CA3066224A1 - Compounds for treating huntington's disease - Google Patents
Compounds for treating huntington's disease Download PDFInfo
- Publication number
- CA3066224A1 CA3066224A1 CA3066224A CA3066224A CA3066224A1 CA 3066224 A1 CA3066224 A1 CA 3066224A1 CA 3066224 A CA3066224 A CA 3066224A CA 3066224 A CA3066224 A CA 3066224A CA 3066224 A1 CA3066224 A1 CA 3066224A1
- Authority
- CA
- Canada
- Prior art keywords
- fluoro
- piperidin
- 8alkyl
- amino
- pyridazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762514999P | 2017-06-05 | 2017-06-05 | |
| US62/514,999 | 2017-06-05 | ||
| PCT/US2018/035954 WO2018226622A1 (en) | 2017-06-05 | 2018-06-05 | Compounds for treating huntington's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3066224A1 true CA3066224A1 (en) | 2018-12-13 |
Family
ID=64566872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3066224A Pending CA3066224A1 (en) | 2017-06-05 | 2018-06-05 | Compounds for treating huntington's disease |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11407753B2 (enExample) |
| EP (2) | EP4151627A1 (enExample) |
| JP (1) | JP7376471B2 (enExample) |
| KR (1) | KR20200033249A (enExample) |
| CN (1) | CN111065626B (enExample) |
| AU (2) | AU2018282154B2 (enExample) |
| BR (1) | BR112019025740A2 (enExample) |
| CA (1) | CA3066224A1 (enExample) |
| EA (1) | EA201992878A1 (enExample) |
| IL (2) | IL300875B2 (enExample) |
| MX (1) | MX2019014514A (enExample) |
| SG (1) | SG11201911615WA (enExample) |
| WO (1) | WO2018226622A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3119019C (en) | 2015-12-10 | 2024-06-11 | Ptc Therapeutics, Inc. | Compounds and methods for treating huntington's disease |
| EP4151627A1 (en) | 2017-06-05 | 2023-03-22 | PTC Therapeutics, Inc. | Compounds for treating huntington's disease |
| CN111163838B (zh) | 2017-06-28 | 2023-03-28 | Ptc医疗公司 | 用于治疗亨廷顿氏病的方法 |
| CN111182898B (zh) | 2017-06-28 | 2024-04-16 | Ptc医疗公司 | 用于治疗亨廷顿氏病的方法 |
| BR112020019373A2 (pt) | 2018-03-27 | 2020-12-29 | Ptc Therapeutics, Inc. | Compostos para o tratamento da doença de hutington |
| IL279688B2 (en) | 2018-06-27 | 2025-01-01 | Ptc Therapeutics Inc | Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease |
| WO2020005882A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| KR20210038845A (ko) | 2018-06-27 | 2021-04-08 | 피티씨 테라퓨틱스, 인크. | 헌팅턴병 치료를 위한 헤테로아릴 화합물 |
| CA3139821A1 (en) | 2019-05-13 | 2020-11-19 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| CN114174514A (zh) | 2019-07-25 | 2022-03-11 | 诺华股份有限公司 | 可调节的表达系统 |
| TW202131920A (zh) | 2019-11-01 | 2021-09-01 | 瑞士商諾華公司 | 剪接調節子用於減慢杭丁頓氏舞蹈症進展的治療之用途 |
| AU2021228284A1 (en) * | 2020-02-28 | 2022-09-29 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| WO2021231571A1 (en) | 2020-05-13 | 2021-11-18 | Chdi Foundation, Inc. | Htt modulators for treating huntington's disease |
| EP4178963A1 (en) | 2020-07-02 | 2023-05-17 | Remix Therapeutics Inc. | 5-[5-(piperidin-4-yl)thieno[3,2-c]pyrazol-2-yl]indazole derivatives and related compounds as modulators for splicing nucleic acids and for the treatment of proliferative diseases |
| MX2023000168A (es) * | 2020-07-02 | 2023-04-20 | Remix Therapeutics Inc | Derivados de 2-(indazol-5-il)-6-(piperidin-4-il)-1,7-naftiridina y compuestos relacionados como moduladores para el corte y empalme de ácidos nucleicos y para el tratamiento de enfermedades proliferativas. |
| EP4244362A1 (en) | 2020-11-12 | 2023-09-20 | PTC Therapeutics, Inc. | Novel rna transcript |
| TW202237119A (zh) * | 2020-12-10 | 2022-10-01 | 美商住友製藥腫瘤公司 | Ａｌｋ﹘５抑制劑和彼之用途 |
| CR20230437A (es) * | 2021-03-17 | 2023-10-16 | Hoffmann La Roche | Nuevos derivados de tiazolopirimidinona |
| EP4308577B1 (en) * | 2021-03-17 | 2024-12-25 | F. Hoffmann-La Roche AG | New thiadiazolopyrimidone derivatives |
| AU2022394333A1 (en) | 2021-11-17 | 2024-06-27 | Chdi Foundation, Inc. | HTT modulators for treating Huntington’s disease |
| US20250326748A1 (en) * | 2022-01-05 | 2025-10-23 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| US20220151938A1 (en) * | 2022-01-28 | 2022-05-19 | Ptc Therapeutics, Inc. | Tablet for use in treating huntington's disease and method of making the same |
| IL314911A (en) * | 2022-03-10 | 2024-10-01 | Hoffmann La Roche | Pyrido[1,2-a]pyrimidin-4-one derivatives |
| EP4526292A1 (en) * | 2022-05-20 | 2025-03-26 | Biogen MA Inc. | Heterocyclic compounds for treating huntington's disease |
| WO2025217430A1 (en) * | 2024-04-11 | 2025-10-16 | Board Of Regents, The University Of Texas System | Heterocyclic compounds as nras inhibitors |
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- 2018-06-05 EP EP22203869.7A patent/EP4151627A1/en active Pending
- 2018-06-05 CN CN201880050893.7A patent/CN111065626B/zh active Active
- 2018-06-05 MX MX2019014514A patent/MX2019014514A/es unknown
- 2018-06-05 EP EP18813494.4A patent/EP3634953B1/en active Active
- 2018-06-05 SG SG11201911615WA patent/SG11201911615WA/en unknown
- 2018-06-05 BR BR112019025740-3A patent/BR112019025740A2/pt not_active Application Discontinuation
- 2018-06-05 WO PCT/US2018/035954 patent/WO2018226622A1/en not_active Ceased
- 2018-06-05 KR KR1020207000124A patent/KR20200033249A/ko not_active Ceased
- 2018-06-05 JP JP2020516795A patent/JP7376471B2/ja active Active
- 2018-06-05 US US16/617,450 patent/US11407753B2/en active Active
- 2018-06-05 EA EA201992878A patent/EA201992878A1/ru unknown
- 2018-06-05 IL IL300875A patent/IL300875B2/en unknown
- 2018-06-05 AU AU2018282154A patent/AU2018282154B2/en active Active
- 2018-06-05 CA CA3066224A patent/CA3066224A1/en active Pending
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2019
- 2019-11-28 IL IL271046A patent/IL271046B2/en unknown
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2022
- 2022-02-25 AU AU2022201299A patent/AU2022201299A1/en not_active Abandoned
- 2022-04-18 US US17/723,163 patent/US12384789B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN111065626B (zh) | 2024-09-27 |
| US12384789B2 (en) | 2025-08-12 |
| NZ759824A (en) | 2025-05-30 |
| EP3634953A1 (en) | 2020-04-15 |
| JP2020522570A (ja) | 2020-07-30 |
| US20220251098A1 (en) | 2022-08-11 |
| CN111065626A (zh) | 2020-04-24 |
| EP4151627A1 (en) | 2023-03-22 |
| AU2018282154B2 (en) | 2022-04-07 |
| EP3634953B1 (en) | 2024-01-03 |
| EA201992878A1 (ru) | 2020-05-08 |
| WO2018226622A8 (en) | 2020-01-16 |
| AU2018282154A1 (en) | 2020-01-02 |
| IL300875B2 (en) | 2026-04-01 |
| BR112019025740A2 (pt) | 2020-06-23 |
| IL271046A (en) | 2020-01-30 |
| IL271046B2 (en) | 2023-08-01 |
| EP3634953A4 (en) | 2021-03-24 |
| IL300875A (en) | 2023-04-01 |
| JP7376471B2 (ja) | 2023-11-08 |
| WO2018226622A1 (en) | 2018-12-13 |
| MX2019014514A (es) | 2020-07-20 |
| US11407753B2 (en) | 2022-08-09 |
| KR20200033249A (ko) | 2020-03-27 |
| IL271046B1 (en) | 2023-04-01 |
| AU2022201299A1 (en) | 2022-03-24 |
| IL300875B1 (en) | 2025-12-01 |
| SG11201911615WA (en) | 2020-01-30 |
| US20200165256A1 (en) | 2020-05-28 |
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