FI64582C - Foerfarande foer framstaellning av foer behandling av agitationstillstaond laempliga 1,2,3,4,5,10-hexahydro-dibenso-(3,4:6,7)cyklohepta(1,2-d)azepiner och analoger med -o- -s- eller -nr3- i 10-staellningen - Google Patents
Foerfarande foer framstaellning av foer behandling av agitationstillstaond laempliga 1,2,3,4,5,10-hexahydro-dibenso-(3,4:6,7)cyklohepta(1,2-d)azepiner och analoger med -o- -s- eller -nr3- i 10-staellningen Download PDFInfo
- Publication number
- FI64582C FI64582C FI771651A FI771651A FI64582C FI 64582 C FI64582 C FI 64582C FI 771651 A FI771651 A FI 771651A FI 771651 A FI771651 A FI 771651A FI 64582 C FI64582 C FI 64582C
- Authority
- FI
- Finland
- Prior art keywords
- dibenzo
- azepine
- tetrahydro
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- formula
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/14—[b,f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/74—Naphthothiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/14—[b,f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Claims (6)
1. Förfarande för framställning av, för behandling av agitations-tillständ lämpliga 1,2,3,4,5,1 O-hexahydro-dibenso (3,4:6,7) cyklohepta-(1,2-d)azepiner och analoger med -0-, -S- eller -NR3~ i 10-ställ-ningen med formeln l1 &(I) , __ Λ __ i vilken betecknar väte, lägrealkyl med högst 6 kolatomer, cykloalkyl-lägrealkyl med högst 10 kolatomer, lägrealkenyl med högst 8 kolatomer, lägrealkinyl med högst 4 kolatomer, dilägrealkyl-aminolägrealkyl med högst 10 kolatomer, hydroxilägrealkyl med högst 8 kolatomer, lägrealkoxilägrealkyl med högst 10 kolatomer, alkanoyloxilägrealkyl med högst 11 kolatomer, lägrealkyltio-lägrealkyl med högst 10 kolatomer, eller eventuellt med klor, metyl eller metoxi substituerad fenyllägrealkyl, och betecknar väte, klor, brom, lägrealkyl med högst 3 kolatomer, hydroxi, lägrealkoxi med högst 3 kolatomer, lägrealkyltio med högst 3 kolatomer, eller cyan, X betecknar epoxi, epitio, metylen eller den tvävärdiga resten med strukturen \ / ? da) R3 vilken betecknar väte eller lägre alkyl med högst 4 kolatomer, samt syra-additionssalter därav, kännetecknat därav, att 64582 45 a) en reaktionsförmägen diester av en dietanol med formeln E- CH_ CH -E I 2 I 2 i vilken E betecknar syraresten av en stark oorganisk eller organisk syra, omsättes med en amin med formeln R1 N1 t111» H H eller b) för framställning av föreningar med formeln I, i vilka R1 betecknar gruppen R^j , vilken betyder detsamma som R^ med undantag av alkanoyloxilägrealkyl, en förening med formeln Qw* \^Ql ^ | (iv) vilken ätminstone den ena av symbolerna Q1 och betecknar en syreatom och den andra eventuellt tvä väteatomer, reduceras, och, om sä önskas, - en erhällen förening med formeln I, i vilken R1 betecknar vcite, omvandlas i en förening med formeln I, i vilken R1 har nägon annan 46 64582 av de ovan angivna betydelserna, - en erhällen förening med formeln 1/ i vilken betecknar en hyd-roxilägrealkylgrupp, medelst acylering omvandlas i en förening med formeln I, i vilken betecknar en alkanoyloxilägrealkylgrupp, - en erhällen förening med formeln I, i vilken R^ betecknar en fenyl-lägrealkylgrupp, medelst hydrogenolys omvandlas i en förening med formeln I, i vilken R^ betecknar väte, - en erhällen förening med formeln I, i vilken X betecknar en tvä-värdig rest med formeln \ / N «3 i vilken R^ betecknar väte, överförs i en förening med formeln I, i vilken R3 betecknar lägrealkyl, - en erhällen förening, i vilken substituenten R2 betecknar lägre-alkoxi, kokas med bromvätesyra för bildning av föreningar i vilka ringsubstituenten är hydroxi, - i en erhällen förening införs cyan säsom substituent R2, och/eller, om sä önskas, överförs en erhällen fri förening i ett sait, och/ eller, om sä önskas, överförs ett erhället sait i den fria föreningen eller i ett annat sait, och/eller, om sä önskas, uppdelas en erhällen isomerblandning i de enskilda isomererna.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att man framställer 3-metyl-2,3,4,5-tetrahydro-1H-dibenso-(2,3:6,7)tiepino(4,5-dj azepin.
3. Förfarande enligt patentkravet 1, kännetecknat därav, att man framställer 3-metyl-2,3,4,5-tetrahydro-lH-dibenso-(2,3:6,7)oxepino(4,5-d)azepin.
4. Förfarande enligt patentkravet 1, kännetecknat därav, att man framställer 3-metyl-7-cyano-2,3,4,5-tetrahydro-1H-dibenso (2,3:6,7)tiepino(4,5-d)azepin.
5. Förfarande enligt patentkravet 1,kännetecknat därav, att man framställer 3-metyl-1,2,3,4,5,10-hexahydro-dibenso-(3,4:6,7)syklohepta(1,2-d)azepin.
6. Förfarande enligt patentkravet 1, kännetecknat därav, att man framställer 3-(2,3,4,5-tetrahydro-1H-dibenso(2,3:6,7)-tiepino(4,5-d)azepin-3-y1)-propanol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH665076 | 1976-05-26 | ||
| CH665076A CH624105A5 (en) | 1976-05-26 | 1976-05-26 | Process for the preparation of novel azatetracyclic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI771651A FI771651A (sv) | 1977-11-27 |
| FI64582B FI64582B (fi) | 1983-08-31 |
| FI64582C true FI64582C (fi) | 1983-12-12 |
Family
ID=4312888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI771651A FI64582C (fi) | 1976-05-26 | 1977-05-24 | Foerfarande foer framstaellning av foer behandling av agitationstillstaond laempliga 1,2,3,4,5,10-hexahydro-dibenso-(3,4:6,7)cyklohepta(1,2-d)azepiner och analoger med -o- -s- eller -nr3- i 10-staellningen |
Country Status (30)
| Country | Link |
|---|---|
| JP (1) | JPS52144687A (sv) |
| AR (2) | AR227608A1 (sv) |
| AT (1) | AT356114B (sv) |
| AU (1) | AU510471B2 (sv) |
| BE (1) | BE855009A (sv) |
| CA (1) | CA1104566A (sv) |
| CH (2) | CH624105A5 (sv) |
| CS (2) | CS225106B2 (sv) |
| CY (1) | CY1211A (sv) |
| DD (1) | DD131169A5 (sv) |
| DE (1) | DE2723105C2 (sv) |
| DK (1) | DK150301C (sv) |
| ES (1) | ES459070A1 (sv) |
| FI (1) | FI64582C (sv) |
| FR (1) | FR2352816A1 (sv) |
| GB (1) | GB1578266A (sv) |
| GR (1) | GR72092B (sv) |
| HK (1) | HK8784A (sv) |
| HU (1) | HU177417B (sv) |
| IE (1) | IE45204B1 (sv) |
| IL (1) | IL52168A (sv) |
| KE (1) | KE3339A (sv) |
| MY (1) | MY8500099A (sv) |
| NL (1) | NL7705707A (sv) |
| NO (1) | NO148489C (sv) |
| NZ (1) | NZ184191A (sv) |
| PT (1) | PT66588B (sv) |
| SE (1) | SE427354B (sv) |
| SG (1) | SG63683G (sv) |
| ZA (1) | ZA773161B (sv) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0030916B1 (de) * | 1979-12-10 | 1984-08-29 | Ciba-Geigy Ag | Azatetracyclische Carbonitrile |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL178593C (nl) * | 1974-01-31 | 1986-04-16 | Akzo Nv | Werkwijze ter bereiding van een farmaceutisch preparaat op basis van een tetracyclische verbinding en werkwijze voor de bereiding van de daarbij te gebruiken tetracyclische verbindingen. |
| CH592095A5 (sv) * | 1974-02-22 | 1977-10-14 | Ciba Geigy Ag |
-
1976
- 1976-05-26 CH CH665076A patent/CH624105A5/de not_active IP Right Cessation
-
1977
- 1977-05-20 GB GB21304/77A patent/GB1578266A/en not_active Expired
- 1977-05-20 CY CY1211A patent/CY1211A/xx unknown
- 1977-05-21 DE DE2723105A patent/DE2723105C2/de not_active Expired
- 1977-05-23 FR FR7715703A patent/FR2352816A1/fr active Granted
- 1977-05-24 DD DD7700199101A patent/DD131169A5/xx unknown
- 1977-05-24 FI FI771651A patent/FI64582C/fi not_active IP Right Cessation
- 1977-05-24 GR GR53547A patent/GR72092B/el unknown
- 1977-05-24 CA CA278,990A patent/CA1104566A/en not_active Expired
- 1977-05-24 PT PT66588A patent/PT66588B/pt unknown
- 1977-05-24 NZ NZ184191A patent/NZ184191A/xx unknown
- 1977-05-24 NL NL7705707A patent/NL7705707A/xx not_active Application Discontinuation
- 1977-05-24 ES ES459070A patent/ES459070A1/es not_active Expired
- 1977-05-25 NO NO771830A patent/NO148489C/no unknown
- 1977-05-25 AT AT372577A patent/AT356114B/de not_active IP Right Cessation
- 1977-05-25 SE SE7706120A patent/SE427354B/sv not_active IP Right Cessation
- 1977-05-25 BE BE177877A patent/BE855009A/xx not_active IP Right Cessation
- 1977-05-25 AU AU25473/77A patent/AU510471B2/en not_active Expired
- 1977-05-25 ZA ZA00773161A patent/ZA773161B/xx unknown
- 1977-05-25 HU HU77CI1744A patent/HU177417B/hu not_active IP Right Cessation
- 1977-05-25 IL IL52168A patent/IL52168A/xx unknown
- 1977-05-25 IE IE1074/77A patent/IE45204B1/en not_active IP Right Cessation
- 1977-05-25 DK DK229977A patent/DK150301C/da not_active IP Right Cessation
- 1977-05-26 CS CS782988A patent/CS225106B2/cs unknown
- 1977-05-26 CS CS773475A patent/CS225103B2/cs unknown
- 1977-05-26 AR AR267787A patent/AR227608A1/es active
- 1977-05-26 JP JP6057877A patent/JPS52144687A/ja active Granted
-
1978
- 1978-06-18 AR AR272606A patent/AR228124A1/es active
-
1980
- 1980-02-01 CH CH83380A patent/CH624106A5/de not_active IP Right Cessation
-
1983
- 1983-10-19 SG SG63683A patent/SG63683G/en unknown
- 1983-10-24 KE KE3339A patent/KE3339A/xx unknown
-
1984
- 1984-02-01 HK HK87/84A patent/HK8784A/xx unknown
-
1985
- 1985-12-30 MY MY99/85A patent/MY8500099A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: CIBA-GEIGY AG |