AR037766A1 - Compuestos triaromaticos analogos de la vitamina d, su utilizacion, composiciones farmaceuticas y cosmeticas que los comprenden y utilizacion cosmetica de dichas composiciones cosmeticas - Google Patents

Compuestos triaromaticos analogos de la vitamina d, su utilizacion, composiciones farmaceuticas y cosmeticas que los comprenden y utilizacion cosmetica de dichas composiciones cosmeticas

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Publication number
AR037766A1
AR037766A1 ARP020104771A ARP020104771A AR037766A1 AR 037766 A1 AR037766 A1 AR 037766A1 AR P020104771 A ARP020104771 A AR P020104771A AR P020104771 A ARP020104771 A AR P020104771A AR 037766 A1 AR037766 A1 AR 037766A1
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AR
Argentina
Prior art keywords
radical
compounds
cosmetic compositions
cosmetic
formula
Prior art date
Application number
ARP020104771A
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English (en)
Inventor
Jean-Michel Bernardon
Thibaud Biadatti
Original Assignee
Galderma Res & Dev
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Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Publication of AR037766A1 publication Critical patent/AR037766A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/26—Polyhydroxylic alcohols containing only six-membered aromatic rings as cyclic part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)

Abstract

Compuestos triaromáticos análogos de la vitamina D, los cuales responden a la fórmula general (1), en la cual: X-Y representa un enlace elegido entre las estructuras siguientes: -CH2-CH2-, -CH2O-, -O-CH2, -CH2N(R4)-; R4 tiene las significaciones que se dan a continuación, R1 representa un radical metilo o un radical etilo; R2 representa un radical etilo, un radical propilo o un radical isopropilo; R3 representa un radical etilo o un radical trifluorometilo; R4 representa un átomo de H, un radical metilo, un radical etilo o un radical propilo, y los isómeros ópticos y geométricos de dichos compuestos de fórmula (1) así como también sus sales. Su utilización, composiciones farmacéuticas y cosméticas que los comprenden, utilización de las composiciones farmacéuticas y utilización cosmética de las composiciones cosméticas. Los compuestos de fórmula (1) son útiles en medicina humana o veterinaria o incluso en composiciones cosméticas. Los compuestos de fórmula (1) tienen una marcada actividad en el campo de la proliferación y de la diferenciación celular y encuentran aplicaciones más particularmente, en el tratamiento tópico y sistémico de las afecciones dermatológicas (u otras) relacionadas con un desorden de la queratinización, de las afecciones de componente inflamatorio y/o inmunoalérgico y de la hiperproliferación de los tejidos de origen actodérmico (piel, epitelio...), ya sea benigna o maligna. Esos compuestos también son particularmente útiles para tratar los trastornos de la cicatrización, para la higiene corporal o capilar, y para prevenir y/o tratar el envejecimiento cutáneo fotoinducido o cronológico.
ARP020104771A 2001-12-10 2002-12-10 Compuestos triaromaticos analogos de la vitamina d, su utilizacion, composiciones farmaceuticas y cosmeticas que los comprenden y utilizacion cosmetica de dichas composiciones cosmeticas AR037766A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0115924A FR2833258B1 (fr) 2001-12-10 2001-12-10 Analogues de la vitamine d

Publications (1)

Publication Number Publication Date
AR037766A1 true AR037766A1 (es) 2004-12-01

Family

ID=8870284

Family Applications (1)

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ARP020104771A AR037766A1 (es) 2001-12-10 2002-12-10 Compuestos triaromaticos analogos de la vitamina d, su utilizacion, composiciones farmaceuticas y cosmeticas que los comprenden y utilizacion cosmetica de dichas composiciones cosmeticas

Country Status (22)

Country Link
EP (1) EP1456160B1 (es)
JP (2) JP4652687B2 (es)
KR (1) KR100939470B1 (es)
CN (1) CN100376530C (es)
AR (1) AR037766A1 (es)
AT (1) ATE455748T1 (es)
AU (1) AU2002366578B2 (es)
BR (1) BR0215124A (es)
CA (1) CA2468892C (es)
CY (1) CY1110600T1 (es)
DE (1) DE60235195D1 (es)
DK (1) DK1456160T3 (es)
ES (1) ES2337990T3 (es)
FR (1) FR2833258B1 (es)
HU (1) HUP0402599A2 (es)
MX (1) MXPA04005552A (es)
PL (1) PL205790B1 (es)
PT (1) PT1456160E (es)
RU (1) RU2301794C2 (es)
SI (1) SI1456160T1 (es)
WO (1) WO2003050067A2 (es)
ZA (1) ZA200403845B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050148557A1 (en) * 2003-07-29 2005-07-07 Jin Tian Use of Vitamin Ds to treat kidney disease
AU2004294728A1 (en) 2003-11-21 2005-06-16 Galderma Research & Development, S.N.C. Sprayable composition for the administration of vitamin D derivatives
FR2863613B1 (fr) * 2003-12-15 2006-01-20 Galderma Res & Dev Nouveaux derives d'acides phenyl-boronique et leurs procedes de preparation.
FR2864083B1 (fr) 2003-12-18 2007-04-13 Galderma Res & Dev Nouveaux derives d'acides phenyl-boroniques et leurs procedes de preparation.
DE602005021484D1 (de) 2004-05-14 2010-07-08 Galderma Res & Dev Neuartige 7,7-disubstituierte derivate von (5h,9h)-6,8-dioxabenzocyclohepten, herstellungsverfahren dafür und ihre verwendung in der synthese von nicht-steroidalen vitamin-d-analogen
FR2870238B1 (fr) * 2004-05-14 2008-07-04 Galderma Res & Dev Nouveaux derives 7,7-disubstitues du (5h,9h)-6,8- dioxabenzocycloheptene, leur preparation et leur utilisation dans la synthese d'analogues non steroidiens de la vitamine d
FR2878245B1 (fr) * 2004-11-19 2007-02-16 Galderma Res & Dev Nouveau procede de preparation du 3-(5'-(3,4-bis hydroxymethyl-benzyloxy)-2'-ethyl-2-propyl-biphenyl-4-yl)- penta-3ol
FR2879601B1 (fr) * 2004-12-22 2007-01-19 Galderma Res & Dev Nouveaux composes derives d'acide phenyl-boronique et leur procede de preparation
FR2885527B1 (fr) * 2005-05-16 2007-06-29 Galderma Res & Dev Composition pharmaceutique comprenant un onguent oleagineux et de la vitamine d ou ses derives a l'etat solubilise
US10570075B2 (en) * 2015-12-18 2020-02-25 Dsm Ip Assets B.V. Compounds
US10336675B2 (en) * 2015-12-18 2019-07-02 Dsm Ip Assets B.V. Biaromatic vitamin D analogs
CN109453180A (zh) * 2018-11-15 2019-03-12 广州南峰生物科技有限公司 生物活性维生素d衍生物或类似物的新用途
WO2022269768A1 (ja) * 2021-06-22 2022-12-29 学校法人神奈川大学 ビタミンｄ３様化合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2801305B1 (fr) * 1999-11-24 2002-12-06 Galderma Res & Dev Analogues de la vitamine d

Also Published As

Publication number Publication date
WO2003050067A2 (fr) 2003-06-19
FR2833258A1 (fr) 2003-06-13
DE60235195D1 (de) 2010-03-11
PL205790B1 (pl) 2010-05-31
CA2468892C (fr) 2013-02-12
CN1620414A (zh) 2005-05-25
KR20040088477A (ko) 2004-10-16
ZA200403845B (en) 2005-03-30
PT1456160E (pt) 2010-02-23
PL369899A1 (en) 2005-05-02
JP4652687B2 (ja) 2011-03-16
JP2011037859A (ja) 2011-02-24
CY1110600T1 (el) 2015-04-29
MXPA04005552A (es) 2004-09-10
FR2833258B1 (fr) 2004-08-27
WO2003050067A3 (fr) 2004-03-04
KR100939470B1 (ko) 2010-01-29
ATE455748T1 (de) 2010-02-15
ES2337990T3 (es) 2010-05-03
EP1456160B1 (fr) 2010-01-20
CN100376530C (zh) 2008-03-26
DK1456160T3 (da) 2010-03-22
RU2004121174A (ru) 2006-01-10
RU2301794C2 (ru) 2007-06-27
JP2005511731A (ja) 2005-04-28
AU2002366578A1 (en) 2003-06-23
CA2468892A1 (fr) 2003-06-19
AU2002366578B2 (en) 2008-05-08
SI1456160T1 (sl) 2010-04-30
BR0215124A (pt) 2004-11-03
EP1456160A2 (fr) 2004-09-15
HUP0402599A2 (hu) 2005-12-28

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