CH527194A - Verfahren zur Herstellung von Isochinolin-Derivaten - Google Patents

Verfahren zur Herstellung von Isochinolin-Derivaten

Info

Publication number
CH527194A
CH527194A CH10370A CH10370A CH527194A CH 527194 A CH527194 A CH 527194A CH 10370 A CH10370 A CH 10370A CH 10370 A CH10370 A CH 10370A CH 527194 A CH527194 A CH 527194A
Authority
CH
Switzerland
Prior art keywords
preparation
isoquinoline derivatives
isoquinoline
derivatives
Prior art date
Application number
CH10370A
Other languages
German (de)
English (en)
Inventor
Alfred Jr Dr Rheiner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to CH1011872A priority Critical patent/CH538477A/de
Priority to CH10370A priority patent/CH527194A/de
Priority to SE17063/70A priority patent/SE368401B/xx
Priority to SE7313623A priority patent/SE386672B/xx
Priority to DE2062001A priority patent/DE2062001C2/de
Priority to ZA708590A priority patent/ZA708590B/xx
Priority to IL35916A priority patent/IL35916A/xx
Priority to NLAANVRAGE7018956,A priority patent/NL171444C/xx
Priority to FI703519A priority patent/FI49503C/fi
Priority to IE6/71A priority patent/IE34859B1/xx
Priority to FR7100097A priority patent/FR2081412B1/fr
Priority to BE761219A priority patent/BE761219A/xx
Priority to NO7121A priority patent/NO135315C/no
Priority to DK2571AA priority patent/DK125021B/da
Priority to GB45471A priority patent/GB1335261A/en
Priority to AT4571A priority patent/AT303041B/de
Priority to ES387016A priority patent/ES387016A1/es
Priority to YU19/71A priority patent/YU33660B/xx
Priority to CA102,060A priority patent/CA999866A/en
Priority to JP7194A priority patent/JPS5515476B1/ja
Priority to PH12087*UA priority patent/PH9682A/en
Publication of CH527194A publication Critical patent/CH527194A/de
Priority to US05/365,921 priority patent/US3947456A/en
Priority to SE7313622A priority patent/SE399879B/xx
Priority to NO740554A priority patent/NO135062C/no
Priority to NO740555A priority patent/NO740555L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CH10370A 1970-01-06 1970-01-06 Verfahren zur Herstellung von Isochinolin-Derivaten CH527194A (de)

Priority Applications (25)

Application Number Priority Date Filing Date Title
CH1011872A CH538477A (de) 1970-01-06 1970-01-06 Verfahren zur Herstellung von Isochinolin-Derivaten
CH10370A CH527194A (de) 1970-01-06 1970-01-06 Verfahren zur Herstellung von Isochinolin-Derivaten
SE17063/70A SE368401B (instruction) 1970-01-06 1970-12-16
SE7313623A SE386672B (sv) 1970-01-06 1970-12-16 Mellanprodukter for framstellning av isokinolinderivat
DE2062001A DE2062001C2 (de) 1970-01-06 1970-12-16 1,2,3,4-Tetrahydro-4-phenylisochinolin-Derivate, deren Säureadditionssalze, Verfahren zu deren Herstellung und pharmazeutisches Präparat
ZA708590A ZA708590B (en) 1970-01-06 1970-12-21 Isoquinoline derivatives
IL35916A IL35916A (en) 1970-01-06 1970-12-28 1,2,3,4-tetrahydro-4-phenyl iso-quinoline derivatives and their preparation
NLAANVRAGE7018956,A NL171444C (nl) 1970-01-06 1970-12-29 Werkwijze voor de bereiding van 1,2,3,4-tetrahydro-4-fenylisochinolinederivaten, alsmede werkwijze voor de bereiding van farmaceutische preparaten met antidepressieve eigenschappen, die deze derivaten bevatten.
FI703519A FI49503C (fi) 1970-01-06 1970-12-31 Analogiamenetelmä 1,2,3,4-tetrahydro-4-fenyyli-isokinoliinijohdannaist en valmistamiseksi.
IE6/71A IE34859B1 (en) 1970-01-06 1971-01-04 Isoquinoline derivatives
BE761219A BE761219A (fr) 1970-01-06 1971-01-05 Derives d'isoquinoleine
FR7100097A FR2081412B1 (instruction) 1970-01-06 1971-01-05
NO7121A NO135315C (instruction) 1970-01-06 1971-01-05
DK2571AA DK125021B (da) 1970-01-06 1971-01-05 Analogifremgangsmåde til fremstilling af 1,2,3,4-tetrahydro-4-phenyl-isoquinolinderivater eller syreadditionssalte deraf eller de tilsvarende optisk aktive forbindelser.
GB45471A GB1335261A (en) 1970-01-06 1971-01-05 Isoquinoline derivatives
AT4571A AT303041B (de) 1970-01-06 1971-01-05 Verfahren zur Herstellung von neuen Isochinolin-Derivaten und ihren Salzen
ES387016A ES387016A1 (es) 1970-01-06 1971-01-05 Un procedimiento para la preparacion de derivado de isoqui-nolina.
YU19/71A YU33660B (en) 1970-01-06 1971-01-06 Process for preparing 1, 2, 3, 4-tetrahydro-4-phenylisoquinoline derivatives
CA102,060A CA999866A (en) 1970-01-06 1971-01-06 Isoquinoline derivatives
JP7194A JPS5515476B1 (instruction) 1970-01-06 1971-01-06
PH12087*UA PH9682A (en) 1970-01-06 1971-01-07 1,2,3,4-tetrahydro-4-phenyl-isoquinoline derivatives and pharmaceutical composition containing same
US05/365,921 US3947456A (en) 1970-01-06 1973-06-01 Substituted 4-phenyl isoquinolines
SE7313622A SE399879B (sv) 1970-01-06 1973-10-05 Kemiska mellanprodukter till anvendning for framstellning av terapeutiskt verdefulla 1,2,3,4-tetrahydro-4-fenyl-isokinolinderivat
NO740554A NO135062C (instruction) 1970-01-06 1974-02-19
NO740555A NO740555L (no) 1970-01-06 1974-02-19 Isokinolinderivater til anvendelse som mellomprodukter for fremstilling av 2-alkyl- eller 2-fenyl-lavere alkyl-1,2,3,4-tetrahydro-4-isokinolinderivater.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH10370A CH527194A (de) 1970-01-06 1970-01-06 Verfahren zur Herstellung von Isochinolin-Derivaten

Publications (1)

Publication Number Publication Date
CH527194A true CH527194A (de) 1972-08-31

Family

ID=4179328

Family Applications (2)

Application Number Title Priority Date Filing Date
CH10370A CH527194A (de) 1970-01-06 1970-01-06 Verfahren zur Herstellung von Isochinolin-Derivaten
CH1011872A CH538477A (de) 1970-01-06 1970-01-06 Verfahren zur Herstellung von Isochinolin-Derivaten

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH1011872A CH538477A (de) 1970-01-06 1970-01-06 Verfahren zur Herstellung von Isochinolin-Derivaten

Country Status (19)

Country Link
JP (1) JPS5515476B1 (instruction)
AT (1) AT303041B (instruction)
BE (1) BE761219A (instruction)
CA (1) CA999866A (instruction)
CH (2) CH527194A (instruction)
DE (1) DE2062001C2 (instruction)
DK (1) DK125021B (instruction)
ES (1) ES387016A1 (instruction)
FI (1) FI49503C (instruction)
FR (1) FR2081412B1 (instruction)
GB (1) GB1335261A (instruction)
IE (1) IE34859B1 (instruction)
IL (1) IL35916A (instruction)
NL (1) NL171444C (instruction)
NO (1) NO135315C (instruction)
PH (1) PH9682A (instruction)
SE (3) SE386672B (instruction)
YU (1) YU33660B (instruction)
ZA (1) ZA708590B (instruction)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595688A (en) * 1983-06-23 1986-06-17 Mcneilab, Inc. Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof
ZA844402B (en) * 1983-06-23 1986-01-29 Mcneil Pharmaceutical Hexahydropyrrolo(2,1-a)isoquinoline derivatives
US4719216A (en) * 1983-06-23 1988-01-12 Mcneilab, Inc. Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
RU2309953C2 (ru) 1999-11-03 2007-11-10 Эймр Текнолоджи, Инк. Арил- и гетероарилзамещенные тетрагидроизохинолины, фармацевтическая композиция и способ лечения на их основе
US7163949B1 (en) * 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
AU784280B2 (en) * 1999-11-03 2006-03-02 Albany Molecular Research, Inc. 4-phenyl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
EP1113007A1 (en) * 1999-12-24 2001-07-04 Pfizer Inc. Tetrahydroisoquinoline compounds as estrogen agonists/antagonists
CA2415532C (en) * 2000-07-11 2010-05-11 Albany Molecular Research, Inc. Novel 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
WO2006020049A2 (en) 2004-07-15 2006-02-23 Amr Technology, Inc. Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
CN101243083A (zh) 2005-06-17 2008-08-13 詹森药业有限公司 萘啶化合物
CN101495184A (zh) 2005-07-15 2009-07-29 Amr科技公司 芳基和杂芳基取代的四氢苯并氮杂及其在阻断去甲肾上腺素多巴胺和血清素的重摄取中的应用
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
KR20120034644A (ko) 2009-05-12 2012-04-12 알바니 몰레큘라 리써치, 인크. 아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도
US8815894B2 (en) 2009-05-12 2014-08-26 Bristol-Myers Squibb Company Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
DK2429296T3 (en) 2009-05-12 2018-03-12 Albany Molecular Res Inc 7 - ([1,2,4,] TRIAZOLO [1,5, -A] PYRIDIN-6-YL) -4- (3,4-DICHLORPHENYL) -1,2,3,4- TETRAHYDROISOQUINOLINE AND USE thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670694B2 (de) * 1966-05-05 1976-07-22 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von tetrahydroisochinolinen

Also Published As

Publication number Publication date
DK125021B (da) 1972-12-18
IE34859B1 (en) 1975-09-03
ES387016A1 (es) 1976-05-01
NL171444C (nl) 1983-04-05
YU33660B (en) 1977-12-31
NL7018956A (instruction) 1971-07-08
ZA708590B (en) 1971-09-29
PH9682A (en) 1976-02-10
JPS5515476B1 (instruction) 1980-04-23
CH538477A (de) 1973-06-30
FR2081412B1 (instruction) 1974-04-12
FI49503C (fi) 1975-07-10
IL35916A0 (en) 1971-02-25
IL35916A (en) 1973-11-28
IE34859L (en) 1971-07-06
NO135315C (instruction) 1977-03-23
GB1335261A (en) 1973-10-24
BE761219A (fr) 1971-07-05
NL171444B (nl) 1982-11-01
DE2062001C2 (de) 1986-10-16
YU1971A (en) 1977-06-30
CA999866A (en) 1976-11-16
DE2062001A1 (de) 1971-07-15
SE368401B (instruction) 1974-07-01
AT303041B (de) 1972-11-10
NO135315B (instruction) 1976-12-13
FI49503B (instruction) 1975-04-01
FR2081412A1 (instruction) 1971-12-03
SE386672B (sv) 1976-08-16
SE399879B (sv) 1978-03-06

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Legal Events

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PL Patent ceased