BE637271A - - Google Patents
Info
- Publication number
- BE637271A BE637271A BE637271DA BE637271A BE 637271 A BE637271 A BE 637271A BE 637271D A BE637271D A BE 637271DA BE 637271 A BE637271 A BE 637271A
- Authority
- BE
- Belgium
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B43/00—Preparation of azo dyes from other azo compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27053463A | 1963-04-04 | 1963-04-04 | |
| US27053763A | 1963-04-04 | 1963-04-04 | |
| US27053663A | 1963-04-04 | 1963-04-04 | |
| US37971464A | 1964-07-01 | 1964-07-01 | |
| US468143A US3331830A (en) | 1963-04-04 | 1965-06-29 | 1-substituted-4-substituted aminoalkylene piperazines |
| US468142A US3331843A (en) | 1963-04-04 | 1965-06-29 | 1-substituted-4-substituted aminoalkylene piperazines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE637271A true BE637271A (fr) | 1900-01-01 |
Family
ID=27559486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE637271D BE637271A (fr) | 1963-04-04 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US3331843A (fr) |
| BE (1) | BE637271A (fr) |
| BR (1) | BR6352303D0 (fr) |
| CH (1) | CH482691A (fr) |
| DE (1) | DE1445425A1 (fr) |
| FI (2) | FI41280C (fr) |
| FR (1) | FR3708M (fr) |
| GB (1) | GB1047935A (fr) |
| LU (1) | LU44424A1 (fr) |
| MC (1) | MC435A1 (fr) |
| NL (1) | NL297170A (fr) |
| NO (1) | NO117694B (fr) |
| SE (2) | SE320667B (fr) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1165283A (en) * | 1967-01-17 | 1969-09-24 | Science Union & Cie | New Purine Derivatives and processes for prepararing them |
| US3491098A (en) * | 1967-05-29 | 1970-01-20 | Sterling Drug Inc | 1-((imidazolyl)-lower-alkyl)-4-substituted-piperazines |
| GB1279843A (en) * | 1969-05-23 | 1972-06-28 | Science Union & Cie | Benzamidoethyl-piperazines and process for their preparation |
| US4081542A (en) * | 1975-04-21 | 1978-03-28 | Merck & Co., Inc. | Piperazinylpyrazines |
| CH653021A5 (fr) * | 1981-04-24 | 1985-12-13 | Delalande Sa | Derives piperidino, piperazino et homopiperazino, n-substitues par un groupe heterocyclique aromatique, leur procede de preparation et composition therapeutique les contenant. |
| US4457931A (en) * | 1982-09-27 | 1984-07-03 | Selvi & C. S.P.A. | Piperazine derivatives with anticholinergic and/or antihistaminic activity |
| HUT43600A (en) * | 1985-06-22 | 1987-11-30 | Sandoz Ag | Process for production of new thiazole derivatives and medical compound containing those |
| US5057517A (en) * | 1987-07-20 | 1991-10-15 | Merck & Co., Inc. | Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents |
| US4977156A (en) * | 1988-07-26 | 1990-12-11 | The Dow Chemical Company | Amino piperazine esters showing biocidal activity |
| US5032604A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Class III antiarrhythmic agents |
| JP3193560B2 (ja) * | 1993-04-16 | 2001-07-30 | 明治製菓株式会社 | 新規ベンゾオキサゾール誘導体 |
| EP1165082A4 (fr) * | 1999-03-03 | 2002-06-12 | Merck & Co Inc | Inhibiteurs de la prenyle-proteine transferase |
| CA2362494A1 (fr) | 1999-03-03 | 2000-09-08 | Merck & Co., Inc. | Inhibiteurs de prenyl-proteine transferases |
| WO2000078716A1 (fr) * | 1999-06-24 | 2000-12-28 | Toray Industries, Inc. | ANTAGONISTES DU RECEPTEUR ADRENERGIQUE-α¿1B? |
| AU6936500A (en) * | 1999-08-24 | 2001-03-19 | Regents Of The University Of California, The | Non-quinoline inhibitors of malaria parasites |
| OA12789A (en) * | 2002-03-13 | 2006-07-10 | Janssen Pharmaceutica Nv | Carbonylamino-derivatives as novel inhibitors of histone deacetylase. |
| EA007270B1 (ru) * | 2002-03-13 | 2006-08-25 | Янссен Фармацевтика Н.В. | Пиперазинил-, пиперидинил- и морфолинилпроизводные как новые ингибиторы гистондеацетилазы |
| PL212089B1 (pl) | 2002-03-13 | 2012-08-31 | Janssen Pharmaceutica Nv | Związki heterocykliczne jako inhibitory deacetylazy histonowej, kompozycja farmaceutyczna je zawierająca, ich zastosowanie, sposób wytwarzania, sposób wykrywania lub identyfikacji HDAC oraz kompozycja |
| JP4725945B2 (ja) | 2002-03-13 | 2011-07-13 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としてのスルホニルアミノ誘導体 |
| BRPI0512676B8 (pt) * | 2004-07-28 | 2021-05-25 | Janssen Pharmaceutica Nv | derivados de indolil alquil amina substituídos como inibidores de histona desacetilase, composição farmacêutica que os compreende, seus processos de preparação e uso |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| UY29177A1 (es) * | 2004-10-25 | 2006-05-31 | Astex Therapeutics Ltd | Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos |
| WO2006089076A2 (fr) | 2005-02-18 | 2006-08-24 | Neurogen Corporation | Thiazole amides, imidazole amides et analogues associes |
| DK1885710T3 (en) | 2005-05-18 | 2015-11-23 | Janssen Pharmaceutica Nv | SUBSTITUTED AMINOPROPENYLPIPERIDINE OR MORPHOLINE DERIVATIVES AS UNKNOWN INHIBITORS OF HISTONDEACETYLASE |
| EP1981875B1 (fr) * | 2006-01-19 | 2014-04-16 | Janssen Pharmaceutica N.V. | Dérivés substitués d'indolyl-alkyl-amine en tant qu'inhibiteurs de l'histone désacétylase |
| ATE432272T1 (de) * | 2006-01-19 | 2009-06-15 | Janssen Pharmaceutica Nv | Aminophenylderivate als neue inhibitoren von histondeacetylase |
| CA2630717C (fr) | 2006-01-19 | 2015-02-24 | Janssen Pharmaceutica N.V. | Derives de pyridine et de pyrimidine en tant qu'inhibiteurs d'histone desacetylase |
| JP5137848B2 (ja) * | 2006-01-19 | 2013-02-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体 |
| EP3421471B1 (fr) | 2006-04-25 | 2021-05-26 | Astex Therapeutics Limited | Dérivés de purine et de déazapurine comme composés pharmaceutiques |
| AU2008277796A1 (en) * | 2007-07-19 | 2009-01-22 | F. Hoffmann-La Roche Ag | Novel heterocyclyl compounds and their use as chemokine antagonists |
| TW201446748A (zh) * | 2007-08-22 | 2014-12-16 | Astrazeneca Ab | 環丙基醯胺衍生物 |
| JP4705695B2 (ja) | 2007-10-11 | 2011-06-22 | アストラゼネカ アクチボラグ | プロテインキナーゼｂ阻害剤としてのピロロ［２，３−ｄ］ピリミジン誘導体 |
| EP2212310A4 (fr) * | 2007-10-15 | 2011-04-20 | Elder Pharmaceuticals Ltd | Procédé pouvant être mis en oeuvre à l'échelle industrielle pour la fabrication de dérivés de bisquinoline au moyen de pipérazines n-monosubstituées sensiblement pures |
| TW201039825A (en) * | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| FR2945289A1 (fr) * | 2009-05-11 | 2010-11-12 | Sanofi Aventis | Derives de 2-cycloamino-5-(pyridin-4-yl)imidazo°2,1-b! °1,3,4!thiadiazole, leur preparation et leur application en therapeutique |
| WO2011095885A1 (fr) * | 2010-02-08 | 2011-08-11 | Matrix Laboratories Ltd. | Procédé amélioré pour la préparation de pipéraquine |
| EP2536702A4 (fr) * | 2010-02-18 | 2013-07-10 | Astrazeneca Ab | Nouvelle forme cristalline d'un dérivé cyclopropyl-benzamide |
| EP2536701A4 (fr) * | 2010-02-18 | 2014-05-07 | Astrazeneca Ab | Formes solides comprenant un dérivé de cyclopropylamide |
| HUE047357T2 (hu) | 2011-04-01 | 2020-04-28 | Astrazeneca Ab | Gyógyászati kezelés |
| EP2718268B1 (fr) | 2011-06-06 | 2016-12-28 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Nouveau procédé pour la synthèse de 7-chloro-4-(pipérazin-1-yl)quinoléine |
| KR102035361B1 (ko) | 2011-11-30 | 2019-11-08 | 아스트라제네카 아베 | 암의 병용 치료 |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| ES2879995T3 (es) | 2015-12-10 | 2021-11-23 | Ptc Therapeutics Inc | Métodos para el tratamiento de la enfermedad de Huntington |
| WO2018226622A1 (fr) | 2017-06-05 | 2018-12-13 | Ptc Therapeutics, Inc. | Composés permettant de traiter la maladie de huntington |
| EP3644996B1 (fr) | 2017-06-28 | 2023-07-26 | PTC Therapeutics, Inc. | Procédés de traitement de la maladie de huntington |
| CA3067592A1 (fr) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | Methodes de traitement de la maladie de huntington |
| JP7399870B2 (ja) | 2018-03-27 | 2023-12-18 | ピーティーシー セラピューティクス， インコーポレイテッド | ハンチントン病を処置するための化合物 |
| CN110606830B (zh) * | 2018-06-14 | 2022-03-18 | 珠海润都制药股份有限公司 | 一种哌嗪套用生产磷酸哌喹中间体喹啉哌嗪盐酸盐的方法 |
| WO2020005873A1 (fr) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Composés hétérocycliques et hétéroaryles pour le traitement de la maladie de huntington |
| US11685746B2 (en) | 2018-06-27 | 2023-06-27 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating Huntington's disease |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2513026A (en) * | 1950-06-27 | Process for preparing same | ||
| NL72956C (fr) * | 1947-11-12 | |||
| US2861072A (en) * | 1952-07-19 | 1958-11-18 | Abbott Lab | Preparation of piperazine derivatives |
| US2794804A (en) * | 1955-03-24 | 1957-06-04 | American Cyanamid Co | Substituted piperazines and method of preparing the same |
| US2949431A (en) * | 1957-07-17 | 1960-08-16 | Mobay Chemical Corp | Preparation of cellular polyurethanes using piperazine catalysts |
| US3098066A (en) * | 1960-03-04 | 1963-07-16 | Ciba Geigy Corp | Diaza-heterocyclic guanidine compounds |
| US3015657A (en) * | 1959-05-28 | 1962-01-02 | Charles F Geschickter | 1-carbalkoxy-4-(aminoalkanol) piperazines |
| US3030366A (en) * | 1961-01-25 | 1962-04-17 | Lakeside Lab Inc | Piperazinoalkyl glycolamides |
| FR1525M (fr) * | 1961-07-25 | 1962-11-16 | Ile De France | Médicaments antiémétiques nouveaux. |
| US3190883A (en) * | 1962-10-05 | 1965-06-22 | Geschickter Fund Med Res | Aminoalkanol derivatives of piperazines |
| US3184382A (en) * | 1963-08-12 | 1965-05-18 | Pure Oil Co | Method of producing tranquilization by hydroxy-loweralkyl-n-substituted carbamic acid esters |
-
0
- NL NL297170D patent/NL297170A/xx unknown
- BE BE637271D patent/BE637271A/xx unknown
-
1963
- 1963-08-06 GB GB30926/63A patent/GB1047935A/en not_active Expired
- 1963-08-28 BR BR152303/63A patent/BR6352303D0/pt unknown
- 1963-09-02 NO NO149944A patent/NO117694B/no unknown
- 1963-09-02 FI FI631675A patent/FI41280C/fi active
- 1963-09-02 SE SE9582/63A patent/SE320667B/xx unknown
- 1963-09-02 DE DE19631445425 patent/DE1445425A1/de active Granted
- 1963-09-10 MC MC453A patent/MC435A1/fr unknown
- 1963-09-11 LU LU44424D patent/LU44424A1/xx unknown
- 1963-09-16 CH CH1141863A patent/CH482691A/fr not_active IP Right Cessation
- 1963-09-16 FR FR947586A patent/FR3708M/fr not_active Expired
-
1965
- 1965-06-29 US US468142A patent/US3331843A/en not_active Expired - Lifetime
- 1965-06-29 US US468143A patent/US3331830A/en not_active Expired - Lifetime
-
1967
- 1967-05-26 SE SE7418/67A patent/SE346316B/xx unknown
-
1968
- 1968-04-04 FI FI680932A patent/FI42440C/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| FI42440B (fr) | 1970-04-30 |
| US3331830A (en) | 1967-07-18 |
| DE1445425A1 (de) | 1968-10-31 |
| FI41280B (fr) | 1969-06-30 |
| SE346316B (fr) | 1972-07-03 |
| FI41280C (fi) | 1969-10-10 |
| CH482691A (fr) | 1969-12-15 |
| FR3708M (fr) | 1965-11-29 |
| BR6352303D0 (pt) | 1973-07-17 |
| GB1047935A (en) | 1966-11-09 |
| FI42440C (fi) | 1970-08-10 |
| NO117694B (fr) | 1969-09-15 |
| US3331843A (en) | 1967-07-18 |
| MC435A1 (fr) | 1964-07-06 |
| NL297170A (fr) | 1900-01-01 |
| LU44424A1 (fr) | 1963-11-11 |
| SE320667B (fr) | 1970-02-16 |