CA3078563A1 - Method and device for fast dissolution of solid protein composition - Google Patents

Method and device for fast dissolution of solid protein composition

Info

Publication number
CA3078563A1
CA3078563A1 CA3078563A CA3078563A CA3078563A1 CA 3078563 A1 CA3078563 A1 CA 3078563A1 CA 3078563 A CA3078563 A CA 3078563A CA 3078563 A CA3078563 A CA 3078563A CA 3078563 A1 CA3078563 A1 CA 3078563A1
Authority
CA
Canada
Prior art keywords
closed container
syringe barrel
seal element
fibrinogen
closed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3078563A
Other languages
English (en)
French (fr)
Inventor
Erez Ilan
Kfir Regev
Dana LEITMAN
Israel Nur
Moti Meron
John Goodman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omrix Biopharmaceuticals Ltd
Original Assignee
Omrix Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL217273A external-priority patent/IL217273A0/en
Application filed by Omrix Biopharmaceuticals Ltd filed Critical Omrix Biopharmaceuticals Ltd
Publication of CA3078563A1 publication Critical patent/CA3078563A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/25—Mixers with loose mixing elements, e.g. loose balls in a receptacle
    • B01F33/251—Mixers with loose mixing elements, e.g. loose balls in a receptacle using balls as loose mixing element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7163—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected in a mouth-to-mouth, end-to-end disposition, i.e. the openings are juxtaposed before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/718—Feed mechanisms characterised by the means for feeding the components to the mixer using vacuum, under pressure in a closed receptacle or circuit system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA3078563A 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition Abandoned CA3078563A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
IL217273 2011-12-29
IL217273A IL217273A0 (en) 2011-12-29 2011-12-29 Fast dissolution of solid fibrinogen
US201261582524P 2012-01-03 2012-01-03
US61/582,524 2012-01-03
US201261677048P 2012-07-30 2012-07-30
US61/677,048 2012-07-30
IL221180 2012-07-30
IL22118012 2012-07-30
CA2861722A CA2861722C (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2861722A Division CA2861722C (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Publications (1)

Publication Number Publication Date
CA3078563A1 true CA3078563A1 (en) 2013-07-04

Family

ID=48696437

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3078563A Abandoned CA3078563A1 (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition
CA2861722A Expired - Fee Related CA2861722C (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2861722A Expired - Fee Related CA2861722C (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Country Status (13)

Country Link
US (2) US10618950B2 (enExample)
EP (1) EP2797681B1 (enExample)
JP (1) JP6223999B2 (enExample)
KR (1) KR102109317B1 (enExample)
AU (1) AU2012360048B2 (enExample)
BR (1) BR112014016193A8 (enExample)
CA (2) CA3078563A1 (enExample)
ES (1) ES2621363T3 (enExample)
IL (1) IL233361B (enExample)
IN (1) IN2014DN05901A (enExample)
MX (1) MX351980B (enExample)
RU (1) RU2605710C2 (enExample)
WO (1) WO2013098805A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10618950B2 (en) 2011-12-29 2020-04-14 Omrix Biopharmaceuticals Ltd. Method and device for fast dissolution of solid protein composition
JP6397933B2 (ja) 2014-01-20 2018-09-26 ユーシービー バイオファルマ エスピーアールエル 固体形態の医薬組成物の再構成のための方法
WO2016036807A1 (en) * 2014-09-03 2016-03-10 Entegrion, Inc. Acceleration of reconstitution of plasma powder by mixing with small beads
US11229702B1 (en) 2015-10-28 2022-01-25 Coherus Biosciences, Inc. High concentration formulations of adalimumab
USD877891S1 (en) 2015-12-22 2020-03-10 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution and delivery device
USD877890S1 (en) 2015-12-22 2020-03-10 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution device
USD829888S1 (en) * 2015-12-22 2018-10-02 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution and delivery device
US10918790B2 (en) * 2015-12-22 2021-02-16 Guangzhou Bioseal Biotech Co., Ltd. Dual syringe with funnel feeding kit
IL244922A0 (en) * 2016-04-05 2016-07-31 Omrix Biopharmaceuticals Ltd Device and method for sample preparation
US11071782B2 (en) * 2016-04-20 2021-07-27 Coherus Biosciences, Inc. Method of filling a container with no headspace
US10150115B2 (en) * 2016-07-21 2018-12-11 Spacepharma SA System and method for rehydrating powder and delivering the rehydrated powder to a reactor
WO2018150375A1 (en) * 2017-02-17 2018-08-23 Baxter International Inc. Devices and methods for forming and delivering a tissue sealant
CA3010633A1 (en) * 2017-07-06 2019-01-06 Plas-Tech Engineering, Inc. Systems and methods related to fluid pumping
WO2023119277A1 (en) 2021-12-21 2023-06-29 Omrix Biopharmaceuticals Ltd. Highly soluble fibrinogen compositions
CN120733180B (zh) * 2025-06-04 2026-06-16 南京巴特弗莱医药包装材料有限责任公司 注射器组件及灌装方法

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DE3203775A1 (de) 1982-02-04 1983-08-11 Behringwerke Ag, 3550 Marburg Fibrinogenzubereitung, verfahen zu ihrer herstellungund ihre verwendung
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Also Published As

Publication number Publication date
AU2012360048A1 (en) 2014-08-14
MX351980B (es) 2017-11-03
KR102109317B1 (ko) 2020-05-29
US20130312868A1 (en) 2013-11-28
IL233361B (en) 2018-06-28
JP2015509084A (ja) 2015-03-26
BR112014016193A2 (pt) 2017-06-13
WO2013098805A1 (en) 2013-07-04
JP6223999B2 (ja) 2017-11-01
IL233361A0 (en) 2014-08-31
HK1203438A1 (en) 2015-10-30
IN2014DN05901A (enExample) 2015-06-05
CA2861722C (en) 2020-06-30
BR112014016193A8 (pt) 2017-07-04
EP2797681A1 (en) 2014-11-05
AU2012360048B2 (en) 2017-05-25
CA2861722A1 (en) 2013-07-04
RU2014131276A (ru) 2016-02-20
US20200262892A1 (en) 2020-08-20
EP2797681B1 (en) 2017-02-01
ES2621363T3 (es) 2017-07-03
CN104144742A (zh) 2014-11-12
RU2605710C2 (ru) 2016-12-27
MX2014008033A (es) 2014-12-08
KR20140108709A (ko) 2014-09-12
US11634473B2 (en) 2023-04-25
US10618950B2 (en) 2020-04-14

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20200416

FZDE Discontinued

Effective date: 20221012