BR112014016193A2 - método e dispositivo para dissilução rápida - Google Patents

método e dispositivo para dissilução rápida

Info

Publication number
BR112014016193A2
BR112014016193A2 BR112014016193A BR112014016193A BR112014016193A2 BR 112014016193 A2 BR112014016193 A2 BR 112014016193A2 BR 112014016193 A BR112014016193 A BR 112014016193A BR 112014016193 A BR112014016193 A BR 112014016193A BR 112014016193 A2 BR112014016193 A2 BR 112014016193A2
Authority
BR
Brazil
Prior art keywords
pressure
devices
methods
aqueous solvent
atmospheric pressure
Prior art date
Application number
BR112014016193A
Other languages
English (en)
Other versions
BR112014016193A8 (pt
Inventor
Leitman Dana
Ilan Erez
Nur Israel
Goodman John
Regev Kfir
Meron Moti
Original Assignee
Omrix Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL217273A external-priority patent/IL217273A0/en
Application filed by Omrix Biopharmaceuticals Ltd filed Critical Omrix Biopharmaceuticals Ltd
Publication of BR112014016193A2 publication Critical patent/BR112014016193A2/pt
Publication of BR112014016193A8 publication Critical patent/BR112014016193A8/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/25—Mixers with loose mixing elements, e.g. loose balls in a receptacle
    • B01F33/251—Mixers with loose mixing elements, e.g. loose balls in a receptacle using balls as loose mixing element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7163—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected in a mouth-to-mouth, end-to-end disposition, i.e. the openings are juxtaposed before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/718—Feed mechanisms characterised by the means for feeding the components to the mixer using vacuum, under pressure in a closed receptacle or circuit system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

abstract provided are methods and devices for dissolving solid protein compositions, such as solid compositions comprising fibrinogen, in an aqueous solvent. the methods comprise use of a closed container containing a volume of solid fibrinogen composition and a head space wherein the pressure within the headspace is sub-atmospheric. aqueous solvent is introduced into the container while maintain the sub-atmospheric pressure, and subsequent to addition of the solvent, the size of the headspace is decreased to bring the pressure to atmospheric pressure. the devices are suitable for use in the disclosed method. _____________________________________________________ tradução resumo resumo patente de invenção: "método e dispositivo para dissilução rápida". a presente invenção refere-se a métodos e dispositivos para dissolver composições sólidas de proteína, como composições compreendendo o fibrinogênio, em um solvente aquoso. os métodos da presente invenção compreendem usar um recipiente fechado contendo um volume de uma composição sólida de fibrinogênio e um espaço livre no qual a pressão interna é sub-atmosférica. um solvente aquoso é introduzido no recipiente enquanto pressão sub-atmosférica é mantida, e subsequentemente à adição do solvente, o tamanho do espaço livre é reduzido para trazer a pressão ao nível da pressão atmosférica. os dispositivos são adequados ao uso no método apresentado.
BR112014016193A 2011-12-29 2012-12-20 método e dispositivo para dissilução rápida BR112014016193A8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IL217273A IL217273A0 (en) 2011-12-29 2011-12-29 Fast dissolution of solid fibrinogen
US201261582524P 2012-01-03 2012-01-03
US201261677048P 2012-07-30 2012-07-30
IL22118012 2012-07-30
PCT/IL2012/000393 WO2013098805A1 (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Publications (2)

Publication Number Publication Date
BR112014016193A2 true BR112014016193A2 (pt) 2017-06-13
BR112014016193A8 BR112014016193A8 (pt) 2017-07-04

Family

ID=48696437

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014016193A BR112014016193A8 (pt) 2011-12-29 2012-12-20 método e dispositivo para dissilução rápida

Country Status (14)

Country Link
US (2) US10618950B2 (pt)
EP (1) EP2797681B1 (pt)
JP (1) JP6223999B2 (pt)
KR (1) KR102109317B1 (pt)
AU (1) AU2012360048B2 (pt)
BR (1) BR112014016193A8 (pt)
CA (2) CA2861722C (pt)
ES (1) ES2621363T3 (pt)
HK (1) HK1203438A1 (pt)
IL (1) IL233361B (pt)
IN (1) IN2014DN05901A (pt)
MX (1) MX351980B (pt)
RU (1) RU2605710C2 (pt)
WO (1) WO2013098805A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2861722C (en) 2011-12-29 2020-06-30 Omrix Biopharmaceuticals Ltd. Method and device for fast dissolution of solid protein composition
BR112016016690A2 (pt) 2014-01-20 2018-03-20 1 Eveon 2 Ucb Biopharma Sprl processo para a reconstituição de uma forma sólida de uma composição farmacêutica
WO2016036807A1 (en) * 2014-09-03 2016-03-10 Entegrion, Inc. Acceleration of reconstitution of plasma powder by mixing with small beads
US11229702B1 (en) 2015-10-28 2022-01-25 Coherus Biosciences, Inc. High concentration formulations of adalimumab
USD877890S1 (en) 2015-12-22 2020-03-10 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution device
USD877891S1 (en) 2015-12-22 2020-03-10 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution and delivery device
US10918790B2 (en) * 2015-12-22 2021-02-16 Guangzhou Bioseal Biotech Co., Ltd. Dual syringe with funnel feeding kit
USD829888S1 (en) * 2015-12-22 2018-10-02 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution and delivery device
IL244922A0 (en) * 2016-04-05 2016-07-31 Omrix Biopharmaceuticals Ltd Device and method for sample preparation
US11071782B2 (en) * 2016-04-20 2021-07-27 Coherus Biosciences, Inc. Method of filling a container with no headspace
US10150115B2 (en) * 2016-07-21 2018-12-11 Spacepharma SA System and method for rehydrating powder and delivering the rehydrated powder to a reactor
WO2018150375A1 (en) * 2017-02-17 2018-08-23 Baxter International Inc. Devices and methods for forming and delivering a tissue sealant
EP3514382A1 (en) * 2017-07-06 2019-07-24 Plas-Tech Engineering, Inc. Systems and methods related to fluid pumping
WO2023119277A1 (en) 2021-12-21 2023-06-29 Omrix Biopharmaceuticals Ltd. Highly soluble fibrinogen compositions

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3052240A (en) 1959-01-29 1962-09-04 Silver Disposable hypodermic syringe
US3405712A (en) * 1966-02-07 1968-10-15 Richard L. Pierick Desiccative syringe
AT366916B (de) * 1980-04-02 1982-05-25 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
AT371719B (de) 1980-08-25 1983-07-25 Immuno Ag Verfahren und vorrichtung zur beschleunigung des aufloesens von schwerloeslichen lyophilisierten arzneimitteln
DE3203775A1 (de) 1982-02-04 1983-08-11 Behringwerke Ag, 3550 Marburg Fibrinogenzubereitung, verfahen zu ihrer herstellungund ihre verwendung
US4610666A (en) * 1985-06-24 1986-09-09 Pizzino Joanne L Dual syringe
US4742128A (en) * 1985-10-15 1988-05-03 Stamicarbon B.V. Process for preparing a polymer alloy, molded product, and reaction injection molded products
US4978336A (en) * 1987-09-29 1990-12-18 Hemaedics, Inc. Biological syringe system
AT397203B (de) 1988-05-31 1994-02-25 Immuno Ag Gewebeklebstoff
AT392972B (de) 1988-08-16 1991-07-25 Chemiefaser Lenzing Ag Verfahren zur herstellung von loesungen von cellulose sowie einrichtung zur durchfuehrung des verfahrens
SU1697836A1 (ru) 1989-01-24 1991-12-15 Московский научно-исследовательский онкологический институт им.П.А.Герцена Устройство дл смешивани и введени жидких быстроструктурирующихс компонентов
US5122117A (en) * 1990-06-05 1992-06-16 Habley Medical Technology Corp. Component mixing syringe
US5181909A (en) * 1991-05-15 1993-01-26 Mcfarlane Richard H Ampule-container medical syringe and methods
US5792835A (en) * 1991-09-05 1998-08-11 Baxter International Inc. Method of preparing a topical fibrinogen complex
EP0534178B1 (en) 1991-09-27 2001-04-18 Omrix Biopharmaceuticals S.A. Improved tissue glue prepared by using cryoprecipitate
JP3063935B2 (ja) 1992-05-12 2000-07-12 宇部興産株式会社 接着性、耐熱性および耐カ−ル性を兼ね備えたポリイミドシロキサン組成物
US5599790A (en) * 1992-06-11 1997-02-04 The Scripps Research Institute Fibrinogen γ chain polypeptide and compositions thereof
US5330974A (en) * 1993-03-01 1994-07-19 Fibratek, Inc. Therapeutic fibrinogen compositions
AT400675B (de) * 1993-10-18 1996-02-26 Immuno Ag Spritzengarnitur zur aufbewahrung und applikation eines mehrkomponentenmaterials, spritzenvorrichtung und betätigungseinrichtung hiefür sowie verfahren zum herstellen einer befüllten, sterilen spritzenvorrichtung
US6965014B1 (en) * 1996-01-16 2005-11-15 Baxter International Inc. Fibrin material and method for producing and using the same
US6599515B1 (en) * 1995-01-16 2003-07-29 Baxter International Inc. Fibrin porous structure
KR100450142B1 (ko) * 1996-03-15 2004-11-16 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 스프레이도포용조직접착제
DE19617369A1 (de) 1996-04-30 1997-11-06 Immuno Ag Lagerstabile Fibrinogen-Präparate
FR2749169B1 (fr) 1996-06-04 1998-08-21 Delab Procede pour constituer une preparation injectable et dispositif pour la mise en oeuvre de ce procede
JP3063935U (ja) * 1999-05-17 1999-12-10 川澄化学工業株式会社 二液同時混合注出器及びプランジャ結合部材
WO2002018546A2 (en) * 2000-09-01 2002-03-07 Virginia Commonwealth University Intellectual Property Foundation Plasma-derived-fibrin-based matrices and tissue
EE05485B1 (et) 2001-05-21 2011-10-17 Omrix Biopharmaceuticals S.A. Plasmi(i)n(ogeen)i eemaldamine valgulahustest
DE10211227A1 (de) 2002-03-13 2003-10-02 Aventis Behring Gmbh Verfahren zur Rekonstitution von Iyophilisierten Proteinen
ATE345277T1 (de) * 2002-08-21 2006-12-15 Pharmacia Corp Injizierbare pharmazeutische suspension in einer phiole mit zwei kammern
DE20216631U1 (de) 2002-10-28 2004-03-11 Haindl, Hans, Dr.med. Selbstentlüftende Spritze für das Mischen von flüssigen und pulverförmigen Substanzen
WO2004067704A2 (en) * 2003-01-30 2004-08-12 Prochon Biotech Ltd. Freeze-dried fibrin matrices and methods for preparation thereof
US6669667B1 (en) * 2003-04-11 2003-12-30 Jih-Hsiung Yang Safety syringe
SI1646659T1 (sl) * 2003-06-23 2014-07-31 Kiacta Sarl Postopek za pripravo spojin 1,3-propan disulfonske kisline
DE102005017985A1 (de) * 2005-04-19 2006-10-26 Theo Arnitz Verfahren und Vorrichtungen zum Auflösen von Medikamenten für Injektionen
CN101175517A (zh) * 2005-05-16 2008-05-07 马林克罗特公司 具有一体化管路的多筒注射器
EP1973475B1 (en) * 2006-01-17 2010-07-14 Baxter International Inc. Device, system and method for mixing
DE102006009611A1 (de) 2006-03-02 2007-09-06 Bernd Hansen System zum Zubereiten und Bereitstellen eines durch Vermischen einer Trockensubstanz mit einem Fluid gebildeten fließfähigen Mediums
BRPI0718145B8 (pt) * 2006-11-02 2021-05-25 Omrix Biopharmaceuticals Ltd método de micronização
US20080221584A1 (en) * 2007-03-06 2008-09-11 Downer David A Lens Delivery System
CN101678086B (zh) 2007-03-22 2013-07-10 财团法人化学及血清疗法研究所 固体纤维蛋白原制剂
DE102008003103A1 (de) 2008-01-01 2009-07-02 Lts Lohmann Therapie-Systeme Ag Einweginjektor mit zweikolbigem Zweikammersystem
US20090198211A1 (en) * 2008-02-06 2009-08-06 Intravena, Llc Convenience IV kits and methods of use
US8512740B2 (en) * 2008-03-26 2013-08-20 Baxter International Inc. Fibrin foam and process for making
JP5264545B2 (ja) * 2008-06-16 2013-08-14 テルモ株式会社 液体混合方法
JP5318684B2 (ja) * 2009-07-14 2013-10-16 テルモ株式会社 シリンジおよびシリンジ連結体
NZ597281A (en) * 2009-09-08 2013-07-26 Baxter Int Syringe for mixing components for wound sealant with screens in each of male and female plunger parts
CA2861722C (en) 2011-12-29 2020-06-30 Omrix Biopharmaceuticals Ltd. Method and device for fast dissolution of solid protein composition

Also Published As

Publication number Publication date
CA3078563A1 (en) 2013-07-04
IN2014DN05901A (pt) 2015-06-05
RU2014131276A (ru) 2016-02-20
MX351980B (es) 2017-11-03
CA2861722C (en) 2020-06-30
KR20140108709A (ko) 2014-09-12
US20130312868A1 (en) 2013-11-28
KR102109317B1 (ko) 2020-05-29
IL233361A0 (en) 2014-08-31
RU2605710C2 (ru) 2016-12-27
CN104144742A (zh) 2014-11-12
AU2012360048B2 (en) 2017-05-25
US10618950B2 (en) 2020-04-14
EP2797681B1 (en) 2017-02-01
JP2015509084A (ja) 2015-03-26
BR112014016193A8 (pt) 2017-07-04
JP6223999B2 (ja) 2017-11-01
WO2013098805A1 (en) 2013-07-04
US20200262892A1 (en) 2020-08-20
HK1203438A1 (en) 2015-10-30
IL233361B (en) 2018-06-28
EP2797681A1 (en) 2014-11-05
AU2012360048A1 (en) 2014-08-14
MX2014008033A (es) 2014-12-08
US11634473B2 (en) 2023-04-25
CA2861722A1 (en) 2013-07-04
ES2621363T3 (es) 2017-07-03

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