BR112014016193A8 - método e dispositivo para dissilução rápida - Google Patents

método e dispositivo para dissilução rápida

Info

Publication number
BR112014016193A8
BR112014016193A8 BR112014016193A BR112014016193A BR112014016193A8 BR 112014016193 A8 BR112014016193 A8 BR 112014016193A8 BR 112014016193 A BR112014016193 A BR 112014016193A BR 112014016193 A BR112014016193 A BR 112014016193A BR 112014016193 A8 BR112014016193 A8 BR 112014016193A8
Authority
BR
Brazil
Prior art keywords
pressure
devices
methods
aqueous solvent
atmospheric pressure
Prior art date
Application number
BR112014016193A
Other languages
English (en)
Other versions
BR112014016193A2 (pt
Inventor
Leitman Dana
Ilan Erez
Nur Israel
Goodman John
Regev Kfir
Meron Moti
Original Assignee
Omrix Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL217273A external-priority patent/IL217273A0/en
Application filed by Omrix Biopharmaceuticals Ltd filed Critical Omrix Biopharmaceuticals Ltd
Publication of BR112014016193A2 publication Critical patent/BR112014016193A2/pt
Publication of BR112014016193A8 publication Critical patent/BR112014016193A8/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/25—Mixers with loose mixing elements, e.g. loose balls in a receptacle
    • B01F33/251—Mixers with loose mixing elements, e.g. loose balls in a receptacle using balls as loose mixing element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7163—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected in a mouth-to-mouth, end-to-end disposition, i.e. the openings are juxtaposed before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/718—Feed mechanisms characterised by the means for feeding the components to the mixer using vacuum, under pressure in a closed receptacle or circuit system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

abstract provided are methods and devices for dissolving solid protein compositions, such as solid compositions comprising fibrinogen, in an aqueous solvent. the methods comprise use of a closed container containing a volume of solid fibrinogen composition and a head space wherein the pressure within the headspace is sub-atmospheric. aqueous solvent is introduced into the container while maintain the sub-atmospheric pressure, and subsequent to addition of the solvent, the size of the headspace is decreased to bring the pressure to atmospheric pressure. the devices are suitable for use in the disclosed method. _____________________________________________________ tradução resumo resumo patente de invenção: "método e dispositivo para dissilução rápida". a presente invenção refere-se a métodos e dispositivos para dissolver composições sólidas de proteína, como composições compreendendo o fibrinogênio, em um solvente aquoso. os métodos da presente invenção compreendem usar um recipiente fechado contendo um volume de uma composição sólida de fibrinogênio e um espaço livre no qual a pressão interna é sub-atmosférica. um solvente aquoso é introduzido no recipiente enquanto pressão sub-atmosférica é mantida, e subsequentemente à adição do solvente, o tamanho do espaço livre é reduzido para trazer a pressão ao nível da pressão atmosférica. os dispositivos são adequados ao uso no método apresentado.
BR112014016193A 2011-12-29 2012-12-20 método e dispositivo para dissilução rápida BR112014016193A8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IL217273A IL217273A0 (en) 2011-12-29 2011-12-29 Fast dissolution of solid fibrinogen
US201261582524P 2012-01-03 2012-01-03
US201261677048P 2012-07-30 2012-07-30
IL22118012 2012-07-30
PCT/IL2012/000393 WO2013098805A1 (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Publications (2)

Publication Number Publication Date
BR112014016193A2 BR112014016193A2 (pt) 2017-06-13
BR112014016193A8 true BR112014016193A8 (pt) 2017-07-04

Family

ID=48696437

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014016193A BR112014016193A8 (pt) 2011-12-29 2012-12-20 método e dispositivo para dissilução rápida

Country Status (14)

Country Link
US (2) US10618950B2 (pt)
EP (1) EP2797681B1 (pt)
JP (1) JP6223999B2 (pt)
KR (1) KR102109317B1 (pt)
AU (1) AU2012360048B2 (pt)
BR (1) BR112014016193A8 (pt)
CA (2) CA2861722C (pt)
ES (1) ES2621363T3 (pt)
HK (1) HK1203438A1 (pt)
IL (1) IL233361B (pt)
IN (1) IN2014DN05901A (pt)
MX (1) MX351980B (pt)
RU (1) RU2605710C2 (pt)
WO (1) WO2013098805A1 (pt)

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AU2015207464B2 (en) 2014-01-20 2019-10-03 Eveon Process for reconstitution of a solid form of a pharmaceutical composition
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US11071782B2 (en) * 2016-04-20 2021-07-27 Coherus Biosciences, Inc. Method of filling a container with no headspace
US10150115B2 (en) * 2016-07-21 2018-12-11 Spacepharma SA System and method for rehydrating powder and delivering the rehydrated powder to a reactor
WO2018150375A1 (en) * 2017-02-17 2018-08-23 Baxter International Inc. Devices and methods for forming and delivering a tissue sealant
US11717797B2 (en) 2017-07-06 2023-08-08 Plas-Tech Engineering, Inc. Systems and methods related to fluid pumping
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Also Published As

Publication number Publication date
AU2012360048B2 (en) 2017-05-25
MX351980B (es) 2017-11-03
US10618950B2 (en) 2020-04-14
RU2605710C2 (ru) 2016-12-27
EP2797681A1 (en) 2014-11-05
WO2013098805A1 (en) 2013-07-04
EP2797681B1 (en) 2017-02-01
RU2014131276A (ru) 2016-02-20
CA2861722A1 (en) 2013-07-04
JP6223999B2 (ja) 2017-11-01
US20200262892A1 (en) 2020-08-20
KR20140108709A (ko) 2014-09-12
US11634473B2 (en) 2023-04-25
CA2861722C (en) 2020-06-30
KR102109317B1 (ko) 2020-05-29
IL233361B (en) 2018-06-28
HK1203438A1 (en) 2015-10-30
IN2014DN05901A (pt) 2015-06-05
US20130312868A1 (en) 2013-11-28
IL233361A0 (en) 2014-08-31
CA3078563A1 (en) 2013-07-04
JP2015509084A (ja) 2015-03-26
MX2014008033A (es) 2014-12-08
ES2621363T3 (es) 2017-07-03
CN104144742A (zh) 2014-11-12
AU2012360048A1 (en) 2014-08-14
BR112014016193A2 (pt) 2017-06-13

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