CH617667A5 - - Google Patents

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Publication number
CH617667A5
CH617667A5 CH418375A CH418375A CH617667A5 CH 617667 A5 CH617667 A5 CH 617667A5 CH 418375 A CH418375 A CH 418375A CH 418375 A CH418375 A CH 418375A CH 617667 A5 CH617667 A5 CH 617667A5
Authority
CH
Switzerland
Prior art keywords
group
amino acid
pca
tripeptide
amide
Prior art date
Application number
CH418375A
Other languages
German (de)
English (en)
Inventor
Daniel Frank Veber
Frederick William Holly
Ruth Nutt-Foelsche
Sandor Lajos Varga
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH617667A5 publication Critical patent/CH617667A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CH418375A 1974-04-03 1975-04-02 CH617667A5 (xx)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45768974A 1974-04-03 1974-04-03
US05/543,734 US3959248A (en) 1974-04-03 1975-01-27 Analogs of thyrotropin-releasing hormone

Publications (1)

Publication Number Publication Date
CH617667A5 true CH617667A5 (xx) 1980-06-13

Family

ID=27038702

Family Applications (2)

Application Number Title Priority Date Filing Date
CH418375A CH617667A5 (xx) 1974-04-03 1975-04-02
CH207779A CH620196A5 (xx) 1974-04-03 1979-03-02

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH207779A CH620196A5 (xx) 1974-04-03 1979-03-02

Country Status (12)

Country Link
US (1) US3959248A (xx)
JP (2) JPS547793B2 (xx)
CH (2) CH617667A5 (xx)
CY (1) CY1071A (xx)
DE (1) DE2514381C3 (xx)
ES (1) ES436027A1 (xx)
FR (1) FR2266515B1 (xx)
GB (1) GB1473480A (xx)
HK (1) HK43480A (xx)
KE (1) KE3067A (xx)
NL (1) NL171700C (xx)
SE (1) SE425659B (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991003487A1 (en) * 1989-09-04 1991-03-21 Hans Bundgaard Prodrug derivatives of thyrotropin-releasing hormone (trh)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2449167C2 (de) * 1974-10-16 1984-05-24 Grünenthal GmbH, 5190 Stolberg N-Acyl-L-histidyl-L-prolinamide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
GB1523598A (en) * 1975-03-08 1978-09-06 Reckitt & Colmann Prod Ltd Tripeptides
JPS5944308B2 (ja) * 1976-03-23 1984-10-29 武田薬品工業株式会社 ペプタイド
JPS5920647B2 (ja) * 1976-10-01 1984-05-15 武田薬品工業株式会社 注射剤
US4161600A (en) * 1976-12-22 1979-07-17 Merck & Co., Inc. Dextro and levo-6-oxo-2-piperidinecarboxylic acid quinine salts
US4066749A (en) * 1977-01-24 1978-01-03 Merck & Co., Inc. Tetrapeptide analog of TRH
AU4125578A (en) * 1977-11-09 1979-05-17 Merck & Co Inc Tripeptides
US4215110A (en) * 1978-09-22 1980-07-29 Merck & Co., Inc. Method of treating hypertension
DE2905502C2 (de) * 1979-02-14 1982-07-15 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von LH-RH bzw. LH-RH-Analoga und Pyroglutamyl-N↑i↑m↑-dinitrophenyl-histidin
HU180926B (en) * 1979-06-28 1983-05-30 Richter Gedeon Vegyeszet Process for preparing trh analogues,tripeptide amides infectives on the central nerve sysrhem
HU180925B (en) * 1979-06-28 1983-05-30 Richter Gedeon Vegyeszet Process for producing tripeptide-amides trh-analogues,effectives on the central nerve systhem
US4254261A (en) * 1979-10-15 1981-03-03 Merck & Co., Inc. Dehydroabietylammonium salts of 6-oxo-2-piperidinecarboxylic acid
US4328134A (en) * 1980-05-06 1982-05-04 Schally Andrew Victor Anorexigenic peptides
US4426378A (en) 1981-04-09 1984-01-17 The United States Of America As Represented By The Secretary Of The Army Thyrotropin releasing hormone in therapy of shock and as a central nervous system stimulant
HU184481B (en) * 1981-10-02 1984-08-28 Richter Gedeon Vegyeszet Process for producing tripeptides for diminishing appetite
JPS59155346A (ja) * 1983-02-24 1984-09-04 Itsuro Sofue ペプタイド
CA1256650A (en) * 1983-03-25 1989-06-27 Toshinari Tamura Process of producing 2-azetidinone-4-substituted compounds, and medicaments containing the compounds
US4608365A (en) * 1984-03-30 1986-08-26 University Of Southern California Treatment of neurologic functions
IT1202426B (it) * 1987-01-26 1989-02-09 Poli Ind Chimica Spa Derivato di acido tiazolidin-4-carbossilico,sua preparazione e composizioni farmaceutiche che lo contengono
US5686420A (en) * 1987-06-05 1997-11-11 Georgetown University Thyrotropin-releasing hormone analogs and method of use
US5151497A (en) * 1989-02-21 1992-09-29 Japan Tobacco Inc. Histidyl peptide derivatives
AT392949B (de) * 1989-03-17 1991-07-10 Gfm Holding Ag Vorrichtung zum abnehmen eines flaechigen werkstueckes von einer anklebenden unterfolie
HU206374B (en) * 1990-09-03 1992-10-28 Richter Gedeon Vegyeszet Process for producing pentapeptide and its salts specifically inhibiting proliferation of epidermic cells, as well as pharmaceutical compositions comprising same as active ingredient
GB0125446D0 (en) * 2001-10-23 2001-12-12 Ferring Bv Novel anti-diabetic agents
US7067257B2 (en) * 2002-04-19 2006-06-27 University Of Florida Thyrotropin-releasing hormone analogues and their therapeutic applications
US7462595B2 (en) * 2004-09-17 2008-12-09 Prange Jr Arthur Jergen Methods for treating cancer-related fatigue

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5714337B2 (xx) * 1973-02-23 1982-03-24

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991003487A1 (en) * 1989-09-04 1991-03-21 Hans Bundgaard Prodrug derivatives of thyrotropin-releasing hormone (trh)
US5405834A (en) * 1989-09-04 1995-04-11 Bundgaard; Hans Prodrug derivatives of thyrotropin-releasing hormone (TRH)

Also Published As

Publication number Publication date
DE2514381B2 (de) 1980-04-17
SE425659B (sv) 1982-10-25
NL171700C (nl) 1983-05-02
FR2266515B1 (xx) 1978-07-28
AU7921575A (en) 1976-09-23
NL171700B (nl) 1982-12-01
NL7503023A (nl) 1975-10-07
JPS50154247A (xx) 1975-12-12
US3959248A (en) 1976-05-25
KE3067A (en) 1980-08-08
ES436027A1 (es) 1977-05-01
JPS5492957A (en) 1979-07-23
GB1473480A (en) 1977-05-11
CY1071A (en) 1980-10-24
SE7503366L (sv) 1975-10-06
DE2514381C3 (de) 1980-12-11
HK43480A (en) 1980-08-22
JPS547793B2 (xx) 1979-04-10
CH620196A5 (xx) 1980-11-14
FR2266515A1 (xx) 1975-10-31
DE2514381A1 (de) 1975-10-09

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