CA2739615C - Fgf21 mutants comprising polyethylene glycol and uses thereof - Google Patents
Fgf21 mutants comprising polyethylene glycol and uses thereof Download PDFInfo
- Publication number
- CA2739615C CA2739615C CA2739615A CA2739615A CA2739615C CA 2739615 C CA2739615 C CA 2739615C CA 2739615 A CA2739615 A CA 2739615A CA 2739615 A CA2739615 A CA 2739615A CA 2739615 C CA2739615 C CA 2739615C
- Authority
- CA
- Canada
- Prior art keywords
- polypeptide
- fgf21
- polymers
- peg
- polyethylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19576108P | 2008-10-10 | 2008-10-10 | |
| US61/195,761 | 2008-10-10 | ||
| PCT/US2009/060045 WO2010042747A2 (en) | 2008-10-10 | 2009-10-08 | Fgf21 mutants and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2739615A1 CA2739615A1 (en) | 2010-04-15 |
| CA2739615C true CA2739615C (en) | 2017-12-05 |
Family
ID=41571715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2739615A Active CA2739615C (en) | 2008-10-10 | 2009-10-08 | Fgf21 mutants comprising polyethylene glycol and uses thereof |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9279013B2 (OSRAM) |
| EP (1) | EP2358749B1 (OSRAM) |
| JP (2) | JP5878757B2 (OSRAM) |
| KR (1) | KR101651703B1 (OSRAM) |
| CN (1) | CN102625811B (OSRAM) |
| AU (1) | AU2009302318A1 (OSRAM) |
| CA (1) | CA2739615C (OSRAM) |
| CL (1) | CL2011000792A1 (OSRAM) |
| CO (1) | CO6362020A2 (OSRAM) |
| CR (1) | CR20110245A (OSRAM) |
| EA (2) | EA032727B1 (OSRAM) |
| IL (1) | IL212061A0 (OSRAM) |
| MA (1) | MA32771B1 (OSRAM) |
| MX (1) | MX341149B (OSRAM) |
| NZ (1) | NZ592009A (OSRAM) |
| PE (1) | PE20120021A1 (OSRAM) |
| SG (1) | SG195542A1 (OSRAM) |
| TN (1) | TN2011000161A1 (OSRAM) |
| UA (1) | UA105016C2 (OSRAM) |
| WO (1) | WO2010042747A2 (OSRAM) |
| ZA (1) | ZA201103356B (OSRAM) |
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| US8981061B2 (en) | 2001-03-20 | 2015-03-17 | Novo Nordisk A/S | Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof |
| GB0426146D0 (en) | 2004-11-29 | 2004-12-29 | Bioxell Spa | Therapeutic peptides and method |
| KR20140012199A (ko) | 2007-03-30 | 2014-01-29 | 암브룩스, 인코포레이티드 | 변형된 ｆｇｆ-21 폴리펩티드 및 그 용도 |
| US8420088B2 (en) | 2008-01-28 | 2013-04-16 | Novartis Ag | Methods and compositions using FGF23 fusion polypeptides |
| TW200936156A (en) | 2008-01-28 | 2009-09-01 | Novartis Ag | Methods and compositions using Klotho-FGF fusion polypeptides |
| JOP20190083A1 (ar) * | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| EA032727B1 (ru) * | 2008-10-10 | 2019-07-31 | Амген Инк. | Мутантный резистентный к протеолизу полипептид fgf21 и его применение |
| JP5599822B2 (ja) | 2009-01-23 | 2014-10-01 | ノヴォ ノルディスク アー／エス | アルブミンバインダーａ−ｂ−ｃ−ｄ−ｅ−を有するｆｇｆ２１誘導体及びそれらの使用 |
| US20110195077A1 (en) * | 2010-01-29 | 2011-08-11 | Novartis Ag | Methods and compositions using fgf23 fusion ppolypeptides |
| JP2013533227A (ja) * | 2010-06-08 | 2013-08-22 | ノヴォ ノルディスク アー／エス | Ｆｇｆ２１類似体および誘導体 |
| CN103124562A (zh) * | 2010-06-08 | 2013-05-29 | 诺沃—诺迪斯克有限公司 | Fgf21的类似物和衍生物 |
| US9655974B2 (en) | 2010-07-20 | 2017-05-23 | Novo Nordisk A/S | N-terminal modified FGF21 compounds |
| EP2609081A1 (en) | 2010-08-23 | 2013-07-03 | Amgen Inc. | Sulfonylpiperazine derivatives that interact with glucokinase regulatory protein for the treatment of diabetes |
| US9023791B2 (en) * | 2010-11-19 | 2015-05-05 | Novartis Ag | Fibroblast growth factor 21 mutations |
| JP2014510145A (ja) | 2011-04-05 | 2014-04-24 | アムジエン・インコーポレーテツド | グルコキナーゼ調節タンパク質と相互作用する糖尿病治療用ベンゾジオキセピンおよびベンゾジオキシン化合物 |
| LT2710035T (lt) | 2011-05-16 | 2017-06-26 | F. Hoffmann-La Roche Ag | Fgfr1 agonistai ir jų naudojimo būdai |
| CN103649127B (zh) | 2011-07-01 | 2021-03-19 | 恩格姆生物制药公司 | 用于代谢病症和疾病治疗的组合物、应用和方法 |
| MX2014002260A (es) * | 2011-08-31 | 2014-08-18 | Amgen Inc | Factor de crecimiento de fibroblasto 21 para usar en el tratamiento de diabetes tipo 1. |
| UY34347A (es) | 2011-09-26 | 2013-04-30 | Novartis Ag | Proteínas de función dual para tratar trastornos metabólicos |
| US9550830B2 (en) | 2012-02-15 | 2017-01-24 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
| SMT201700488T1 (it) | 2012-02-15 | 2017-11-15 | Novo Nordisk As | Anticorpi che legano e bloccano il recettore d'innesco espresso sulle cellule mieloidi-1 (trem-1) |
| SI2814842T1 (sl) | 2012-02-15 | 2018-10-30 | Novo Nordisk A/S | Protitelesa, ki vežejo peptidoglikal prepoznan protein 1 |
| WO2013123444A1 (en) | 2012-02-17 | 2013-08-22 | Amgen Inc. | Sulfonyl compounds that interact with glucokinase regulatory protein |
| WO2013173382A1 (en) | 2012-05-15 | 2013-11-21 | Amgen Inc. | Benzothiophene sulfonamides and other compounds that interact with glucokinase regulatory protein |
| TWI513705B (zh) | 2012-06-11 | 2015-12-21 | Lilly Co Eli | 纖維母細胞生長因子２１蛋白質 |
| WO2013188182A1 (en) | 2012-06-11 | 2013-12-19 | Eli Lilly And Company | Fibroblast growth factor 21 variants |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| WO2014085365A2 (en) | 2012-11-28 | 2014-06-05 | Ngm Biopharmaceuticals, Inc. | Compositions and methods for treatment of metabolic disorders and diseases |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| KR102607543B1 (ko) | 2012-12-27 | 2023-11-30 | 엔지엠 바이오파마슈티컬스, 아이엔씨. | 담즙산 항상성의 조절 및 담즙산 질환 및 질병의 치료 방법 |
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| WO2015103782A1 (en) * | 2014-01-13 | 2015-07-16 | Wenzhou Medical College Biological Pharmaceuticals And Nature Products Ltd., Co | Fgf21 mutant and conjugate thereof |
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| US11638745B2 (en) | 2015-05-20 | 2023-05-02 | University of Pittsburgh—Of the Commonwealth Cvctom of Hierher Education | Method to improve neurologic outcomes in temperature managed patients |
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| UA105016C2 (uk) | 2014-04-10 |
| KR20110093790A (ko) | 2011-08-18 |
| KR101651703B1 (ko) | 2016-08-26 |
| ZA201103356B (en) | 2012-02-29 |
| EA201990619A1 (ru) | 2019-07-31 |
| PE20120021A1 (es) | 2012-02-10 |
| TN2011000161A1 (en) | 2012-12-17 |
| CR20110245A (es) | 2011-08-29 |
| IL212061A0 (en) | 2011-06-30 |
| US20110195895A1 (en) | 2011-08-11 |
| EA201100516A1 (ru) | 2011-10-31 |
| CL2011000792A1 (es) | 2011-08-26 |
| MX341149B (es) | 2016-08-09 |
| EA032727B1 (ru) | 2019-07-31 |
| MA32771B1 (fr) | 2011-11-01 |
| CO6362020A2 (es) | 2012-01-20 |
| CN102625811B (zh) | 2016-09-21 |
| US9279013B2 (en) | 2016-03-08 |
| JP2015165801A (ja) | 2015-09-24 |
| NZ592009A (en) | 2012-11-30 |
| AU2009302318A1 (en) | 2010-04-15 |
| JP2012504965A (ja) | 2012-03-01 |
| CA2739615A1 (en) | 2010-04-15 |
| EP2358749B1 (en) | 2018-07-18 |
| MX2011003788A (es) | 2011-08-03 |
| SG195542A1 (en) | 2013-12-30 |
| US20160244497A1 (en) | 2016-08-25 |
| WO2010042747A3 (en) | 2010-06-17 |
| JP5878757B2 (ja) | 2016-03-08 |
| CN102625811A (zh) | 2012-08-01 |
| WO2010042747A2 (en) | 2010-04-15 |
| EP2358749A2 (en) | 2011-08-24 |
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