CA2981737A1 - Tgf-beta superfamily type i and type ii receptor heteromultimers and uses thereof - Google Patents

Tgf-beta superfamily type i and type ii receptor heteromultimers and uses thereof Download PDF

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Publication number
CA2981737A1
CA2981737A1 CA2981737A CA2981737A CA2981737A1 CA 2981737 A1 CA2981737 A1 CA 2981737A1 CA 2981737 A CA2981737 A CA 2981737A CA 2981737 A CA2981737 A CA 2981737A CA 2981737 A1 CA2981737 A1 CA 2981737A1
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Prior art keywords
polypeptide
seq
amino acid
heteromultimer
acid sequence
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CA2981737A
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English (en)
French (fr)
Inventor
Ravindra Kumar
Asya Grinberg
Dianne S. Sako
Robert Scott Pearsall
Roselyne CASTONGUAY
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Acceleron Pharma Inc
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Acceleron Pharma Inc
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Publication of CA2981737A1 publication Critical patent/CA2981737A1/en
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Diabetes (AREA)
  • Wood Science & Technology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biotechnology (AREA)
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  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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CA2981737A 2015-04-06 2016-04-06 Tgf-beta superfamily type i and type ii receptor heteromultimers and uses thereof Pending CA2981737A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562143579P 2015-04-06 2015-04-06
US62/143,579 2015-04-06
PCT/US2016/000033 WO2016164089A2 (en) 2015-04-06 2016-04-06 Tgf-beta superfamily type i and type ii receptor heteromultimers and uses thereof

Publications (1)

Publication Number Publication Date
CA2981737A1 true CA2981737A1 (en) 2016-10-13

Family

ID=57072866

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2981833A Pending CA2981833A1 (en) 2015-04-06 2016-04-06 Alk7:actriib heteromultimers and uses thereof
CA2981737A Pending CA2981737A1 (en) 2015-04-06 2016-04-06 Tgf-beta superfamily type i and type ii receptor heteromultimers and uses thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2981833A Pending CA2981833A1 (en) 2015-04-06 2016-04-06 Alk7:actriib heteromultimers and uses thereof

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US (7) US10227393B2 (enExample)
EP (5) EP3280728B1 (enExample)
JP (3) JP7055636B2 (enExample)
KR (2) KR20180002661A (enExample)
CN (4) CN114736307A (enExample)
AU (4) AU2016246708B2 (enExample)
BR (1) BR112017021510A2 (enExample)
CA (2) CA2981833A1 (enExample)
DK (1) DK3280728T3 (enExample)
EA (2) EA037293B1 (enExample)
ES (1) ES2863564T3 (enExample)
HK (2) HK1250373A1 (enExample)
MA (4) MA41920B1 (enExample)
MX (1) MX391964B (enExample)
WO (2) WO2016164503A1 (enExample)

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JP7654402B2 (ja) * 2018-02-09 2025-04-01 アクセルロン ファーマ インコーポレイテッド 異所性骨化を処置するための方法
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