CA2856646C - Traitement combine du cancer - Google Patents
Traitement combine du cancer Download PDFInfo
- Publication number
- CA2856646C CA2856646C CA2856646A CA2856646A CA2856646C CA 2856646 C CA2856646 C CA 2856646C CA 2856646 A CA2856646 A CA 2856646A CA 2856646 A CA2856646 A CA 2856646A CA 2856646 C CA2856646 C CA 2856646C
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- combination
- azd5363
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
Abstract
La présente invention concerne une combinaison comprenant AZD5363, ou un sel pharmaceutiquement acceptable de celui-ci, et au moins un modulateur de signalisation de récepteur aux androgènes, choisi parmi le MDV-3100 (également connu comme enzalutamide), l'AZD3514, l'abiratérone (ou un promédicament ester de celle-ci : par exemple, l'acétate d'abiratérone), et le bicalutamide ; ou un sel pharmaceutiquement acceptable de celui-ci. Chacune de ces combinaisons peut être utile dans le traitement du cancer. L'invention concerne également des compositions pharmaceutiques comprenant de telles combinaisons, et concerne en outre des procédés de traitement comprenant l'administration simultanée, séquentielle ou séparée d'AZD5363, ou d'un sel pharmaceutiquement acceptable de celui-ci, avec au moins un modulateur de signalisation de récepteur aux androgènes tel que décrit ci-dessus, à un animal à sang chaud, tel qu'un être humain, pour le traitement du cancer. L'invention concerne également une trousse comprenant de telles combinaisons.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161564975P | 2011-11-30 | 2011-11-30 | |
US61/564,975 | 2011-11-30 | ||
PCT/GB2012/052969 WO2013079964A1 (fr) | 2011-11-30 | 2012-11-30 | Traitement combiné du cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2856646A1 CA2856646A1 (fr) | 2013-06-06 |
CA2856646C true CA2856646C (fr) | 2020-01-14 |
Family
ID=47295082
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2856646A Active CA2856646C (fr) | 2011-11-30 | 2012-11-30 | Traitement combine du cancer |
Country Status (25)
Country | Link |
---|---|
US (2) | US20140329786A1 (fr) |
EP (1) | EP2785349B2 (fr) |
JP (1) | JP6309454B2 (fr) |
KR (1) | KR102035361B1 (fr) |
CN (1) | CN103945849B (fr) |
AU (1) | AU2012321110B2 (fr) |
CA (1) | CA2856646C (fr) |
CY (1) | CY1122624T1 (fr) |
DK (1) | DK2785349T4 (fr) |
ES (1) | ES2762250T5 (fr) |
FI (1) | FI2785349T4 (fr) |
HK (1) | HK1202253A1 (fr) |
HR (1) | HRP20191982T4 (fr) |
HU (1) | HUE046667T2 (fr) |
IL (1) | IL232530B (fr) |
LT (1) | LT2785349T (fr) |
MX (1) | MX367640B (fr) |
MY (1) | MY175800A (fr) |
PL (1) | PL2785349T5 (fr) |
PT (1) | PT2785349T (fr) |
RS (1) | RS59493B2 (fr) |
RU (1) | RU2640485C2 (fr) |
SG (1) | SG11201401471PA (fr) |
SI (1) | SI2785349T2 (fr) |
WO (1) | WO2013079964A1 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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US20100048913A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
HUE048293T2 (hu) | 2008-10-02 | 2020-07-28 | Salix Pharmaceuticals Ltd | Eljárások hepatikus enkefalopátia kezelésére |
AU2010210422A1 (en) | 2009-02-05 | 2011-08-18 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal CYP17 inhibitors/antiandrogens |
SI3124481T1 (en) | 2010-02-16 | 2018-06-29 | Aragon Pharmaceuticals, Inc. | Androgen receptor modulators and their use |
EP2663189B1 (fr) | 2011-01-11 | 2018-07-04 | Novartis AG | Combinaison de bortezomib avec l'afuresertib et utilisation de celle-ci dans le traitement du cancer |
AU2012358219A1 (en) * | 2011-12-22 | 2014-07-10 | Tokai Pharmaceuticals, Inc. | Methods and compositions for combination therapy using P13K/mTOR inhibitors |
AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
MY180834A (en) | 2012-09-26 | 2020-12-10 | Aragon Pharmaceuticals Inc | Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer |
JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
BR112015023098A2 (pt) | 2013-03-14 | 2017-07-18 | Univ Jefferson | agentes de infrarregulação do receptor de andrógeno e usos dos mesmos |
CN105636594A (zh) | 2013-08-12 | 2016-06-01 | 托凯药业股份有限公司 | 使用雄激素靶向疗法用于治疗肿瘤性疾病的生物标记物 |
MX2016004265A (es) * | 2013-10-01 | 2016-07-08 | Novartis Ag | Combinacion. |
CN105792825A (zh) * | 2013-10-01 | 2016-07-20 | 诺华股份有限公司 | 组合 |
WO2015116696A1 (fr) * | 2014-01-28 | 2015-08-06 | Massachusetts Institute Of Technology | Thérapies de combinaison et procédés d'utilisation associés pour le traitement du cancer |
EP3824908A1 (fr) | 2015-04-10 | 2021-05-26 | Capsugel Belgium NV | Formulations lipidiques d'acétate d'abiratérone |
TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
US11478453B2 (en) | 2016-07-21 | 2022-10-25 | Hadasit Medical Research Services And Development Ltd. | Treatment for glioblastoma |
CN110049765B (zh) * | 2016-12-16 | 2022-02-01 | 康朴生物医药技术(上海)有限公司 | 一种组合、其应用及治疗方法 |
CN107670048B (zh) * | 2017-08-30 | 2019-04-26 | 南京明臻医药科技有限公司 | 具有协同抗癌活性的中间体药物和聚乙二醇偶联协同抗癌药物、及其制备方法和应用 |
AU2018335391A1 (en) * | 2017-09-22 | 2020-03-26 | AustinPx, LLC | Abiraterone-cyclic oligomer pharmaceutical formulations and methods of formation and administration thereof |
AU2018351714A1 (en) | 2017-10-16 | 2020-04-30 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer |
CN108486041A (zh) * | 2018-03-28 | 2018-09-04 | 华南农业大学 | PI3K/Akt信号通路在鸡胚成纤维细胞内对马立克氏病毒增殖的应用及其检测方法 |
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2012
- 2012-11-30 WO PCT/GB2012/052969 patent/WO2013079964A1/fr active Application Filing
- 2012-11-30 RS RS20191392A patent/RS59493B2/sr unknown
- 2012-11-30 RU RU2014119713A patent/RU2640485C2/ru active
- 2012-11-30 SI SI201231690T patent/SI2785349T2/sl unknown
- 2012-11-30 LT LT12795842T patent/LT2785349T/lt unknown
- 2012-11-30 PL PL12795842.9T patent/PL2785349T5/pl unknown
- 2012-11-30 MY MYPI2014701394A patent/MY175800A/en unknown
- 2012-11-30 SG SG11201401471PA patent/SG11201401471PA/en unknown
- 2012-11-30 ES ES12795842T patent/ES2762250T5/es active Active
- 2012-11-30 AU AU2012321110A patent/AU2012321110B2/en active Active
- 2012-11-30 US US14/361,718 patent/US20140329786A1/en not_active Abandoned
- 2012-11-30 JP JP2014543977A patent/JP6309454B2/ja active Active
- 2012-11-30 CN CN201280059109.1A patent/CN103945849B/zh active Active
- 2012-11-30 DK DK12795842.9T patent/DK2785349T4/da active
- 2012-11-30 PT PT127958429T patent/PT2785349T/pt unknown
- 2012-11-30 MX MX2014006547A patent/MX367640B/es active IP Right Grant
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