CA3059820A1 - Constructs specifically recognizing glypican 3 and uses thereof - Google Patents

Constructs specifically recognizing glypican 3 and uses thereof Download PDF

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Publication number
CA3059820A1
CA3059820A1 CA3059820A CA3059820A CA3059820A1 CA 3059820 A1 CA3059820 A1 CA 3059820A1 CA 3059820 A CA3059820 A CA 3059820A CA 3059820 A CA3059820 A CA 3059820A CA 3059820 A1 CA3059820 A1 CA 3059820A1
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Canada
Prior art keywords
amino acid
seq
gpc3
acid sequence
variant
Prior art date
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Pending
Application number
CA3059820A
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English (en)
French (fr)
Inventor
Pengbo Zhang
Yiyang XU
Javier Morales
Yoko Nakano
Hong Liu
Jingyi Xiang
Timothy ACKER
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Eureka Therapeutics Inc
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Eureka Therapeutics Inc
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Publication of CA3059820A1 publication Critical patent/CA3059820A1/en
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00118—Cancer antigens from embryonic or fetal origin
    • A61K39/001181—Alpha-feto protein
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    • A61K40/4261—Proteoglycans, e.g. glypican, brevican or CSPG4
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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CA3059820A 2017-04-26 2018-04-24 Constructs specifically recognizing glypican 3 and uses thereof Pending CA3059820A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762490586P 2017-04-26 2017-04-26
US62/490,586 2017-04-26
PCT/US2018/029221 WO2018200586A1 (en) 2017-04-26 2018-04-24 Constructs specifically recognizing glypican 3 and uses thereof

Publications (1)

Publication Number Publication Date
CA3059820A1 true CA3059820A1 (en) 2018-11-01

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Application Number Title Priority Date Filing Date
CA3059820A Pending CA3059820A1 (en) 2017-04-26 2018-04-24 Constructs specifically recognizing glypican 3 and uses thereof

Country Status (15)

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US (2) US11447564B2 (enExample)
EP (1) EP3615574A4 (enExample)
JP (2) JP7295030B2 (enExample)
KR (2) KR20240067275A (enExample)
CN (1) CN110741019B (enExample)
AU (1) AU2018258049B2 (enExample)
CA (1) CA3059820A1 (enExample)
IL (2) IL270138B2 (enExample)
MX (1) MX2024009388A (enExample)
MY (1) MY201065A (enExample)
PH (1) PH12019502412A1 (enExample)
SG (2) SG10201913582XA (enExample)
TW (1) TWI878207B (enExample)
WO (1) WO2018200586A1 (enExample)
ZA (1) ZA202000027B (enExample)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
EP4527465A3 (en) * 2021-10-15 2025-07-09 Concept to Medicine Biotech Co., Ltd. Anti-glypican 3 antibodies

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AU2016342041B2 (en) 2015-10-23 2021-12-02 Eureka Therapeutics, Inc. Antibody/T-cell receptor chimeric constructs and uses thereof
EP3615574A4 (en) 2017-04-26 2021-02-24 Eureka Therapeutics, Inc. SPECIFIC GLYPICAN 3 RECOGNIZING CONSTRUCTS AND THEIR USE
WO2018200585A1 (en) 2017-04-26 2018-11-01 Eureka Therapeutics, Inc. Cells expressing chimeric antigen receptors and secondary effectors and uses thereof
KR20210025525A (ko) 2018-06-22 2021-03-09 카이트 파마 인코포레이티드 키메라 막횡단 단백질 및 그의 용도
CA3123177A1 (en) * 2018-12-21 2020-06-25 Kymab Limited Fixaxfx bispecific antibody with common light chain
JP2022523749A (ja) * 2019-02-01 2022-04-26 クレージュ メディカル カンパニー，リミテッド Ｔｃｒ融合タンパク質およびｔｃｒ融合タンパク質を発現する細胞
WO2020227447A1 (en) * 2019-05-07 2020-11-12 The Board Of Trustees Of The Leland Stanford Junior University Chimeric antigen receptors targeting glypican-2
BR112021025735A2 (pt) 2019-06-21 2022-03-08 Kite Pharma Inc Receptores de tgf-ss e métodos de uso
JP2023507369A (ja) * 2019-12-20 2023-02-22 メディミューン，エルエルシー グリピカン３を標的とするキメラ抗原受容体を用いて癌を治療する組成物及び方法
IL295421A (en) * 2020-02-14 2022-10-01 Univ Leland Stanford Junior Chimeric antigen receptors with cd2 activation
WO2021170100A1 (en) * 2020-02-27 2021-09-02 Nanjing Legend Biotech Co., Ltd. Antibodies and chimeric antigen receptors targeting glypican-3 (gpc3) and methods of use thereof
CA3176125A1 (en) * 2020-03-18 2021-09-23 Eutilex Co., Ltd. Gpc3 car- t cells secreting il-18 and methods of making and using the same
EP4146702A4 (en) * 2020-05-07 2024-07-10 Phanes Therapeutics, Inc. Anti-tumor associated antigen antibodies and uses thereof
WO2021261597A1 (ja) * 2020-06-26 2021-12-30 協和キリン株式会社 ＧＰＣ３とＴｆＲに結合するバイスペシフィック抗体
EP4319810A4 (en) * 2021-04-05 2025-06-18 Naya Biosciences Inc. Bispecific antibodies targeting nkp46 and gpc3 and methods of use thereof
EP4326780A4 (en) * 2021-04-23 2025-02-26 Shanghai Henlius Biotech, Inc. Anti-gpc3 antibodies, multispecific antibodies and methods of use
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