CH589716A5 - Antibiotics S 7481-F-1 and 2 - prepd. from new strains of Cylindrocarbon or Trichoderma esp. useful as immunosuppressant - Google Patents
Antibiotics S 7481-F-1 and 2 - prepd. from new strains of Cylindrocarbon or Trichoderma esp. useful as immunosuppressantInfo
- Publication number
- CH589716A5 CH589716A5 CH1711173A CH1711173A CH589716A5 CH 589716 A5 CH589716 A5 CH 589716A5 CH 1711173 A CH1711173 A CH 1711173A CH 1711173 A CH1711173 A CH 1711173A CH 589716 A5 CH589716 A5 CH 589716A5
- Authority
- CH
- Switzerland
- Prior art keywords
- sep
- antibiotics
- new
- prepd
- methanol
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title claims abstract description 18
- 229940088710 antibiotic agent Drugs 0.000 title claims abstract description 18
- 241000223259 Trichoderma Species 0.000 title 1
- 229960003444 immunosuppressant agent Drugs 0.000 title 1
- 230000001861 immunosuppressant effect Effects 0.000 title 1
- 239000003018 immunosuppressive agent Substances 0.000 title 1
- 241000875119 Cylindrocarpon lucidum Species 0.000 claims abstract description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 57
- 235000015097 nutrients Nutrition 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 6
- 230000002538 fungal effect Effects 0.000 claims description 4
- 241000228245 Aspergillus niger Species 0.000 abstract description 6
- 206010003246 arthritis Diseases 0.000 abstract description 4
- 230000001506 immunosuppresive effect Effects 0.000 abstract description 4
- 241000700159 Rattus Species 0.000 abstract description 3
- 230000005764 inhibitory process Effects 0.000 abstract description 3
- 238000011321 prophylaxis Methods 0.000 abstract description 3
- 238000011282 treatment Methods 0.000 abstract description 3
- 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 abstract description 2
- 241000699670 Mus sp. Species 0.000 abstract description 2
- 208000025747 Rheumatic disease Diseases 0.000 abstract description 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 2
- 230000004083 survival effect Effects 0.000 abstract description 2
- 241000123975 Trichoderma polysporum Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 22
- 239000000243 solution Substances 0.000 description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 13
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 12
- 239000000741 silica gel Substances 0.000 description 12
- 229910002027 silica gel Inorganic materials 0.000 description 12
- 238000012360 testing method Methods 0.000 description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 9
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- 239000003480 eluent Substances 0.000 description 8
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- 239000000126 substance Substances 0.000 description 7
- 239000000284 extract Substances 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 230000003115 biocidal effect Effects 0.000 description 5
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- 239000000725 suspension Substances 0.000 description 5
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- 239000007788 liquid Substances 0.000 description 4
- WHBHBVVOGNECLV-OBQKJFGGSA-N 11-deoxycortisol Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 WHBHBVVOGNECLV-OBQKJFGGSA-N 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
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- 235000002017 Zea mays subsp mays Nutrition 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 235000005822 corn Nutrition 0.000 description 3
- XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 description 3
- 235000010344 sodium nitrate Nutrition 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 230000000274 adsorptive effect Effects 0.000 description 2
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- 150000001413 amino acids Chemical class 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 2
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 2
- 235000019797 dipotassium phosphate Nutrition 0.000 description 2
- 238000000921 elemental analysis Methods 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
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- 238000000605 extraction Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- KDCIHNCMPUBDKT-UHFFFAOYSA-N hexane;propan-2-one Chemical compound CC(C)=O.CCCCCC KDCIHNCMPUBDKT-UHFFFAOYSA-N 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 2
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- SJHPCNCNNSSLPL-CSKARUKUSA-N (4e)-4-(ethoxymethylidene)-2-phenyl-1,3-oxazol-5-one Chemical compound O1C(=O)C(=C/OCC)\N=C1C1=CC=CC=C1 SJHPCNCNNSSLPL-CSKARUKUSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 description 1
- QWCKQJZIFLGMSD-UHFFFAOYSA-N 2-Aminobutanoic acid Natural products CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- QWCKQJZIFLGMSD-GSVOUGTGSA-N D-alpha-aminobutyric acid Chemical compound CC[C@@H](N)C(O)=O QWCKQJZIFLGMSD-GSVOUGTGSA-N 0.000 description 1
- 206010014025 Ear swelling Diseases 0.000 description 1
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- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- -1 N-methyleucine Chemical compound 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000364057 Peoria Species 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
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- 230000007123 defense Effects 0.000 description 1
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- 201000002491 encephalomyelitis Diseases 0.000 description 1
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- 230000035931 haemagglutination Effects 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 244000059217 heterotrophic organism Species 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 239000000401 methanolic extract Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
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- 210000000944 nerve tissue Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
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- 239000007858 starting material Substances 0.000 description 1
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- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1711173A CH589716A5 (en) | 1973-12-06 | 1973-12-06 | Antibiotics S 7481-F-1 and 2 - prepd. from new strains of Cylindrocarbon or Trichoderma esp. useful as immunosuppressant |
| DE2463138A DE2463138C2 (de) | 1973-12-06 | 1974-11-26 | Das Antibiotikum Cyclosporin B (S 7481/F-2), seine Herstellung und Verwendung |
| DE2455859A DE2455859C2 (de) | 1973-12-06 | 1974-11-26 | Das Antibiotikum Cyclosporin A (S 7481/F-1), seine Herstellung und Verwendung |
| DK617074AA DK136780B (da) | 1973-12-06 | 1974-11-27 | Fremgangsmåde til fremstilling af antibiotika S 7481/F-1 og S 7481/F-2. |
| FI743434A FI52851C (fi) | 1973-12-06 | 1974-11-27 | Menetelmä uusien terapeuttisesti käytettävien peptidiantibioottien S 7 481/F-1 ja S 7481/F-2 valmistamiseksi. |
| NO744292A NO744292L (cs) | 1973-12-06 | 1974-11-28 | |
| SE7415027A SE423720B (sv) | 1973-12-06 | 1974-11-29 | Framstellning av nya peptidantibiotika |
| NLAANVRAGE7415682,A NL179220C (nl) | 1973-12-06 | 1974-12-02 | Werkwijze voor het bereiden van een geneesmiddel dat een antibioticum bevat, de onder toepassing van deze werkwijze verkregen gevormde geneesmiddelen en werkwijze voor het bereiden van de hierbij toegepaste antibiotica. |
| GB52013/74A GB1491509A (en) | 1973-12-06 | 1974-12-02 | Metabolites s7481/f-1 and 1f-2 |
| IL46180A IL46180A (en) | 1973-12-06 | 1974-12-04 | Antibiotics s7481/f-1 and s7481/f-2,their preparation and pharmaceutical compositions containing them |
| ES432559A ES432559A1 (es) | 1973-12-06 | 1974-12-04 | Procedimiento para la produccion de antibioticos. |
| NZ176117A NZ176117A (en) | 1973-12-06 | 1974-12-04 | Antibiotics from cylindrocarpon lucidum and trichoderma polysporum and pharmaceutical compositions and fermentation liquors containing them |
| AU76081/74A AU500889B2 (en) | 1973-12-06 | 1974-12-04 | Metabolites 27481/f-1 & f-2 |
| DD182775A DD115695A5 (cs) | 1973-12-06 | 1974-12-04 | |
| IE2502/74A IE40549B1 (en) | 1973-12-06 | 1974-12-04 | Metabolites s7481/f-1 and /f-2 |
| PL1974176171A PL92561B1 (cs) | 1973-12-06 | 1974-12-04 | |
| AT971874A AT347032B (de) | 1973-12-06 | 1974-12-05 | Verfahren zur herstellung neuer antibiotika |
| BE151206A BE823008A (fr) | 1973-12-06 | 1974-12-05 | Nouveaux antibiotiques extraits de bouillons de culture de cylindrocarpon lucidum ou de trichoderma polysporum |
| JP13893874A JPS5615235B2 (cs) | 1973-12-06 | 1974-12-05 | |
| CA215,287A CA1030469A (en) | 1973-12-06 | 1974-12-05 | Antibiotics s7481/f-1 and f-2 from cylindrocarpon or tolypocladium |
| FR7439877A FR2253531B1 (cs) | 1973-12-06 | 1974-12-05 | |
| ZA00747791A ZA747791B (en) | 1973-12-06 | 1974-12-06 | Improvements in or relating to organic compounds |
| FI771201A FI54606C (fi) | 1973-12-06 | 1977-04-15 | Foerfarande foer framstaellning av de nya peptidantibiotika s 7481/f-1 och s 7481/f-2 |
| PH19702A PH13773A (en) | 1973-12-06 | 1977-04-22 | Antibiotics s7481/f-1 and s7481/f-2 and process of preparation thereof |
| HK538/80A HK53880A (en) | 1973-12-06 | 1980-09-25 | Metabolites s748/f-1 and /f-2 |
| MY203/81A MY8100203A (en) | 1973-12-06 | 1981-12-30 | Metabolites 57481/f-1 and/f-2 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1711173A CH589716A5 (en) | 1973-12-06 | 1973-12-06 | Antibiotics S 7481-F-1 and 2 - prepd. from new strains of Cylindrocarbon or Trichoderma esp. useful as immunosuppressant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH589716A5 true CH589716A5 (en) | 1977-07-15 |
Family
ID=4422861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1711173A CH589716A5 (en) | 1973-12-06 | 1973-12-06 | Antibiotics S 7481-F-1 and 2 - prepd. from new strains of Cylindrocarbon or Trichoderma esp. useful as immunosuppressant |
Country Status (5)
| Country | Link |
|---|---|
| AT (1) | AT347032B (cs) |
| BE (1) | BE823008A (cs) |
| CH (1) | CH589716A5 (cs) |
| PL (1) | PL92561B1 (cs) |
| ZA (1) | ZA747791B (cs) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670478A (en) * | 1992-09-07 | 1997-09-23 | Galena, A.S. | Pharmaceutical containing N-methylated cyclic undecapeptides |
| US6423233B1 (en) | 2000-08-15 | 2002-07-23 | Biogal Gyogyszergyar Rt. | Purification process |
-
1973
- 1973-12-06 CH CH1711173A patent/CH589716A5/de not_active IP Right Cessation
-
1974
- 1974-12-04 PL PL1974176171A patent/PL92561B1/pl unknown
- 1974-12-05 AT AT971874A patent/AT347032B/de not_active IP Right Cessation
- 1974-12-05 BE BE151206A patent/BE823008A/xx active Protection Beyond IP Right Term
- 1974-12-06 ZA ZA00747791A patent/ZA747791B/xx unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670478A (en) * | 1992-09-07 | 1997-09-23 | Galena, A.S. | Pharmaceutical containing N-methylated cyclic undecapeptides |
| US6706192B2 (en) | 1997-03-25 | 2004-03-16 | Biogal Gyogyszergyar Rt. | Purification process |
| US6423233B1 (en) | 2000-08-15 | 2002-07-23 | Biogal Gyogyszergyar Rt. | Purification process |
Also Published As
| Publication number | Publication date |
|---|---|
| PL92561B1 (cs) | 1977-04-30 |
| ZA747791B (en) | 1976-10-27 |
| AT347032B (de) | 1978-12-11 |
| ATA971874A (de) | 1978-04-15 |
| BE823008A (fr) | 1975-06-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| SPCF | Supplementary protection certificate filed |
Free format text: IKS 44915,IKS 44916, 950901 |
|
| SPCR | Supplementary protection certificate rejected | ||
| SPCF | Supplementary protection certificate filed |
Free format text: IKS 44915,44916/821228, 950901 |
|
| SPCR | Supplementary protection certificate rejected |
Free format text: IKS 44915,44916/821228, 950901 |
|
| PL | Patent ceased |