CH616087A5 - Dispersion of lipid spherules - Google Patents
Dispersion of lipid spherules Download PDFInfo
- Publication number
- CH616087A5 CH616087A5 CH830776A CH830776A CH616087A5 CH 616087 A5 CH616087 A5 CH 616087A5 CH 830776 A CH830776 A CH 830776A CH 830776 A CH830776 A CH 830776A CH 616087 A5 CH616087 A5 CH 616087A5
- Authority
- CH
- Switzerland
- Prior art keywords
- dispersion
- spherules
- lipid
- encapsulated
- phase
- Prior art date
Links
- 239000006185 dispersion Substances 0.000 title claims abstract description 87
- 150000002632 lipids Chemical class 0.000 title claims description 48
- -1 lipid compounds Chemical class 0.000 claims abstract description 40
- 239000008346 aqueous phase Substances 0.000 claims abstract description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000013543 active substance Substances 0.000 claims abstract description 18
- 239000007864 aqueous solution Substances 0.000 claims abstract description 12
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 11
- 239000000600 sorbitol Substances 0.000 claims abstract description 11
- 239000012071 phase Substances 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 28
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims description 14
- 238000002604 ultrasonography Methods 0.000 claims description 13
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical class OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 12
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 12
- 239000002537 cosmetic Substances 0.000 claims description 9
- 150000002148 esters Chemical class 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 9
- 230000008569 process Effects 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 229920005862 polyol Polymers 0.000 claims description 7
- 229920005654 Sephadex Polymers 0.000 claims description 6
- 239000012507 Sephadex™ Substances 0.000 claims description 6
- 150000001412 amines Chemical class 0.000 claims description 6
- 235000012000 cholesterol Nutrition 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000000975 dye Substances 0.000 claims description 6
- 150000003077 polyols Chemical class 0.000 claims description 6
- 150000003839 salts Chemical group 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 150000002191 fatty alcohols Chemical class 0.000 claims description 5
- 229940099367 lanolin alcohols Drugs 0.000 claims description 5
- 229920000223 polyglycerol Polymers 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 4
- 150000001299 aldehydes Chemical class 0.000 claims description 4
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 claims description 4
- 238000005538 encapsulation Methods 0.000 claims description 4
- 235000013305 food Nutrition 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims description 4
- 239000004215 Carbon black (E152) Substances 0.000 claims description 3
- 229930186217 Glycolipid Natural products 0.000 claims description 3
- 125000001931 aliphatic group Chemical group 0.000 claims description 3
- 229930183167 cerebroside Natural products 0.000 claims description 3
- 150000001784 cerebrosides Chemical class 0.000 claims description 3
- 150000002170 ethers Chemical class 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 229930195733 hydrocarbon Natural products 0.000 claims description 3
- 239000007800 oxidant agent Substances 0.000 claims description 3
- 230000035515 penetration Effects 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 238000009210 therapy by ultrasound Methods 0.000 claims description 3
- MNQZXJOMYWMBOU-VKHMYHEASA-N D-glyceraldehyde Chemical compound OC[C@@H](O)C=O MNQZXJOMYWMBOU-VKHMYHEASA-N 0.000 claims description 2
- 208000001840 Dandruff Diseases 0.000 claims description 2
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 229940124091 Keratolytic Drugs 0.000 claims description 2
- 229930182558 Sterol Natural products 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 125000005037 alkyl phenyl group Chemical group 0.000 claims description 2
- 150000008051 alkyl sulfates Chemical class 0.000 claims description 2
- 150000001414 amino alcohols Chemical class 0.000 claims description 2
- 210000004381 amniotic fluid Anatomy 0.000 claims description 2
- 230000001166 anti-perspirative effect Effects 0.000 claims description 2
- 239000003213 antiperspirant Substances 0.000 claims description 2
- 239000003212 astringent agent Substances 0.000 claims description 2
- 239000003638 chemical reducing agent Substances 0.000 claims description 2
- 239000002781 deodorant agent Substances 0.000 claims description 2
- 230000002951 depilatory effect Effects 0.000 claims description 2
- 229940120503 dihydroxyacetone Drugs 0.000 claims description 2
- 150000002009 diols Chemical class 0.000 claims description 2
- UQPHVQVXLPRNCX-UHFFFAOYSA-N erythrulose Chemical compound OCC(O)C(=O)CO UQPHVQVXLPRNCX-UHFFFAOYSA-N 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- 239000000796 flavoring agent Substances 0.000 claims description 2
- 235000019634 flavors Nutrition 0.000 claims description 2
- 239000003349 gelling agent Substances 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 230000035876 healing Effects 0.000 claims description 2
- 239000003906 humectant Substances 0.000 claims description 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims description 2
- 229960000367 inositol Drugs 0.000 claims description 2
- 230000001530 keratinolytic effect Effects 0.000 claims description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 2
- 239000003605 opacifier Substances 0.000 claims description 2
- 239000002304 perfume Substances 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 claims description 2
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 229940080236 sodium cetyl sulfate Drugs 0.000 claims description 2
- GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 claims description 2
- 150000003432 sterols Chemical class 0.000 claims description 2
- 235000003702 sterols Nutrition 0.000 claims description 2
- 239000000516 sunscreening agent Substances 0.000 claims description 2
- 230000001256 tonic effect Effects 0.000 claims description 2
- 239000003643 water by type Substances 0.000 claims description 2
- 239000002502 liposome Substances 0.000 claims 10
- 239000007788 liquid Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- 238000003756 stirring Methods 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 claims 1
- 229940093541 dicetylphosphate Drugs 0.000 claims 1
- 238000010828 elution Methods 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 230000008020 evaporation Effects 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 230000008520 organization Effects 0.000 claims 1
- 229940059574 pentaerithrityl Drugs 0.000 claims 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims 1
- 229940067631 phospholipid Drugs 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 229960002920 sorbitol Drugs 0.000 claims 1
- 239000010409 thin film Substances 0.000 claims 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims 1
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 abstract description 2
- 229920002125 Sokalan® Polymers 0.000 abstract description 2
- 238000013019 agitation Methods 0.000 abstract description 2
- 239000004584 polyacrylic acid Substances 0.000 abstract description 2
- 229920000136 polysorbate Polymers 0.000 abstract description 2
- 230000007935 neutral effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 36
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 26
- 239000000203 mixture Substances 0.000 description 26
- 238000002474 experimental method Methods 0.000 description 18
- 239000011780 sodium chloride Substances 0.000 description 13
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 239000003995 emulsifying agent Substances 0.000 description 7
- 239000000499 gel Substances 0.000 description 7
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 5
- ALSTYHKOOCGGFT-UHFFFAOYSA-N cis-oleyl alcohol Natural products CCCCCCCCC=CCCCCCCCCO ALSTYHKOOCGGFT-UHFFFAOYSA-N 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 description 2
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000002353 niosome Substances 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 description 1
- MGYUQZIGNZFZJS-KTKRTIGZSA-N 2-[2-[(z)-octadec-9-enoxy]ethoxy]ethanol Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCOCCO MGYUQZIGNZFZJS-KTKRTIGZSA-N 0.000 description 1
- QYOVMAREBTZLBT-KTKRTIGZSA-N CCCCCCCC\C=C/CCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO QYOVMAREBTZLBT-KTKRTIGZSA-N 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- WPMWEFXCIYCJSA-UHFFFAOYSA-N Tetraethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCO WPMWEFXCIYCJSA-UHFFFAOYSA-N 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229960001305 cysteine hydrochloride Drugs 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000008040 ionic compounds Chemical class 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 238000000199 molecular distillation Methods 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- BUKHSQBUKZIMLB-UHFFFAOYSA-L potassium;sodium;dichloride Chemical compound [Na+].[Cl-].[Cl-].[K+] BUKHSQBUKZIMLB-UHFFFAOYSA-L 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000010583 slow cooling Methods 0.000 description 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/34—Higher-molecular-weight carboxylic acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/04—Preparations for care of the skin for chemically tanning the skin
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K19/00—Liquid crystal materials
- C09K19/52—Liquid crystal materials characterised by components which are not liquid crystals, e.g. additives with special physical aspect: solvents, solid particles
- C09K19/54—Additives having no specific mesophase characterised by their chemical composition
- C09K19/542—Macromolecular compounds
- C09K19/544—Macromolecular compounds as dispersing or encapsulating medium around the liquid crystal
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K19/00—Liquid crystal materials
- C09K19/52—Liquid crystal materials characterised by components which are not liquid crystals, e.g. additives with special physical aspect: solvents, solid particles
- C09K2019/523—Organic solid particles
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K19/00—Liquid crystal materials
- C09K19/52—Liquid crystal materials characterised by components which are not liquid crystals, e.g. additives with special physical aspect: solvents, solid particles
- C09K2019/528—Surfactants
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Cosmetics (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Colloid Chemistry (AREA)
- Liquid Crystal Substances (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7520456A FR2315991A1 (fr) | 1975-06-30 | 1975-06-30 | Procede de fabrication de dispersions aqueuses de spherules lipidiques et nouvelles compositions correspondantes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH616087A5 true CH616087A5 (en) | 1980-03-14 |
Family
ID=9157266
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH830776A CH616087A5 (en) | 1975-06-30 | 1976-06-29 | Dispersion of lipid spherules |
| CH42980A CH623236A5 (en) | 1975-06-30 | 1980-01-18 | Dispersion of lipid spherules |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH42980A CH623236A5 (en) | 1975-06-30 | 1980-01-18 | Dispersion of lipid spherules |
Country Status (14)
| Country | Link |
|---|---|
| JP (2) | JPS588287B2 (es) |
| AT (1) | AT361893B (es) |
| AU (1) | AU505843B2 (es) |
| BE (1) | BE843300A (es) |
| BR (1) | BR7604270A (es) |
| CA (1) | CA1063908A (es) |
| CH (2) | CH616087A5 (es) |
| DE (3) | DE2660069C2 (es) |
| DK (1) | DK150967C (es) |
| ES (1) | ES449312A1 (es) |
| FR (1) | FR2315991A1 (es) |
| GB (1) | GB1539625A (es) |
| IT (1) | IT1062389B (es) |
| NL (1) | NL168715C (es) |
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| FR2986422B1 (fr) | 2012-02-06 | 2014-02-21 | Oreal | Composition solaire non pulverulente comprenant une phase huileuse polaire et des particules d'aerogel de silice hydrophobes |
| FR2992858B1 (fr) | 2012-07-04 | 2015-10-30 | Oreal | Composition cosmetique photoprotectrice. |
| FR2993176B1 (fr) | 2012-07-13 | 2014-06-27 | Oreal | Composition cosmetique contenant des particules composites filtrantes de taille moyenne superieure a 0,1 micron et des particules de filtre inorganique et une phase aqueuse |
| ES2822151T5 (es) | 2012-07-13 | 2024-03-18 | Oreal | Pigmento compuesto y procedimiento para prepararlo |
| CN104394835B (zh) | 2012-07-13 | 2018-09-07 | 莱雅公司 | 化妆品组合物 |
| FR3001136B1 (fr) | 2013-01-21 | 2015-06-19 | Oreal | Emulsion cosmetique ou dermatologique comprenant une merocyanine et un systeme emulsionnant contenant un polymere amphiphile comportant au moins un motif acide acrylamido 2-methylpropane sulfonique |
| FR3001133B1 (fr) | 2013-01-21 | 2015-03-20 | Oreal | Composition cosmetique ou dermatologique comprenant une merocyanine et une phase huileuse comprenant au moins un compose amide particulier |
| JP6509743B2 (ja) | 2013-01-21 | 2019-05-08 | ロレアル | メロシアニン、有機ｕｖｂ遮蔽剤及び追加の有機ｕｖａ遮蔽剤を含む化粧用又は皮膚用組成物 |
| FR3001216B1 (fr) | 2013-01-21 | 2015-02-27 | Oreal | Composition cosmetique ou dermatologique comprenant une merocyanine, une phase huileuse et un mono-alcanol en c1-c4 |
| EP2945603B1 (en) | 2013-01-21 | 2019-03-27 | L'Oréal | Cosmetic or dermatological composition comprising a merocyanine and a uva-screening agent of the amino-substituted 2-hydroxybenzophenone type and/or a hydrophilic organic uva-screening agent |
| JP6466344B2 (ja) | 2013-01-21 | 2019-02-06 | ロレアル | メロシアニン並びに親油性ベンゾトリアゾールｕｖ遮蔽剤及び／又はビスレゾルシニルトリアジン化合物を含む化粧用又は皮膚用組成物 |
| FR3001128B1 (fr) | 2013-01-21 | 2015-06-19 | Oreal | Emulsion cosmetique ou dermatologique comprenant une merocyanine et un systeme emulsionnant contenant un sel de metal alcalin d'ester d'acide phosphorique et d'alcool gras |
| FR3001131B1 (fr) | 2013-01-21 | 2015-06-19 | Oreal | Emulsion cosmetique ou dermatologique comprenant une merocyanine et un systeme emulsionnant contenant un tensioactif gemine. |
| JP6487337B2 (ja) | 2013-01-21 | 2019-03-20 | ロレアル | メロシアニンと不溶性有機ｕｖ遮蔽剤及び／又は不溶性無機ｕｖ遮蔽剤とを含む化粧用又は皮膚用組成物 |
| FR3006176B1 (fr) | 2013-05-29 | 2015-06-19 | Oreal | Particules composites a base de filtre uv inorganique et de perlite ; compositions cosmetiques ou dermatologiques les contenant |
| ES2765208T3 (es) | 2013-05-30 | 2020-06-08 | Oreal | Composición cosmética |
| JP2016521679A (ja) | 2013-06-18 | 2016-07-25 | ロレアル | 化粧用組成物 |
| FR3046927B1 (fr) | 2016-01-26 | 2018-03-02 | L'oreal | Composition cosmetique ou dermatologique comprenant une merocyanine et une phase huileuse comprenant au moins un ether d'isosorbide |
| FR3046930B1 (fr) | 2016-01-26 | 2018-03-02 | L'oreal | Composition cosmetique ou dermatologique comprenant une merocyanine et une phase huileuse comprenant au moins un polyalkyleneglycol |
| FR3046929B1 (fr) | 2016-01-26 | 2018-03-02 | L'oreal | Composition cosmetique ou dermatologique comprenant une merocyanine et une phase huileuse comprenant au moins un ester d'acide di ou tricarboxylique |
| FR3046928B1 (fr) | 2016-01-26 | 2019-08-09 | L'oreal | Composition cosmetique ou dermatologique comprenant une merocyanine et une phase huileuse comprenant au moins un amide n-substitue |
| FR3068354B1 (fr) | 2017-06-29 | 2020-07-31 | Oreal | Compositions photoprotectrices comprenant un derive dibenzoylmethane, un compose merocyanine et un compose susceptible d'accepter l'energie de niveau excite triplet du compose dibenzoylmethane |
| FR3073408B1 (fr) | 2017-11-15 | 2019-10-11 | L'oreal | Compositions comprenant au moins un polymere acrylique et au moins un filtre organique insoluble |
| FR3073409B1 (fr) | 2017-11-15 | 2019-10-11 | L'oreal | Composition cosmetique ou dermatologique comprenant une merocyanine et un polymere acrylique. |
| FR3083097B1 (fr) | 2018-06-28 | 2020-11-27 | Oreal | Composition cosmetique ou dermatologique comprenant une merocyanine et une phase huileuse comprenant au moins un carbonate d’alkyle ou d’alkylene |
| EP3854377A1 (fr) | 2020-01-22 | 2021-07-28 | Laboratoires Genevrier Sas | Composition comprenant de l'acide hyaluronique et un polyol ou de carboxyméthylcellulose |
| CN115485048A (zh) * | 2020-04-14 | 2022-12-16 | 陶氏环球技术有限责任公司 | 基于聚甘油醚的泡沫控制剂及其在生物乙醇处理中的用途 |
| FR3117824A1 (fr) | 2020-12-18 | 2022-06-24 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine et une phase huileuse comprenant au moins un ester d’acide citrique |
| FR3117825A1 (fr) | 2020-12-18 | 2022-06-24 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine, un filtre UV triazine, et un polysaccharide modifié par des chaînes hydrophobes |
| FR3119988B1 (fr) | 2021-02-25 | 2023-12-29 | Oreal | Composition aqueuse comprenant un filtre UV organique, un polymère superabsorbant, de la perlite et un alcool gras |
| FR3124698A1 (fr) | 2021-06-30 | 2023-01-06 | L'oreal | Composition comprenant au moins un filtre UV, du nitrure de bore, et un tensioactif non ionique de type ester |
| FR3128118A1 (fr) | 2021-10-14 | 2023-04-21 | L'oreal | ProceDE de traitement des cheveux comprenant l’application d’une émulsion huile-dans-eau comprenant une phase aqueuse, une phase grasse et un polymère |
| FR3130594A1 (fr) | 2021-12-17 | 2023-06-23 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine et du resvératrol et/ou un dérivé de resvératrol |
| FR3130597A1 (fr) | 2021-12-17 | 2023-06-23 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine et au moins un diol comportant de 4 à 7 atomes de carbone |
| FR3130599A1 (fr) | 2021-12-17 | 2023-06-23 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine et une gamma-butyrolactone et/ou un gamma-butyrolactame |
| FR3130593A1 (fr) | 2021-12-17 | 2023-06-23 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine et le dipropylène glycol |
| FR3141059A1 (fr) | 2022-10-20 | 2024-04-26 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine et une gamma-butyrolactone et/ou un gamma-butyrolactame |
| EP4447897A1 (en) | 2021-12-17 | 2024-10-23 | L'oreal | Cosmetic or dermatological composition comprising a merocyanine and a gamma-butyrolactone and/or a gamma-butyrolactam |
| FR3130598A1 (fr) | 2021-12-17 | 2023-06-23 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine et du tétra hydroxycinnamate de di-t-butyle pentaérythrityle |
| FR3132637A1 (fr) | 2022-02-15 | 2023-08-18 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine et un complexe polyionique |
| FR3141062A1 (fr) | 2022-10-21 | 2024-04-26 | L'oreal | Composition comprenant un filtre organique lipophile, un filtre organique hydrophile, avec une quantité en poids de phase grasse entre 20 et 70 % et un ratio massique filtres organiques hydrophiles / filtres organiques lipophiles supérieur à 0,3 |
| FR3141060A1 (fr) | 2022-10-21 | 2024-04-26 | L'oreal | Composition comprenant un filtre UV organique lipophile, un filtre UV organique hydrophile et un polymère gélifiant hydrophile spécifique |
| WO2024083567A1 (en) | 2022-10-21 | 2024-04-25 | L'oreal | Composition comprising a lipophilic organic screening agent, a hydrophilic organic screening agent, with an amount by weight of fatty phase between 20 and 70% |
| FR3141061A1 (fr) | 2022-10-21 | 2024-04-26 | L'oreal | Composition comprenant un filtre organique lipophile, un filtre organique hydrophile, des particules sphériques de silice poreuse, des particules sphériques de cellulose, et une poudre d’acide aminé N-acylé |
| FR3142897A1 (fr) | 2022-12-09 | 2024-06-14 | L'oreal | Composition comprenant un filtre organique hydrodispersible et au moins un complexe polyionique contenant un polysaccharide cationique et un acide non polymérique ayant au moins 3 valeurs de pKa et/ou l’un de ses sels |
| FR3143344A1 (fr) | 2022-12-16 | 2024-06-21 | L'oreal | Composition comprenant un filtre UV, un polymère lipophile convenablement sélectionné, et un carraghénane |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2249552A1 (de) * | 1971-10-12 | 1973-05-30 | Inchema S A | Verfahren zur inkapsulation von insbesondere wasserloeslichen verbindungen |
-
1975
- 1975-06-30 FR FR7520456A patent/FR2315991A1/fr active Granted
-
1976
- 1976-06-23 BE BE168219A patent/BE843300A/xx not_active IP Right Cessation
- 1976-06-28 AT AT470376A patent/AT361893B/de not_active IP Right Cessation
- 1976-06-28 ES ES449312A patent/ES449312A1/es not_active Expired
- 1976-06-29 GB GB27094/76A patent/GB1539625A/en not_active Expired
- 1976-06-29 DE DE2660069A patent/DE2660069C2/de not_active Expired - Lifetime
- 1976-06-29 CA CA255,929A patent/CA1063908A/fr not_active Expired
- 1976-06-29 AU AU15393/76A patent/AU505843B2/en not_active Expired
- 1976-06-29 DE DE2629100A patent/DE2629100C3/de not_active Expired
- 1976-06-29 DK DK291376A patent/DK150967C/da not_active IP Right Cessation
- 1976-06-29 CH CH830776A patent/CH616087A5/fr not_active IP Right Cessation
- 1976-06-29 DE DE2661108A patent/DE2661108C2/de not_active Expired - Lifetime
- 1976-06-30 JP JP51076601A patent/JPS588287B2/ja not_active Expired
- 1976-06-30 NL NLAANVRAGE7607210,A patent/NL168715C/xx not_active IP Right Cessation
- 1976-06-30 IT IT68608/76A patent/IT1062389B/it active
- 1976-06-30 BR BR7604270A patent/BR7604270A/pt unknown
-
1980
- 1980-01-18 CH CH42980A patent/CH623236A5/fr not_active IP Right Cessation
-
1981
- 1981-01-07 JP JP51981A patent/JPS56108528A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| IT1062389B (it) | 1984-10-10 |
| AU1539376A (en) | 1978-01-05 |
| BE843300A (fr) | 1976-12-23 |
| BR7604270A (pt) | 1977-04-05 |
| JPS588287B2 (ja) | 1983-02-15 |
| AU505843B2 (en) | 1979-12-06 |
| DK150967C (da) | 1988-02-15 |
| JPS526375A (en) | 1977-01-18 |
| ATA470376A (de) | 1980-09-15 |
| CH623236A5 (en) | 1981-05-29 |
| NL7607210A (nl) | 1977-01-03 |
| DE2660069C2 (es) | 1990-09-13 |
| DK291376A (da) | 1976-12-31 |
| JPS56108528A (en) | 1981-08-28 |
| NL168715C (nl) | 1982-05-17 |
| CA1063908A (fr) | 1979-10-09 |
| JPS6156016B2 (es) | 1986-12-01 |
| DK150967B (da) | 1987-10-05 |
| DE2629100A1 (de) | 1977-01-20 |
| ES449312A1 (es) | 1977-08-16 |
| DE2661108C2 (de) | 1993-12-16 |
| FR2315991A1 (fr) | 1977-01-28 |
| DE2629100B2 (de) | 1979-11-29 |
| GB1539625A (en) | 1979-01-31 |
| FR2315991B1 (es) | 1977-12-02 |
| DE2629100C3 (de) | 1980-08-14 |
| AT361893B (de) | 1981-04-10 |
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| Date | Code | Title | Description |
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| PL | Patent ceased |