CH539642A - Verfahren zur Herstellung von Pyrimidinylpyrazolderivaten - Google Patents
Verfahren zur Herstellung von PyrimidinylpyrazolderivatenInfo
- Publication number
- CH539642A CH539642A CH1163470A CH1163470A CH539642A CH 539642 A CH539642 A CH 539642A CH 1163470 A CH1163470 A CH 1163470A CH 1163470 A CH1163470 A CH 1163470A CH 539642 A CH539642 A CH 539642A
- Authority
- CH
- Switzerland
- Prior art keywords
- pyrimidinylpyrazole
- derivatives
- preparation
- pyrimidinylpyrazole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/30—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3060669 | 1969-04-18 | ||
JP3060369 | 1969-04-18 | ||
JP3060169A JPS471928B1 (de) | 1969-04-18 | 1969-04-18 | |
JP3222069 | 1969-04-24 | ||
JP4187369 | 1969-05-28 | ||
JP4221369A JPS4834749B1 (de) | 1969-05-29 | 1969-05-29 | |
JP5286869A JPS4828437B1 (de) | 1969-07-03 | 1969-07-03 | |
JP6121869 | 1969-08-02 | ||
JP6454269A JPS505195B1 (de) | 1969-08-15 | 1969-08-15 | |
JP5454269 | 1969-08-15 | ||
JP6510669 | 1969-08-18 | ||
DE19702017060 DE2017060C3 (de) | 1969-04-18 | 1970-04-09 | Verfahren zur Herstellung von 1,3-Dihydro-2H-1,4-benzodiazepinon-(2)derivaten |
DE19702065290 DE2065290C3 (de) | 1970-04-09 | 1 -(beta-Alkenyk>xy*Uiyl)-5-phenyl-7-chlor-1,3-dlhydro-2H-1,4-benzodiazepin-2-on-Oerivate und ihre Salze, Verfahren zu Ihrer Herstellung und Arzneimittel | |
GB1797470 | 1970-04-15 | ||
BE749136 | 1970-04-17 | ||
NL7005566A NL7005566A (de) | 1969-04-18 | 1970-04-17 | |
FR707014027A FR2042345B1 (de) | 1969-04-18 | 1970-04-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH539642A true CH539642A (de) | 1973-09-14 |
Family
ID=27585847
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH582270A CH549029A (de) | 1969-04-18 | 1970-04-17 | Verfahren zur herstellung von dihydrobenzodiazepinonen. |
CH1163470A CH539642A (de) | 1969-04-18 | 1970-07-31 | Verfahren zur Herstellung von Pyrimidinylpyrazolderivaten |
CH1234870A CH536310A (de) | 1969-04-18 | 1970-08-18 | Verfahren zur Herstellung von Dibenzazepin-Derivaten |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH582270A CH549029A (de) | 1969-04-18 | 1970-04-17 | Verfahren zur herstellung von dihydrobenzodiazepinonen. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH1234870A CH536310A (de) | 1969-04-18 | 1970-08-18 | Verfahren zur Herstellung von Dibenzazepin-Derivaten |
Country Status (9)
Country | Link |
---|---|
US (2) | US3778433A (de) |
AT (1) | AT303043B (de) |
BE (1) | BE749136A (de) |
CH (3) | CH549029A (de) |
DE (2) | DE2065675A1 (de) |
FR (2) | FR2042345B1 (de) |
GB (2) | GB1309947A (de) |
NL (2) | NL7005566A (de) |
SE (2) | SE385701B (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU162330B (de) * | 1970-03-11 | 1973-01-29 | ||
GB1307144A (en) * | 1970-04-23 | 1973-02-14 | Sumitomo Chemical Co | Benzodiazepine derivatives processes for producing them and compo sitions containing them |
ES412186A1 (es) * | 1973-02-28 | 1976-01-01 | Made Labor Sa | Un procedimiento para la preparacion de derivados de tieno-diazepinona. |
US4208327A (en) * | 1979-04-03 | 1980-06-17 | G. D. Searle & Co. | 5-Aryl-1-(2-oxazolin-2-yl)-1H-1,4-benzodiazepines and related compounds |
US4405743A (en) * | 1979-08-31 | 1983-09-20 | Hokko Chemical Industry Co., Ltd. | Pyrazolylpyrimidine derivatives |
US4820834A (en) * | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
CA1332410C (en) * | 1984-06-26 | 1994-10-11 | Roger M. Freidinger | Benzodiazepine analogs |
US5141735A (en) * | 1990-06-18 | 1992-08-25 | Hoffman-La Roche, Inc. | Substituted amino-benzodiazepines having anitviral activity |
TW312694B (de) * | 1994-09-26 | 1997-08-11 | Daiichi Seiyaku Co | |
US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
KR101255356B1 (ko) | 2002-06-12 | 2013-04-17 | 케모센트릭스, 인크. | 염증 및 면역 질병의 치료를 위한 ccr1 길항물질로서사용하기 위한 1-아릴-4-치환된 피페라진 유도체 |
US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
AU2003288352A1 (en) * | 2002-10-30 | 2004-06-07 | Centre National De La Recherche Scientifique (Cnrs) | Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses |
FR2846653B1 (fr) * | 2002-10-30 | 2007-04-20 | Neuro3D | Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations |
FR2850379B1 (fr) * | 2003-01-28 | 2006-11-17 | Aventis Pharma Sa | Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation |
US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
JP4845873B2 (ja) * | 2004-03-03 | 2011-12-28 | ケモセントリックス インコーポレーティッド | 二環式および架橋した窒素複素環 |
CA2675511A1 (en) | 2006-10-10 | 2008-04-17 | Amgen Inc. | N-aryl pyrazole compounds for use against diabetes |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1510315A (fr) * | 1966-02-03 | 1968-01-19 | Ciba Geigy | Procédé pour la préparation de 4-diaza-cyclo-alcano-pyrazoles substitués en position 1 par des restes hétérocycliques bicycliques |
CH535777A (de) * | 1967-03-01 | 1973-04-15 | Ciba Geigy Ag | Verfahren zur Herstellung neuer azacycloaliphatischer Verbindungen |
-
1970
- 1970-04-07 US US00026409A patent/US3778433A/en not_active Expired - Lifetime
- 1970-04-09 DE DE2065675*A patent/DE2065675A1/de active Pending
- 1970-04-15 GB GB1797470A patent/GB1309947A/en not_active Expired
- 1970-04-17 CH CH582270A patent/CH549029A/de not_active IP Right Cessation
- 1970-04-17 AT AT352270A patent/AT303043B/de not_active IP Right Cessation
- 1970-04-17 BE BE749136D patent/BE749136A/xx unknown
- 1970-04-17 FR FR707014027A patent/FR2042345B1/fr not_active Expired
- 1970-04-17 NL NL7005566A patent/NL7005566A/xx unknown
- 1970-04-17 SE SE7005303A patent/SE385701B/xx unknown
- 1970-07-31 GB GB37193/70A patent/GB1287659A/en not_active Expired
- 1970-07-31 SE SE10572/70A patent/SE367200B/xx unknown
- 1970-07-31 NL NL7011354A patent/NL7011354A/xx unknown
- 1970-07-31 FR FR7028456*A patent/FR2060076B1/fr not_active Expired
- 1970-07-31 US US00060112A patent/US3723433A/en not_active Expired - Lifetime
- 1970-07-31 CH CH1163470A patent/CH539642A/de not_active IP Right Cessation
- 1970-08-03 DE DE19702038503 patent/DE2038503A1/de active Pending
- 1970-08-18 CH CH1234870A patent/CH536310A/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FR2060076A1 (de) | 1971-06-11 |
CH536310A (de) | 1973-04-30 |
FR2060076B1 (de) | 1974-08-30 |
DE2065290A1 (de) | 1973-04-26 |
FR2042345B1 (de) | 1974-06-14 |
GB1309947A (en) | 1973-03-14 |
DE2038503A1 (de) | 1971-02-25 |
DE2017060A1 (de) | 1970-10-29 |
CH549029A (de) | 1974-05-15 |
DE2065290B2 (de) | 1976-09-09 |
SE385701B (sv) | 1976-07-19 |
AT303043B (de) | 1972-11-10 |
US3723433A (en) | 1973-03-27 |
DE2017060B2 (de) | 1975-08-21 |
FR2042345A1 (de) | 1971-02-12 |
NL7005566A (de) | 1970-10-20 |
SE367200B (de) | 1974-05-20 |
DE2065675A1 (de) | 1974-11-21 |
US3778433A (en) | 1973-12-11 |
NL7011354A (de) | 1971-02-04 |
GB1287659A (en) | 1972-09-06 |
BE749136A (fr) | 1970-10-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AT298508B (de) | Verfahren zur Herstellung von Mercaptoalkylalkoxysilanen | |
CH539642A (de) | Verfahren zur Herstellung von Pyrimidinylpyrazolderivaten | |
AT302277B (de) | Verfahren zur Herstellung von Chinondiiminen | |
CH526566A (de) | Verfahren zur Herstellung von 5-Pyridyl-2-imidazolonen | |
CH508604A (de) | Verfahren zur Herstellung von Ureidophenylguanidinen | |
CH521934A (de) | Verfahren zur Herstellung von Buten-2-ol-4-Derivaten | |
AT304774B (de) | Verfahren zur Herstellung von 16β-Methyl-9α-fluor-steroiden | |
CH525881A (de) | Verfahren zur Herstellung von 4-Alkylprolinen | |
CH505041A (de) | Verfahren zur Herstellung von Cycloalkenonen | |
CH531480A (de) | Verfahren zur Herstellung von Aminoadamantanen | |
AT296961B (de) | Verfahren zur Herstellung von Alkyldihydroxybenzolen | |
AT319485B (de) | Verfahren zur Herstellung von 19-Norsteroiden | |
CH511225A (de) | Verfahren zur Herstellung von Amidophenylthioharnstoffen | |
CH529108A (de) | Verfahren zur Herstellung von y-Cyanbutyraldiminen | |
AT308086B (de) | Verfahren zur Herstellung von 1-Alkoxyanthrachinonen | |
CH530408A (de) | Verfahren zur Herstellung von Chinolylpiperazinen | |
CH532069A (de) | Verfahren zur Herstellung von 3-Hydroxyisoxazolderivaten | |
AT299905B (de) | Verfahren zur Herstellung von β-Acetoxypivalinaldehyd | |
AT296297B (de) | Verfahren zur Herstellung von N-Tritylimidazolen und -triazolen | |
CH532070A (de) | Verfahren zur Herstellung von 3-Methyl-isoxazol | |
CH530358A (de) | Verfahren zur Herstellung von 2-Methyl-4-halogen-but-2-en-1-alen | |
AT294833B (de) | Verfahren zur Herstellung von N-Tritylimidazolen und -triazolen | |
AT299907B (de) | Verfahren zur Herstellung von Trimethyl-2-cyclohexen-1-onen | |
AT296298B (de) | Verfahren zur Herstellung von N-Tritylimidazolen und -triazolen | |
AT294834B (de) | Verfahren zur Herstellung von 4-Alkoxy-piperidinen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PL | Patent ceased |