) 1984-02-13
SG63683G (en) 1984-07-27
SE427354B (sv) 1983-03-28
NL7705707A (nl) 1977-11-29
ZA773161B (en) 1978-04-26
AU510471B2 (en) 1980-06-26
PT66588B (en) 1978-10-23
FI64582C (fi) 1983-12-12
FI64582B (fi) 1983-08-31
CY1211A (en) 1984-04-06
FR2352816B1 (sv) 1980-01-18
BE855009A (fr) 1977-11-25
DD131169A5 (de) 1978-06-07
IL52168A0 (en) 1977-07-31
SE7706120L (sv) 1977-11-27
JPH0141627B2 (sv) 1989-09-06
PT66588A (en) 1977-06-01
NO771830L (no) 1977-11-29
MY8500099A (en) 1985-12-31
DE2723105C2 (sv) 1987-03-12
DK150301C (da) 1988-01-04
DK229977A (da) 1977-11-27
AT356114B (de) 1980-04-10
FR2352816A1 (fr) 1977-12-23
HK8784A (en) 1984-02-10
DK150301B (da) 1987-02-02
NO148489C (no) 1983-10-19

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