MA32771B1 - Mutants fgf21 et leurs utilisations - Google Patents
Mutants fgf21 et leurs utilisationsInfo
- Publication number
- MA32771B1 MA32771B1 MA33815A MA33815A MA32771B1 MA 32771 B1 MA32771 B1 MA 32771B1 MA 33815 A MA33815 A MA 33815A MA 33815 A MA33815 A MA 33815A MA 32771 B1 MA32771 B1 MA 32771B1
- Authority
- MA
- Morocco
- Prior art keywords
- polypeptides
- fgf21 mutants
- mutant fgf21
- fgf21 polypeptides
- treatment
- Prior art date
Links
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 title abstract 4
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 title abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des molécules d'acides nucléiques codant pour des polypeptides FGF21 mutants, des polypeptides FGF21 mutants, des compositions pharmaceutiques comprenant des polypeptides FGF21 mutants et des procédés de traitement de troubles métaboliques au moyen desdits acides nucléiques, polypeptides ou compositions pharmaceutiques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19576108P | 2008-10-10 | 2008-10-10 | |
PCT/US2009/060045 WO2010042747A2 (fr) | 2008-10-10 | 2009-10-08 | Mutants fgf21 et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32771B1 true MA32771B1 (fr) | 2011-11-01 |
Family
ID=41571715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33815A MA32771B1 (fr) | 2008-10-10 | 2011-05-05 | Mutants fgf21 et leurs utilisations |
Country Status (21)
Country | Link |
---|---|
US (2) | US9279013B2 (fr) |
EP (1) | EP2358749B1 (fr) |
JP (2) | JP5878757B2 (fr) |
KR (1) | KR101651703B1 (fr) |
CN (1) | CN102625811B (fr) |
AU (1) | AU2009302318A1 (fr) |
CA (1) | CA2739615C (fr) |
CL (1) | CL2011000792A1 (fr) |
CO (1) | CO6362020A2 (fr) |
CR (1) | CR20110245A (fr) |
EA (2) | EA032727B1 (fr) |
IL (1) | IL212061A0 (fr) |
MA (1) | MA32771B1 (fr) |
MX (1) | MX341149B (fr) |
NZ (1) | NZ592009A (fr) |
PE (1) | PE20120021A1 (fr) |
SG (1) | SG195542A1 (fr) |
TN (1) | TN2011000161A1 (fr) |
UA (1) | UA105016C2 (fr) |
WO (1) | WO2010042747A2 (fr) |
ZA (1) | ZA201103356B (fr) |
Families Citing this family (68)
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GB0426146D0 (en) | 2004-11-29 | 2004-12-29 | Bioxell Spa | Therapeutic peptides and method |
CN104163864B (zh) | 2007-03-30 | 2017-08-01 | Ambrx公司 | 经修饰fgf‑21多肽和其用途 |
TW200936156A (en) | 2008-01-28 | 2009-09-01 | Novartis Ag | Methods and compositions using Klotho-FGF fusion polypeptides |
US8420088B2 (en) | 2008-01-28 | 2013-04-16 | Novartis Ag | Methods and compositions using FGF23 fusion polypeptides |
JOP20190083A1 (ar) * | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
PE20120021A1 (es) * | 2008-10-10 | 2012-02-10 | Amgen Inc | Mutantes fgf21 |
AU2010207721B2 (en) | 2009-01-23 | 2015-03-26 | Novo Nordisk A/S | FGF21 derivatives with albumin binder A-B-C-D-E- and their use |
WO2011154349A2 (fr) * | 2010-06-08 | 2011-12-15 | Novo Nordisk A/S | Analogues et dérivés du fgf21 |
US20110195077A1 (en) * | 2010-01-29 | 2011-08-11 | Novartis Ag | Methods and compositions using fgf23 fusion ppolypeptides |
CN103124562A (zh) * | 2010-06-08 | 2013-05-29 | 诺沃—诺迪斯克有限公司 | Fgf21的类似物和衍生物 |
EP2595647A1 (fr) | 2010-07-20 | 2013-05-29 | Novo Nordisk A/S | Composés fgf21 n-terminaux modifiés |
EP2609081A1 (fr) | 2010-08-23 | 2013-07-03 | Amgen Inc. | Dérivés de sulfonylpipérazine qui interagissent avec la protéine régulatrice de la glucokinase pour le traitement du diabète |
US9023791B2 (en) * | 2010-11-19 | 2015-05-05 | Novartis Ag | Fibroblast growth factor 21 mutations |
EP2694491A1 (fr) | 2011-04-05 | 2014-02-12 | Amgen Inc. | Benzodioxépine et composés de benzodioxine qui interagissent avec la protéine régulatrice de la glucokinase pour le traitement du diabète |
EA030462B1 (ru) | 2011-05-16 | 2018-08-31 | Дженентек, Инк. | Агонисты fgfr1 и способы их применения |
US8951966B2 (en) | 2011-07-01 | 2015-02-10 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides, and uses and methods thereof for treatment of metabolic disorders and diseases |
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US9458214B2 (en) | 2011-09-26 | 2016-10-04 | Novartis Ag | Dual function fibroblast growth factor 21 proteins |
EP3196214B1 (fr) | 2012-02-15 | 2019-07-31 | Novo Nordisk A/S | Anticorps liant et bloquant un récepteur de déclenchement exprimé sur des cellules-1 myéloïdes (trem-1) |
US9550830B2 (en) | 2012-02-15 | 2017-01-24 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
EP2814842B1 (fr) | 2012-02-15 | 2018-08-22 | Novo Nordisk A/S | Anticorps liant peptidoglycane reconnaissance protéine 1 |
WO2013123444A1 (fr) | 2012-02-17 | 2013-08-22 | Amgen Inc. | Composés de sulfonyle qui interagissent avec la protéine régulatrice de la glucokinase |
WO2013173382A1 (fr) | 2012-05-15 | 2013-11-21 | Amgen Inc. | Benzothiophène sulfonamides et autres composés qui interagissent avec une protéine régulatrice de la glucokinase |
TWI513705B (zh) | 2012-06-11 | 2015-12-21 | Lilly Co Eli | 纖維母細胞生長因子21蛋白質 |
CA2871656A1 (fr) | 2012-06-11 | 2013-12-19 | Eli Lilly And Company | Variants du facteur de croissance des fibroblastes 21 |
US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
ES2828505T3 (es) | 2012-11-28 | 2021-05-26 | Ngm Biopharmaceuticals Inc | Composiciones y métodos para el tratamiento de trastornos y enfermedades metabólicos |
IL292303A (en) | 2012-12-27 | 2022-06-01 | Ngm Biopharmaceuticals Inc | Methods of regulating bile acid homeostasis and treatment of bile acid disorders and diseases |
US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
WO2014149699A1 (fr) | 2013-03-15 | 2014-09-25 | Eli Lilly And Company | Protéine bifonctionnelle |
EP3062881B1 (fr) | 2013-10-28 | 2019-10-02 | NGM Biopharmaceuticals, Inc. | Modèles de cancer et procédés associés |
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JP6837840B2 (ja) | 2014-01-24 | 2021-03-10 | エヌジーエム バイオファーマシューティカルス,インコーポレーテッド | 結合タンパク質及びその使用方法 |
US20170065678A1 (en) | 2014-03-11 | 2017-03-09 | Novartis Ag | Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling |
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EP3155005A4 (fr) | 2014-06-16 | 2018-07-11 | NGM Biopharmaceuticals, Inc. | Procédés et utilisations pour la modulation de l'homéostasie de l'acide biliaire et le traitement de troubles et maladies de l'acide biliaire |
KR102465120B1 (ko) | 2014-07-17 | 2022-11-10 | 노보 노르디스크 에이/에스 | 점도를 감소시키기 위한 trem-1 항체의 부위 지정 돌연변이유발 |
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WO2016179140A1 (fr) * | 2015-05-05 | 2016-11-10 | The Regents Of The University Of California | Polymères à facteur de croissance des fibroblastes, procédés de fabrication associés et leurs applications |
US11638745B2 (en) | 2015-05-20 | 2023-05-02 | University of Pittsburgh—Of the Commonwealth Cvctom of Hierher Education | Method to improve neurologic outcomes in temperature managed patients |
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KR102668200B1 (ko) * | 2015-10-28 | 2024-05-23 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
JP6728352B2 (ja) | 2015-11-09 | 2020-07-22 | エヌジーエム バイオファーマシューティカルス,インコーポレーテッド | 胆汁酸に関係した障害の治療方法 |
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US11123438B2 (en) | 2016-08-19 | 2021-09-21 | Ampsource Biopharma Shanghai Inc. | Linker peptide for constructing fusion protein |
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- 2009-10-08 EP EP09748878.7A patent/EP2358749B1/fr active Active
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Also Published As
Publication number | Publication date |
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CA2739615A1 (fr) | 2010-04-15 |
MX341149B (es) | 2016-08-09 |
CO6362020A2 (es) | 2012-01-20 |
EA201990619A1 (ru) | 2019-07-31 |
AU2009302318A1 (en) | 2010-04-15 |
ZA201103356B (en) | 2012-02-29 |
CR20110245A (es) | 2011-08-29 |
EA032727B1 (ru) | 2019-07-31 |
CN102625811B (zh) | 2016-09-21 |
PE20120021A1 (es) | 2012-02-10 |
US20160244497A1 (en) | 2016-08-25 |
JP2012504965A (ja) | 2012-03-01 |
NZ592009A (en) | 2012-11-30 |
CL2011000792A1 (es) | 2011-08-26 |
WO2010042747A2 (fr) | 2010-04-15 |
UA105016C2 (uk) | 2014-04-10 |
US9279013B2 (en) | 2016-03-08 |
WO2010042747A3 (fr) | 2010-06-17 |
EA201100516A1 (ru) | 2011-10-31 |
TN2011000161A1 (en) | 2012-12-17 |
KR101651703B1 (ko) | 2016-08-26 |
CN102625811A (zh) | 2012-08-01 |
EP2358749B1 (fr) | 2018-07-18 |
US20110195895A1 (en) | 2011-08-11 |
KR20110093790A (ko) | 2011-08-18 |
CA2739615C (fr) | 2017-12-05 |
JP5878757B2 (ja) | 2016-03-08 |
JP2015165801A (ja) | 2015-09-24 |
MX2011003788A (es) | 2011-08-03 |
EP2358749A2 (fr) | 2011-08-24 |
SG195542A1 (en) | 2013-12-30 |
IL212061A0 (en) | 2011-06-30 |
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