CN101573333B - 组蛋白脱乙酰酶抑制剂 - Google Patents
组蛋白脱乙酰酶抑制剂 Download PDFInfo
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- CN101573333B CN101573333B CN2007800486643A CN200780048664A CN101573333B CN 101573333 B CN101573333 B CN 101573333B CN 2007800486643 A CN2007800486643 A CN 2007800486643A CN 200780048664 A CN200780048664 A CN 200780048664A CN 101573333 B CN101573333 B CN 101573333B
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- alkyl
- compound
- oxazepan
- pharmaceutically acceptable
- acceptable salt
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- 0 CC(*=C1)=CCC1=C* Chemical compound CC(*=C1)=CCC1=C* 0.000 description 33
- MGNZXYYWBUKAII-UHFFFAOYSA-N C1C=CC=CC1 Chemical compound C1C=CC=CC1 MGNZXYYWBUKAII-UHFFFAOYSA-N 0.000 description 2
- KAAITWOSDOCHEH-UHFFFAOYSA-N C(c1ccccc1)N1CC(C2)CNCC2C1 Chemical compound C(c1ccccc1)N1CC(C2)CNCC2C1 KAAITWOSDOCHEH-UHFFFAOYSA-N 0.000 description 1
- CQBPNUUZVJRSKK-UHFFFAOYSA-N C=Nc1n[o]c2ccccc12 Chemical compound C=Nc1n[o]c2ccccc12 CQBPNUUZVJRSKK-UHFFFAOYSA-N 0.000 description 1
- ROUYFJUVMYHXFJ-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1=O)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1=O)=O ROUYFJUVMYHXFJ-UHFFFAOYSA-N 0.000 description 1
- JFLCCGFMLBSXBA-UHFFFAOYSA-N CC(C)(C)OC(N1CC(C2)CN(Cc3ccccc3)CC2C1)=O Chemical compound CC(C)(C)OC(N1CC(C2)CN(Cc3ccccc3)CC2C1)=O JFLCCGFMLBSXBA-UHFFFAOYSA-N 0.000 description 1
- DJNHXPXSANTYBV-UHFFFAOYSA-N CCC(CC(CN)C1)CN1c1nccc(C(F)(F)F)c1 Chemical compound CCC(CC(CN)C1)CN1c1nccc(C(F)(F)F)c1 DJNHXPXSANTYBV-UHFFFAOYSA-N 0.000 description 1
- RVKFYIXQBZVPKN-UHFFFAOYSA-N CCOC(c(cc1)ccc1C1=Nc(cc(cc2)Cl)c2Nc2c1cccc2)=O Chemical compound CCOC(c(cc1)ccc1C1=Nc(cc(cc2)Cl)c2Nc2c1cccc2)=O RVKFYIXQBZVPKN-UHFFFAOYSA-N 0.000 description 1
- RWJWELIPVLENEW-UHFFFAOYSA-N CCOC(c(cc1)ccc1C1=Nc(cccc2)c2Oc2c1cccc2)=O Chemical compound CCOC(c(cc1)ccc1C1=Nc(cccc2)c2Oc2c1cccc2)=O RWJWELIPVLENEW-UHFFFAOYSA-N 0.000 description 1
- VVYBDFRQJHWOSV-UHFFFAOYSA-N CCOC(c(cc1)ccc1C1=Nc(cccc2)c2Oc2c1cccn2)=O Chemical compound CCOC(c(cc1)ccc1C1=Nc(cccc2)c2Oc2c1cccn2)=O VVYBDFRQJHWOSV-UHFFFAOYSA-N 0.000 description 1
- SZVILHVKVLEASQ-UHFFFAOYSA-N CCOC(c1ccc(C2Nc(cccc3)c3Oc3c2cccc3)cc1)=O Chemical compound CCOC(c1ccc(C2Nc(cccc3)c3Oc3c2cccc3)cc1)=O SZVILHVKVLEASQ-UHFFFAOYSA-N 0.000 description 1
- DGHBWVVOJLVMFF-UHFFFAOYSA-N COC(c1cc(F)ccc1O)=O Chemical compound COC(c1cc(F)ccc1O)=O DGHBWVVOJLVMFF-UHFFFAOYSA-N 0.000 description 1
- URLKBWYHVLBVBO-UHFFFAOYSA-N Cc1ccc(C)cc1 Chemical compound Cc1ccc(C)cc1 URLKBWYHVLBVBO-UHFFFAOYSA-N 0.000 description 1
- USQRYWGUCOATEU-UHFFFAOYSA-N ClC1=Nc(cccc2)c2Oc2c1cccc2 Chemical compound ClC1=Nc(cccc2)c2Oc2c1cccc2 USQRYWGUCOATEU-UHFFFAOYSA-N 0.000 description 1
- BMYGETSQNBGAJF-UHFFFAOYSA-N ClC1=Nc(cccc2)c2Oc2ncccc12 Chemical compound ClC1=Nc(cccc2)c2Oc2ncccc12 BMYGETSQNBGAJF-UHFFFAOYSA-N 0.000 description 1
- SCBOZTWAALXNEK-UHFFFAOYSA-N Clc(cc1)cc2c1Nc(cccc1)c1C(Cl)=N2 Chemical compound Clc(cc1)cc2c1Nc(cccc1)c1C(Cl)=N2 SCBOZTWAALXNEK-UHFFFAOYSA-N 0.000 description 1
- KTADHXXSCNRJRT-UHFFFAOYSA-N NC(c1c(CC2)cccc1)c1c2cccc1 Chemical compound NC(c1c(CC2)cccc1)c1c2cccc1 KTADHXXSCNRJRT-UHFFFAOYSA-N 0.000 description 1
- MKWSFGXGPHIVEI-UHFFFAOYSA-N ONC(c1ccc(C2Nc3ccccc3Oc3c2cccc3)cc1)=O Chemical compound ONC(c1ccc(C2Nc3ccccc3Oc3c2cccc3)cc1)=O MKWSFGXGPHIVEI-UHFFFAOYSA-N 0.000 description 1
- RJUKZCSTFWFPCQ-UHFFFAOYSA-N ONC(c1cnc(NC(c2c(CC3)cccc2)c2c3cccc2)nc1)=O Chemical compound ONC(c1cnc(NC(c2c(CC3)cccc2)c2c3cccc2)nc1)=O RJUKZCSTFWFPCQ-UHFFFAOYSA-N 0.000 description 1
- BGPHHUWYPVJKBY-UHFFFAOYSA-N Oc(cccc1)c1NC(c1cccnc1Cl)=O Chemical compound Oc(cccc1)c1NC(c1cccnc1Cl)=O BGPHHUWYPVJKBY-UHFFFAOYSA-N 0.000 description 1
- PWKNBLFSJAVFAB-UHFFFAOYSA-N [O-][N+](c1ccccc1F)=O Chemical compound [O-][N+](c1ccccc1F)=O PWKNBLFSJAVFAB-UHFFFAOYSA-N 0.000 description 1
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- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
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- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
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- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
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- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
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- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
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- C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
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- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
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- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
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- C07D267/18—[b, e]-condensed
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