AU2012360048B2 - Method and device for fast dissolution of solid protein composition - Google Patents

Method and device for fast dissolution of solid protein composition Download PDF

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Publication number
AU2012360048B2
AU2012360048B2 AU2012360048A AU2012360048A AU2012360048B2 AU 2012360048 B2 AU2012360048 B2 AU 2012360048B2 AU 2012360048 A AU2012360048 A AU 2012360048A AU 2012360048 A AU2012360048 A AU 2012360048A AU 2012360048 B2 AU2012360048 B2 AU 2012360048B2
Authority
AU
Australia
Prior art keywords
closed container
syringe barrel
fibrinogen
seal element
reservoir
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2012360048A
Other languages
English (en)
Other versions
AU2012360048A1 (en
Inventor
John Goodman
Erez Ilan
Dana LEITMAN
Moti Meron
Israel Nur
Kfir Regev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omrix Biopharmaceuticals Ltd
Original Assignee
Omrix Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL217273A external-priority patent/IL217273A0/en
Application filed by Omrix Biopharmaceuticals Ltd filed Critical Omrix Biopharmaceuticals Ltd
Publication of AU2012360048A1 publication Critical patent/AU2012360048A1/en
Application granted granted Critical
Publication of AU2012360048B2 publication Critical patent/AU2012360048B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/25—Mixers with loose mixing elements, e.g. loose balls in a receptacle
    • B01F33/251—Mixers with loose mixing elements, e.g. loose balls in a receptacle using balls as loose mixing element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7163—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected in a mouth-to-mouth, end-to-end disposition, i.e. the openings are juxtaposed before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/718—Feed mechanisms characterised by the means for feeding the components to the mixer using vacuum, under pressure in a closed receptacle or circuit system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
AU2012360048A 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition Ceased AU2012360048B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
IL217273 2011-12-29
IL217273A IL217273A0 (en) 2011-12-29 2011-12-29 Fast dissolution of solid fibrinogen
US201261582524P 2012-01-03 2012-01-03
US61/582,524 2012-01-03
US201261677048P 2012-07-30 2012-07-30
US61/677,048 2012-07-30
IL221180 2012-07-30
IL22118012 2012-07-30
PCT/IL2012/000393 WO2013098805A1 (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Publications (2)

Publication Number Publication Date
AU2012360048A1 AU2012360048A1 (en) 2014-08-14
AU2012360048B2 true AU2012360048B2 (en) 2017-05-25

Family

ID=48696437

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012360048A Ceased AU2012360048B2 (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Country Status (13)

Country Link
US (2) US10618950B2 (enExample)
EP (1) EP2797681B1 (enExample)
JP (1) JP6223999B2 (enExample)
KR (1) KR102109317B1 (enExample)
AU (1) AU2012360048B2 (enExample)
BR (1) BR112014016193A8 (enExample)
CA (2) CA3078563A1 (enExample)
ES (1) ES2621363T3 (enExample)
IL (1) IL233361B (enExample)
IN (1) IN2014DN05901A (enExample)
MX (1) MX351980B (enExample)
RU (1) RU2605710C2 (enExample)
WO (1) WO2013098805A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3078563A1 (en) 2011-12-29 2013-07-04 Omrix Biopharmaceuticals Ltd. Method and device for fast dissolution of solid protein composition
EP3096743B1 (en) 2014-01-20 2022-02-16 Eveon Process for reconstitution of a solid form of a pharmaceutical composition
US20170274012A1 (en) * 2014-09-03 2017-09-28 Entegrion, Inc. Acceleration of Reconstitution of Plasma Powder by Mixing with Small Beads
US11229702B1 (en) 2015-10-28 2022-01-25 Coherus Biosciences, Inc. High concentration formulations of adalimumab
USD877890S1 (en) 2015-12-22 2020-03-10 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution device
US10918790B2 (en) * 2015-12-22 2021-02-16 Guangzhou Bioseal Biotech Co., Ltd. Dual syringe with funnel feeding kit
USD829888S1 (en) * 2015-12-22 2018-10-02 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution and delivery device
USD877891S1 (en) 2015-12-22 2020-03-10 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution and delivery device
IL244922A0 (en) 2016-04-05 2016-07-31 Omrix Biopharmaceuticals Ltd Device and method for sample preparation
WO2017184880A1 (en) 2016-04-20 2017-10-26 Coherus Biosciences, Inc. A method of filling a container with no headspace
US10150115B2 (en) * 2016-07-21 2018-12-11 Spacepharma SA System and method for rehydrating powder and delivering the rehydrated powder to a reactor
WO2018150375A1 (en) * 2017-02-17 2018-08-23 Baxter International Inc. Devices and methods for forming and delivering a tissue sealant
CA3010633A1 (en) 2017-07-06 2019-01-06 Plas-Tech Engineering, Inc. Systems and methods related to fluid pumping
US20250073313A1 (en) 2021-12-21 2025-03-06 Omrix Biopharmaceuticals Ltd. Highly soluble fibrinogen compositions
CN120733180A (zh) * 2025-06-04 2025-10-03 南京巴特弗莱医药包装材料有限责任公司 注射器组件及灌装方法

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US6965014B1 (en) * 1996-01-16 2005-11-15 Baxter International Inc. Fibrin material and method for producing and using the same
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US3052240A (en) * 1959-01-29 1962-09-04 Silver Disposable hypodermic syringe
US3405712A (en) * 1966-02-07 1968-10-15 Richard L. Pierick Desiccative syringe
US5122117A (en) * 1990-06-05 1992-06-16 Habley Medical Technology Corp. Component mixing syringe
US6965014B1 (en) * 1996-01-16 2005-11-15 Baxter International Inc. Fibrin material and method for producing and using the same
US20040039366A1 (en) * 2002-08-21 2004-02-26 Macleod Steven K. Injectable pharmaceutical suspension in a two-chamber vial
DE20216631U1 (de) * 2002-10-28 2004-03-11 Haindl, Hans, Dr.med. Selbstentlüftende Spritze für das Mischen von flüssigen und pulverförmigen Substanzen
DE102005017985A1 (de) * 2005-04-19 2006-10-26 Theo Arnitz Verfahren und Vorrichtungen zum Auflösen von Medikamenten für Injektionen
US20110196342A1 (en) * 2008-01-01 2011-08-11 Rudolf Matusch Disposable injector with dual-piston dual-chamber system

Also Published As

Publication number Publication date
ES2621363T3 (es) 2017-07-03
JP6223999B2 (ja) 2017-11-01
CA2861722C (en) 2020-06-30
IL233361B (en) 2018-06-28
AU2012360048A1 (en) 2014-08-14
RU2605710C2 (ru) 2016-12-27
US11634473B2 (en) 2023-04-25
BR112014016193A2 (pt) 2017-06-13
HK1203438A1 (en) 2015-10-30
CA3078563A1 (en) 2013-07-04
IN2014DN05901A (enExample) 2015-06-05
RU2014131276A (ru) 2016-02-20
BR112014016193A8 (pt) 2017-07-04
US20200262892A1 (en) 2020-08-20
US20130312868A1 (en) 2013-11-28
EP2797681B1 (en) 2017-02-01
CN104144742A (zh) 2014-11-12
EP2797681A1 (en) 2014-11-05
MX351980B (es) 2017-11-03
KR102109317B1 (ko) 2020-05-29
US10618950B2 (en) 2020-04-14
IL233361A0 (en) 2014-08-31
WO2013098805A1 (en) 2013-07-04
KR20140108709A (ko) 2014-09-12
MX2014008033A (es) 2014-12-08
JP2015509084A (ja) 2015-03-26
CA2861722A1 (en) 2013-07-04

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired