CA2822776A1 - Inhibitors of histone deacetylase - Google Patents

Inhibitors of histone deacetylase Download PDF

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Publication number
CA2822776A1
CA2822776A1 CA2822776A CA2822776A CA2822776A1 CA 2822776 A1 CA2822776 A1 CA 2822776A1 CA 2822776 A CA2822776 A CA 2822776A CA 2822776 A CA2822776 A CA 2822776A CA 2822776 A1 CA2822776 A1 CA 2822776A1
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CA
Canada
Prior art keywords
c6alkyl
diazabicyclo
c3alkyl
heptan
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2822776A
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English (en)
French (fr)
Inventor
Robert Deziel
Silvana Leit
Patrick Beaulieu
Yves Andre Chantigny
John Mancuso
Pierre Tessier
Gideon Shapiro
Richard Chesworth
David Smil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Methylgene Inc
Forum Pharmaceuticals Inc
Original Assignee
Methylgene Inc
EnVivo Phamaceuticals Inc
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Filing date
Publication date
Application filed by Methylgene Inc, EnVivo Phamaceuticals Inc filed Critical Methylgene Inc
Publication of CA2822776A1 publication Critical patent/CA2822776A1/en
Abandoned legal-status Critical Current

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    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
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    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
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