CA3198619A1 - Image analysis and measurement of biological samples - Google Patents

Image analysis and measurement of biological samples

Info

Publication number
CA3198619A1
CA3198619A1 CA3198619A CA3198619A CA3198619A1 CA 3198619 A1 CA3198619 A1 CA 3198619A1 CA 3198619 A CA3198619 A CA 3198619A CA 3198619 A CA3198619 A CA 3198619A CA 3198619 A1 CA3198619 A1 CA 3198619A1
Authority
CA
Canada
Prior art keywords
sample
cells
light
cell
cuvette
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3198619A
Other languages
English (en)
French (fr)
Inventor
Chinmay PANGARKAR
Karan MOHAN
James R. Wasson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labrador Diagnostics LLC
Original Assignee
Theranos IP Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theranos IP Co LLC filed Critical Theranos IP Co LLC
Publication of CA3198619A1 publication Critical patent/CA3198619A1/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1012—Calibrating particle analysers; References therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/088—Condensers for both incident illumination and transillumination
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/12—Condensers affording bright-field illumination
    • G02B21/125—Condensers affording bright-field illumination affording both dark- and bright-field illumination
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G02B21/244—Devices for focusing using image analysis techniques
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B7/00—Mountings, adjusting means, or light-tight connections, for optical elements
    • G02B7/02—Mountings, adjusting means, or light-tight connections, for optical elements for lenses
    • G02B7/04—Mountings, adjusting means, or light-tight connections, for optical elements for lenses with mechanism for focusing or varying magnification
    • G02B7/09—Mountings, adjusting means, or light-tight connections, for optical elements for lenses with mechanism for focusing or varying magnification adapted for automatic focusing or varying magnification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1012—Calibrating particle analysers; References therefor
    • G01N2015/1014—Constitution of reference particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N2021/1738—Optionally different kinds of measurements; Method being valid for different kinds of measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70589—CD45
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Optics & Photonics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Multimedia (AREA)
  • Dispersion Chemistry (AREA)
  • Ecology (AREA)
  • Clinical Laboratory Science (AREA)
  • Mathematical Physics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA3198619A 2012-07-25 2013-07-25 Image analysis and measurement of biological samples Pending CA3198619A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261675811P 2012-07-25 2012-07-25
US61/675,811 2012-07-25
US201261676178P 2012-07-26 2012-07-26
US61/676,178 2012-07-26
US201361766116P 2013-02-18 2013-02-18
US61/766,116 2013-02-18
US201361802194P 2013-03-15 2013-03-15
US61/802,194 2013-03-15
CA2878957A CA2878957A1 (en) 2012-07-25 2013-07-25 Image analysis and measurement of biological samples

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2878957A Division CA2878957A1 (en) 2012-07-25 2013-07-25 Image analysis and measurement of biological samples

Publications (1)

Publication Number Publication Date
CA3198619A1 true CA3198619A1 (en) 2014-01-30

Family

ID=48951590

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3198619A Pending CA3198619A1 (en) 2012-07-25 2013-07-25 Image analysis and measurement of biological samples
CA2878957A Pending CA2878957A1 (en) 2012-07-25 2013-07-25 Image analysis and measurement of biological samples

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2878957A Pending CA2878957A1 (en) 2012-07-25 2013-07-25 Image analysis and measurement of biological samples

Country Status (14)

Country Link
US (8) US9395302B2 (enExample)
EP (2) EP2877834B1 (enExample)
JP (5) JP6273276B2 (enExample)
KR (1) KR102090776B1 (enExample)
CN (2) CN112557301A (enExample)
AU (2) AU2013295679A1 (enExample)
BR (1) BR112015001592B1 (enExample)
CA (2) CA3198619A1 (enExample)
ES (1) ES2700498T3 (enExample)
IL (1) IL236819A0 (enExample)
MX (2) MX345757B (enExample)
SG (1) SG11201500347SA (enExample)
TW (2) TW201831881A (enExample)
WO (1) WO2014018805A2 (enExample)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
GB201210403D0 (en) * 2012-06-13 2012-07-25 Ffei Ltd Mircoscope colour chart
EP2877834B1 (en) 2012-07-25 2018-09-05 Theranos, Inc. System for analysing a sample
US9513224B2 (en) 2013-02-18 2016-12-06 Theranos, Inc. Image analysis and measurement of biological samples
MX362545B (es) * 2013-02-18 2019-01-24 Theranos Ip Co Llc Analisis de imagen y medicion de muestras biologicas.
US9562860B1 (en) 2013-06-19 2017-02-07 Theranos, Inc. Methods and devices for sample analysis
DE102013216124A1 (de) * 2013-08-14 2015-02-19 Carl Zeiss Microscopy Gmbh Hochauflösende 3D-Fluoreszenzmikroskopie
MX384530B (es) 2013-09-06 2025-03-14 Labrador Diagnostics Llc Dispositivos, sistemas, metodos y equipos para recibir un hisopo.
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
US9784670B1 (en) 2014-01-22 2017-10-10 Theranos, Inc. Unified detection system for fluorometry, luminometry and spectrometry
CN105980854A (zh) 2014-02-06 2016-09-28 思甘诺基公司 用于检测靶标分析物的检测单元和方法
US20150286043A1 (en) * 2014-04-04 2015-10-08 Bio-Rad Laboratories, Inc. Annular illumination structure
US10661268B2 (en) * 2014-06-30 2020-05-26 Beacon Technologies, LLC Pipette tip system, device and method of use
US9574989B2 (en) * 2014-08-08 2017-02-21 Omnivision Technologies, Inc. Lens-free imaging system and method for detecting particles in sample deposited on image sensor
GB201506992D0 (en) * 2014-11-14 2015-06-10 Nplex Pty Ltd A portable in-vitro diagnostic detector
EP3232778A4 (en) 2014-11-24 2018-10-10 Massachusetts Institute of Technology Systems, apparatus, and methods for analyzing blood cell dynamics
TWI566742B (zh) * 2015-02-26 2017-01-21 華邦電子股份有限公司 分析處理裝置
WO2016191004A1 (en) * 2015-05-26 2016-12-01 Becton, Dickinson And Company Methods and systems for high resolution fluorescence microscopy of polymeric dye-labeled samples using polarized light
US10458902B2 (en) * 2015-09-13 2019-10-29 Australian Sensing and Indentification Systems Pty. Ltd. Analysis instrument, associated systems and methods
EP3368220B1 (en) 2015-10-26 2020-07-22 IDEXX Laboratories, Inc. Hematology test slide
CN105284240B (zh) * 2015-10-30 2017-10-03 山东省农作物种质资源中心 种子籽粒颜色分辨台及分辨方法
US10288557B2 (en) * 2015-12-18 2019-05-14 Abbott Laboratories Spectral differentiation of histological stains
WO2017117553A1 (en) * 2015-12-31 2017-07-06 Mec Dynamics Micro mechanical methods and systems for performing assays
TWI568464B (zh) * 2016-02-05 2017-02-01 Guo-Zhi Liao Drug release and detection device, method of operation of drug release and detection device, and method for detecting fluorescent substance
US11054365B2 (en) * 2016-02-23 2021-07-06 Shimadzu Corporation Microscopic analysis device
EP3423881B1 (en) * 2016-03-01 2022-07-13 Molecular Devices, LLC Imaging system and method with scattering to reduce source auto-fluorescence and improve uniformity
JP6913323B2 (ja) * 2016-03-11 2021-08-04 株式会社ニコン 評価装置、観察装置、及びプログラム
WO2017159011A1 (ja) * 2016-03-15 2017-09-21 ソニー株式会社 情報処理装置、情報処理方法、プログラム及び情報処理システム
US10768406B2 (en) * 2016-06-20 2020-09-08 Scanogen Inc. Imaging system
US11204322B2 (en) * 2016-06-20 2021-12-21 Plair S.a. Device and method for detecting and/or characterizing fluid-borne particles
US20190323939A1 (en) * 2016-06-22 2019-10-24 Kyocera Corporation Fine particle counter
WO2018009384A1 (en) * 2016-07-06 2018-01-11 Advanced Instruments, Llc Cuvette and rotor system for blood plasma separation
US10768105B1 (en) * 2016-07-29 2020-09-08 Labrador Diagnostics Llc Image analysis and measurement of biological samples
TWI595372B (zh) 2016-08-31 2017-08-11 義守大學 用以檢測蛋白特徵物之顯微影像檢測系統以及顯微影像檢測方法
JP6514832B2 (ja) * 2016-09-29 2019-05-15 オリンパス株式会社 観察装置
WO2018062215A1 (ja) * 2016-09-30 2018-04-05 オリンパス株式会社 観察装置
CN108226043B (zh) * 2016-12-22 2024-07-02 赛默飞世尔（上海）仪器有限公司 用于水质监测的测量单元及测量系统
CN106706643B (zh) * 2017-02-23 2019-07-02 马青山 一种肝癌对比切片检测方法
JP6938986B2 (ja) * 2017-03-15 2021-09-22 住友金属鉱山株式会社 粒子形状の評価方法
CN110914672A (zh) 2017-04-20 2020-03-24 生物梅里埃公司 光学测试平台
WO2018220670A1 (ja) 2017-05-29 2018-12-06 オリンパス株式会社 観察装置
EP4292520A3 (en) 2017-10-16 2024-07-10 Massachusetts Institute of Technology Systems, devices and methods for non-invasive hematological measurements
CN109697450B (zh) * 2017-10-20 2023-04-07 曦医生技股份有限公司 细胞分类方法
CN111970970A (zh) * 2017-10-26 2020-11-20 Essenlix公司 血小板的快速测量
CN107976439B (zh) * 2017-12-06 2019-02-05 张哲� 一种检测血液和尿液样品的光学检测装置
JP6687656B2 (ja) * 2018-03-19 2020-04-28 ファナック株式会社 検査装置およびその検査方法
EP3756166A4 (en) * 2018-04-27 2021-10-27 Hewlett-Packard Development Company, L.P. IMAGING THREE-DIMENSIONAL VOLUMES
US11371986B2 (en) 2018-05-25 2022-06-28 Scanogen Inc. Detection units and methods for detecting a target analyte
NL2021377B1 (en) 2018-07-03 2020-01-08 Illumina Inc Interposer with first and second adhesive layers
US20200033260A1 (en) * 2018-07-25 2020-01-30 Pauleologos Cusulos Coagulation and aggregation refracted light indexing device and method
CA3107949A1 (en) * 2018-08-01 2020-02-06 Cdx Medical Ip, Inc. Enhanced extended depth of focusing on biological samples
SE542345C2 (en) * 2018-08-03 2020-04-14 Redsense Medical Ab Device for measuring a property of a measurement object by luminescence
EP3611695A1 (en) * 2018-08-15 2020-02-19 Koninklijke Philips N.V. Generating annotation data of tissue images
CN109084734B (zh) * 2018-08-17 2020-06-16 中国科学院自动化研究所 基于单目显微视觉的微球姿态测量装置及测量方法
WO2020037176A1 (en) 2018-08-17 2020-02-20 Enrich Therapeutics Inc. A system and method to select and isolate particles and cells and uses thereof
CN109100352B (zh) * 2018-08-30 2024-07-23 天津港东科技股份有限公司 显微镜多功能液体测试装置
JP2022001889A (ja) * 2018-09-27 2022-01-06 富士フイルム株式会社 フォーカス位置評価装置、方法及びプログラム、並びに判別器
CN109583470A (zh) * 2018-10-17 2019-04-05 阿里巴巴集团控股有限公司 一种异常检测的解释特征确定方法和装置
EP4667998A3 (en) * 2018-11-02 2026-01-21 Hologic, Inc. Digital imaging system and method
KR20210106024A (ko) 2019-01-22 2021-08-27 어플라이드 머티어리얼스, 인코포레이티드 확대된 이미지들의 캡처 및 저장
US10724956B1 (en) 2019-02-01 2020-07-28 Essen Instruments, Inc. Spectral unmixing
KR102114135B1 (ko) 2019-02-28 2020-05-22 서강대학교산학협력단 현미경 장치 및 현미경 장치의 동작방법
CN110057730A (zh) * 2019-03-12 2019-07-26 天津大学 一种人体颗粒物主动吸入浓度测试方法
EP3938763A4 (en) 2019-03-14 2022-12-07 Applied Materials, Inc. IDENTIFICATION OF LANDMARK MARKERS IN MICROSCOPE IMAGES
US11255785B2 (en) 2019-03-14 2022-02-22 Applied Materials, Inc. Identifying fiducial markers in fluorescence microscope images
EP3948226A4 (en) 2019-04-05 2023-09-06 Essenlix Corporation TEST ACCURACY AND RELIABILITY IMPROVEMENT
WO2021007443A1 (en) * 2019-07-09 2021-01-14 The Regents Of The University Of California Automated rapid on-site evaluation machine and stain
US20220360699A1 (en) * 2019-07-11 2022-11-10 Sensibility Pty Ltd Machine learning based phone imaging system and analysis method
CN114401669B (zh) 2019-07-24 2023-01-17 麻省理工学院 用于甲襞成像装置的手指插入件
US11803962B2 (en) 2019-07-31 2023-10-31 Dig Labs Corporation Animal health assessment
US11763920B2 (en) 2019-07-31 2023-09-19 Dig Labs Corporation Mucus analysis for animal health assessments
CN110490882B (zh) * 2019-08-19 2022-12-27 腾讯科技（深圳）有限公司 细胞膜染色图像分析方法、装置及系统
MX2022003307A (es) * 2019-09-22 2022-04-12 Ecole Polytechnique Fed Lausanne Epfl Dispositivo y metodo para la valoracion del riesgo de nacimiento prematuro.
KR20220066944A (ko) 2019-09-24 2022-05-24 어플라이드 머티어리얼스, 인코포레이티드 조직 분할을 위한 머신 러닝 모델의 상호작용 트레이닝
CN112630197B (zh) * 2019-10-10 2021-10-19 东北农业大学 一种判定蛋白质能否发生液-液相分离的方法
CN114585958B (zh) * 2019-10-19 2024-05-28 美国赛库莱特生物有限公司 显微镜和用于使流体通道中的荧光标记成像的方法
GB2588627B (en) * 2019-10-29 2023-03-29 Oxford Nanoimaging Ltd An optical imaging system
EP3836020B1 (en) * 2019-12-12 2024-08-28 National Cheng Kung University A method for determining cellular nuclear-to-cytoplasmic ratio
US20210182531A1 (en) 2019-12-17 2021-06-17 Applied Materials, Inc. Registration techniques for multiplexed fluorescence in-situ hybridization images
US10823662B1 (en) * 2020-02-18 2020-11-03 Horiba Instruments, Incorporated Special purpose cuvette assembly and method for optical microscopy of nanoparticle colloids
EP4118419A4 (en) * 2020-03-13 2024-03-13 Advanced Animal Diagnostics, Inc. FAST MOBILE SCREENING AND TRIAGE FOR INFECTIONS AND SERIOUS INFECTIONS
US20220163782A1 (en) * 2020-03-27 2022-05-26 Convergence Technology Co.Ltd. Dark field illuminator for microscopic imaging
US20210301245A1 (en) * 2020-03-29 2021-09-30 Agilent Technologies, Inc. Systems and methods for electronically and optically monitoring biological samples
WO2021203291A1 (zh) * 2020-04-08 2021-10-14 深圳华大生命科学研究院 无透镜显微成像系统、方法及生化物质检测系统、方法
GB202006259D0 (en) * 2020-04-28 2020-06-10 Leeds Teaching Hospitals Nhs Trust Stain Assessment
US11925456B2 (en) 2020-04-29 2024-03-12 Hyperspectral Corp. Systems and methods for screening asymptomatic virus emitters
WO2021242983A1 (en) 2020-05-28 2021-12-02 Leuko Labs, Inc. A method to detect white blood cells and/or white blood cell subtypes form non-invasive capillary videos
US12144619B2 (en) 2020-07-06 2024-11-19 Look Tec Co., Ltd Blood measurement device
WO2022016887A1 (en) * 2020-07-24 2022-01-27 Bioland Laboratory Methods and apparatus for detecting molecules
KR102331711B1 (ko) * 2020-08-21 2021-12-01 동아대학교 산학협력단 현장진료를 위한 미세유체칩 다중 채널 형광측정 장치
US12111257B2 (en) * 2020-08-26 2024-10-08 Honeywell International Inc. Fluid composition sensor device and method of using the same
JP7568212B2 (ja) * 2020-08-27 2024-10-16 リプロバイオ株式会社 精子運動性能評価システム及び精子運動性能評価方法
EP4528353A3 (de) * 2020-09-01 2025-09-17 BMG Labtech GmbH Autofokussystem für eine optische mess- oder mikroskopievorrichtung, verfahren zur fokuseinstellung bei einer optischen mess- oder mikroskopievorrichtung sowie optische mess- oder mikroskopievorrichtung
WO2022076920A1 (en) * 2020-10-08 2022-04-14 Essenlix Corporation Assay error reduction
US12209964B2 (en) 2020-10-15 2025-01-28 Visera Technologies Company Limited Bio-chip, bio-detection system and bio-detection method
TWI767415B (zh) * 2020-11-18 2022-06-11 中國醫藥大學 自動化血液分析系統及自動化血液分析方法
CN112419295B (zh) * 2020-12-03 2024-08-23 腾讯科技（深圳）有限公司 医学图像处理方法、装置、计算机设备和存储介质
KR102501486B1 (ko) * 2020-12-10 2023-02-17 한국화학연구원 나노 입자 또는 나노 구조체에서 발생된 분광 신호 분석 시스템 및 분석 방법
CN112903569A (zh) 2021-01-20 2021-06-04 贝克曼库尔特生物科技（苏州）有限公司 用于计算液滴延迟时间的系统和方法以及分选装置
CN214844688U (zh) 2021-01-22 2021-11-23 贝克曼库尔特生物科技（苏州）有限公司 用于样本处理仪的透明管组件和流式池及样本处理仪
CN214895849U (zh) 2021-01-28 2021-11-26 贝克曼库尔特生物科技（苏州）有限公司 气泡检测装置和样本处理仪
WO2022168434A1 (ja) * 2021-02-05 2022-08-11 株式会社堀場製作所 粒子分析装置、粒子分析方法、及び、粒子分析装置用プログラム
WO2022246155A1 (en) * 2021-05-20 2022-11-24 Gleghorn Jason P Method for enumeration and physical characterization of nanoparticles
EP4336238A4 (en) * 2021-07-19 2025-05-14 Hamamatsu Photonics K.K. Focal position estimation system, focal position estimation method, focal position estimation program, semiconductor inspection system and biological observation system
EP4377669A1 (en) * 2021-07-29 2024-06-05 Technische Universität München Detection of molecular biological objects, cellular biological objects and cell aggregates using quantitative phase-contrast microscopy
WO2023018085A1 (ko) * 2021-08-10 2023-02-16 주식회사 루닛 병리 슬라이드 이미지와 관련된 정보를 출력하는 방법 및 장치
CN113790671B (zh) * 2021-09-03 2022-05-17 苏州天准科技股份有限公司 一种口径可调的落射光源及影像测量仪
TWI914451B (zh) 2021-12-06 2026-02-11 邑流微測股份有限公司 光學影像系統
CN118715549A (zh) * 2021-12-23 2024-09-27 雷迪奥米特医学公司 具有基于光设置的细胞分类的生物流体分析仪
EP4453628A1 (en) * 2021-12-23 2024-10-30 Radiometer Medical ApS Biological fluid analyser with adaptive light source assembly
TWI813145B (zh) * 2022-01-25 2023-08-21 佛教慈濟醫療財團法人 多重螢光組織影像分析方法及其系統
US20250216394A1 (en) * 2022-01-28 2025-07-03 University Of Southern California Liquid biopsy analytes to define cancer stages
CN116698707A (zh) * 2022-02-24 2023-09-05 杭州迅数科技有限公司 一种双光路双波长的光染色菌落成像装置
WO2023166655A1 (ja) * 2022-03-03 2023-09-07 オリンパス株式会社 照明ユニットおよび撮影システム
BR102023003038A2 (pt) 2022-03-17 2024-01-02 Sysmex Corporation Método para classificar glóbulos brancos em subpopulações
JP7863436B2 (ja) * 2022-03-17 2026-05-21 シスメックス株式会社 白血球を亜集団に分類する方法
CN114895449B (zh) * 2022-03-17 2023-06-23 华东师范大学 一种基于压缩感知的四维高速荧光显微成像装置
TWI798041B (zh) * 2022-03-31 2023-04-01 中原大學 用於執行全內反射散射量測的裝置與方法
US20250251402A1 (en) * 2022-04-08 2025-08-07 The General Hospital Corporation Methods of detecting molecular aggregates using image correlation spectroscopy (ics)
KR102537348B1 (ko) * 2022-08-04 2023-05-30 한국기계연구원 디지털 pcr 분석용 기판 및 이의 제작방법
JP2024071282A (ja) * 2022-11-14 2024-05-24 沢井製薬株式会社 錠剤の評価方法および評価装置
TWI866690B (zh) * 2023-02-07 2024-12-11 邦睿生技股份有限公司 生物樣品檢測裝置
TWI876356B (zh) * 2023-05-30 2025-03-11 天亮醫療器材股份有限公司 檢測管、檢測系統及待測體參數的光學檢測方法
TWI860738B (zh) * 2023-06-05 2024-11-01 崑山科技大學 染色輔助螢光影像偵測現地環境氯苯之方法
CN119394870A (zh) * 2023-07-21 2025-02-07 上海浚真生命科学有限公司 光学成像传感器和生物反应系统
US20250199286A1 (en) * 2023-12-15 2025-06-19 Idexx Laboratories, Inc. Process and systems for autofocusing and measuring tilt of sample plane
WO2025137530A1 (en) * 2023-12-22 2025-06-26 Idexx Laboratories, Inc. Systems and methods for uniform oblique illumination for optical imaging
WO2025145095A1 (en) * 2023-12-29 2025-07-03 Beckman Coulter, Inc. Customized sample handling in biological analysis
WO2026115476A1 (en) * 2024-11-29 2026-06-04 Istituto Nazionale Di Astrofisica Method, device and system for detecting a viral agent by means of fluorescence spectroscopy
KR102832369B1 (ko) * 2025-05-19 2025-07-14 (주)디로펫 정량적 위상 이미징 장치와 이를 이용한 비브리오패혈증 모니터링 방법

Family Cites Families (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4066362A (en) * 1968-08-16 1978-01-03 E. I. Du Pont De Nemours And Company Apparatus and method for performing photometric analysis
GB1382081A (en) 1972-03-14 1975-01-29 Ici Ltd Transmission spectra
US3849654A (en) 1973-10-19 1974-11-19 H Malvin Fluorescence cuvette
US4305816A (en) * 1980-02-11 1981-12-15 Borden, Inc. Apparatus and method for inspecting containers
US5109429A (en) * 1985-11-04 1992-04-28 Cell Analysis Systems,Inc. Apparatus and method for analyses of biological specimens
US4868126A (en) 1985-12-11 1989-09-19 Flow Cytometry Standards Corporation Method of calibrating a fluorescent microscope using fluorescent calibration microbeads simulating stained cells
US4896966A (en) 1986-08-15 1990-01-30 Hamilton-Thorn Research Motility scanner and method
US5289255A (en) * 1991-03-28 1994-02-22 Minnesota Mining And Manufacturing Co. Cuvette for use in making a measurement of a blood parameter and assembly utilizing the same
JPH05240774A (ja) * 1992-03-02 1993-09-17 Hitachi Ltd 光学セル及び光学検出装置とこれを用いる試料分離検出装置
US5292484A (en) * 1992-07-16 1994-03-08 Spectrum Systems, Inc. Cuvette and cuvette cartridge for a chemical analyzer
US5585246A (en) * 1993-02-17 1996-12-17 Biometric Imaging, Inc. Method for preparing a sample in a scan capillary for immunofluorescent interrogation
ES2150985T3 (es) 1993-02-26 2000-12-16 E Y Lab Inc Procedimiento y sistema de analisis optico de muestras.
US5374531A (en) * 1993-03-22 1994-12-20 Zynaxis, Inc. Immunoassay for determination of cells
US5534416A (en) * 1993-04-13 1996-07-09 Molecular Probes, Inc. Fluorescent viability assay using cyclic-substituted unsymmetrical cyanine dyes
US5407638A (en) 1993-04-28 1995-04-18 Shell Oil Company Detector-cell adapted for continuous-flow absorption detection
DE69404652T2 (de) 1993-05-28 1998-01-15 Fisons Plc Analysegerät
US5510621A (en) * 1994-10-03 1996-04-23 Optical Solutions, Inc. Apparatus and method for measuring components in a bag
US5869689A (en) * 1995-10-17 1999-02-09 Molecular Probes, Inc Stains for acidic organelles
AU2139597A (en) * 1996-05-13 1997-12-05 Dhc Analysis, Inc. Sampling device for spectrometric measurements
JP3322579B2 (ja) 1996-10-17 2002-09-09 株式会社エンプラス サイドライト型面光源装置
US7117098B1 (en) 1997-02-27 2006-10-03 Cellomics, Inc. Machine-readable storage medium for analyzing distribution of macromolecules between the cell membrane and the cell cytoplasm
JP4294740B2 (ja) * 1997-05-23 2009-07-15 ソレクサ・インコーポレイテッド 分析物の系列的プロセシングのためのシステムおよび装置
GB2326229A (en) * 1997-06-13 1998-12-16 Robert Jeffrey Geddes Carr Detecting and analysing submicron particles
DE19735119C2 (de) 1997-08-13 2000-05-18 Deutsches Krebsforsch Verfahren zur Fluoreszenzkorrelationsspektroskopie, insbesbesondere zur Mehrfarben-Fluoreszenzkorrelationsspektroskopie und Vorrichtung zur Durchführung des Verfahrens
US20030205681A1 (en) 1998-07-22 2003-11-06 Ljl Biosystems, Inc. Evanescent field illumination devices and methods
DE19801139B4 (de) 1998-01-14 2016-05-12 Till Photonics Gmbh Punktabtastendes Luminiszenz-Mikroskop
US6529835B1 (en) * 1998-06-25 2003-03-04 Caliper Technologies Corp. High throughput methods, systems and apparatus for performing cell based screening assays
SE9802558D0 (sv) 1998-07-16 1998-07-16 Hanning Instr Ab Device for detection of fluorescent
EP1123499A2 (en) * 1998-09-22 2001-08-16 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US7450229B2 (en) 1999-01-25 2008-11-11 Amnis Corporation Methods for analyzing inter-cellular phenomena
US20020019062A1 (en) 1999-06-18 2002-02-14 Peter Lea Assay devices
JP3820806B2 (ja) 1999-07-21 2006-09-13 三菱電機株式会社 レーザ検査装置
WO2001008552A1 (en) 1999-08-03 2001-02-08 Biophysica, Llc Spectroscopic systems and methods for detecting tissue properties
IL131282A (en) 1999-08-05 2009-02-11 Orbotech Ltd Apparatus and methods for inspection of objects
DE10017823B4 (de) * 2000-04-10 2004-08-26 Till I.D. Gmbh Mikroskopische Beleuchtungsvorrichtung
US20020192763A1 (en) * 2000-04-17 2002-12-19 Jiangchun Xu Compositions and methods for the therapy and diagnosis of prostate cancer
DE10029946A1 (de) 2000-06-17 2001-12-20 Merck Patent Gmbh Integrierte optische Wellenleiter für mikrofluidische Analysensysteme
US6599475B1 (en) * 2000-09-27 2003-07-29 Becton, Dickinson And Company Apparatus for producing thin liquid samples for microscopic analysis
DE10124055A1 (de) 2001-05-16 2002-11-21 Fisher Rosemount Mfg Gmbh & Co Gerät zur optischen Untersuchung von Gasen
AU2002363076A1 (en) * 2001-10-26 2003-05-06 Virtual Arrays, Inc. Assay systems with adjustable fluid communication
JP2003139687A (ja) * 2001-11-06 2003-05-14 Fuji Photo Film Co Ltd 測定チップ集合体および測定チップ取出し装置
JP3801914B2 (ja) * 2001-12-25 2006-07-26 富士写真フイルム株式会社 測定チップの再使用方法
US7756305B2 (en) * 2002-01-23 2010-07-13 The Regents Of The University Of California Fast 3D cytometry for information in tissue engineering
US20050153435A1 (en) 2002-02-14 2005-07-14 Solus Biosystems, Inc. Multiple sample screening using a silicon substrate
WO2003083458A2 (de) * 2002-04-03 2003-10-09 Johann Wolfgang Goethe-Universität Frankfurt am Main Infrarotmessvorrichtung, insbesondere für die spektrometrie wässriger systeme, vorzugsweise von mehrkomponentensystemen
US6723288B2 (en) * 2002-04-29 2004-04-20 Dade Behring Inc. Method of providing assay processing in a multi-analyzer system
US7354389B2 (en) * 2002-05-28 2008-04-08 Autogenomics, Inc. Microarray detector and methods
GB0216934D0 (en) * 2002-07-20 2002-08-28 Council Cent Lab Res Councils Optical apparatus
US7122384B2 (en) 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
JP2006507504A (ja) * 2002-11-22 2006-03-02 ソルス バイオシステムズ インコーポレーテッド 並列振動分光法による高スループットのスクリーニング
US20110259744A1 (en) * 2003-04-30 2011-10-27 Moyle William R Sensors for biomolecular detection and cell classification
CA2526368A1 (en) * 2003-05-20 2004-12-02 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
JP2007516413A (ja) 2003-06-25 2007-06-21 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 高感度でエバネッセント場を検出する表面構造を有するサポート
EP1494007B8 (de) 2003-06-30 2014-09-24 Tecan Trading AG Vorrichtung und Verfahren zum Analysieren von Proben
AU2003904237A0 (en) * 2003-08-08 2003-08-21 Garvan Institute Of Medical Research Novel translocation assay
JP3879001B2 (ja) 2003-11-06 2007-02-07 独立行政法人情報通信研究機構 生物試料を高精度に測定する方法
WO2005089637A2 (en) * 2004-03-11 2005-09-29 The General Hospital Corporation Method and system for tomographic imaging using fluorescent proteins
US8103080B2 (en) * 2004-03-16 2012-01-24 Amnis Corporation Method for imaging and differential analysis of cells
JP2005316383A (ja) * 2004-03-29 2005-11-10 Nikon Corp 蛍光顕微鏡
DE602005023141D1 (de) 2004-04-16 2010-10-07 Univ Auburn Mikroskopbeleuchtungsvorrichtung und adapter dafür
WO2005121864A2 (en) 2004-06-07 2005-12-22 Fluidigm Corporation Optical lens system and method for microfluidic devices
US8313713B2 (en) * 2004-06-17 2012-11-20 Ortho-Clinical Diagnostics, Inc. Stabilizing a cuvette during measurement
JP4363649B2 (ja) 2004-09-30 2009-11-11 富士フイルム株式会社 全反射減衰を利用した測定装置及び方法
JP2006162427A (ja) * 2004-12-07 2006-06-22 Toshiba Corp Ｌｅｄチップの検査方法及びｌｅｄチップの検査装置
US20060184040A1 (en) 2004-12-09 2006-08-17 Keller Kurtis P Apparatus, system and method for optically analyzing a substrate
US20060166305A1 (en) 2005-01-27 2006-07-27 Genetix Limited Animal cell confluence detection method and apparatus
MX2007009124A (es) * 2005-01-31 2007-10-08 Univ Illinois Metodos y dispositivos para caracterizar particulas en medios transparentes y turbios.
US7344273B2 (en) * 2005-03-22 2008-03-18 Binary Works, Inc. Ring light with user manipulable control
MX2007013985A (es) 2005-05-09 2008-02-22 Theranos Inc Sistemas de fluidos de punto de cuidado y usos de los mismos.
US7817273B2 (en) 2005-06-30 2010-10-19 Life Technologies Corporation Two-dimensional spectral imaging system
JP2007127449A (ja) 2005-11-01 2007-05-24 Olympus Corp 測定容器
DE102005062439B3 (de) 2005-12-23 2007-05-10 JOMESA Meßsysteme GmbH Verfahren für die Partikelanalyse und Partikelanalysesystem
US8101368B2 (en) * 2006-02-13 2012-01-24 Dvs Sciences Inc. Quantitation of cellular DNA and cell numbers using element labeling
JP2007271360A (ja) * 2006-03-30 2007-10-18 Fujifilm Corp 測定装置及びセンサユニットの保持方法
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
JP2007333497A (ja) * 2006-06-14 2007-12-27 Hitachi High-Technologies Corp 蛍光検出デバイスおよび装置
US8501099B2 (en) 2006-07-11 2013-08-06 The Curators Of The University Of Missouri Photo-acoustic detection device and method
CN101622522A (zh) * 2007-01-26 2010-01-06 贝克顿·迪金森公司 用于细胞计数和分析的方法、系统和组合物
US7936463B2 (en) 2007-02-05 2011-05-03 Palo Alto Research Center Incorporated Containing analyte in optical cavity structures
JP5286774B2 (ja) 2007-04-11 2013-09-11 株式会社ニコン 顕微鏡装置と、これに用いられる蛍光キューブ
GB2460981B (en) * 2007-04-13 2011-11-09 Technologies Inc C Interactive variable pathlength device
EP2012110A1 (en) 2007-07-06 2009-01-07 Bp Oil International Limited Optical cell
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
US7952705B2 (en) * 2007-08-24 2011-05-31 Dynamic Throughput Inc. Integrated microfluidic optical device for sub-micro liter liquid sample microspectroscopy
JP5057377B2 (ja) * 2007-08-30 2012-10-24 国立大学法人埼玉大学 生体成分又はその機能の測定方法及び装置
CN104297506B (zh) 2007-10-02 2017-05-03 赛拉诺斯股份有限公司 模块化现场护理装置及其应用
CN101952710A (zh) * 2007-11-05 2011-01-19 皇家飞利浦电子股份有限公司 微电子光学倏逝场传感器
CN201156031Y (zh) 2008-02-02 2008-11-26 施慧勇 生化分析仪比色杯
ES2588223T3 (es) 2008-03-21 2016-10-31 Abbott Point Of Care, Inc. Procedimiento para el análisis de células individuales o partículas en la sangre usando fluorescencia y absorción de un colorante
ES2560098T3 (es) * 2008-03-21 2016-02-17 Abbott Point Of Care, Inc. Método y aparato para detectar y contar plaquetas individualmente y en agregados
WO2009142312A1 (ja) * 2008-05-20 2009-11-26 株式会社ニコン 顕微鏡装置
JP2010060854A (ja) * 2008-09-04 2010-03-18 Nikon Corp 顕微鏡装置
JP2010091679A (ja) * 2008-10-06 2010-04-22 Nikon Corp 顕微鏡装置とこれに用いられる蛍光キューブ
JP2010091809A (ja) * 2008-10-08 2010-04-22 Nikon Corp 顕微鏡装置
WO2010057490A1 (de) 2008-11-19 2010-05-27 Dr. Fröse Software Solutions Zellaufbau für lichtstreudetektoren mit selbstfokussierenden eigenschaften
US8329117B2 (en) 2009-05-14 2012-12-11 Canon U.S. Life Sciences, Inc. Microfluidic chip features for optical and thermal isolation
US8891086B2 (en) * 2009-06-15 2014-11-18 Thermo Scientific Portable Analytical Instruments Inc. Optical scanning systems and methods for measuring a sealed container with a layer for reducing diffusive scattering
JP2011118264A (ja) * 2009-12-07 2011-06-16 Nikon Corp 顕微鏡装置
WO2011072401A1 (en) 2009-12-18 2011-06-23 University Health Network System and method for sub-surface fluorescence imaging
EP2339327A1 (en) * 2009-12-23 2011-06-29 F. Hoffmann-La Roche AG Automatic test for imaging units
JP5344629B2 (ja) * 2010-04-30 2013-11-20 レーザーテック株式会社 検査装置及び検査方法
WO2011161499A1 (en) 2010-06-22 2011-12-29 Koninklijke Philips Electronics N.V. Detection of magnetic particles and their clustering
JP5703609B2 (ja) 2010-07-02 2015-04-22 ソニー株式会社 顕微鏡及び領域判定方法
TW201224425A (en) * 2010-12-03 2012-06-16 Microtek Int Inc Carrying device and method of containing specimen within the carrying device
KR20120080056A (ko) * 2011-01-06 2012-07-16 삼성전자주식회사 디스크 및 이를 이용한 검사장치의 보정방법
CN103477197B (zh) 2011-01-21 2016-08-17 提拉诺斯公司 样品使用最大化的系统和方法
WO2012119243A2 (en) 2011-03-07 2012-09-13 James Stewart Aitchison Method and system for cell detection and analysis
KR101167649B1 (ko) * 2011-04-20 2012-07-20 한국과학기술원 세포 환경 내에서의 단일 분자 수준의 단백질-단백질 상호작용 분석 장치
US8934698B2 (en) 2011-06-22 2015-01-13 The Johns Hopkins University System and device for characterizing cells
US8380541B1 (en) 2011-09-25 2013-02-19 Theranos, Inc. Systems and methods for collecting and transmitting assay results
CN202514348U (zh) 2011-12-23 2012-11-07 鹤山健豪灯饰企业有限公司 具观赏生命成长过程的组合式小夜灯
US20140193892A1 (en) 2012-07-25 2014-07-10 Theranos, Inc. Image analysis and measurement of biological samples
EP2877834B1 (en) 2012-07-25 2018-09-05 Theranos, Inc. System for analysing a sample
US9513224B2 (en) 2013-02-18 2016-12-06 Theranos, Inc. Image analysis and measurement of biological samples
MX362545B (es) 2013-02-18 2019-01-24 Theranos Ip Co Llc Analisis de imagen y medicion de muestras biologicas.
US20150071541A1 (en) 2013-08-14 2015-03-12 Rice University Automated method for measuring, classifying, and matching the dynamics and information passing of single objects within one or more images
EP3036753B1 (en) 2013-08-22 2022-10-05 California Institute of Technology Variable-illumination fourier ptychographic imaging devices, systems, and methods
TWI496112B (zh) 2013-09-13 2015-08-11 Univ Nat Cheng Kung 細胞影像分割方法以及核質比評估方法
WO2017110653A1 (ja) 2015-12-22 2017-06-29 オリンパス株式会社 顕微鏡システム
US9930243B2 (en) 2016-05-02 2018-03-27 Mitutoyo Corporation Variable focal length imaging system
US10768406B2 (en) 2016-06-20 2020-09-08 Scanogen Inc. Imaging system
US10768105B1 (en) * 2016-07-29 2020-09-08 Labrador Diagnostics Llc Image analysis and measurement of biological samples

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