CA2963991A1 - Bispecific molecules comprising an hiv-1 envelope targeting arm - Google Patents
Bispecific molecules comprising an hiv-1 envelope targeting arm Download PDFInfo
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- CA2963991A1 CA2963991A1 CA2963991A CA2963991A CA2963991A1 CA 2963991 A1 CA2963991 A1 CA 2963991A1 CA 2963991 A CA2963991 A CA 2963991A CA 2963991 A CA2963991 A CA 2963991A CA 2963991 A1 CA2963991 A1 CA 2963991A1
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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Applications Claiming Priority (5)
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| US201462056834P | 2014-09-29 | 2014-09-29 | |
| US62/056,834 | 2014-09-29 | ||
| US201562206586P | 2015-08-18 | 2015-08-18 | |
| US62/206,586 | 2015-08-18 | ||
| PCT/US2015/053027 WO2016054101A1 (en) | 2014-09-29 | 2015-09-29 | Bispecific molecules comprising an hiv-1 envelope targeting arm |
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| CA2963991A1 true CA2963991A1 (en) | 2016-04-07 |
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| CA2963991A Pending CA2963991A1 (en) | 2014-09-29 | 2015-09-29 | Bispecific molecules comprising an hiv-1 envelope targeting arm |
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| US (2) | US10717778B2 (OSRAM) |
| EP (1) | EP3201227A4 (OSRAM) |
| JP (1) | JP6932639B2 (OSRAM) |
| CN (1) | CN107108721B (OSRAM) |
| AU (1) | AU2015323860B2 (OSRAM) |
| BR (1) | BR112017006515A8 (OSRAM) |
| CA (1) | CA2963991A1 (OSRAM) |
| IL (1) | IL251437B (OSRAM) |
| MX (1) | MX386297B (OSRAM) |
| SG (1) | SG11201702544WA (OSRAM) |
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| CN107108721B (zh) | 2014-09-29 | 2021-09-07 | 杜克大学 | 包含hiv-1包膜靶向臂的双特异性分子 |
| TW202208440A (zh) | 2015-12-14 | 2022-03-01 | 美商宏觀基因股份有限公司 | 對於pd-1和ctla-4具有免疫反應性的雙特異性分子及其使用方法 |
| MX2018014950A (es) * | 2016-06-07 | 2019-04-25 | Macrogenics Inc | Terapia de combinacion. |
| WO2018053328A1 (en) * | 2016-09-16 | 2018-03-22 | Duke University | Bispecific molecules comprising an hiv-1 envelope targeting arm |
| CN108728463A (zh) * | 2017-04-14 | 2018-11-02 | 深圳新诺微环生物科技有限公司 | 一种表达IgG抗体的微环DNA载体及其制备方法和应用 |
| CN108728465A (zh) * | 2017-04-14 | 2018-11-02 | 深圳新诺微环生物科技有限公司 | 一种表达靶细胞-效应细胞桥接器的微环dna载体及其制备方法和应用 |
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| BR112017006515A2 (pt) | 2017-12-19 |
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| BR112017006515A8 (pt) | 2018-02-27 |
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| CN107108721A (zh) | 2017-08-29 |
| ZA201702235B (en) | 2021-09-29 |
| US20200354439A1 (en) | 2020-11-12 |
| AU2015323860A1 (en) | 2017-05-11 |
| JP2017534296A (ja) | 2017-11-24 |
| EP3201227A1 (en) | 2017-08-09 |
| MX386297B (es) | 2025-03-18 |
| JP6932639B2 (ja) | 2021-09-08 |
| SG11201702544WA (en) | 2017-04-27 |
| IL251437B (en) | 2021-02-28 |
| US20180148497A1 (en) | 2018-05-31 |
| EP3201227A4 (en) | 2018-04-18 |
| AU2015323860B2 (en) | 2021-05-27 |
| US10717778B2 (en) | 2020-07-21 |
| MX2017004076A (es) | 2017-07-04 |
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