HK1248733A1 - TGF-β超家族I型和II型受體異多聚體及其用途 - Google Patents

TGF-β超家族I型和II型受體異多聚體及其用途

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Publication number
HK1248733A1
HK1248733A1 HK18108636.3A HK18108636A HK1248733A1 HK 1248733 A1 HK1248733 A1 HK 1248733A1 HK 18108636 A HK18108636 A HK 18108636A HK 1248733 A1 HK1248733 A1 HK 1248733A1
Authority
HK
Hong Kong
Prior art keywords
type
tgf
beta superfamily
receptor heteromultimers
heteromultimers
Prior art date
Application number
HK18108636.3A
Other languages
English (en)
Inventor
Ravindra Kumar
Asya Grinberg
Dianne S Sako
Robert Scott Pearsall
Roselyne Castonguay
Original Assignee
Acceleron Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acceleron Pharma Inc filed Critical Acceleron Pharma Inc
Publication of HK1248733A1 publication Critical patent/HK1248733A1/zh

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P7/06—Antianaemics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
HK18108636.3A 2015-04-06 2018-07-04 TGF-β超家族I型和II型受體異多聚體及其用途 HK1248733A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562143579P 2015-04-06 2015-04-06
PCT/US2016/000033 WO2016164089A2 (en) 2015-04-06 2016-04-06 Tgf-beta superfamily type i and type ii receptor heteromultimers and uses thereof

Publications (1)

Publication Number Publication Date
HK1248733A1 true HK1248733A1 (zh) 2018-10-19

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Family Applications (4)

Application Number Title Priority Date Filing Date
HK18108639.0A HK1248735A1 (zh) 2015-04-06 2018-07-04 Alk7:actriib異多聚體和其用途
HK18108636.3A HK1248733A1 (zh) 2015-04-06 2018-07-04 TGF-β超家族I型和II型受體異多聚體及其用途
HK18109788.7A HK1250373A1 (zh) 2015-04-06 2018-07-30 Alk7:actriib異多聚體和其用途
HK18112314.4A HK1252957A1 (zh) 2015-04-06 2018-09-26 TGF-β超家族I型和II型受體異多聚體及其用途

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HK18108639.0A HK1248735A1 (zh) 2015-04-06 2018-07-04 Alk7:actriib異多聚體和其用途

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HK18109788.7A HK1250373A1 (zh) 2015-04-06 2018-07-30 Alk7:actriib異多聚體和其用途
HK18112314.4A HK1252957A1 (zh) 2015-04-06 2018-09-26 TGF-β超家族I型和II型受體異多聚體及其用途

Country Status (15)

Country Link
US (6) US10227393B2 (zh)
EP (4) EP3280435B1 (zh)
JP (3) JP7037363B2 (zh)
KR (2) KR20180002661A (zh)
CN (4) CN115073610A (zh)
AU (4) AU2016244750B2 (zh)
BR (1) BR112017021510A2 (zh)
CA (2) CA2981833A1 (zh)
DK (1) DK3280728T3 (zh)
EA (2) EA037293B1 (zh)
ES (1) ES2863564T3 (zh)
HK (4) HK1248735A1 (zh)
MA (4) MA41920B1 (zh)
MX (1) MX2017012846A (zh)
WO (2) WO2016164503A1 (zh)

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JP2021522793A (ja) * 2018-05-03 2021-09-02 アクセルロン ファーマ インコーポレイテッド ＴＧＦβスーパーファミリーリガンドの多特異性バインダーおよびその使用
KR20210006952A (ko) * 2018-05-09 2021-01-19 케로스 테라퓨틱스, 인크. 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법
TW202003580A (zh) 2018-05-21 2020-01-16 美商坎伯斯治療有限責任公司 用於增強nk細胞對標靶細胞之殺死之組合物及方法
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