TR200202164T2 - Matris metaloproteinaz inhibitörleri olarak kullanışlı olan hidroksamik asit bileşikleri. - Google Patents
Matris metaloproteinaz inhibitörleri olarak kullanışlı olan hidroksamik asit bileşikleri.Info
- Publication number
- TR200202164T2 TR200202164T2 TR2002/02164T TR200202164T TR200202164T2 TR 200202164 T2 TR200202164 T2 TR 200202164T2 TR 2002/02164 T TR2002/02164 T TR 2002/02164T TR 200202164 T TR200202164 T TR 200202164T TR 200202164 T2 TR200202164 T2 TR 200202164T2
- Authority
- TR
- Turkey
- Prior art keywords
- matrix metalloproteinase
- compounds
- formula
- acid compounds
- compounds useful
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 title 1
- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 title 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 208000025865 Ulcer Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 231100000397 ulcer Toxicity 0.000 abstract 2
- 206010002091 Anaesthesia Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010061217 Infestation Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 206010064996 Ulcerative keratitis Diseases 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000037005 anaesthesia Effects 0.000 abstract 1
- 208000007474 aortic aneurysm Diseases 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 210000002808 connective tissue Anatomy 0.000 abstract 1
- 201000007717 corneal ulcer Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
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- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Health & Medical Sciences (AREA)
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Abstract
Formül (I) Formül (I) bilesikleri hayvanlarda matris metaloproteinaz enzimlerinin inhibe edilmesinde yararlidir ve baglayici dokularin parçalanmasindan kaynaklanan hastaliklari önler ve tevdi eder. Ayrica bu tip bilesiklerin, bunlari içeren farmasötik bilesimlerin hazirlanmasi için yöntemler ve çoklu skleroz, ateroskleroz plak parçalanmasi, restenoz, aort anevrizmasi, kalp rahatsizligi, periodontal hastalik, kornea ülseri, yaniklar, decubital ülserler, kronik ülserler veya yaralar, kanser metastazi, tümör anjiojenezi, osteoporoz, römatoid veya osteoartrit, böbrek hastaligi, sol ventiküler büyüme veya dokularin lökosit istilasini bagli diger oto-bagisiklik veya iltihap hastaliklari dahil matris metaloproteinazlarin yer aldigi hastaliklarin tedavisinde kullanilmasi tarif edilmektedir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14966099P | 1999-08-18 | 1999-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200202164T2 true TR200202164T2 (tr) | 2002-11-21 |
Family
ID=22531286
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2002/00410T TR200200410T2 (tr) | 1999-08-18 | 2000-08-10 | Matris metaloproteinaz inhibitörleri olarak kullanışlı olan hidroksamik asit bileşikleri. |
| TR2002/02164T TR200202164T2 (tr) | 1999-08-18 | 2000-08-10 | Matris metaloproteinaz inhibitörleri olarak kullanışlı olan hidroksamik asit bileşikleri. |
| TR2002/02163T TR200202163T2 (tr) | 1999-08-18 | 2000-08-10 | Matris metaloproteinaz inhibitörleri olarak kullanışlı olan hidroksamik asit bileşikleri |
| TR2002/02211T TR200202211T2 (tr) | 1999-08-18 | 2000-08-10 | Matris metaloproteinaz inhibitörleri olarak kullanışlı olan hidroksamik asit bileşikleri |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2002/00410T TR200200410T2 (tr) | 1999-08-18 | 2000-08-10 | Matris metaloproteinaz inhibitörleri olarak kullanışlı olan hidroksamik asit bileşikleri. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2002/02163T TR200202163T2 (tr) | 1999-08-18 | 2000-08-10 | Matris metaloproteinaz inhibitörleri olarak kullanışlı olan hidroksamik asit bileşikleri |
| TR2002/02211T TR200202211T2 (tr) | 1999-08-18 | 2000-08-10 | Matris metaloproteinaz inhibitörleri olarak kullanışlı olan hidroksamik asit bileşikleri |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6677355B1 (tr) |
| EP (1) | EP1210326B1 (tr) |
| JP (1) | JP2003507362A (tr) |
| AR (1) | AR030160A1 (tr) |
| AT (1) | ATE260251T1 (tr) |
| AU (1) | AU6764400A (tr) |
| BR (1) | BR0013390A (tr) |
| CA (1) | CA2378332A1 (tr) |
| CO (1) | CO5300407A1 (tr) |
| DE (1) | DE60008548T2 (tr) |
| DK (1) | DK1210326T3 (tr) |
| ES (1) | ES2216938T3 (tr) |
| MX (1) | MXPA01013324A (tr) |
| PE (1) | PE20010486A1 (tr) |
| PT (1) | PT1210326E (tr) |
| TR (4) | TR200200410T2 (tr) |
| UY (1) | UY26302A1 (tr) |
| WO (1) | WO2001012592A2 (tr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8088737B2 (en) | 2003-04-04 | 2012-01-03 | Incyte Corporation | Compositions, methods and kits relating to Her-2 cleavage |
| GB0326546D0 (en) * | 2003-11-14 | 2003-12-17 | Amersham Plc | Inhibitor imaging agents |
| PE20060426A1 (es) * | 2004-06-02 | 2006-06-28 | Schering Corp | DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa |
| US7638513B2 (en) * | 2004-06-02 | 2009-12-29 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| US7488745B2 (en) * | 2004-07-16 | 2009-02-10 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| US7504424B2 (en) * | 2004-07-16 | 2009-03-17 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| AU2005275213A1 (en) | 2004-07-16 | 2006-02-23 | Schering Corporation | Hydantoin derivatives for the treatment of inflammatory disorders |
| PE20071240A1 (es) * | 2006-01-17 | 2008-01-14 | Schering Corp | Compuestos derivados de hidantoina para el tratamiento de trastornos inflamatorios |
| CL2007003108A1 (es) | 2006-10-28 | 2008-07-18 | Methylgene Inc Envivo Pharmace | Compuestos derivados de n-hidroxiamida sustituida con heterociclos, inhibidores de histona desacetilasa; composicion farmaceutica que comprende a dichos compuestos; y uso para tratar una enfermedad del grupo que consiste en enfermedad de huntington, |
| PE20090223A1 (es) * | 2007-05-04 | 2009-03-08 | Wyeth Corp | Compuestos triciclicos como inhibidores de metaloproteinasas matriciales |
| TW201024304A (en) | 2008-09-24 | 2010-07-01 | Schering Corp | Compounds for the treatment of inflammatory disorders |
| US8450355B2 (en) | 2008-09-24 | 2013-05-28 | Merck Sharp & Dohme Corp. | Compounds for the treatment of inflammatory diseases |
| EP2356111A1 (en) | 2008-11-10 | 2011-08-17 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| US8569336B2 (en) | 2008-11-10 | 2013-10-29 | Ling Tong | Compounds for the treatment of inflammatory disorders |
| BRPI0922938A2 (pt) * | 2008-12-05 | 2017-06-06 | Intermed Discovery Gmbh | inibidores de acúmulo de proteína hif-1 |
| BR112021006407A8 (pt) | 2018-10-04 | 2022-12-06 | Inst Nat Sante Rech Med | uso de inibidores do egfr para ceratodermas |
| CN113336670B (zh) * | 2021-05-28 | 2023-06-02 | 河南大学 | 一种轴手性芴胺-苯酚类衍生物及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6376506B1 (en) | 1997-01-23 | 2002-04-23 | Syntex (U.S.A.) Llc | Sulfamide-metalloprotease inhibitors |
| ZA98376B (en) * | 1997-01-23 | 1998-07-23 | Hoffmann La Roche | Sulfamide-metalloprotease inhibitors |
| PL334846A1 (en) | 1997-01-23 | 2000-03-27 | Hoffmann La Roche | Sulphamidic inhibitors of metaloproteases |
| HUP0002960A3 (en) * | 1997-08-08 | 2001-12-28 | Pfizer Prod Inc | Aryloxyarylsulfonylamino hydroxamic acid derivatives |
-
2000
- 2000-08-10 AU AU67644/00A patent/AU6764400A/en not_active Abandoned
- 2000-08-10 TR TR2002/00410T patent/TR200200410T2/tr unknown
- 2000-08-10 AT AT00955435T patent/ATE260251T1/de not_active IP Right Cessation
- 2000-08-10 MX MXPA01013324A patent/MXPA01013324A/es active IP Right Grant
- 2000-08-10 DE DE60008548T patent/DE60008548T2/de not_active Expired - Fee Related
- 2000-08-10 ES ES00955435T patent/ES2216938T3/es not_active Expired - Lifetime
- 2000-08-10 WO PCT/US2000/021884 patent/WO2001012592A2/en active IP Right Grant
- 2000-08-10 TR TR2002/02164T patent/TR200202164T2/tr unknown
- 2000-08-10 DK DK00955435T patent/DK1210326T3/da active
- 2000-08-10 TR TR2002/02163T patent/TR200202163T2/tr unknown
- 2000-08-10 JP JP2001516893A patent/JP2003507362A/ja active Pending
- 2000-08-10 TR TR2002/02211T patent/TR200202211T2/tr unknown
- 2000-08-10 PT PT00955435T patent/PT1210326E/pt unknown
- 2000-08-10 BR BR0013390-6A patent/BR0013390A/pt not_active IP Right Cessation
- 2000-08-10 CA CA002378332A patent/CA2378332A1/en not_active Abandoned
- 2000-08-10 US US10/049,544 patent/US6677355B1/en not_active Expired - Fee Related
- 2000-08-10 EP EP00955435A patent/EP1210326B1/en not_active Expired - Lifetime
- 2000-08-17 PE PE2000000833A patent/PE20010486A1/es not_active Application Discontinuation
- 2000-08-17 UY UY26302A patent/UY26302A1/es not_active Application Discontinuation
- 2000-08-17 CO CO00061938A patent/CO5300407A1/es not_active Application Discontinuation
- 2000-08-17 AR ARP000104249A patent/AR030160A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20010486A1 (es) | 2001-04-20 |
| EP1210326A2 (en) | 2002-06-05 |
| TR200202211T2 (tr) | 2002-11-21 |
| US6677355B1 (en) | 2004-01-13 |
| TR200200410T2 (tr) | 2002-06-21 |
| WO2001012592A2 (en) | 2001-02-22 |
| AU6764400A (en) | 2001-03-13 |
| PT1210326E (pt) | 2004-07-30 |
| MXPA01013324A (es) | 2002-07-02 |
| DE60008548D1 (de) | 2004-04-01 |
| CA2378332A1 (en) | 2001-02-22 |
| DE60008548T2 (de) | 2004-08-05 |
| CO5300407A1 (es) | 2003-07-31 |
| DK1210326T3 (da) | 2004-06-21 |
| EP1210326B1 (en) | 2004-02-25 |
| BR0013390A (pt) | 2002-04-30 |
| JP2003507362A (ja) | 2003-02-25 |
| WO2001012592A3 (en) | 2001-07-05 |
| ES2216938T3 (es) | 2004-11-01 |
| ATE260251T1 (de) | 2004-03-15 |
| TR200202163T2 (tr) | 2002-11-21 |
| AR030160A1 (es) | 2003-08-13 |
| UY26302A1 (es) | 2000-10-31 |
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